Publication List

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                "Nischwitz, S"
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            "source": "Plastic Surgical Club meets FACECOUTURE; OCT, 17-18, 2019; Leogang, AUSTRIA. 2019. ",
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            "title": "Chair: Pierluigi Canta ",
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            "authors": [
                "Rappl, T"
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            "title": "Chair: Breast",
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            "authors": [
                "Lumenta, DB",
                "Rappl, T"
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            "id": 182462,
            "title": "Meek-Technik – eine unterschätzte und fast vergessene Technologie.",
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            "authors": [
                "Luze",
                "H, Nischwitz, S",
                "Kamolz, LP"
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            "year": 2019,
            "source": "Jatros Dermatologie & Plastische Chirurgie. 2019; ",
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            "title": "BBLN triggers CAMK2D pathology in mice under cardiac pressure overload and potentially in unrepaired hearts with tetralogy of Fallot.",
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                "Abd, Alla, J",
                "Langer, A",
                "Wolf, S",
                "Fu, X",
                "Rageh, MA",
                "Quitterer, U"
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            "year": 2023,
            "source": "Nat Cardiovasc Res. 2023; 2(11): 1044-1059. ",
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            "id": 182483,
            "title": "Possible links between iron and tryptophan metabolism in individuals with iron deficiency and anaemia.",
            "abstract": "In our study, we evaluated potential associations of tryptophan, kynurenine, and kynurenic acid with indicators of iron metabolism (i.e., mean corpuscular volume, mean corpuscular haemoglobin, ferritin, transferrin saturation, serum iron, transferrin, soluble transferrin receptor, reticulocyte haemoglobin) and haemoglobin in 430 individuals grouped by the presence or absence of iron deficiency or anaemia. \r\n\r\nAll study participants, which were included in this cross-sectional study provided their written informed consent. They were admitted for a medical check-up of their actual iron status and underwent venous blood sampling after an overnight fasting state in the morning (between 8.00 and 10.00 a.m.).  The samples were used to investigate the iron metabolism (i.e., haemoglobin, mean corpuscular volume, mean corpuscular haemoglobin, ferritin, transferrin saturation, serum iron, transferrin, soluble transferrin receptor, reticulocyte haemoglobin), the tryptophan metabolism (tryptophan, kynurenine, kynurenic acid, kynurenine/tryptophan ratio, kynurenic acid/kynurenine index), the renal function (creatinine, estimated glomerular filtration rate [eGFR]), and the C-reactive protein.\r\n\r\nIndicators of tryptophan metabolism were positively correlated with haemoglobin and markers of iron metabolism (p-values: <0.001 – 0.038; r-values: 0.100 – 0.305). The strongest correlation was observed between tryptophan and haemoglobin (p < 0.001, r = 0.305). The cubic regression model yielded the highest R-square values between haemoglobin and tryptophan markers. Overall, 115 patients with iron deficiency showed lower tryptophan and kynurenic acid concentrations compared to 315 individuals without iron deficiency. Six patients with anaemia of chronic disease were observed with the lowest serum tryptophan levels and the highest kynurenine/tryptophan ratio compared to 11 individuals with iron deficiency anaemia and 413 non-anaemic patients. \r\n\r\nThis study showed little to moderate associations between haemoglobin, biomarkers of iron metabolism and tryptophan markers. Further studies are needed to get better insight in the causality of these findings.",
            "authors": [
                "Wenninger, J"
            ],
            "year": 2020,
            "source": "Doktoratsstudium der Medizinischen Wissenschaft; Humanmedizin; [ Dissertation ] Graz Medical University; 2020. pp. 112",
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        {
            "id": 182484,
            "title": "Bronchopulmonale Dysplasie, ihr möglicher Zusammenhang mit Ureaplasmen-Kolonisation und der Nutzen von Clarithromycin als Vorbeugung bei Frühgeborenen mit Gestationsalter von 23+0 bis 27+6 - eine retrospektive Studie -.",
            "abstract": "Einleitung: Seit 2013 wird aufgrund einer Studie von Ozdemir et al. (1) an der Abteilung für Neonatologie des LKH Graz bei postpartal intubierten und beatmeten Frühgeborenen mit Gestationsalter von 23+0 bis 27+6 das Antibiotikum Clarithromycin prophylaktisch zur Eradizierung von Ureaplasmen und somit zur Vorbeugung einer Bronchopulmonalen Dysplasie direkt nach der Geburt verabreicht. Davor sollte ein Abstrich aus dem Rachen/der Trachea des Kindes entnommen werden, um retrospektiv den Ureaplasmen-Status festzustellen. Diese Diplomarbeit evaluiert das Outcome der Frühgeborenen nach Einführen dieser Prophylaxe an der Neonatologie des LKH Graz.\r\n\r\nMethoden: Retrospektive Datenanalyse von 175 Kindern mit einem Gestationsalter von 23+0 bis 27+6, welche zwischen 20.01.2011 und 31.12.2018 geboren wurden. Die erste Gegenüberstellung verglich die Gruppe vor Einführung der Prophylaxe (20.01.2011-30.09.2013, Gruppe 1) mit denjenigen Frühgeborenen, die danach geboren wurden (01.11.2013-31.12.2018, Gruppe 2). Beim zweiten Vergleich wurden diejenigen Kinder aus Gruppe 2, die Clarithromycin erhalten hatten (Gruppe Cp) mit denen verglichen, die es nicht bekamen (Gruppe Cn). Bei der letzten Gegenüberstellung handelte es sich um den Vergleich zwischen Ureaplasmen-positiven (Gruppe Up) und -negativen (Gruppe Un) Kindern aus Gruppe 2. Die Signifikanz wurde mit t-Test, Mann-Whitney-U-Test und Chi-Quadrat-Test berechnet.