Publication List

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            "id": 181749,
            "title": "Non-Coding RNAs as novel emerging tumor markers in testicular cancer patients.",
            "abstract": "Testicular cancer is a disease that is becoming more and more important due to the increasing incidence in young men aged 15-35 years worldwide. A variety of tumor entities are described, with germ cell tumors (GCTs) forming the largest group (95%). Histological examination of the testicular tissue after orchiectomy plays an important role alongside patient history, imaging, clinical presentation and laboratory parameters. Surgical procedures and chemotherapeutic treatment provide a 99% chance of cure in the early stages, and advanced testicular tumors are also treatable, unlike other solid tumors. Nonetheless, these procedures are not sufficient to monitor patients and to detect early recurrences.\r\nTumor markers play an important role in testicular cancer, in particular for diagnosis and prognosis estimation and in the follow-up. The common markers are lactate dehydrogenase (LDH), α-fetoprotein (AFP) and the β-subunit of human chorionic gonadotropin (β-hCG). Unfortunately, these tumor markers only have a sensitivity of about 60%, in pure seminoma even lower with about 20%. Therefore, the development of new tumor markers is an important topic.\r\nThe analysis of epigenetic modification and microRNAs (miRNAs) are the most promising tumor markers in future. miRNAs are small RNAs secreted by testicular tumors that can circulate and be measured in body fluids. In recent years, miRNAs of the miR-371-373 cluster in particular have been identified as potentially superior tumor markers. In this work it could be shown that miR-371a-3p and miR-302/367 clearly differ in the expression patterns between testicular tumors and healthy testicular tissue. These miRNAs significantly exceed the sensitivity and specificity of conventional tumor markers and can facilitate the diagnosis, follow-up, and early detection of recurrences. However, further studies are needed to identify the weaknesses of these tumor markers.\r\nThe study of additional miRNAs involved in tumorigenesis will play a crucial role in the future.",
            "authors": [
                "Regouc, M"
            ],
            "year": 2020,
            "source": "Humanmedizin; [ Diplomarbeit ] Graz Medical University; 2020. pp. 58",
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        {
            "id": 181751,
            "title": "Die Pharmakotherapie von Akne.",
            "abstract": "Hintergrund: Akne ist eine multifaktorielle, chronische Erkrankung der Haar-TalgdrüsenEinheiten der Haut. Die Prävalenz dieser Hautkrankheit bei Jugendlichen ist mit über 80 % angegeben. Akne vermag die Lebensqualität der Betroffenen erheblich einzuschränken und geht mit starken psychischen Belastungen einher, wie geringem Selbstwertgefühl, sozialen Ängsten, Depressionen bis hin zu suizidalen Absichten. Durch eine adäquate topische und/oder systemische medikamentöse Therapie kann den Leidenden in aller Regel gut weitergeholfen werden und unerwünschte Spätfolgen wie Narben und Pigmentierungsstörungen können so verhindert werden. In dieser Arbeit werden verschiedene Aknemittel vorgestellt und es wird auf ihre Rolle in der nach Erkrankungsschwere orientierten Therapie eingegangen. Im Speziellen werden dabei die Besonderheiten der Anwendung in der Schwangerschaft beleuchtet.\r\n\r\nMethoden: Die Diplomarbeit ist auf Grundlage einer ausgiebigen Literaturrecherche entstanden. Sie stellt eine Übersichtsarbeit über die pharmakologischen Interventionsmöglichkeiten bei Akne dar. Für die Wissensgewinnung wurden in erster Linie Suchoberflächen wie PubMed, ScienceDirect, Ovid und Google Scholar verwendet. Des Weiteren wurden aktuelle Guidelines, insbesondere die „Europäischen evidenzbasierten (S3) Guidelines für die Behandlung von Akne“, herangezogen.\r\n\r\nSchlussfolgerung: Zu den klassischen topisch applizierten Therapeutika in der Aknetherapie gehören Benzoylperoxid und Azelainsäure, sowie Retinoide und Antibiotika. Bei den Retinoiden ist Adapalen gegenüber Tretinoin und Isotretinoin der Vorrang zu geben. Bei milden Krankheitsverläufen wie bei Acne comedonica ist das antikomedogen wirksame Adapalen empfohlen, während bei schwerer Akne orales Isotretinoin das Mittel der Wahl ist. Alternativ kann hier ein systemisches Antibiotikum in Kombination mit einem Topikum empfohlen werden. Für Frauen kann als weitere therapeutische Option eine Therapie mit Antiandrogenen oder kombinierten oralen Kontrazeptiva in Betracht gezogen werden. Ebenso relevant wie die medikamentöse Therapie als solche sind Maßnahmen, welche die Adhärenz der zumeist jungen Aknepatientinnen und -patienten steigern können.",
            "authors": [
                "Heusel, D"
            ],
            "year": 2020,
            "source": "Humanmedizin; [ Diplomarbeit ] Medizinische Universitaet Graz; 2020. pp. 75",
