List publications.

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id (integer)

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name (string)

Name of doctoral school.

emails (string[])

Contact emails.

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  • pubmed: iexact, contains, icontains, startswith, istartswith
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  • impact: isnull, gt, gte, lt, lte
  • imported: isnull, gt, gte, lt, lte, date
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        {
            "id": 197510,
            "title": "Adjuvant Melanoma therapy with Nivolumab, Pembrolizumab, or Dabrafenib plus Trametinib – a real life study",
            "abstract": "Introduction\r\nWith the use of immunotherapy and targeted therapy, a breakthrough in oncological medicine was achieved in the last few years. This study should now bring first results of efficacy and safety in real-life practice.\r\n\r\nMethods\r\nFor this study, we retrospectively enrolled 51 stage III or IV melanoma patients after R0-resection, who received adjuvant treatment with PD-1-antibodies nivolumab or pembrolizumab or a combination of BRAF/MEK-inhibitors dabrafenib and trametinib. Primary endpoint was recurrence-free survival (RFS), secondary endpoints included overall survival (OS) and subgroup and safety analyses.\r\n\r\nResults\r\nSurvival analysis revealed a one-year RFS of 70 % in the D+T, 59 % in the NIV, and 50 % in the PEM treated group. After two years, subjects showed a RFS of 44 % in the D+T, 43 % in the NIV, and 50 % in the PEM treated group. If we combine the two PD-1-antibodies, 58 % of patients were relapse free after one year, and 43 % after two years. OS was very similar in PD-1 (82 %) and BRAF/MEK treated patients (78 %). In the PD-1 treated group, factors that significantly improved RFS were age under 65 (HR for relapse 0.43 vs. 1.96; p=0.045; 95 % CI), only one positive lymph node (HR for relapse 0.5 vs. 1.5; p=0.02; 95 % CI), and a time to start of therapy that is less than three months (HR for relapse 0.4 vs. 2.2; p=0.028; 95 % CI). Immune-related adverse events due to immunotherapy did not indicate a reduced recurrence risk in our study. In the BRAF/MEK group, no factor leading to an improvement in RFS could be observed. Serious adverse events were similar in the PD-1 (25.8 %) and BRAF/MEK treated group (25 %) and no new toxicity signs were identified.\r\n\r\nConclusion\r\nImmunotherapy and targeted therapy agents continue to be very effective treatments for advanced melanoma. Nevertheless, there are multiple difficulties, since a number of patients do not respond to the treatment or experience severe adverse events. Therefore, early recurrence of advanced melanoma remains a challenge in medicine even to this date and intensive research is still needed for therapy improvement.",
            "authors": [
                "Kainbacher, N"
            ],
            "year": 2022,
            "source": "Humanmedizin; [ Diplomarbeit ] Medizinische Universität Graz; 2022. pp. 79",
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            "id": 197511,
            "title": "Einfluss kongenitaler Gesichtsfehlbildungen auf die Lebensgegebenheiten der Eltern",
            "abstract": "EINFÜHRUNG\r\nLippen-, Kiefer-, Gaumenspalten zählen mit einer Inzidenz von 1:700 Neugeborenen zu den häufigsten angeborenen Fehbildungen weltweit. Die Häufigkeit des Auftretens impliziert, dass sich eine Vielzahl an Familien mit den Herausforderungen und Folgen dieser Fehlbildungen täglich beschäftigen und auseinandersetzen. \r\nDie mit der Fehlbildung assoziierten Symptome und Probleme sind vielseitig und beziehen sich unter anderem auf die Sprache und die Lautbildung, die Nahrungsaufnahme, das Hörvermögen, das Mittelgesichtswachstum, sowie auf anatomische Veränderungen von Lippe und Nase, welche Ästhetik und Funktion nachhaltig beeinträchtigen können. \r\nUm in der Behandlung von Lippen-, Kiefer-, Gaumenspalten Patient*innen gute Outcomes erzielen zu können, bedarf es einer langjährigen interdisziplinären medizinischen Zusammenarbeit durch erfahrene Spezialisten unterschiedlicher Fachbereiche. \r\nDie Fragestellung