\r\n\r\nErgebnisse: Es konnte bei keinem Vergleich ein signifikantes Ergebnis erreicht werden. Gruppe 1 und 2: In Gruppe 1 wurde bei 72,7% der Frühgeborenen die Diagnose BPD gestellt, in Gruppe 2 bei 81,7% (p=0,165). Die Sauerstoffgabe betrug in Gruppe 1 46 Tage, in Gruppe 2 54 Tage (p=0,103). Der durchschnittliche stationäre Aufenthalt in Gruppe 1 war 84 Tage und in Gruppe 2 89 Tage (p=0,247). Die Zahl an Pylorusstenosen stieg von 0% in Gruppe 1 auf 1,8% in Gruppe 2 (p=0,268). Gruppe Cp und Cn: In Gruppe Cp erhielten 84,7% der Frühgeborenen die Diagnose BPD, in Gruppe Cn hingegen 70,8% (p=0,121). Die Dauer der Sauerstoffgabe betrug in Gruppe Cp 56 Tage, in Gruppe Cn 45 Tage (p=0,193). Die stationäre Aufenthaltsdauer und das Auftreten von Pylorusstenosen waren annähernd gleich. Gruppe Up und Un: Das Vorkommen der Bronchopulmonalen Dysplasie war ähnlich, genauso wie die Dauer der Sauerstoffgabe und der stationäre Aufenthalt. Das Auftreten von Pylorusstenosen blieb gleich. Alle Gruppen: Die Vergleichsgruppen unterschieden sich jeweils im Gestationsalter. Gruppe Cp und Cn hatten zusätzlich signifikante Unterschiede bei der Gabe von Surfactant. Das Geburtsgewicht, die Geschlechterverteilung, die Beatmung, die Gabe von pränatalen Steroiden und das Auftreten eines persistierenden Ductus arteriosus waren in den jeweiligen Vergleichsgruppen ähnlich.\r\n\r\nDiskussion: Diese Studie kam zu unterschiedlichen Ergebnissen als die Ausgangsstudie von Ozdemir et al. (1). Der Nutzen einer prophylaktischen Gabe von Clarithromycin zur Vorbeugung einer Bronchopulmonalen Dysplasie konnte in dieser Diplomarbeit in unserer Population nicht gezeigt werden.\r\n\r\n1. Ozdemir R, Erdeve O, Dizdar EA, Oguz SS, Uras N, Saygan S, u. a. Clarithromycin in Preventing Bronchopulmonary Dysplasia in Ureaplasma urealyticum-Positive Preterm Infants. Pediatrics. 2011;128(6):e1496–501.",
            "authors": [
                "Mayrhofer, N"
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            "year": 2020,
            "source": "Humanmedizin; [ Diplomarbeit ] Medizinische Universität Graz; 2020. pp. 57",
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        {
            "id": 182485,
            "title": "Leveraging Word Embeddings for Biomedical Natural Language Processing.",
            "abstract": "Driven by the decreasing costs of whole genome sequencing, the field of Precision Medicine has gained traction to allow targeted treatment choices for patients with specific biomarkers. To reach that goal, automated processing of the huge unstructured data pool in electronic health records and online resources such as PubMed is necessary to aid time-constrained health professionals not only in delivering precise treatments but also in building representative cohorts for new clinical trials. While Natural Language Processing (NLP) has shown great progress in several domains with the public availability of huge collections that enable Deep Learning (DL) approaches, the same has not been seen in the clinical field due to ethical concerns with data and model sharing. To overcome that disparity, recent advances in transfer learning methods --- such as context-based Word Embeddings (WE) --- have facilitated partial reuse of these large models.\r\nWith the overall goal of improving precision medicine, this work leverages WE for biomedical NLP in three lines of research: (a) clinical text cleansing; (b) clinical text classification; and (c) biomedical information retrieval. In the line of research (a), I demonstrated a novel method that associates WE with a minimal set of filtering rules to expand acronyms in a totally unsupervised way. This method outperformed traditional approaches using both n-grams and a hand-crafted sense inventory. In the line of research (b), I explored several methods for clinical phenotyping and cohort building. I verified that logistic regression associated with WE constituted a better model for clinical text classification than more complex DL architectures and also determined that embeddings pre-trained on a larger corpus were not better than embeddings trained on the target dataset. Finally, in the line of research (c), we proposed a method for query expansion that does not affect the precision of results in a biomedical information retrieval scenario. Using this method, I showed that WE could be effectively used to increase recall when structured resources were not available and additionally revealed that the benefit of query expansion was larger in a small dataset.",
            "authors": [
                "Oleynik, M"
            ],
            "year": 2020,
            "source": "PhD-Studium (Doctor of Philosophy); Humanmedizin; [ Dissertation ] Graz Medical University; 2020. pp. 127",
            "category": 5,
            "document_type": 16,
            "sci": null,
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        {
            "id": 182486,
            "title": "Effect of Patient, Tumor, and Treatment Variables on Outcome in a Cohort of Patients With Merkel Cell Carcinoma - Retrospective Study.",
            "abstract": "Introduction\r\nMerkel cell carcinoma (MCC) is a rare and aggressive skin cancer with high rates of recurrence and mortality. Known risk factors include ultraviolet radiation, immu-nosuppression, and Merkel cell polyomavirus (MCPyV). However, knowledge concerning pathophysiology and clinical behavior is lacking. Especially identifying prognostic factors to potentially improve MCC outcomes is of utmost importance. \r\n\r\nMaterial and Methods\r\nThis retrospective study involved a cohort of 89 patients diagnosed with MCC between 1992 and 2016. Medical records were reviewed concerning host-, tumor-, diagnostic- and treatment variables. We used descriptive and inferential statistics to summarize characteristics and demonstrate associations with disease recurrence, overall survival and MCC-specific death.