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            "id": 181752,
            "title": "Pathophysiological Mechanism of Endocardial Fibroelastosis Development in Hypoplastic Left Heart Syndrome.",
            "abstract": "Background: \r\nEndothelial-to-mesenchymal-transition (EndMT) plays a major role in cardiac fibrosis, including endocardial fibrosis (EFE), which is associated with congenital heart defects such as hypoplastic left heart syndrome (HLHS). The stimuli for EndMT leading to EFE formation are still unknown but we speculate that mechanical forces and young age are associated with the development of this unique form of fibrosis. The aims of the study were to identify stimuli and regulator pathways leading to the development of EFE.\r\n\r\nMaterial and Methods: \r\nEndothelial cells (EC) in culture were exposed to 8hrs of 10% uniaxial stretch or direct stimulation of EndMT through addition of TGF-b to the media. Inhibition of the TGF-β pathway was performed by local application of: BMP7, a TGF-ß inhibitor SB431542 or Losartan. Immature and mature isolated perfused rat hearts (n=7/group) were exposed to 3h stretch through a weight attached to the apex of the LV. The same groups as in the isolated cell culture experiments were tested. Additionally, EFE tissue resected from the LV of 24 HLHS patients and macroscopically ‘EFE-like’ tissue of 6 non-HLHS patients with known flow disturbances in the LV outflow tract was analyzed. Amount of collagen/elastin, vascularity/cellularity and presence of active EndMT was determined by immunohistochemical staining. Tissue remodeling through degradation of elastic fibers/collagen by matrix metalloproteinases was determined by in situ zymography.\r\n\r\nResults: \r\nStretch induced EndMT in isolated ECs in culture was determined by significantly more CD-31/alpha-SMA double-stained endothelial cells (46±13% of total cell count), and confirmed in whole hearts (15.9±2% of total cell count) compared to controls (cells: 7±2%; heart: 3.1±0.1; p<0.05). However, only immature hearts showed endocardial EndMT. Inhibition of the TGF-ß pathway significantly decreased the number of double-stained cells following stretch, comparable to controls (cells/heart: control: 7±2/3.1±0.1%, stretch: 46±13/15±2%, BMP7: 7±2/2.9±0.1%, 5.2±1.3%, Losartan (heart only): 0.89±0.1%; p<0.001). \r\n“EFE-like” tissue obtained from non-HLHS patients, showed the same characteristics as EFE tissue from HLHS patients. Active EndMT was found in all 24 HLHS samples and all 6 non-HLHS patients. In the “non-HLHS” patient group with valvar disease, predominantly a jet across a stenotic mitral valve was present. In situ zymography displayed a balance between degradation of elastin/collagen and elastase/gelatinase activity. \r\n\r\nConclusion: \r\nEndMT was induced in in vitro and ex vivo experiments by mechanical strain on the endocardium, however, only in immature hearts. By use of specific inhibitors such as BMP-7 and Losartan, the TGF-ß pathway was identified as the main stimulator for EndMT development. Mechanical forces such as flow disturbances and stretch exposing endocardial endothelial cells to altered mechanical force are triggers for induction of EndMT. In human EFE pathology, prolonged exposure of endcardial endothelial cells to altered mechanical forces leads to reoccurrence of EFE displaying with a more infiltrative growth pattern into the underlying myocardium. These alterations are not limited to HLHS but are associated with severe congenital valve diseases with flow turbulences.",
            "authors": [
                "Weixler, V"
            ],
            "year": 2020,
            "source": "Doktoratsstudium der Medizinischen Wissenschaft; Humanmedizin; [ Dissertation ] Graz Medical University; 2020. pp. 82",
            "category": 5,
            "document_type": 16,
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        {
            "id": 181753,
            "title": "Harnsäure und deren Einfluss auf den akuten ischämischen Schlaganfall.",
            "abstract": "Hintergrund: Harnsäure ist das Abbauprodukt des Purin-Stoffwechsels und spielt aufgrund ihrer einerseits antioxidativen, andererseits aber auch prooxidativen Eigenschaften sowohl in der Abwehr als auch in der Entstehung von Oxidativem Stress eine wichtige Rolle. Während hohe Harnsäurespiegel einerseits mit einem erhöhten Risiko für die Entwicklung von Gicht sowie verschiedenen kardiovaskulären Krankheiten einhergehen, wird Harnsäure andererseits als potentiell neuroprotektive Substanz mit günstigen Auswirkungen auf den Verlauf des akuten ischämischen Schlaganfalls gehandelt. Zunächst wird in dieser Arbeit ein allgemeiner Überblick zu den Themen Harnsäure und Hyperurikämie geschaffen. Anschließend werden anhand einer Übersicht zur aktuellen Studienlage die verschiedenen Einflüsse der Harnsäure auf den ischämischen Schlaganfall diskutiert und des Weiteren erörtert, ob eine therapeutische Harnsäuregabe in Zukunft eine mögliche Therapieoption zusätzlich zur rt-PA-Therapie bei Schlaganfällen darstellen könnte.