Publication List
List publications.
Fields
id (integer)
Primary key.
name (string)
Name of doctoral school.
emails (string[])
Contact emails.
Expansions
To activate relation expansion add the desired fields as a comma separated
list to the expand query parameter like this:
?expand=<field>,<field>,<field>,...
The following relational fields can be expanded:
personscategorydocumentorganization_authorship
Filters
To filter for exact value matches:
?<fieldname>=<value>
Possible exact filters:
yearcategorydocumentpersons
For advanced filtering use lookups:
?<fieldname>__<lookup>=<value>
All fields with advanced lookups can also be used for exact value matches as described above.
Possible advanced lookups:
year:gt,gte,lt,ltesci:iexact,contains,icontains,startswith,istartswithpubmed:iexact,contains,icontains,startswith,istartswithdoi:iexact,contains,icontains,startswith,istartswithpmc:iexact,contains,icontains,startswith,istartswithorganization_authorship:inimpact:isnull,gt,gte,lt,lteimported:isnull,gt,gte,lt,lte,date
GET /v1/research/publication/?format=api&offset=152600&ordering=impactfactor
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(ISBN: 1509-3492 )", "category": 2, "document_type": 9, "sci": null, "pubmed": null, "doi": null, "pmc": null, "organizations": [ "210080-14050", "210080-14052" ], "persons": [ "210080-100991", "210080-50696", "210080-53237", "210080-61131", "210080-61927", "210080-87214" ], "imported": "2024-06-19T16:38:40+02:00", "journal": null, "issn": "2084-4336", "collection_publisher": null, "collection_title": null, "edition": null, "university": null, "country": null, "case_report": false, "impactfactor": null, "impactfactor_year": null, "impactfactor_norm": null, "impactfactor_norm_year": null, "impactfactor_norm_category": null, "impactfactor_norm_super": null, "impactfactor_norm_super_year": null, "impactfactor_norm_super_category": null, "citations": null, "conference_name": true, "conference_place": true, "conference_international": true, "scientific_event": true, "invited_lecture": false, "keynote_speaker": false, "selected_presentation": true, "biobank_use": false, "bmf_use": false, "zmf_use": false, "local_affiliation": true }, { "id": 210079, "title": "Solitary and oligometastatic bone metastases in renal cell carcinoma patients are associated with favourable survival, modification of the OPTIModel.", "abstract": null, "authors": [ "van Broekhoven, D", "Dootjes, L", "van der Wal, G", "Willeumier, J", "van der Zwaal, P", "Leithner, A", "Fiocco, M", "van der Linden, Y." ], "year": 2024, "source": "Ortopedia Traumatologia Rehabilitacja;. 2024; 26(Supp 1):105--36th Annual Meeting of the European Musculo-Skeletal Oncology Society; JUN 12-14, 2024; Szczecin, POLAND. 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(ISBN: 1509-3492 )", "category": 2, "document_type": 9, "sci": null, "pubmed": null, "doi": null, "pmc": null, "organizations": [ "210078-14052" ], "persons": [ "210078-53237" ], "imported": "2024-06-19T16:34:36+02:00", "journal": null, "issn": "2084-4336", "collection_publisher": null, "collection_title": null, "edition": null, "university": null, "country": null, "case_report": false, "impactfactor": null, "impactfactor_year": null, "impactfactor_norm": null, "impactfactor_norm_year": null, "impactfactor_norm_category": null, "impactfactor_norm_super": null, "impactfactor_norm_super_year": null, "impactfactor_norm_super_category": null, "citations": null, "conference_name": true, "conference_place": true, "conference_international": true, "scientific_event": true, "invited_lecture": true, "keynote_speaker": false, "selected_presentation": false, "biobank_use": false, "bmf_use": false, "zmf_use": false, "local_affiliation": true }, { "id": 210077, "title": "Results of a questionnaire by the Euro Ewing Concsortium Surgical Subgroup regarding SOPs for the surgical treatment of Ewing Sarcoma in different centers across Europe.", "abstract": null, "authors": [ "Funovics, PT", "Andreou, D", "Bronowicki, K", "Gracia, I", "van der Heijden, L", "Petersen, MM", "Schubert, T", "Zaikova, O", "Hardes, J", "" ], "year": 2024, "source": "Ortopedia Traumatologia Rehabilitacja;. 