besteht darin, ob ein Zusammenhang zwischen der angeborenen Fehlbildung der Kinder und den Lebensgegebenheiten der Eltern nachweisbar ist, und ob eine Spaltbildung im ästhetisch sichtbaren Bereich zu mehr Einschränkungen und Veränderungen führt. \r\n\r\nMATERIAL UND METHODEN\r\nDie Fragebogenstudie stützte sich auf eine retrospektive Datenauswertung von 53 Elternteilen, welche mit ihren Kindern aufgrund der Diagnose einer Lippen-, Kiefer-, Gaumenspalte an der klinischen Abteilung für Mund-, Kiefer- und Gesichtschirurgie der Universitätsklinik für Zahnmedizin und Mundgesundheit am LKH-Univ. Klinikum Graz behandelt wurden. Gegenstand unserer Analyse war ein validierter Fragebogen (Family impact scale-FIS) mit dessen Hilfe männliche und weibliche Elternteile von Patient*innen mit Lippen-, Kiefer-, Gaumenspalte befragt wurden. Dieses validierte Tool setzt sich aus 14 Fragen zusammen, welche unterschiedliche Teilbereiche der elterlichen Lebensgegebenheiten abbilden sollen. Der Fragebogen diente der adäquaten Beantwortung aller relevanten Punkte der Studie, um den Einfluss von Lippen-, Kiefer-, Gaumenspalten auf die Lebensgegebenheiten der Eltern beleuchten zu können.\r\n\r\nRESULTATE\r\nDas Resultat der Fragebogenstudie bestätigte ein höheres Belastungsniveau der Eltern, sowie eine eingeschränkte Lebensqualität in gewissen Lebenslagen Mehr als die Hälfte der befragten Elternteile gaben an, dass Kinder mit LKG-spalten mehr Aufmerksamkeit beanspruchen, als jene Geschwister ohne vergleichbare Diagnosen. \r\nIm direkten Vergleich der Diagnosen „isolierte Gaumenspalte“ (ICP) und „unilaterale Lippen-, Kiefer-, Gaumenspalte“ (UCLP) zeigte sich zusammenfassend eine stärker beeinträchtigte Lebensqualität der Elternteile von Kindern mit der Diagnose „UCLP“. Ebenso schnitt die Diagnose „ICP“ bezüglich Notwendigkeit einer beruflichen Auszeit und bestehender Eifersucht gegenüber anderen Familienmitgliedern im Vergleich zur Diagnose „UCLP“ besser ab. Insgesamt und unabhängig von der Spaltdiagnose des eigenen Kindes konnte bei der durchgeführten Erhebung gezeigt werden, dass bei Eltern die Sorge um reduzierte Chancengleichheit im Vergleich zu anderen Kindern ohne vergleichbare Diagnosen eine größere Rolle spielt. Der Bildungsabschluss der Eltern, das Geschlecht der Eltern, sowie die Anzahl der im Haushalt lebenden Kinder waren in Hinblick auf die analysierte Lebenszufriedenheit der Eltern ebenso bedeutungsvoll.\r\n\r\nDISKUSSION\r\nDie psychosoziale Entwicklung kann bei Kindern mit Lippen-, Kiefer-, Gaumenspalten durch die zugrundeliegende Diagnose negativ beeinflusst werden. Hier sind alle Ausprägungsgrade von Lippen-, Kiefer-, Gaumenspalten miteingenommen, da all diese morphologische und funktionelle Beeinträchtigungen hervorrufen, welche Einfluss auf die psychosoziale Integration nehmen können. Gleichermaßen kann die Diagnose Lippen-, Kiefer-, Gaumenspalte die Lebensgegebenheiten der Eltern und die Familiendynamik verändern. Letzteres zeigte sich deutlich in den Ergebnissen unserer Studie. Neben der Sorge verminderter Chancengleichheit, schien vor allem die",
            "authors": [
                "Koller, S"
            ],
            "year": 2022,
            "source": "Zahnmedizin; [ Diplomarbeit ] Medizinische Universität Graz; 2022. pp. 80",
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            "document_type": 15,
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        {
            "id": 197512,
            "title": "p53 in adipose tissue metabolism and homeostasis",
            "abstract": "Historically viewed as a passive site for energy storage, it is now well accepted that limitations in the degree of adipose tissue (AT) plasticity drive the progression of obesity-associated sequelae. As effective interventions against the metabolic syndrome, fasting regimens like intermittent fasting (IF) confer health benefits (like improved serum levels of cardiometabolic risk factors and amelioration of insulin resistance) beyond weight reduction. Tissue-specific metabolic adaptions to fasting include marked changes in AT morphology, physiology, and cellular composition. Recent studies emphasized an involvement of nutrient-responsive