\r\n\r\nMethoden: Eine Literaturrecherche zum Thema Harnsäure und Schlaganfall wurde durchgeführt. Als Quellen dienten dabei Studien, die über Pubmed gefunden wurden. Des Weiteren wurden verschiedene aktuelle Fachbücher und Leitlinien als Quellen herangezogen. Die Suche auf Pubmed erfolgte anhand passender MeSH-Terms sowie im Freitext. Zusätzlich wurde Literatur zum Thema aus den Literaturverzeichnissen inkludierter Arbeiten miteinbezogen. \r\n\r\nResultate: Erhöhte Harnsäurespiegel gehen mit erhöhter Schlaganfall-Inzidenz und -Mortalität in beiden Geschlechtern einher, Hyperurikämie kann somit wohl zu den Risikofaktoren des Schlaganfalls gezählt werden. \r\nGleichzeitig sind hohe Harnsäurespiegel in verschiedenen Studien mit niedrigeren NIHSS-Scores und niedrigeren mRS-Scores assoziiert. Diese Beobachtungen sprechen für einen günstigen Einfluss von Harnsäure auf den Verlauf des Schlaganfalls. Studien im Zell- und Tiermodell, in denen eine therapeutische Harnsäuregabe getestet wurde, konnten zudem Zusammenhänge zwischen Harnsäureverabreichung und vermindertem neuronalen Zelltod, verminderter ROS-Bildung, kleineren Infarktvolumina und geringeren neurologischen Defiziten, sowie verminderter Schädigung durch Hyperämie in der Reperfusionsphase nachweisen. Auch wurden durch die kombinierte Therapie mit Harnsäure und rt-PA bessere Ergebnisse erzielt als durch eine jeweilige Einzeltherapie. \r\nDiese vielversprechenden Ergebnisse könnten auf einen möglichen therapeutischen Nutzen einer Harnsäuretherapie hindeuten. Im klinischen Setting konnte bislang allerdings kein signifikanter Effekt einer Harnsäureverabreichung auf das Outcome des Schlaganfalls nachgewiesen werden. Die Resultate verschiedener Subgruppenanalysen einer Studie liefern dennoch Hinweise auf einen möglichen therapeutischen Effekt einer Harnsäuregabe. Da es bislang jedoch noch keine weiteren Vergleichsstudien gibt, bedarf es weiterer Arbeiten, um genauere Aussagen über die Auswirkungen einer Harnsäuretherapie auf den Verlauf des ischämischen Schlaganfalls tätigen zu können.",
            "authors": [
                "Kofler, T"
            ],
            "year": 2020,
            "source": "Humanmedizin; [ Diplomarbeit ] Medizinische Universitaet Graz; 2020. pp. 56",
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        {
            "id": 213171,
            "title": "Der periphere „Nerven-Loop“ als operative Behandlungsmethode von schmerzhaften Neuromen peripherer Nerven.",
            "abstract": null,
            "authors": [
                "Kohlhauser, M",
                "Holter, M",
                "Riegler, G",
                "Girsch, W"
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            "year": 2024,
            "source": "DAM, 45. Jahrestagung; Mikrochirurgie - Grenzen überschreitend ; NOV 7-9; 2024; Aachen, GERMANY. 2024. ",
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                "213171-14045",
                "213171-14076"
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                "213171-119869"
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        {
            "id": 181754,
            "title": "Untersuchung prognostischer Faktoren beim follikulären Lymphom.",
            "abstract": "Einleitung: Das follikuläre Lymphom ist das häufigste indolente Non-Hodgkin Lymphom in Westeuropa und den USA. Mit seinem sehr heterogenen Krankheitsverlauf ist es schwierig zum Diagnosezeitpunkt eine Aussage über die Prognose für die PatientInnen zu treffen, weshalb zur Risikoabschätzung verschiedene klinische Scores wie der FLIPI-Score entwickelt wurden. Zuletzt wurden für die Klassifikation und Prognostik auch vermehrt molekulargenetische Marker einbezogen. Ziel dieser Arbeit war es, die routinemäßig erhobenen Parameter aus dem PatientInnenkollektiv des LKH Graz auf ihre prognostische Relevanz hinsichtlich des Outcome zu untersuchen.\r\nMaterial und Methoden: Die molekulargenetischen und klinischen Daten von 238 PatientInnen des LKH Graz wurden in eine Datenbank überführt und mittels Excel und SPSS  in einer retrospektiven Analyse ausgewertet. Die Assoziation mit POD24 wurde mit Hilfe von Kreuztabellen und dem Chi-Quadrat-Test untersucht. Das Gesamtüberleben sowie das progressionsfreie Überleben wurden mittels Kaplan-Meier-Kurven und anschließendem Log-rank-Test sowie einer univariaten Cox-Regression überprüft.\r\nErgebnisse: Es konnte ein signifikanter Zusammenhang zwischen einem negativen Expressionsgrad für CD3 und einem positiven POD24-Wert gefunden werden (p=0,044).  