2024; 26(Supp 1):73--36th Annual Meeting of the European Musculo-Skeletal Oncology Society; JUN 12-14, 2024; Szczecin, POLAND. (ISBN: 1509-3492 )", "category": 2, "document_type": 9, "sci": null, "pubmed": null, "doi": null, "pmc": null, "organizations": [ "210077-14052" ], "persons": [ "210077-115078" ], "imported": "2024-06-19T16:33:43+02:00", "journal": null, "issn": "2084-4336", "collection_publisher": null, "collection_title": null, "edition": null, "university": null, "country": null, "case_report": false, "impactfactor": null, "impactfactor_year": null, "impactfactor_norm": null, "impactfactor_norm_year": null, "impactfactor_norm_category": null, "impactfactor_norm_super": null, "impactfactor_norm_super_year": null, "impactfactor_norm_super_category": null, "citations": null, "conference_name": true, "conference_place": true, "conference_international": true, "scientific_event": true, "invited_lecture": false, "keynote_speaker": false, "selected_presentation": true, "biobank_use": false, "bmf_use": false, "zmf_use": false, "local_affiliation": true }, { "id": 210076, "title": "Perioperative strategies may influence long-term survival: a multicentric survey on patients treated for osteosarcoma.", "abstract": null, "authors": [ "Ratto, N", "Andreou, D", "Hardes, J", "Raux, S", "van de sande, M", "Boffano, M", "Gerrand, C", "Staals, E", "Pantziarka, P." ], "year": 2024, "source": "Ortopedia Traumatologia Rehabilitacja;. 2024; 26(Supp 1):34--36th Annual Meeting of the European Musculo-Skeletal Oncology Society; JUN 12-14, 2024; Szczecin, POLAND. (ISBN: 1509-3492 )", "category": 2, "document_type": 9, "sci": null, "pubmed": null, "doi": null, "pmc": null, "organizations": [ "210076-14052" ], "persons": [ "210076-115078" ], "imported": "2024-06-19T16:31:11+02:00", "journal": null, "issn": "2084-4336", "collection_publisher": null, "collection_title": null, "edition": null, "university": null, "country": null, "case_report": false, "impactfactor": null, "impactfactor_year": null, "impactfactor_norm": null, "impactfactor_norm_year": null, "impactfactor_norm_category": null, "impactfactor_norm_super": null, "impactfactor_norm_super_year": null, "impactfactor_norm_super_category": null, "citations": null, "conference_name": true, "conference_place": true, "conference_international": true, "scientific_event": true, "invited_lecture": false, "keynote_speaker": false, "selected_presentation": true, "biobank_use": false, "bmf_use": false, "zmf_use": false, "local_affiliation": true }, { "id": 210074, "title": "Prognostic factors for periprosthetic joint infection in musculoskeletal oncology.", "abstract": null, "authors": [ "Bortoli, M", "Sambri, A", "Fiore, M", "Campanacci, DA", "Smolle, MA", "Leithner, A", "Cevaloni, L", "Vyrva, O", "Oliveira, V", "Özkan, K", "Van der Waal, R", "van de Sande, M", "Leitinen, M", "Krieg, AH", "Jutte, P", "Joo, MW", "Pollock, R", "Morris, G", "Pala, E", "Ruggieri, P", "De Paolis, M", "" ], "year": 2024, "source": "Ortopedia Traumatologia Rehabilitacja;. 2024; 26(Supp 1):16--36th Annual Meeting of the European Musculo-Skeletal Oncology Society; JUN 12-14, 2024; Szczecin, POLAND. (ISBN: 1509-3492 )", "category": 2, "document_type": 9, "sci": null, "pubmed": null, "doi": null, "pmc": null, "organizations": [ "210074-14052" ], "persons": [ "210074-53237", "210074-95171" ], "imported": "2024-06-19T16:26:30+02:00", "journal": null, "issn": "2084-4336", "collection_publisher": null, "collection_title": null, "edition": null, "university": null, "country": null, "case_report": false, "impactfactor": null, "impactfactor_year": null, "impactfactor_norm": null, "impactfactor_norm_year": null, "impactfactor_norm_category": null, "impactfactor_norm_super": null, "impactfactor_norm_super_year": null, "impactfactor_norm_super_category": null, "citations": null, "conference_name": true, "conference_place": true, "conference_international": true, "scientific_event": true, "invited_lecture": false, "keynote_speaker": false, "selected_presentation": true, "biobank_use": false, "bmf_use": false, "zmf_use": false, "local_affiliation": true }, { "id": 210073, "title": "Local Relapse in patients with high-grade osteosarcoma: a European retrospective study.", "abstract": null, "authors": [ "Palmerini, E", "Ramacci, V", "Frega, G", "Evenhuis, R", "Wunder, J", "Ortiz, EC", "Ratto, N", "Raux, S", "Cristina, MF", "Biau, D", "Trikoupis, G", "Leithner, A", "Luca, C", "De Meo, S", "Longhi, A", "Cesari, M", "Campanacci, L", "Paioli, A", "Hakim, R", "Marrari, A", "Donati, DM", "can de Sande, M", "Staals, EL", "Ibrahim, T." ], "year": 2024, "source": "Orthopedia Traumatologica Rehabilitacja;. 2024; 26(Supp 1):14-15.-36th Annual Meeting of the European Musculo-Skeletal Oncology Society; JUN 12-14, 2024; Szczecin, POLAND. (ISBN: 1509-3492 )", "category": 2, "document_type": 9, "sci": null, "pubmed": null, "doi": null, "pmc": null, "organizations": [ "210073-14052" ], "persons": [ "210073-53237" ], "imported": "2024-06-19T16:21:59+02:00", "journal": null, "issn": "2084-4336", "collection_publisher": null, "collection_title": null, "edition": null, "university": null, "country": null, "case_report": false, "impactfactor": null, "impactfactor_year": null, "impactfactor_norm": null, "impactfactor_norm_year": null, "impactfactor_norm_category": null, "impactfactor_norm_super": null, "impactfactor_norm_super_year": null, "impactfactor_norm_super_category": null, "citations": null, "conference_name": true, "conference_place": true, "conference_international": true, "scientific_event": true, "invited_lecture": false, "keynote_speaker": false, "selected_presentation": true, "biobank_use": false, "bmf_use": false, "zmf_use": false, "local_affiliation": true }, { "id": 210072, "title": "Preliminary results of the EMSOS study on grade 2 chondrosarcoma treated by intralesional curettage: follow-up vs resection.", "abstract": null, "authors": [ "Sambri, A", "Fiore, M", "Bortoli, M", "Campanacci, DA", "Scanferla, R", "Aycan, OE", "Dogan, B", "Khan, A", "Tarrago, LT", "van de Sande, M", "Oliveira, V", "van der Geest, I", "Doodkorte, R", "Mahdal, M", "Joo, MW", "Andreani, L", "Staals, E", "Donati, DM", "Biau, D", "Smolle, M", "Leithner, A", "Leitinen, M", "Jeys, L", "Paolis, MD." ], "year": 2024, "source": "Orthopedia Traumatologica Rehabilitacja;. 2024; 26(Supp 1):8--36th Annual Meeting of the European Musculo-Skeletal Oncology Society; JUN 12-14, 2024; Szczecin, POLAND. (ISBN: 1509-3492 )", "category": 2, "document_type": 9, "sci": null, "pubmed": null, "doi": null, "pmc": null, "organizations": [ "210072-14052" ], "persons": [ "210072-53237", "210072-95171" ], "imported": "2024-06-19T16:16:23+02:00", "journal": null, "issn": "2084-4336", "collection_publisher": null, "collection_title": null, "edition": null, "university": null, "country": null, "case_report": false, "impactfactor": null, "impactfactor_year": null, "impactfactor_norm": null, "impactfactor_norm_year": null, "impactfactor_norm_category": null, "impactfactor_norm_super": null, "impactfactor_norm_super_year": null, "impactfactor_norm_super_category": null, "citations": null, "conference_name": true, "conference_place": true, "conference_international": true, "scientific_event": true, "invited_lecture": false, "keynote_speaker": false, "selected_presentation": true, "biobank_use": false, "bmf_use": false, "zmf_use": false, "local_affiliation": true }, { "id": 210071, "title": "Atypical cartilaginous tumour: an Enigma.", "abstract": null, "authors": [ "Leithner, A" ], "year": 2024, "source": "Orthopedia Traumatologica Rehabilitacja;. 