Publication List
List publications.
Fields
id (integer)
Primary key.
name (string)
Name of doctoral school.
emails (string[])
Contact emails.
Expansions
To activate relation expansion add the desired fields as a comma separated
list to the expand query parameter like this:
?expand=<field>,<field>,<field>,...
The following relational fields can be expanded:
personscategorydocumentorganization_authorship
Filters
To filter for exact value matches:
?<fieldname>=<value>
Possible exact filters:
yearcategorydocumentpersons
For advanced filtering use lookups:
?<fieldname>__<lookup>=<value>
All fields with advanced lookups can also be used for exact value matches as described above.
Possible advanced lookups:
year:gt,gte,lt,ltesci:iexact,contains,icontains,startswith,istartswithpubmed:iexact,contains,icontains,startswith,istartswithdoi:iexact,contains,icontains,startswith,istartswithpmc:iexact,contains,icontains,startswith,istartswithorganization_authorship:inimpact:isnull,gt,gte,lt,lteimported:isnull,gt,gte,lt,lte,date
GET /v1/research/publication/?format=api&offset=150200&ordering=year
{ "count": 157150, "next": "https://api-test.medunigraz.at/v1/research/publication/?format=api&limit=20&offset=150220&ordering=year", "previous": "https://api-test.medunigraz.at/v1/research/publication/?format=api&limit=20&offset=150180&ordering=year", "results": [ { "id": 209987, "title": "Kognitive Fähigkeiten und psychosoziale Funktionsfähigkeit bei \r\nbipolarer Störung: Ergebnisse der BIPLONG-Studie", "abstract": null, "authors": [ "Schönthaler, E", "Dalkner, N", "Stross, T", "Bengesser, SA", "Ilic, J", "Fellendorf, FT", "Finner, A", "Maget, A", "Lenger, M", "Queissner, R", "Schmiedhofer, F", "Smolle, S", "Tmava-Berisha, A", "Reininghaus, EZ\r\n" ], "year": 2024, "source": "24. Jahrestagung der Österreichischen Gesellschaft für Psychiatrie, Psychotherapie und Psychosomatik; APR 24-27, 2024; Vienna, AUSTRIA. 2024. ", "category": 3, "document_type": null, "sci": null, "pubmed": null, "doi": null, "pmc": null, "organizations": [ "209987-29444" ], "persons": [ "209987-109162", "209987-99972", "209987-111460", "209987-113091", "209987-123273", "209987-124495", "209987-50654", "209987-61097", "209987-79733", "209987-79771", "209987-86429", "209987-91818", "209987-92607", "209987-96232" ], "imported": "2024-06-16T15:47:58+02:00", "journal": null, "issn": null, "collection_publisher": null, "collection_title": null, "edition": null, "university": null, "country": null, "case_report": false, "impactfactor": null, "impactfactor_year": null, "impactfactor_norm": null, "impactfactor_norm_year": null, "impactfactor_norm_category": null, "impactfactor_norm_super": null, "impactfactor_norm_super_year": null, "impactfactor_norm_super_category": null, "citations": null, "conference_name": true, "conference_place": true, "conference_international": false, "scientific_event": true, "invited_lecture": false, "keynote_speaker": false, "selected_presentation": true, "biobank_use": false, "bmf_use": false, "zmf_use": false, "local_affiliation": true }, { "id": 209994, "title": "What all surgeons should know about sub-group analysis", "abstract": null, "authors": [ "Dziri, C", "Uranues, S", "Zheng, MH", "Fingerhut, A" ], "year": 2024, "source": "ANN LAPAROSC ENDOSC. 