In den Kaplan-Meier-Kurven zeigte sich ein signifikant besseres Gesamtüberleben (OS) für einen hohen Expressionsgrad von CD3 (p<0,001) und CD5 (p=0,029) sowie für hohe und mittlere Expressionsgrade von CD10 (p<0,001). Ein signifikant niedrigeres OS war bei positiven MUM-1 Expressionsgrad (p=0,006) sowie bei negativen CD23 (p=0,034) und CD8 (p=0,003) Expressionsgraden zu beobachten. Ein signifikant besseres progressionsfreies Überleben (PFS) zeigte sich für einen stark positiven Expressionsgrad von CD3  (p<0,001) und CD79a (p=0,034). Ein positiver Expressionsgrad von MUM1 war mit einem signifikant schlechteren PFS assoziiert (p=0,012). In der univariaten Cox-Regression konnten die Ergebnisse für das OS bei CD3 (p<0,001), CD10 (p=0,014; p<0,001), CD23 (p=0,026) und MUM-1 (p=0,008) bestätigt werden. Für das PFS bestätigten sich die Ergebnisse von CD3 (p<0,001), MUM-1 (p=0,009) und CD79a (p=0,049).\r\nDiskussion: Bei der Evaluierung der erhobenen molekulargenetischen Daten konnten verschiedenen Marker identifiziert werden, deren Expressionsgrade eine Assoziation mit dem Outcome der PatientInnen aufwiesen. Im Kontext der Risikoabschätzung und prognostischen Relevanz erwies sich MUM-1 als vielversprechendster der untersuchten Marker und damit als Kandidat für die die potenzielle Einbeziehung in zukünftige Scores zur Risikoabschätzung.",
            "authors": [
                "Hagenah, J"
            ],
            "year": 2020,
            "source": "Humanmedizin; [ Diplomarbeit ] Medizinische Universitaet Graz; 2020. pp. 73",
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        },
        {
            "id": 181755,
            "title": "Keratokonuslokalisation Vergleich unterschiedlicher tomographischer Parameter.",
            "abstract": "Hintergrund\r\nAls Keratokonus bezeichnet man eine nicht entzündliche Veränderung der Hornhaut (Kornea), die durch eine kegelförmige Vorwölbung sowie Ausdünnung charakterisiert ist. Die exakte tomographische Determination der Keratokonus Lokalisation wird sowohl für die Diagnostik als auch für die Therapie immer wichtiger. In dieser Arbeit wurden Distanzen zwischen Lokalisationen von unterschiedlichen Punkten zur Beschreibung des Keratokonus retrospektiv analysiert und ausgewertet.\r\n\r\nPatienten und Methoden\r\nKoordinaten von PM, MAE, MPE, Kmax sowie tKmax wurden von insgesamt 92 PatientInnen bzw. 163 Augen bestimmt und die Distanzen zwischen ihnen errechnet. In die Auswertung eingeschlossen wurden sowohl weibliche als auch männliche Patienten zwischen 12 und 44 Jahren. Zu den Ausschlusskriterien zählten: eine stattgehabte Augenoperation, eine zentrale Hornhauttrübung sowie fehlerhafte Messungen der Pentacam. \r\nDie Abstände der Lokalisationen dieser Punkte zueinander wurden in verschiedenen Stadien des Keratokonus betrachtet. Für die Abschätzung des Erkrankungsstadiums wurde der D Wert herangezogen.\r\n\r\nErgebnisse\r\nDie geringsten Abstände zeigten sich zwischen MPE und MAE (im Median 0.2 mm für linke Augen bzw. 0.3 mm für rechte Augen), gefolgt von PM und MPE (0.4 mm im Median links und 0.3 mm rechts) sowie PM und MAE (0.5 mm und 0.6 mm). Es konnte ein signifikantes indirektes Verhältnis zwischen dem D Wert und den relativen Abständen in allen Gruppen aufgezeigt werden, was bedeutet, dass in fortgeschritteneren Stadien der Erkrankung die relativen Unterschiede geringer werden.\r\n\r\nSchlussfolgerung\r\nEs gibt Unterschiede zwischen den verschiedenen, hier berechneten Messparametern, eines Keratokonus. In beginnenden Stadien sind diese Unterschiede größer als in fortgeschrittenen Stadien. PM, MAE und MPE scheinen sich am besten zur Beschreibung des Keratokonuszentrums zu eignen da die Unterschiede zwischen diesen Parametern am geringsten sind.",
            "authors": [
                "Kollenc, A"
            ],
            "year": 2020,
            "source": "Humanmedizin; [ Diplomarbeit ] Medizinische Universitaet Graz; 2020. pp. 61",
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            "bmf_use": false,
            "zmf_use": false,
            "local_affiliation": false
        },
        {
            "id": 181758,
            "title": "A CASE REPORT OF A PATIENT PRESENTING WITH ACUTE RENAL FAILURE SUFFERING FROM THE RARE HISTIOCYTIC NEOPLASM OF ERDHEIM-CHESTER DISEASE.",
            "abstract": "OBJECTIVE\r\nThe aim of this work is on the one hand to add information to the scarce literature on the topic of Erdheim-Chester disease, a rare multisystemic disease, a non-Langerhans cell histiocytosis with multiorgan involvement, declared a histiocytic neoplasm by the World Health Organization in 2016, particulary in connection with renal involvement (70 PubMed entries), and on the other hand, to find out whether the presence of particular symptoms might be indicative of the diagnosis of this rare disease or not.\r\n\r\nMETHODS\r\nA retrospective data assessment of a 60-year-old male patient presenting with acute renal failure, suffering from the rare histiocytic neoplasm of Erdheim-Chester disease at the Department of Urology at the Medical University of Graz – including medical history, diagnoses, laboratory data and therapy plans retrieved from electronic patient records - from 2010 to 2018, were included into this case report.