\r\n\r\nResults\r\nAmong 89 patients with MCC, we observed several statistically significant associations. Sex (p = 0.009), tumor extent at time of diagnosis (p = 0.045) and initial treatment modality (p = 0.026) were associated with disease recurrence. Chemotherapy (p = 0.048) was further associated with a higher risk of recurrence. Initial treatment modality and pathologic nodal evaluation results (p = 0.045), were associated with overall survival. Age (p = 0.027), disease recurrence (p = 0.001), 1 to 6 months (p = 0.039) and 7 to 12 months (p = 0.003) to recurrence were associated with reduced overall survival. Musculoskeletal disease (p = 0.04) and radiotherapy (p = 0.005) were associated with improved overall survival. Tumor extent at time of diagnosis (p = 0.031) was further associated with MCC-specific death. Age (p = 0.031) and disease recurrence (p = <0.001) were associated with a higher risk of MCC-specific death.\r\n\r\nConclusion\r\nMCC outcome was associated with sex, age, musculoskeletal disease, tumor ex¬tent, pathologic nodal evaluation results, initial treatment modality, chemotherapy and radiotherapy. These findings may help to assess risk and prognostic factors for MCC and may assist with clinical decisions concerning diagnostic or therapeutic management. Nonetheless, further studies with larger study populations may be useful to examine the statistical relevance of these findings.",
            "authors": [
                "Reiter, M"
            ],
            "year": 2020,
            "source": "Humanmedizin; [ Diplomarbeit ] Graz Medical University; 2020. pp. 69",
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        {
            "id": 182487,
            "title": "Vaskuläre Rezidiverkrankungen junger SchlaganfallpatientInnen.",
            "abstract": "Hintergrund: In Industrieländern betreffen rund 25% der gesamten Schlaganfälle PatientInnen im erwerbsfähigen Alter, was zu einer enormen sozioökonomischen und gesundheitlichen Belastung führt. Entgegen früherer Meinungen bestehen trotz des Anstiegs an typischen vaskulären Risikofaktoren im jüngeren Erwachsenenalter, signifikante Unterschiede zu älteren PatientInnen bezüglich Ätiologie, Risikofaktoren und Langzeitfolgen. \r\nDie vorliegende Diplomarbeit hat sich zum Ziel gesetzt, die Charakteristika junger SchlaganfallpatientInnen und ihre Korrelation zu vaskulären Rezidiverkrankungen retrospektiv zu untersuchen.\r\nMethoden: Mithilfe einer Datenbankabfrage wurden alle PatientInnen im Alter von 17-50 Jahren identifiziert, welche zwischen 01.01.2008 und 31.12.2017 an der Stroke-Unit der Universitätsklinik für Neurologie Graz aufgrund eines akuten Schlaganfalls behandelt wurden. Klinische und demographische Daten wurden zum Zeitpunkt des Index-Ereignisses und der Follow-Up-Untersuchungen ermittelt, ebenfalls wurden vaskuläre Rezidiverkrankungen im Beobachtungszeitraum bis Juli 2018 erhoben. \r\nErgebnisse: Die PatientInnenkohorte umfasste 350 SchlaganfallpatientInnen (59% Männer, Altersdurchschnitt 41±8 Jahre). Bei 82% der PatientInnen konnte zum Zeitpunkt der letzten Follow-Up-Untersuchung zumindest ein zerebrovaskulärer Risikofaktor erhoben werden. Insgesamt kam es bei 44 (13%) SchlaganfallpatientInnen zu einem vaskulären Rezidivereignis, dabei erlitten 32 ein Schlaganfall-Rezidiv und 12 ein anderes vaskuläres Ereignis (Myokardinfarkt, Pulmonalarterienembolie, tiefe Venenthrombose oder periphere arterielle Embolie). PatientInnen mit einem vaskulären Rezidivereignis waren zum Zeitpunkt des Index-Schlaganfalls signifikant älter als jene ohne Rezidiv (45±5 Jahre vs. 40±8 Jahre; p=0,001), auch die Anzahl der zerebrovaskulären Risikofaktoren war signifikant höher (2,3±1 vs. 1,6±1; p<0,001). Eine statistisch signifikante positive Assoziation zu vaskulären Rezidivereignissen bestand bei den folgenden Risikofaktoren: arterielle Hypertonie (OR 2,16; p=0,02), Hyperlipidämie (OR 2,31; p=0,01), Nikotinabusus (OR 2,06; p=0,03) und Alkoholabusus (OR 4,26; p=0,002).\r\nBei einer medianen Follow-Up-Zeit von 3 Jahren und einem Monat erreichten 79% der PatientInnen einen exzellenten funktionellen Outcome (entsprechend einer modified Rankin Scale von 0-1). Diese Gruppe wies einen niedrigeren Altersdurchschnitt auf (40±9 vs. 43±8; p=0,03) und hatte weniger zerebrovaskuläre Risikofaktoren (1,5±1 vs. 2,1±1; p=0,004) als PatientInnen mit einem ungünstigen funktionellen Outcome. Zwischen dem Auftreten vaskulärer Rezidivereignisse und einem exzellenten funktionellen Outcome bestand eine statistisch signifikante negative Assoziation (OR 0,24; p<0.001). \r\nDiskussion: In dieser Studienkohorte konnte gezeigt werden, dass für junge SchlaganfallpatientInnen über Jahre hinweg ein relevantes vaskuläres Rezidivrisiko besteht. Die erhebliche Last an klassischen, modifizierbaren zerebrovaskulären Risikofaktoren ist hierfür wohl hauptverantwortlich. \r\nTrotz überwiegend exzellentem funktionellem Langzeitoutcome zeigt dieses relativ hohe Rezidivrisiko, sowie die Zunahme der schlaganfallassoziierten Risikofaktoren, die Dringlichkeit einer adäquaten Identifikation und Behandlung schlaganfallassoziierter Risikofaktoren, einer professionellen zerebrovaskulären Nachsorge und der Entwicklung von Richtlinien zur Sekundärprävention des juvenilen Schlaganfalls mit Unterstützung von multizentrischen Studien.",
            "authors": [
                "Posch, H"
            ],
            "year": 2020,
            "source": "Humanmedizin; [ Diplomarbeit ] Medizinische Universität Graz; 2020. pp. 80",
            "category": 5,
            "document_type": 15,
            "sci": null,
            "pubmed": null,
            "doi": null,
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            "journal": null,
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            "collection_publisher": null,
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            "edition": null,
            "university": "Medizinische Universität Graz",
            "country": "40",
            "case_report": false,
            "impactfactor": null,
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            "local_affiliation": false
        },
        {
            "id": 182488,