2024; 26(Supp 1):8--36th Annual Meeting of the European Musculo-Skeletal Oncology Society; JUN 12-14, 2024; Szczecin, POLAND. (ISBN: 1509-3492 )", "category": 2, "document_type": 9, "sci": null, "pubmed": null, "doi": null, "pmc": null, "organizations": [ "210071-14052" ], "persons": [ "210071-53237" ], "imported": "2024-06-19T16:11:30+02:00", "journal": null, "issn": "2084-4336", "collection_publisher": null, "collection_title": null, "edition": null, "university": null, "country": null, "case_report": false, "impactfactor": null, "impactfactor_year": null, "impactfactor_norm": null, "impactfactor_norm_year": null, "impactfactor_norm_category": null, "impactfactor_norm_super": null, "impactfactor_norm_super_year": null, "impactfactor_norm_super_category": null, "citations": null, "conference_name": true, "conference_place": true, "conference_international": true, "scientific_event": true, "invited_lecture": true, "keynote_speaker": true, "selected_presentation": false, "biobank_use": false, "bmf_use": false, "zmf_use": false, "local_affiliation": true }, { "id": 213550, "title": "The endolysosomal phospholipid bis(monoacylglycero)phosphate is synthesized via intra- and extralysosomal pathways", "abstract": null, "authors": [ "Bulfon, D", "Breithofer, J", "Grabner, GF", "Fawzy, N", "Pirchheim, A", "Wolinski, H", "Kolb, D", "Hartig, L", "Bramerdorfer, G", "Lass, A", "Taschler, U", "Kratky, D", "Greimel, P", "Zimmermann, R" ], "year": 2024, "source": "9th International Symposium on Lipid and Membrane Biology; April, 18-20; Graz. 2024. ", "category": 3, "document_type": null, "sci": null, "pubmed": null, "doi": null, "pmc": null, "organizations": [ "213550-14013", "213550-25164" ], "persons": [ "213550-106493", "213550-124190", "213550-51904", "213550-58881" ], "imported": "2025-01-30T13:23:46+01:00", "journal": null, "issn": null, "collection_publisher": null, "collection_title": null, "edition": null, "university": null, "country": null, "case_report": false, "impactfactor": null, "impactfactor_year": null, "impactfactor_norm": null, "impactfactor_norm_year": null, "impactfactor_norm_category": null, "impactfactor_norm_super": null, "impactfactor_norm_super_year": null, "impactfactor_norm_super_category": null, "citations": null, "conference_name": true, "conference_place": true, "conference_international": false, "scientific_event": true, "invited_lecture": false, "keynote_speaker": false, "selected_presentation": true, "biobank_use": false, "bmf_use": false, "zmf_use": true, "local_affiliation": true }, { "id": 210066, "title": "Increase of Group A Streptococcus (GAS) infections in Austria in 2023 – a genome-based characterization of invasive and non-invasive Streptococcus pyogenes isolates\r\n", "abstract": null, "authors": [ "Cardoso, M.J", "Cabal Rosel, A", "Richter, L", "Stoeger, A", "Hasenberger, P", "Stadlbauer, S", "Kerschner, H", "Zeitlberger, E.M", "Leitner-Meyer", "E", "Diab-Elschahawi, M", "Hobisch-Pirkel, M", "Govrins, M", "Indra, A", "Hell, A", "Ruppitsch, W" ], "year": 2023, "source": "ESCAID 2023 Detailed Programme. 2023; -European Scientific Conference on Applied Infectious Disease Epidemiology (ESCAIDE); NOV 20-22; Stockholm, Sweden. ", "category": 2, "document_type": 19, "sci": null, "pubmed": null, "doi": null, "pmc": null, "organizations": [ "210066-14023" ], "persons": [ "210066-50527" ], "imported": "2024-06-19T11:55:41+02:00", "journal": null, "issn": null, "collection_publisher": null, "collection_title": null, "edition": null, "university": null, "country": null, "case_report": false, "impactfactor": null, "impactfactor_year": null, "impactfactor_norm": null, "impactfactor_norm_year": null, "impactfactor_norm_category": null, "impactfactor_norm_super": null, "impactfactor_norm_super_year": null, "impactfactor_norm_super_category": null, "citations": null, "conference_name": true, "conference_place": true, "conference_international": true, "scientific_event": true, "invited_lecture": false, "keynote_speaker": false, "selected_presentation": false, "biobank_use": false, "bmf_use": false, "zmf_use": false, "local_affiliation": true }, { "id": 210065, "title": "The Yersinia enterocolitica gap in the BD MAX enteric bacterial panel - how to deal with it?", "abstract": null, "authors": [ "Leitner, E", "Pekard-Amenitsch