\r\nAt the same time, a systematic literature review was conducted, mainly consisting of ‘PubMed’ and ‘Google Scholar’, as well as at the University Library of the Medical University of Graz.\r\n\r\nRESULTS\r\nThe rare case of a 60-year-old male patient suffering from untreated polydipsia and polyuria for 5 years before presenting with bilateral hydronephrosis and acute renal failure at the Department of Urology of the Medical University of Graz, is reported. Importantly, the respective patient underwent a resection of a small, rightsided neck tumor as early as November 2010 at the Department of Dermatology of the Medical University of Graz, which was histologically diagnosed as a potential Langerhans-cell histiocytosis. The patient continued to be clinically asymptomatic until the development of diabetes insipidus in August 2012, as well as several skeletal and multiple extraskeletal manifestations. Nevertheless, it took more than another 6 years until the diagnosis of Erdheim-Chester disease was confirmed histologically, as well as genetically, thanks to the surgical removal of multiple rightsided ureteral biopsies in April 2018, and thus the patient was able to consecutively receive state-of-the-art medical treatment with a selective BRAF-inhibitor.\r\n\r\nCONCLUSION\r\nDespite its rarity, Erdheim-Chester disease represents an important (differential) diagnosis that can be associated with numerous and often unspecific symptoms, e.g. bone pain, fever, night sweats and fatigue. For a correct diagnosis of this rare disease it is paramount that all available patient evaluations, examinations and results are documented in a meticulous fashion and are made accessible for all interdisciplinary medical experts involved in the treatment of a patient, in order to be able to timely start state-of-the-art medical treatment whenever necessary.",
            "authors": [
                "Ciochirca-Rath, M"
            ],
            "year": 2020,
            "source": "Humanmedizin; [ Diplomarbeit ] Graz Medical University; 2020. pp. 53",
            "category": 5,
            "document_type": 15,
            "sci": null,
            "pubmed": null,
            "doi": null,
            "pmc": null,
            "organizations": [],
            "persons": [],
            "imported": "2020-04-01T16:54:09+02:00",
            "journal": null,
            "issn": null,
            "collection_publisher": null,
            "collection_title": null,
            "edition": null,
            "university": "Graz Medical University",
            "country": "40",
            "case_report": false,
            "impactfactor": null,
            "impactfactor_year": null,
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            "selected_presentation": false,
            "biobank_use": false,
            "bmf_use": false,
            "zmf_use": false,
            "local_affiliation": false
        },
        {
            "id": 181759,
            "title": "The role of endogenous thrombin potential, fibrinolytic markers and their functional gene polymorphisms in the pathogenesis of central serous chorioretinopathy.",
            "abstract": "Background:\r\n\r\nCentral serous chorioretinopathy (CSC) is a common chorioretinal disease, characterized by choroidal hyperpermeability leading to neurosensory and/or retinal pigment epithelial detachments. Hypofibrinolysis due to higher plasma concentrations of plasminogen activator type 1 (PAI-1) or lower activity of tissue-type plasminogen activator (t-PA) has been implicated in the pathogenesis of CSC. Clotting factors, fibrinolysis markers and functional polymorphisms in the PAI-1 (SERPINE 1) and t-PA (PLAT) gene are thus potential risk factors for CSC. \r\nThe aim of the present thesis was therefore to investigate a hypothesized association between endogenous thrombin potential (ETP), a global coagulation marker, t-PA antigen plasma levels and the PAI-1 4G/5G and the t-PA -7351C>T gene variants and the presence of CSC. \r\n\r\n\r\nMethods:\r\n\r\nThe present dissertation includes data from two different studies.\r\nFirst, ETP and t-PA antigen plasma levels were investigated in 59/ 63 patients and 58 control subjects. ETP was determined with INNOVANCE® ETP (BCS® XP Coagulation System, Siemens Healthineers, Vienna, Austria), whereas t-PA antigen levels were determined with Quantikine® ELISA (R&D Systems, Inc., Minneapolis, USA).\r\nIn a second step, we collected blood samples of 172 CSC patients and 313 control subjects for genotyping of the PAI-1 4G/5G and the t-PA -7351C>T polymorphisms.\r\nGenotypes of the aforementioned polymorphisms were determined by TaqManTM fluorogenic 5´-exonuclease assays (Applied Biosystems, Vienna, Austria).