            "title": "Peri- and postinterventional management of stroke patients treated with mechanical thrombectomy.",
            "abstract": "Background\r\nMechanical thrombectomy has become the primary treatment strategy for stroke due to large vessel occlusion of the anterior cerebral circulation. However, many questions regarding the optimal peri- and postinterventional management remain unanswered. \r\nWe aimed to investigate the clinical impact of periinterventional blood pressure drops and of the duration of mechanical ventilation in stroke patients treated with mechanical thrombectomy.\r\n\r\nMethods \r\nWe identified consecutive patients with stroke due to anterior circulation large vessel occlusion from our thrombectomy registry, in which clinical data were prospectively collected. For the investigation of periinterventional blood pressure, patients were included from January 2011 to June 2016. Periprocedural data were additionally extracted from electronic anaesthesia records, blood pressure was measured by invasive monitoring. \r\nFor the examination of ventilation time, patients in the time period between January 2011 to April 2019 were included. The duration of ventilation time was both analysed as a continuous variable and grouped into extubation within six hours (\"early\"), 6-24 hours (\"delayed\") and >24 hours (\"late\"). \r\nThe main outcome variable in both studies was favourable functional neurological outcome, defined as modified Rankin Scale scores of 0-2 at a follow-up examination three months post-stroke. \r\n\r\nResults \r\nWe were able to analyse 115 patients with complete electronic periinterventional vital sign recordings and found that single severe blood pressure drops were associated with unfavourable outcome. The strongest effect was seen in mean arterial pressure drops below 60 mmHg (p=0.01), which remained independently associated with poor functional outcome in multivariable analysis (p<0.01).\r\nRegarding ventilation time, we included 441 patients with available follow-up data. Favourable outcome correlated with shorter ventilation time (Spearman’s Rho=0.39, p<0.001). Specifically, we found that extubation within six hours was associated with favourable outcome compared to delayed extubation (6-24 hours, odds ratio 2.40, p<0.001). This association remained statistically significant in multivariable analysis (p=0.01). Patients who were extubated after more than 24 hours often had severe stroke-related complications and generally much worse outcome. \r\n \r\nConclusion\r\nBoth the avoidance of severe periinterventional blood pressure drops and the strategy of early extubation after mechanical thrombectomy are associated with favourable outcome after three months in stroke patients and should therefore be recommended in the peri- and postinterventional stroke management.",
            "authors": [
                "Fandler-Hoefler, S"
            ],
            "year": 2020,
            "source": "Doktoratsstudium der Medizinischen Wissenschaft; Humanmedizin;  [ Dissertation ] Graz Medical University; 2020. pp.80. ",
            "category": 5,
            "document_type": 16,
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            "doi": null,
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            "organizations": [
                "182488-14051"
            ],
            "persons": [
                "182488-82411"
            ],
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            "university": "Graz Medical University",
            "country": "40",
            "case_report": false,
            "impactfactor": null,
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        },
        {
            "id": 216977,
            "title": "Patient-Reported Well-Being in Value-Based Routine Care Using Tildrakizumab: 52-week Interim Data of the Phase IV Positive Study.",
            "abstract": null,
            "authors": [
                "Mrowietz, U",
                "Sommer, R",
                "Gerdes, S",
                "Reguiai, Z",
                "Weger, W",
                "Daudén, E",
                "Maul, JT",
                "Ghislain, PD",
                "Laws, PM",
                "Naldi, L",
                "De, Jong, E",
                "Mburu, S",
                "Koscielny, V",
                "Massana, E",
                "Domenech, A",
                "Gaarn, du, Jardin, K",
                "Kasujee, I",
                "Augustin, M"
            ],
            "year": 2025,
            "source": "Psoriasis (Auckl). 2025; 15:  243-259. ",
            "category": 1,
            "document_type": 1,
            "sci": "ISI:001522159800001",
            "pubmed": "40605963",
            "doi": "10.2147/PTT.S526748",
            "pmc": "PMC12219165",
            "organizations": [
                "216977-14047"
            ],
            "persons": [
                "216977-50153-6"
            ],
            "imported": "2025-07-07T02:00:00+02:00",
            "journal": "Psoriasis (Auckl)",
            "issn": "2230-326X",
            "collection_publisher": null,
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            "edition": null,
            "university": null,
            "country": null,
            "case_report": false,
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            "citations": true,
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            "local_affiliation": true
        },
        {
            "id": 182490,
            "title": "Prevalence of drug resistance mutations against dolutegravir, lamivudine, and rilpivirine in ART-naïve residents of South-East Austria.",