S.", "Steinmetz, I.D." ], "year": 2024, "source": "Clinical Chemistry and Laboratory Medicine (CCLM), P8\r\n. 2024; 62(6):-13th International Symposium on Molecular Diagnostics (ISMD); JUN 13-14, 2024; Graz, AUSTRIA. ", "category": 2, "document_type": 9, "sci": null, "pubmed": null, "doi": null, "pmc": null, "organizations": [ "210065-14023" ], "persons": [ "210065-50527", "210065-95832" ], "imported": "2024-06-19T11:39:35+02:00", "journal": null, "issn": null, "collection_publisher": null, "collection_title": null, "edition": null, "university": null, "country": null, "case_report": false, "impactfactor": null, "impactfactor_year": null, "impactfactor_norm": null, "impactfactor_norm_year": null, "impactfactor_norm_category": null, "impactfactor_norm_super": null, "impactfactor_norm_super_year": null, "impactfactor_norm_super_category": null, "citations": null, "conference_name": true, "conference_place": true, "conference_international": false, "scientific_event": true, "invited_lecture": false, "keynote_speaker": false, "selected_presentation": false, "biobank_use": false, "bmf_use": false, "zmf_use": false, "local_affiliation": true }, { "id": 210064, "title": "Effects of different dental prophylaxis methods on teeth and restorations. ", "abstract": null, "authors": [ "Arefnia, B", "Haas, M", "" ], "year": 2024, "source": "GBT Summit Poland; May 24, 2024; Wisla, POLAND. 2024. ", "category": 3, "document_type": null, "sci": null, "pubmed": null, "doi": null, "pmc": null, "organizations": [ "210064-14057", "210064-14111" ], "persons": [ "210064-83202" ], "imported": "2024-06-19T11:21:03+02:00", "journal": null, "issn": null, "collection_publisher": null, "collection_title": null, "edition": null, "university": null, "country": null, "case_report": false, "impactfactor": null, "impactfactor_year": null, "impactfactor_norm": null, "impactfactor_norm_year": null, "impactfactor_norm_category": null, "impactfactor_norm_super": null, "impactfactor_norm_super_year": null, "impactfactor_norm_super_category": null, "citations": null, "conference_name": true, "conference_place": true, "conference_international": true, "scientific_event": true, "invited_lecture": true, "keynote_speaker": false, "selected_presentation": false, "biobank_use": false, "bmf_use": false, "zmf_use": false, "local_affiliation": true }, { "id": 210063, "title": "Management von keratisiertem Gewebe", "abstract": null, "authors": [ "Arefnia, B", "Laknizi, Imam", "" ], "year": 2023, "source": "Young ITI Summer Meeting Austria ; JUN 16-17, 2023; Attersee, AUSTRIA. 2023. ", "category": 3, "document_type": null, "sci": null, "pubmed": null, "doi": null, "pmc": null, "organizations": [ "210063-14111" ], "persons": [ "210063-83202" ], "imported": "2024-06-19T11:17:11+02:00", "journal": null, "issn": null, "collection_publisher": null, "collection_title": null, "edition": null, "university": null, "country": null, "case_report": false, "impactfactor": null, "impactfactor_year": null, "impactfactor_norm": null, "impactfactor_norm_year": null, "impactfactor_norm_category": null, "impactfactor_norm_super": null, "impactfactor_norm_super_year": null, "impactfactor_norm_super_category": null, "citations": null, "conference_name": true, "conference_place": true, "conference_international": false, "scientific_event": true, "invited_lecture": true, "keynote_speaker": false, "selected_presentation": false, "biobank_use": false, "bmf_use": false, "zmf_use": false, "local_affiliation": true }, { "id": 210062, "title": " Parodontale und periimplantäre Therapie Konservative und chirurgische Möglichkeiten.", "abstract": null, "authors": [ "Arefnia, B", "" ], "year": 2023, "source": "23. Kärntner Seensymposium ÖGZMK Kärnten; MAY 5, 2023; Pörtschach, AUSTRIA. 