\r\n\r\nResults:\r\n\r\nMean ETP levels (375.0 +- 57.2 mE vs. 367.1 +- 51.3 mE, p=0.43) did not significantly differ between patients and controls. Mean plasma t-PA antigen concentrations were significantly higher in CSC patients compared to controls (3673.1 +- 1281.6 pg/ml vs. 3228.0 +- 1079.8 pg/ml, p=0.04). Allelic frequencies or genotype distributions of neither the PAI-1 4G/5G nor the t-PA -7531C>T polymorphisms were significantly different between patients with CSC and control subjects (PAI-1 4G/4G: 24.4% vs. 20.4, p=0.36; t-PA -7351CC: 42.4% vs. 46.0%, p=0.50). After adjusting for age and gender presence of the PAI-1 4G/4G genotype was associated with a non-significant odds ratio of 1.21 (95% confidence interval [95% CI]: 0.77 - 1.92, p=0.41), while homozygosity for the t-PA -7351C allele yielded a non-significant odds ratio of 0.91 (95% CI: 0.62 – 1.33, p=0.62) for CSC. \r\n\r\nConclusion:\r\n\r\nThe present study indicates that increased t-PA antigen plasma concentrations are associated with a higher risk for CSC. In contrast, the present data suggest that neither ETP levels nor the - t-PA -7351C>T and the PAI-1 4G/5G gene polymorphisms are major risk factors for CSC.",
            "authors": [
                "Malle, E"
            ],
            "year": 2020,
            "source": "Doktoratsstudium der Medizinischen Wissenschaft; Humanmedizin; [ Dissertation ] Graz Medical University; 2020. pp. 93",
            "category": 5,
            "document_type": 16,
            "sci": null,
            "pubmed": null,
            "doi": null,
            "pmc": null,
            "organizations": [],
            "persons": [],
            "imported": "2020-04-01T16:54:09+02:00",
            "journal": null,
            "issn": null,
            "collection_publisher": null,
            "collection_title": null,
            "edition": null,
            "university": "Graz Medical University",
            "country": "40",
            "case_report": false,
            "impactfactor": null,
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            "local_affiliation": false
        },
        {
            "id": 204160,
            "title": "Die Nuckzyste- eine sehr seltene Diagnose bei erwachsenen Frauen.",
            "abstract": null,
            "authors": [
                "Kohlhauser, M"
            ],
            "year": 2023,
            "source": "Deutscher Chirurgie Kongress (DCK.digitale). 2023; -Gemeinsam lernen und heilen; APR 18-20, 2023; Munich, GERMANY. ",
            "category": 2,
            "document_type": 19,
            "sci": null,
            "pubmed": null,
            "doi": null,
            "pmc": null,
            "organizations": [
                "204160-14076"
            ],
            "persons": [
                "204160-119869"
            ],
            "imported": "2023-08-25T17:00:05+02:00",
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            "conference_name": true,
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            "selected_presentation": true,
            "biobank_use": false,
            "bmf_use": false,
            "zmf_use": false,
            "local_affiliation": true
        },
        {
            "id": 213172,
            "title": "How to become a Microsurgeon in Austria.",
            "abstract": null,
            "authors": [
                "Kamolz, LP"
            ],
            "year": 2024,
            "source": "DAM, 45. Jahrestagung; Mikrochirurgie - Grenzen überschreitend ; NOV 7-9; 2024; Aachen, GERMANY. 2024. ",
            "category": 3,
            "document_type": null,
            "sci": null,
            "pubmed": null,
            "doi": null,
            "pmc": null,
            "organizations": [
                "213172-14076"
            ],
            "persons": [
                "213172-80111"
            ],
            "imported": "2025-01-15T15:05:30+01:00",
            "journal": null,
            "issn": null,
            "collection_publisher": null,
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            "edition": null,
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            "case_report": false,
            "impactfactor": null,
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            "conference_name": true,
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            "selected_presentation": true,
            "biobank_use": false,
            "bmf_use": false,
            "zmf_use": false,
            "local_affiliation": true
        },
        {
            "id": 181762,
            "title": "Die konservative Seite der Orthopädie.",
            "abstract": null,
            "authors": [
                "Leithner, A",
                "MACHACEK, P"
            ],
            "year": 2020,
            "source": "Jatros / Orthopädie, Rheumatologie, Sportmedizin. 2020; 25(2): 7",
            "category": 1,
            "document_type": 4,
            "sci": null,
            "pubmed": null,
            "doi": null,
            "pmc": null,
            "organizations": [
                "181762-14052"
            ],
            "persons": [
                "181762-53237"
            ],
            "imported": "2020-04-02T09:55:50+02:00",