            "abstract": "Background: Although a lot of progress has been made regarding antiretroviral therapy, no cure for HIV has been found and lifelong treatment is needed. Long-term drug exposure is accompanied by various side effects and toxicities. With the successful introduction of two-drug regimens in recent years, lowered cumulative drug exposure while maintaining viral suppression has been made possible. \r\n\r\nObjectives: To ensure successful treatment, anti-retroviral therapy (ART) should ideally start as soon as possible after HIV-1 diagnosis. In order to guarantee high efficacy of initial combination regimens, data on local prevalence of drug resistance mutations is of great importance. The aim of this project was to identify transmitted HIV-1 drug resistance mutations (DRMs) against drugs currently recommended for two-drug regimes, dolutegravir (DTG), lamivudine (3TC), and rilpivirine (RPV). In addition, the local transmission network of HIV-1 in South-East Austria was reconstructed.\r\n\r\nMaterial and Methods: In this study, 192 HIV patients who had been diagnosed between 2013-2018 living in South-East Austria were included. Conventional Sanger sequencing analysis was performed and sequences were analyzed for DRMs including DTG, 3TC, and RPV. Molecular network analysis was carried out to determine presumed relations and to identify shared DRMs. \r\n\r\nResults and Conclusion: Of all ART-naïve patients, 16% showed clinically relevant DRMs against DTG, 3TC, and/or RPV. The prevalence of these DRMs was significantly higher in genetic transmission clusters when compared to non-genetically linked individuals. Within clusters, the majority of DRMs were shared, indicating an elevated risk of transmission of resistant HIV-1 strains. However, of all patients with clinically relevant DRMs, only 2% were not eligible for at least one of the currently suggested two-drug regimens.",
            "authors": [
                "Benezeder, A"
            ],
            "year": 2020,
            "source": "Humanmedizin; [ Diplomarbeit ] Graz Medical University; 2020. pp. 51",
            "category": 5,
            "document_type": 15,
            "sci": null,
            "pubmed": null,
            "doi": null,
            "pmc": null,
            "organizations": [],
            "persons": [],
            "imported": "2020-06-18T13:01:17+02:00",
            "journal": null,
            "issn": null,
            "collection_publisher": null,
            "collection_title": null,
            "edition": null,
            "university": "Graz Medical University",
            "country": "40",
            "case_report": false,
            "impactfactor": null,
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            "biobank_use": false,
            "bmf_use": false,
            "zmf_use": false,
            "local_affiliation": false
        },
        {
            "id": 182491,
            "title": "Comparison of automated extraction platforms on quantification of plasma hepatitis D virus RNA.",
            "abstract": "Background: Hepatitis D (HDV) is the most severe and rapidly progressive form of chronic viral hepatitis needing a reliable diagnostic approach. The aim of this study was to make results comparable when using the CE/IVD-labeled RoboGene® HDV RNA Quantification Kit 2.0 (Analytik Jena AG) with two different laboratory settings. \r\n\r\nMaterials and Methods: All samples were extracted either with the eMAG® (bioMérieux S.A., Marcy l´Etoile, France) or the MagNA Pure 24 (Roche Molecular Diagnostics, Rotkreuz, Switzerland) platform. Amplification and detection were performed on the LightCycler 480II instrument (Roche). After determination of correction factors (CF) utilizing the 1st WHO International Standard for HDV RNA, the limit of detection (LOD) was determined for both test systems followed by accuracy testing using a reference panel. Furthermore, 30 clinical plasma samples (25 of them HDV RNA positive and 5 of them HDV RNA negative) were tested and results compared. \r\n\r\nResults: The CF was 922 for the test system including the eMAG® and 190 for the test system including the MagNA Pure 24. LODs were found to be 2.65 log10 IU/mL and 2.37 log10 IU/mL, respectively. One member of the reference panel containing 2.03 log10 IU/mL tested negative with both test systems and another member containing 3.11 log10 IU/mL gave a negative result with the test system including the eMAG®. Of 25 HDV RNA positive samples, 15 tested positive with both test systems, 2 gave discrepant results, and in 8 samples, HDV RNA was not detected with both of the methods. All clinical samples that did not contain HDV RNA tested negative with both test systems.\r\n\r\nConclusions: Quantification of plasma HDV RNA depends on the extraction platform used. To make results comparable, it is mandatory to determine the specific CF for the test system employed. Harmonization of results is essential for monitoring patients undergoing anti-HDV therapy and making results obtained from clinical studies comparable.",
            "authors": [
                "Miklau, F"
            ],
            "year": 2020,
            "source": "Humanmedizin; [ Diplomarbeit ] Graz Medical University; 2020. pp. 33",
            "category": 5,
            "document_type": 15,
            "sci": null,
            "pubmed": null,
            "doi": null,
            "pmc": null,
            "organizations": [],
            "persons": [],
            "imported": "2020-06-18T13:01:17+02:00",
            "journal": null,
            "issn": null,
            "collection_publisher": null,
            "collection_title": null,
            "edition": null,
            "university": "Graz Medical University",
            "country": "40",
            "case_report": false,
            "impactfactor": null,
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            "keynote_speaker": false,
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            "bmf_use": false,
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            "local_affiliation": false
        },
        {
            "id": 182492,
            "title": "Volume CT Perfusion (VCTP) Imaging in Evaluation of the Significance in Oncologic Follow-up: Imaging of Metastasizing RCC - Comparison between changes in Perfusion and Changes in Size in the early period of targeted therapy.",