2023. ", "category": 3, "document_type": null, "sci": null, "pubmed": null, "doi": null, "pmc": null, "organizations": [ "210062-14111" ], "persons": [ "210062-83202" ], "imported": "2024-06-19T11:10:14+02:00", "journal": null, "issn": null, "collection_publisher": null, "collection_title": null, "edition": null, "university": null, "country": null, "case_report": false, "impactfactor": null, "impactfactor_year": null, "impactfactor_norm": null, "impactfactor_norm_year": null, "impactfactor_norm_category": null, "impactfactor_norm_super": null, "impactfactor_norm_super_year": null, "impactfactor_norm_super_category": null, "citations": null, "conference_name": true, "conference_place": true, "conference_international": false, "scientific_event": true, "invited_lecture": true, "keynote_speaker": false, "selected_presentation": false, "biobank_use": false, "bmf_use": false, "zmf_use": false, "local_affiliation": true }, { "id": 210061, "title": "Pulverstrahl am Vormarsch.", "abstract": null, "authors": [ "Arefnia, B", "Haas, M", "Koller, M", "" ], "year": 2023, "source": "Gemeinschaftstagung ÖGZMK Graz Zahn; APR 15, 2023; Graz, AUSTRIA. 2023. ", "category": 3, "document_type": null, "sci": null, "pubmed": null, "doi": null, "pmc": null, "organizations": [ "210061-14057", "210061-14111" ], "persons": [ "210061-59805", "210061-83202" ], "imported": "2024-06-19T11:07:47+02:00", "journal": null, "issn": null, "collection_publisher": null, "collection_title": null, "edition": null, "university": null, "country": null, "case_report": false, "impactfactor": null, "impactfactor_year": null, "impactfactor_norm": null, "impactfactor_norm_year": null, "impactfactor_norm_category": null, "impactfactor_norm_super": null, "impactfactor_norm_super_year": null, "impactfactor_norm_super_category": null, "citations": null, "conference_name": true, "conference_place": true, "conference_international": false, "scientific_event": true, "invited_lecture": true, "keynote_speaker": false, "selected_presentation": false, "biobank_use": false, "bmf_use": false, "zmf_use": false, "local_affiliation": true }, { "id": 210058, "title": "The impact of different mitochondrial Ca2+ modulators on lifespan and health of C. elegans.", "abstract": "Aging is a highly complex and poorly understood process that makes the body vulnerable to age-related diseases such as cardiovascular and neurodegenerative diseases. As we live in an increasingly aging society, it is crucial to understand the molecular mechanisms behind aging and to find new therapeutic approaches to intervene and delay aging and associated diseases. Mitochondria are crucial to cellular metabolism as they are the production site of ATP and reactive oxygen species (ROS) and can trigger apoptosis. Calcium (Ca2+) is a key regulator of mitochondrial function and is able to enter the mitochondrial matrix through the mitochondrial Ca2+ ([Ca2+]mito) transporter (MCU). However, aging is often associated with mitochondrial dysfunction caused by disturbances in ROS, and Ca2+ homeostasis. We therefore set out to investigate how modulation of [Ca2+]mito homeostasis during aging affects life- and health span in the model organism Caenorhabditis elegans (C. elegans). In this study, we used lifespan analyses, [Ca2+]mito measurements, and motility assays to answer these questions. To modulate the Ca2+ homeostasis, we induced mcu-1 knockdown to the worms and used pharmacological inhibitors of the MCU complex, such as the anti-cancer drug mitoxantrone and the small molecule MCU-i11. Ca2+ measurements from mcu-1 worms revealed reduced basal [Ca2+]mito concentrations and matrix Ca2+ uptake compared to wild type worms. Lifespan analyses have shown that the knockdown of mcu-1 and its inhibition by treatment with mitoxantrone leads to an extension of the lifespan of C. elegans. Also, mcu-1 knockdown and mitoxantrone treatment led to increased motility in old age, thereby extending health span. The second MCU inhibitor, MCU-i11, improved survival in middle-age but had no effect on life expectancy in old age. Motility assays showed a similar result, with increased worm activity only present in middle-age. We suspect that the inhibitor is unable to prevent Ca2+ influx during high Ca2+ concentrations