transcription factor p53 in regulating metabolism and tissue homeostasis in noncancerous settings, but the distinct function of p53 in the fasting response of adipocytes remains poorly characterized. \r\nTherefore, we generated an inducible, adipocyte-specific p53 knock-out (KO) mouse model and triggered obesity by high fat diet feeding. Selective ablation of p53 in obese mice accelerated the catabolic state during IF, as reflected by increased weight loss, decreased adipocyte size, and elevated plasma fatty acid levels. Furthermore, fasted obese p53 KO mice showed improved insulin sensitivity and trending decreased plasma TNFa levels. Morphologically, we observed an increase in the abundance of crown-like structures in epididymal white AT (eWAT) of IF-obese mice compared to ad libitum fed control, which was largely blunted in IF-p53 KO mice. Performing single-nuclei RNA sequencing of eWAT confirmed a marked increase in lipid-associated macrophage (LAM) infiltration upon IF. Strikingly, this fasting-mediated increase in LAMs was completely absent in obese p53 KO mice, in line with a significant reduction in the expression of pro-inflammatory marker genes and abundance of proteins involved in immune processes. In vitro studies of human, mature adipocytes confirmed the involvement of p53 in the regulation of adipocyte cytokine/chemokine signalling. Furthermore, a common, metabolically relevant SNP of p53 influenced the response of obese and diabetic humans to a fasting-mimicking diet, indicating a translational relevance of p53 in the nutritional control.  \r\nTaken together, we showed that AT underlies a remarkable heterogeneity, flexibly adapting its composition according to metabolic demands to ensure systemic energy homeostasis in an AT-cell-type collaborative fashion. Importantly, we revealed adipocyte p53 as a master regulator of eWAT plasticity and innate immune cell composition upon IF in obese mice.",
            "authors": [
                "Reinisch, I"
            ],
            "year": 2022,
            "source": "PhD-Studium (Doctor of Philosophy); Humanmedizin; [ Dissertation ] Medizinische Universität Graz; 2022. pp. ",
            "category": 5,
            "document_type": 16,
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        {
            "id": 197513,
            "title": "Optical Control of Neuronal Signaling with Organic Bioelectronics",
            "abstract": "Neurological disorders or injuries after traumatic events often destroy the natural function of neurons to process or transduce information. The artificial connection between technology and the living organism can treat, monitor, or restore such functions and conditions. All bioelectronic devices must address two main challenges: biocompatibility and power supply. In this work, I introduce two novel approaches based on light-sensitive organic pigments that require no wiring or genetic modification to control cell stimulation and that are safe in terms of use with living cells.\r\nIn this thesis, I have investigated the interaction of neuronal cell membranes with colloidal macrocrystals made from Epindolidione pigments that feature a 3D-shaped microstructure on their surface. Neurons developed extensive networks and stable interactions with these structures. Neurites that grew toward the organic pigments attached to them and remodeled connections during cell maturation. Photothermocapacitive stimulation of neuron-pigment complexes with laser light depolarized the cell membrane but was unable to induce action potential firing.\r\nI also benchmarked the performance of Organic Electrolytic Photocapacitors (OEPCs) on photocapacitive stimulation of mammalian cells with visible red light that can penetrate through the skin into tissues. OEPCs form a planar photovoltaic device with the n- and p-type semiconducting pigments N,N’-dimethyl perylene tetracarboxylicdiimide (PTCDI) and metal free phthalocyanine (H2Pc). Electrophysiology recordings of human embryonic kidney (HEK) cells transfected with the voltage-gated potassium channel Kv1.3 showed a time-dependent channel activation and a channel conductance shift of around 30 mV when placed on OEPCs. Neurons stimulated with millisecond pulses fired reliably action potentials on single and repetitive light pulses.\r\nThe findings demonstrate that organic pigment-based bioelectronics are safe to use in vitro and enable a nongenetic manipulation of neuronal signaling with light and high precision for future in vivo applications.",