            "abstract": "Introduction: Since 2004 when first antiangiogenic agent was approved for the treatment of colorectal cancer, oncologic treatment in many solid tumors has changed. Main targets for oncologic therapy have been switched from heterogeneous proliferating tumor cells to more homogenous tumor vasculature targeted by antiangiogenic agents. Because of different mechanism of action and due to different pattern of treatment response at imaging during follow-up, a current challenge is to find appropriate surrogate biomarkers of the tumor vasculature for appropriate follow up of tumor response to antiangiogenic treatment. Recent work has led to development of non-invasive quantitative dynamic imaging techniques, such as CT perfusion (CTP) that assess early changes in tumor angiogenesis, therewith tumor physiology. \r\nThe aim of this thesis was to analyze whether volume CT perfusion (VCTP) imaging of tumors treated with targeted therapy may allow for earlier response assessment than conventional CT imaging with size measurements. An additional aim was to analyze, whether there was any evidence of association between perfusion parameters and clinical outcome.\r\n\r\nMaterial and Methods: VCTP imaging was performed in ten patients with histologically verified metastasizing renal cell carcinoma (RCC) before and one month after initiation of targeted therapy using a 320-slice Volume CT scanner.  Blood flow (BF), blood volume (BV) and clearance (CL) were calculated for both time points using compartmental analysis algorithms. In addition, the longest tumor diameter (LD) was measured. Perfusion parameters and LD before and after treatment were compared, and their relative change was correlated against disease progression time (TTP) and associated to tumor response. \r\n\r\nResults: For patients who responded to therapy, perfusion parameters have significantly decreased; BF by -37.5%, BV by -28.9% and CL by -50.8% on average. Decrease in tumor size was -9.4%. For non-responders, change in perfusion parameters was inconsistent. Overview of individual cases showed that relative change of BV was the most important perfusion parameter, with highest difference between responders and non-responders (90%). Other parameters increased specificity of perfusion imaging. The most valuable predictor of TTP for patients who responded to therapy was the relative change of BF, with lowest relative deviation from true value of TTP, confirmed by multiple linear regression analysis. \r\n\r\nConclusion: In the early period after targeted therapy VCTP may be able to discriminate responders from non-responders, sooner than the currently used changes in tumor size.  Different percentage change of all three parameters indicated that the therapy has probably affected the physiological processes of angiogenesis in varying degrees and, therefore, all perfusion parameters may have to be considered independently of one another. A decrease of all three perfusion parameters, no matter on percentage change, may be interpreted as positive response to antiangiogenic therapy. Relative change of BV was the most important parameter for detection of non-responders, whereas use of other parameters increased the CTP specificity. In addition, relative change of BF may be a promising parameter for prediction of TTP.",
            "authors": [
                "Vehabovic-Delic, A"
            ],
            "year": 2020,
            "source": "Doktoratsstudium der Medizinischen Wissenschaft; Humanmedizin; [ Dissertation ] Graz Medical University; 2020. pp. 89",
            "category": 5,
            "document_type": 16,
            "sci": null,
            "pubmed": null,
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            "edition": null,
            "university": "Graz Medical University",
            "country": "40",
            "case_report": false,
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            "biobank_use": false,
            "bmf_use": false,
            "zmf_use": false,
            "local_affiliation": false
        },
        {
            "id": 182493,
            "title": "Polypharmazie in Langzeitpflegeeinrichtungen - Eine retrospektive Studie zu Effekten und Nachhaltigkeit von Schulungsmaßnahmen in Bezug auf potentiell inadäquate Medikation.",
            "abstract": "Hintergrund: Eine immer älter werdende Bevölkerung stellt die Medizin vor neue Herausforderungen. Mit zunehmendem Lebensalter steigt die Anzahl an chronischen Erkrankungen. Diese Multimorbidität führt häufig durch eine leitliniengetreue Therapie der einzelnen Erkrankungen zu einer Polypharmazie der PatientInnen. Diese kann aufgrund von Medikamenteninteraktionen und der Verordnung von potentiell inadäquaten Präparaten für die Betroffenen schwere Folgen haben. Diese stellen unter anderen eine verminderte Lebensqualität, zunehmende Gebrechlichkeit, häufigere Spitalseinweisungen und letztlich eine erhöhte Mortalität dar. Zu einer besonders vulnerablen Gruppe gehören hierbei BewohnerInnen von Langzeitpflegeeinrichtungen. AllgemeinmedizinerInnen nehmen eine Schlüsselrolle in der medizinischen Versorgung und im Medikationsmanagement geriatrischer PatientInnen ein. In der vorliegenden Arbeit wurde untersucht, ob das Verschreibungsverhalten von AllgemeinmedizinerInnen durch gezielte Schulungsmaßnahmen beeinflusst werden kann.\r\nMethoden: Während der RIMO-Studie im Jahr 2014 wurden AllgemeinmedizinerInnen Schulungsmaßnahmen zu den STOPP/START-Kriterien zur Optimierung des Medikationsmanagements bei geriatrischen PatientInnen aus drei Langzeitpflegeeinrichtungen angeboten. Anhand der retrospektiven Auswertung der Medikationsdaten der BewohnerInnen der drei Langzeitpflegeeinrichtungen vor und nach der Intervention zu insgesamt vier Messzeitpunkten wurde ein möglicher Einfluss von Schulungsmaßnahmen auf das Verschreibungsverhalten der AllgemeinmedizinerInnen analysiert. Dabei wurde erhoben, ob durch die Intervention eine Reduktion an potentiell inadäquaten Präparaten erreicht werden kann.\r\nErgebnisse: Die Durchführung von Schulungsmaßnahmen führte zu einem deutlichen Rückgang der durchschnittlichen Zahl an Medikamenten pro BewohnerIn. Bereits nach der Ankündigung der Intervention konnte ein vermehrtes Absetzen von Verordnungen durch die AllgemeinmedizinerInnen beobachtet werden. Der Anteil an potentiell inadäquaten Präparaten an der Gesamtzahl an abgesetzten Präparaten blieb über den Messzeitraum jedoch konstant. Es bleibt offen, ob eine Modifikation bzw. Erweiterung der Interventionsmaßnahmen zu einer stärkeren Reduktion an für ältere PatientInnen potentiell inadäquaten Präparaten führen kann.\r\nSchlussfolgerung: Das Verschreibungsverhalten von AllgemeinmedizinerInnen kann durch eine Intervention in Form von Schulungsmaßnahmen beeinflusst werden. Um eine stärkere Reduktion an potentiell inadäquaten Verordnungen zu erreichen, erscheint es angesichts der Ergebnisse dieser Studie jedoch als notwendig, die Interventionsmaßnahmen weiter zu modifizieren bzw. zu erweitern.",