            "journal": null,
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            "edition": null,
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            "country": null,
            "case_report": false,
            "impactfactor": null,
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            "citations": null,
            "conference_name": null,
            "conference_place": null,
            "conference_international": false,
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            "selected_presentation": false,
            "biobank_use": false,
            "bmf_use": false,
            "zmf_use": false,
            "local_affiliation": false
        },
        {
            "id": 181783,
            "title": "Spectrum of Refractive Surgery 2019",
            "abstract": null,
            "authors": [
                "Steinwender, G"
            ],
            "year": 2019,
            "source": "SPEKTRUM AUGENHEILKD. 2019; 33(6): 133-133. ",
            "category": 1,
            "document_type": 4,
            "sci": "ISI:000519672900001",
            "pubmed": null,
            "doi": "10.1007/s00717-019-00443-4",
            "pmc": null,
            "organizations": [
                "181783-14043"
            ],
            "persons": [
                "181783-87194-2"
            ],
            "imported": "2020-04-03T11:33:19+02:00",
            "journal": "SPEKTRUM AUGENHEILKD",
            "issn": "0930-4282",
            "collection_publisher": null,
            "collection_title": "SPEKTRUM DER AUGENHEILKUNDE; ",
            "edition": null,
            "university": null,
            "country": null,
            "case_report": false,
            "impactfactor": null,
            "impactfactor_year": null,
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            "impactfactor_norm_category": null,
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            "citations": false,
            "conference_name": null,
            "conference_place": null,
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            "selected_presentation": false,
            "biobank_use": false,
            "bmf_use": false,
            "zmf_use": false,
            "local_affiliation": true
        },
        {
            "id": 181788,
            "title": "Phakic posterior chamber intraocular lenses",
            "abstract": null,
            "authors": [
                "Kook, D",
                "Mayer, WJ",
                "Steinwender, G",
                "Kohnen, T"
            ],
            "year": 2019,
            "source": "SPEKTRUM AUGENHEILKD. 2019; 33(6): 160-164. ",
            "category": 1,
            "document_type": 1,
            "sci": "ISI:000519672900006",
            "pubmed": null,
            "doi": "10.1007/s00717-019-00438-1",
            "pmc": null,
            "organizations": [
                "181788-14043"
            ],
            "persons": [
                "181788-87194-6"
            ],
            "imported": "2020-04-03T11:33:19+02:00",
            "journal": "SPEKTRUM AUGENHEILKD",
            "issn": "0930-4282",
            "collection_publisher": null,
            "collection_title": "SPEKTRUM DER AUGENHEILKUNDE; ",
            "edition": null,
            "university": null,
            "country": null,
            "case_report": false,
            "impactfactor": null,
            "impactfactor_year": null,
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            "selected_presentation": false,
            "biobank_use": false,
            "bmf_use": false,
            "zmf_use": false,
            "local_affiliation": true
        },
        {
            "id": 181789,
            "title": "Surface ablation procedures in refractive surgery",
            "abstract": null,
            "authors": [
                "Mayer, WJ",
                "Shajari, M",
                "Kook, D",
                "Luft, N",
                "Priglinger, S",
                "Steinwender, G",
                "Kohnen, T"
            ],
            "year": 2019,
            "source": "SPEKTRUM AUGENHEILKD. 2019; 33(6): 134-138. ",
            "category": 1,
            "document_type": 1,
            "sci": "ISI:000519672900002",
            "pubmed": null,
            "doi": "10.1007/s00717-019-00439-0",
            "pmc": null,
            "organizations": [
                "181789-14043"
            ],
            "persons": [
                "181789-87194-6"
            ],
            "imported": "2020-04-03T11:33:19+02:00",
            "journal": "SPEKTRUM AUGENHEILKD",
            "issn": "0930-4282",
            "collection_publisher": null,
            "collection_title": "SPEKTRUM DER AUGENHEILKUNDE; ",
            "edition": null,
            "university": null,
            "country": null,
            "case_report": false,
            "impactfactor": null,
            "impactfactor_year": null,