in old age. Based on the results of MCU knockdown and inhibition by mitoxantrone, we conclude that the impaired Ca2+ conditions in early life mechanisms might be related to longevity.", "authors": [ "Lederer, S" ], "year": 2024, "source": " [ Diplomarbeit/Master Thesis (UNI) ] Universität Graz; 2024. pp.43. ", "category": 5, "document_type": 15, "sci": null, "pubmed": null, "doi": null, "pmc": null, "organizations": [], "persons": [], "imported": "2024-06-19T08:54:25+02:00", "journal": null, "issn": null, "collection_publisher": null, "collection_title": null, "edition": null, "university": "Universität Graz", "country": "40", "case_report": false, "impactfactor": null, "impactfactor_year": null, "impactfactor_norm": null, "impactfactor_norm_year": null, "impactfactor_norm_category": null, "impactfactor_norm_super": null, "impactfactor_norm_super_year": null, "impactfactor_norm_super_category": null, "citations": null, "conference_name": null, "conference_place": null, "conference_international": false, "scientific_event": false, "invited_lecture": false, "keynote_speaker": false, "selected_presentation": false, "biobank_use": false, "bmf_use": false, "zmf_use": false, "local_affiliation": false }, { "id": 176570, "title": "The Role of 15-Prostaglandindehydrogenase in Idiopathic Pulmonary Fibrosis", "abstract": "Idiopathic pulmonary fibrosis (IPF) is a disease linked to a high 5-year mortality, with few therapeutic options. Prostaglandin (PG)E2 exhibits antifibrotic properties and is reduced in the broncho-alveolar lavage from IPF patients. 15-prostaglandin dehydrogenase (15-PGDH) is a key enzyme in PGE2 metabolism under the control of transforming growth factor-β and microRNA 218.\nWe observed that expression patterns of 15-PGDH differ between healthy and IPF lungs, with areas of more pronounced expression in IPF. Treatment of mice with SW033291, an inhibitor of 15-PGDH, was beneficial against bleomycin-induced lung fibrosis in mice, reducing collagen content and improving lung function. These favorable effects were also observed when treatment was started after lung injury and established fibrosis. Fibrocytes are bone marrow derived cells that have been implicated in fibrotic remodeling. We found that PGE2 inhibited human fibrocyte differentiation in vitro both in healthy donors and IPF patients, and observed a reduction of fibrocyte counts in bleomycin treated mice after treatment with 15-PGDH inhibitor, along with decreased alveolar epithelial cell apoptosis and fibroblast proliferation. In precision-cut lung slices from IPF patients, 15-PGDH inhibition increased PGE2 levels and decreased collagen secretion. Finally, microRNA 218-5p, which is downregulated in IPF patients, suppressed 15-PGDH expression in vivo and in vitro. \nIn summary, these data suggest that 15-PGDH plays a crucial role in the metabolism of PGE2 and inhibition of its activity positively affects the development of lung fibrosis through the antifibrotic effects of PGE2. Thus 15-PGDH inhibition might be a promising novel approach for the treatment of IPF.\n", "authors": [ "Baernthaler, T" ], "year": 2019, "source": "PhD-Studium (Doctor of Philosophy); Humanmedizin; [ Dissertation ] Graz Medical University; 2019. pp. 124", "category": 5, "document_type": 16, "sci": null, "pubmed": null, "doi": null, "pmc": null, "organizations": [], "persons": [], "imported": "2019-09-03T11:29:53+02:00", "journal": null, "issn": null, "collection_publisher": null, "collection_title": null, "edition": null, "university": "Graz Medical University", "country": "40", "case_report": false, "impactfactor": null, "impactfactor_year": null, "impactfactor_norm": null, "impactfactor_norm_year": null, "impactfactor_norm_category": null, "impactfactor_norm_super": null, "impactfactor_norm_super_year": null, "impactfactor_norm_super_category": null, "citations": null, "conference_name": null, "conference_place": null, "conference_international": false, "scientific_event": false, "invited_lecture": false, "keynote_speaker": false, "selected_presentation": false, "biobank_use": false, "bmf_use": false, "zmf_use": false, "local_affiliation": false }, { "id": 210057, "title": "Rewiring of mitochondrial Ca2+ by T3 affecting metabolism and proliferation of breast cancer cells.", "abstract": "Thyroid hormones are crucial regulators of cell metabolism and impact various processes, including mitochondrial function. The biologically active triiodothyronine (T3) can interfere with multiple intracellular pathways, such as Ca2+ signaling, by altering gene expression. Ca2+ ions affect mitochondrial energy metabolism, as they are required for the activity of specific dehydrogenases involved in the tricarboxylic acid cycle. Notably, T3 can boost mitochondrial metabolism in HeLa cells by facilitating the mitochondrial Ca2+ uniporter (MCU) complex-mediated Ca2+ uptake, resulting in enhanced ATP and ROS production.\r\n\r\nIn the current study, we tested whether the T3-sensitivity of different cancer cells is dependent on mitochondrial Ca2+ remodeling. Consequently, we investigated the T3-induced signaling in T3-sensitive human breast cancer cell line MCF7 and in T3-insensitive human prostate carcinoma cell line PC3. After treating MCF7 with T3 for 3 h, fluorescence live cell imaging revealed a significant increase of mitochondrial Ca2+ ([Ca2+]mito) uptake, while [Ca2+]mito uptake remained unchanged in PC3 cells. The enhanced [Ca2+]mito uptake correlated with our results of the mitochondrial ATP ([ATP]mito) assessment, indicating a T3-dependent boost of mitochondrial energy metabolism in MCF7. Our results imply that the elevated metabolic activity in response to T3 is mediated by the [Ca2+]mito uptake machinery since an inhibition of MCU or the uncoupling proteins (UCP) UCP2 and UCP3 interacting with the MCU complex prevented the T3-induced alterations.\r\n\r\nAnalysis of mRNA expression revealed that the T3-dependent changes in mitochondrial metabolism of MCF7 cells rely on upregulation of the inositol 1,4,5-trisphosphate receptor (IP3R) isoforms IP3R1 and IP3R3. This finding was further supported by live cell imaging, as there were no T3-related differences observed in MCF7 cells in the case of siRNA-induced knockdown of IP3R1 or IP3R3, neither in [Ca2+]mito uptake nor in [ATP]mito.\r\n\r\nFurthermore, we found that MCF7 cells might use the elevated metabolic activity to promote cell proliferation. Notably, the increased cell proliferation is associated with an altered [Ca2+]mito uptake since inhibition of MCU or UCP2/3 counteracted the T3-induced proliferation boost.\r\n\r\nBased on our results, breast cancer cells utilize T3-dependent [Ca2+]mito -remodeling to boost [ATP]mito production and cell proliferation via an upregulation of different IP3R isoforms. Since the observed T3-induced effects rely on elevated [Ca2+]mito uptake, an inhibition of components involved in this process might provide a new therapeutic aspect inhibiting the proliferation of specific cancer cells.", "authors": [ "Schlick, K" ], "year": 2023, "source": " [ Diplomarbeit/Master Thesis (FH) ] TU Graz; 2023. pp.79. ", "category": 5, "document_type": 28, "sci": null, "pubmed": null, "doi": null, "pmc": null, "organizations": [], "persons": [], "imported": "2024-06-19T08:52:15+02:00", "journal": null, "issn": null, "collection_publisher": null, "collection_title": null, "edition": null, "university": "TU Graz", "country": "40", "case_report": false, "impactfactor": null, "impactfactor_year": null, "impactfactor_norm": null, "impactfactor_norm_year": null, "impactfactor_norm_category": null, "impactfactor_norm_super": null, "impactfactor_norm_super_year": null, "impactfactor_norm_super_category": null, "citations": null, "conference_name": null, "conference_place": null, "conference_international": false, "scientific_event": false, "invited_lecture": false, "keynote_speaker": false, "selected_presentation": false, "biobank_use": false, "bmf_use": false, "zmf_use": false, "local_affiliation": false } ] }