            "authors": [
                "Pucher, C"
            ],
            "year": 2020,
            "source": "Humanmedizin; [ Diplomarbeit ] Medizinische Universität Graz; 2020. pp. 82",
            "category": 5,
            "document_type": 15,
            "sci": null,
            "pubmed": null,
            "doi": null,
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            "journal": null,
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            "university": "Medizinische Universität Graz",
            "country": "40",
            "case_report": false,
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            "local_affiliation": false
        },
        {
            "id": 182494,
            "title": "Tumor Genome Stratification and Network Analyses based on Non-invasive Liquid Biopsies.",
            "abstract": "Colorectal cancer is the third most commonly diagnosed malignancy worldwide. The mortality of colorectal cancer has been decreasing in recent decades due to improved diagnostic procedures, which allow the identification of patients with early-stage disease. However, the survival of patients with advanced diseases is still unsatisfactory. Recently, targeted therapies, e.g., anti-EGFR and anti-VEGF treatments, have shown promising results in late-stage colorectal cancer patients. However, the survival benefit of targeted therapies is usually limited to a few months, and acquired resistance occurs frequently. Liquid biopsy, which refers to the analysis of tumor content from a body fluid such as blood, has become a promising method for early diagnosis and the management of patients. In the project described in this thesis, we employed whole-genome sequencing of plasma DNA, which in patients with cancer contains circulating tumor DNA (ctDNA) to evaluate the tumor genome of patients with colorectal cancer (CRC). A focus was on those patients who received targeted treatment, to validate the usage of ctDNA for acquired resistance and patient outcome prediction, and also to determine novel resistance mechanisms.\r\nUsing longitudinal plasma analyses, we studied the evolution of tumor genomes in a metastatic colorectal cancer cohort. Interestingly, two patients under anti-EGFR treatment showed focal amplification in resistance-related genes (i.e., KRAS and ERBB2) when the disease progressed. Moreover, focal amplification in CDK6 (resistance-related) was found in one patient under anti-ERBB2 treatment. These results suggested that liquid biopsy is a promising tool for identification of emerging focal amplifications, which may be associated with acquired resistance prediction. In addition to focal amplifications with established driver genes, we also identified recurrent focal amplifications, which had not yet been investigated in detail, such as an amplicon on chromosome 13q12.2. By analysis of CRC cases from the TCGA database, we confirmed that amplification of 13q12.2 was associated with more advanced stages. We first defined the minimally amplified region and then tested the function of all genes included with two in vitro cell models. We found evidence for POLR1D being the potential driver gene within the amplicon, which impacted cell proliferation by inducing the expression of some oncogenes (e.g., VEGFA and EREG). The upregulation of VEGFA, an essential regulator of angiogenesis, has been implicated in the resistance to bevacizumab treatment. Interestingly, by serial monitoring of two patients under bevacizumab treatment, we observed the emergence of the 13q12.2 amplification when the respective tumors developed resistance to the therapy. All the results indicated that POLR1D is the potential driver gene in 13q12.2 and plays a role in bevacizumab resistance. \r\nTo this end, we confirmed that liquid biopsy as a non-invasive method applicable for acquired resistance and patient outcome prediction in the clinic. Liquid biopsy is also a useful tool in cancer research, which allows the identification of novel driver genes.",
            "authors": [
                "Zhou, Q"
            ],
            "year": 2020,
            "source": "PhD-Studium (Doctor of Philosophy); Humanmedizin; [ Dissertation ] Graz Medical University; 2020. pp. 125",
            "category": 5,
            "document_type": 16,
            "sci": null,
            "pubmed": null,
            "doi": null,
            "pmc": null,
            "organizations": [],
            "persons": [],
            "imported": "2020-06-18T13:01:17+02:00",
            "journal": null,
            "issn": null,
            "collection_publisher": null,
            "collection_title": null,
            "edition": null,
            "university": "Graz Medical University",
            "country": "40",
            "case_report": false,
            "impactfactor": null,
            "impactfactor_year": null,
            "impactfactor_norm": null,
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            "conference_name": null,
            "conference_place": null,
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            "selected_presentation": false,
            "biobank_use": false,
            "bmf_use": false,
            "zmf_use": false,
            "local_affiliation": false
        },
        {
            "id": 182495,