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            "selected_presentation": false,
            "biobank_use": false,
            "bmf_use": false,
            "zmf_use": false,
            "local_affiliation": true
        },
        {
            "id": 181793,
            "title": "LASIK and Femto-LASIK: a review of the current situation in 2019",
            "abstract": null,
            "authors": [
                "Kohnen, T",
                "Steinwender, G"
            ],
            "year": 2019,
            "source": "SPEKTRUM AUGENHEILKD. 2019; 33(6): 139-146. ",
            "category": 1,
            "document_type": 1,
            "sci": "ISI:000519672900003",
            "pubmed": null,
            "doi": "10.1007/s00717-019-00437-2",
            "pmc": null,
            "organizations": [
                "181793-14043"
            ],
            "persons": [
                "181793-87194-6"
            ],
            "imported": "2020-04-03T11:33:19+02:00",
            "journal": "SPEKTRUM AUGENHEILKD",
            "issn": "0930-4282",
            "collection_publisher": null,
            "collection_title": "SPEKTRUM DER AUGENHEILKUNDE; ",
            "edition": null,
            "university": null,
            "country": null,
            "case_report": false,
            "impactfactor": null,
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            "selected_presentation": false,
            "biobank_use": false,
            "bmf_use": false,
            "zmf_use": false,
            "local_affiliation": true
        },
        {
            "id": 181811,
            "title": "Uro-Onkologie: Therapie - Prostatakarzinom.",
            "abstract": null,
            "authors": [
                "Hutterer, GC"
            ],
            "year": 2019,
            "source": "Fortbildungstagung der Österreichischen Gesellschaft für Urologie und Andrologie; 08.-09.11.2019; Linz. 2019. ",
            "category": 3,
            "document_type": null,
            "sci": null,
            "pubmed": null,
            "doi": null,
            "pmc": null,
            "organizations": [
                "181811-14056"
            ],
            "persons": [
                "181811-50839"
            ],
            "imported": "2020-04-03T12:23:50+02:00",
            "journal": null,
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            "country": null,
            "case_report": false,
            "impactfactor": null,
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            "conference_name": true,
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            "selected_presentation": true,
            "biobank_use": false,
            "bmf_use": false,
            "zmf_use": false,
            "local_affiliation": true
        },
        {
            "id": 181812,
            "title": "Das Wichtigste aus 2017: Urothelkarzinom.",
            "abstract": null,
            "authors": [
                "Hutterer, GC"
            ],
            "year": 2017,
            "source": "Fortbildungstagung der Österreichischen Gesellschaft für Urologie und Andrologie; 10.-11.11.2017; Linz. 2017. ",
            "category": 3,
            "document_type": null,
            "sci": null,
            "pubmed": null,
            "doi": null,
            "pmc": null,
            "organizations": [
                "181812-14056"
            ],
            "persons": [
                "181812-50839"
            ],
            "imported": "2020-04-03T12:31:17+02:00",
            "journal": null,
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            "edition": null,
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            "country": null,
            "case_report": false,
            "impactfactor": null,
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            "conference_name": true,
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            "selected_presentation": true,
            "biobank_use": false,
            "bmf_use": false,
            "zmf_use": false,
            "local_affiliation": true
        },
        {
            "id": 181813,
            "title": "Das Wichtigste aus 2016: Nierenzellkarzinom",
            "abstract": null,
            "authors": [
                "Hutterer, GC"
            ],
            "year": 2016,
            "source": "J UROL UROGYNÄKOL 2016; 23 (3). 2016; -Fortbildungstagung der Österreichischen Gesellschaft für Urologie und Andrologie; 04.-05.11.2016; Linz. ",
            "category": 2,
            "document_type": 9,
            "sci": null,
            "pubmed": null,
            "doi": null,
            "pmc": null,
            "organizations": [
                "181813-14056"
            ],
            "persons": [
                "181813-50839"
            ],
            "imported": "2020-04-03T12:39:29+02:00",
            "journal": null,
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