            "authors": [
                "Schmidt, T"
            ],
            "year": 2022,
            "source": "PhD-Studium (Doctor of Philosophy); Humanmedizin; [ Dissertation ] Medizinische Universität Graz; 2022. pp. 131",
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            "document_type": 16,
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        {
            "id": 197514,
            "title": "Opening, Welcome Note",
            "abstract": null,
            "authors": [
                "Litscher, G"
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            "year": 2022,
            "source": "21st International ISLA Congress for Medical Laser Applications; SEP 9-10, 2022; Beverungen, GERMANY. 2022. ",
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            "title": "The role of cannabinoid receptors in the tumour microenvironment of KP cell syngrafts",
            "abstract": null,
            "authors": [
                "Sarsembayeva, A",
                "Kienzl, M",
                "Rudolf Schicho, R"
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            "year": 2021,
            "source": "DOCTORAL DAY 2021 Medical University of Graz; FEB 12, 2021; Graz, Austria. 2021. ",
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                "197516-99558"
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        {
            "id": 197518,
            "title": "Rätsel Mikrochimärismus – wenn wir über unsere Grenzen hinauswachsen.",
            "abstract": null,
            "authors": [
                "Kroneis, T"
            ],
            "year": 2022,
            "source": "Österr. Hebammenzeitung. 2022; (3): 8-14. ",
            "category": 1,
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            "title": "Development of an Architecture to Implement Machine Learning Based Risk Prediction in Clinical Routine: A Service-Oriented Approach.",
            "abstract": null,
            "authors": [
                "Schrempf, M",
                "Polat, Erdeniz, S",
                "Kramer, D",
                "Jauk, S",
                "Veeranki, SPK",
                "Ribitsch, W",
                "Leodolter, W",
                "Rainer, PP"
            ],
            "year": 2022,
            "source": "Stud Health Technol Inform. 2022; 293:  262-269. ",
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            "pubmed": "35592992",
            "doi": "10.3233/SHTI220379",
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                "197520-59568-6"
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            "imported": "2022-09-16T02:00:00+02:00",
            "journal": "Stud Health Technol Inform",
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            "id": 197521,
            "title": "Der Zusammenhang zwischen körperlicher Aktivität und Sitzverhalten in der Schwangerschaft und dem maternalen Glukosestoffwechsel, Geburtsgewicht und neonataler Adipositas ",
            "abstract": null,
            "authors": [
                "Dieberger, AM",
                "Obermayer-Pietsch, B",
                "Harreiter, J",
                "Desoye, G",
                "van Poppel, MNM",
                "DALI Core Investigator Gruppe"
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            "year": 2022,
            "source": "XXVII. Akademische Tagung Deutschsprechender Hochschullehrer in der Gynäkologie und Geburtshilfe; SEPT 15-17, 2022; Linz, Österreich. 2022. ",
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                "197521-14080"
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                "197521-51809"
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            "imported": "2022-09-17T12:17:07+02:00",
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