            "title": "Therapy of positional skull deformitites with head orthoses - a retrospective analysis.",
            "abstract": "Since the \"Back to Sleep\" campaign in 1992, newborns and toddlers have been positioned on their back or side more often. As a result, there has been an increased number of cranial deformities.\r\nHead orthoses can help to restore a natural skull shape and to reduce the deformation caused by the positioning.\r\nOften this is not only an aesthetic issue, but can also cause functional problems that come within the deformity.\r\nThe head shape has been compared by using 3D photo scans before and after the treatment.\r\nThe aim of this diploma thesis is to present and analyze the progress and to compare positional head deformities from toddlers before and after the therapy.\r\nUntreated skull deformities can lead to visual as well as a variety of functional problems.\r\nIt can be expected that after the head orthoses, the positional deformities will regress and a normal skull shape will develop.\r\nIn both plagiocephalus and brachycephalus a decrease in the number and severity of positional skull deformities could be observed, using the severity scale",
            "authors": [
                "Sandmayr, A"
            ],
            "year": 2020,
            "source": "Humanmedizin; [ Diplomarbeit ] Graz Medical University; 2020. pp. 62",
            "category": 5,
            "document_type": 15,
            "sci": null,
            "pubmed": null,
            "doi": null,
            "pmc": null,
            "organizations": [],
            "persons": [],
            "imported": "2020-06-18T13:01:17+02:00",
            "journal": null,
            "issn": null,
            "collection_publisher": null,
            "collection_title": null,
            "edition": null,
            "university": "Graz Medical University",
            "country": "40",
            "case_report": false,
            "impactfactor": null,
            "impactfactor_year": null,
            "impactfactor_norm": null,
            "impactfactor_norm_year": null,
            "impactfactor_norm_category": null,
            "impactfactor_norm_super": null,
            "impactfactor_norm_super_year": null,
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            "citations": null,
            "conference_name": null,
            "conference_place": null,
            "conference_international": false,
            "scientific_event": false,
            "invited_lecture": false,
            "keynote_speaker": false,
            "selected_presentation": false,
            "biobank_use": false,
            "bmf_use": false,
            "zmf_use": false,
            "local_affiliation": false
        },
        {
            "id": 182499,
            "title": "Fibromuskuläre Dysplasie.",
            "abstract": null,
            "authors": [
                "Jud, P"
            ],
            "year": 2020,
            "source": "Universum Innere Medizin. 2020; Suppl 22(4): 16-17. ",
            "category": 1,
            "document_type": 3,
            "sci": null,
            "pubmed": null,
            "doi": null,
            "pmc": null,
            "organizations": [
                "182499-14079"
            ],
            "persons": [
                "182499-94413"
            ],
            "imported": "2020-06-19T21:16:18+02:00",
            "journal": null,
            "issn": null,
            "collection_publisher": null,
            "collection_title": null,
            "edition": null,
            "university": null,
            "country": null,
            "case_report": false,
            "impactfactor": null,
            "impactfactor_year": null,
            "impactfactor_norm": null,
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            "impactfactor_norm_category": null,
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            "citations": null,
            "conference_name": null,
            "conference_place": null,
            "conference_international": false,
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            "keynote_speaker": false,
            "selected_presentation": false,
            "biobank_use": false,
            "bmf_use": false,
            "zmf_use": false,
            "local_affiliation": true
        },
        {
            "id": 182505,
            "title": "Akute Schmerzen – Differenzierter Einsatz von Schmerzmitteln.",
            "abstract": null,
            "authors": [
                "Lang-Illievich, K"
            ],
            "year": 2020,
            "source": "Allgemeinmedizin Update Refresher; JUN 17-20, 2020; Vienna, AUSTRIA. 2020. ",
            "category": 3,
            "document_type": null,
            "sci": null,
            "pubmed": null,
            "doi": null,
            "pmc": null,
            "organizations": [
                "182505-14070"
            ],
            "persons": [
                "182505-60261"
            ],
            "imported": "2020-06-21T11:39:21+02:00",
            "journal": null,
            "issn": null,
            "collection_publisher": null,
            "collection_title": null,
            "edition": null,
            "university": null,
            "country": null,
            "case_report": false,
            "impactfactor": null,
            "impactfactor_year": null,
            "impactfactor_norm": null,
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            "impactfactor_norm_category": null,
            "impactfactor_norm_super": null,
            "impactfactor_norm_super_year": null,
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            "citations": null,
            "conference_name": true,
            "conference_place": true,
            "conference_international": true,
            "scientific_event": true,
            "invited_lecture": true,
            "keynote_speaker": false,
            "selected_presentation": false,
            "biobank_use": false,
            "bmf_use": false,
            "zmf_use": false,
            "local_affiliation": true
        }
    ]
}