2024; 9: 20", "category": 1, "document_type": 2, "sci": "ISI:001226972100010", "pubmed": null, "doi": "10.21037/ales-24-3", "pmc": null, "organizations": [ "209994-14073" ], "persons": [ "209994-51612-6" ], "imported": "2024-06-17T09:15:37+02:00", "journal": "ANN LAPAROSC ENDOSC", "issn": "2518-6973", "collection_publisher": null, "collection_title": "ANNALS OF LAPAROSCOPIC AND ENDOSCOPIC SURGERY; ", "edition": null, "university": null, "country": null, "case_report": false, "impactfactor": null, "impactfactor_year": null, "impactfactor_norm": null, "impactfactor_norm_year": null, "impactfactor_norm_category": null, "impactfactor_norm_super": null, "impactfactor_norm_super_year": null, "impactfactor_norm_super_category": null, "citations": false, "conference_name": null, "conference_place": null, "conference_international": false, "scientific_event": false, "invited_lecture": false, "keynote_speaker": false, "selected_presentation": false, "biobank_use": false, "bmf_use": false, "zmf_use": false, "local_affiliation": true }, { "id": 213540, "title": "The microchimeric mouse atlas.", "abstract": null, "authors": [ "Sallinger, K", "Schönberger, J", "Schuch K", "Bramreiter, B", "Slaats, E", "Kroneis, T" ], "year": 2024, "source": "; 2024-08-30; Fred Hutchinson Cancer Center - Seattle, USA. 2024. ", "category": 3, "document_type": null, "sci": null, "pubmed": null, "doi": null, "pmc": null, "organizations": [ "213540-14017" ], "persons": [ "213540-104057", "213540-104139", "213540-115382", "213540-116463", "213540-54171", "213540-114270" ], "imported": "2025-01-29T20:14:51+01:00", "journal": null, "issn": null, "collection_publisher": null, "collection_title": null, "edition": null, "university": null, "country": null, "case_report": false, "impactfactor": null, "impactfactor_year": null, "impactfactor_norm": null, "impactfactor_norm_year": null, "impactfactor_norm_category": null, "impactfactor_norm_super": null, "impactfactor_norm_super_year": null, "impactfactor_norm_super_category": null, "citations": null, "conference_name": null, "conference_place": true, "conference_international": true, "scientific_event": true, "invited_lecture": true, "keynote_speaker": false, "selected_presentation": true, "biobank_use": false, "bmf_use": false, "zmf_use": false, "local_affiliation": true }, { "id": 213546, "title": "On the search for new lipid hydrolases and their substrate specificity", "abstract": null, "authors": [ "Pirchheim, A", "Breithofer, J", "Rainer", "S", "Zimmermann", "R", "Kratky, D" ], "year": 2024, "source": "9th International Symposium on Lipid and Membrane Biology; April, 18-20; Graz. 2024. ", "category": 3, "document_type": null, "sci": null, "pubmed": null, "doi": null, "pmc": null, "organizations": [ "213546-14013" ], "persons": [ "213546-50245", "213546-51904", "213546-106493" ], "imported": "2025-01-30T10:49:45+01:00", "journal": null, "issn": null, "collection_publisher": null, "collection_title": null, "edition": null, "university": null, "country": null, "case_report": false, "impactfactor": null, "impactfactor_year": null, "impactfactor_norm": null, "impactfactor_norm_year": null, "impactfactor_norm_category": null, "impactfactor_norm_super": null, "impactfactor_norm_super_year": null, "impactfactor_norm_super_category": null, "citations": null, "conference_name": true, "conference_place": true, "conference_international": false, "scientific_event": true, "invited_lecture": false, "keynote_speaker": false, "selected_presentation": true, "biobank_use": false, "bmf_use": false, "zmf_use": true, "local_affiliation": true }, { "id": 213547, "title": "Inhibition of lysosomal acid lipase in in vitro models leads to lipid accumulation without affecting myofiber formation", "abstract": null, "authors": [ "Akhmetshina, A", "Amor, M", "Kuentzel, KB", "Leithner, K", "Vujić, N", "Kratky, D" ], "year": 2024, "source": "9th International Symposium on Lipid and Membrane Biology; April, 18-20; Graz. 2024. ", "category": 3, "document_type": null, "sci": null, "pubmed": null, "doi": null, "pmc": null, "organizations": [ "213547-14009", "213547-14013", "213547-14022" ], "persons": [ "213547-103617", "213547-51904", "213547-57557", "213547-75396" ], "imported": "2025-01-30T10:53:04+01:00", "journal": null, "issn": null, "collection_publisher": null, "collection_title": null, "edition": null, "university": null, "country": null, "case_report": false, "impactfactor": null, "impactfactor_year": null, "impactfactor_norm": null, "impactfactor_norm_year": null, "impactfactor_norm_category": null, "impactfactor_norm_super": null, "impactfactor_norm_super_year": null, "impactfactor_norm_super_category": null, "citations": null, "conference_name": true, "conference_place": true, "conference_international": false, "scientific_event": true, "invited_lecture": false, "keynote_speaker": false, "selected_presentation": true, "biobank_use": false, "bmf_use": false, "zmf_use": true, "local_affiliation": true }, { "id": 210029, "title": "Polytrauma mit Neurotrauma: Quo vadis? Worst Case Scenario in 10 Jahren", "abstract": null, "authors": [ "Puchwein, P" ], "year": 2024, "source": "37.Wissenschaftliche Sitzung der ADNANI; JUN 14-15, 2024; Graz. 2024. ", "category": 3, "document_type": null, "sci": null, "pubmed": null, "doi": null, "pmc": null, "organizations": [ "210029-14052" ], "persons": [ "210029-62925" ], "imported": "2024-06-17T12:07:10+02:00", "journal": null, "issn": null, "collection_publisher": null, "collection_title": null, "edition": null, "university": null, "country": null, "case_report": false, "impactfactor": null, "impactfactor_year": null, "impactfactor_norm": null, "impactfactor_norm_year": null, "impactfactor_norm_category": null, "impactfactor_norm_super": null, "impactfactor_norm_super_year": null, "impactfactor_norm_super_category": null, "citations": null, "conference_name": true, "conference_place": true, "conference_international": false, "scientific_event": true, "invited_lecture": true, "keynote_speaker": false, "selected_presentation": false, "biobank_use": false, "bmf_use": false, "zmf_use": false, "local_affiliation": false }, { "id": 210030, "title": "Importance of device-specific follow-up for patients post standard EVAR for Abdominal Aortic Aneurysm", "abstract": null, "authors": [ "T. Cohnert, T", "Siegl, G", "Koter, S", "Portugaller,H" ], "year": 2024, "source": "8TH ANNUAL International Meeting on Aortic Diseases; JUN 13-15, 2024; Liege, BELGIUM. 2024. ", "category": 3, "document_type": null, "sci": null, "pubmed": null, "doi": null, "pmc": null, "organizations": [ "210030-14045", "210030-14074", "210030-14108" ], "persons": [ "210030-50860", "210030-50933", "210030-51955", "210030-82944" ], "imported": "2024-06-17T13:38:59+02:00", "journal": null, "issn": null, "collection_publisher": null, "collection_title": null, "edition": null, "university": null, "country": null, "case_report": false, "impactfactor": null, "impactfactor_year": null, "impactfactor_norm": null, "impactfactor_norm_year": null, "impactfactor_norm_category": null, "impactfactor_norm_super": null, "impactfactor_norm_super_year": null, "impactfactor_norm_super_category": null, "citations": null, "conference_name": true, "conference_place": true, "conference_international": true, "scientific_event": true, "invited_lecture": true, "keynote_speaker": false, "selected_presentation": false, "biobank_use": false, "bmf_use": false, "zmf_use": false, "local_affiliation": true }, { "id": 210031, "title": "Endovascular Treatment is difficult in Ruptured Popliteal Aneurysm ", "abstract": null, "authors": [ "Cohnert, T", "Siegl, G", "Muehlbacher, N", "Baumann, A" ], "year": 2024, "source": "Journal of Vascular and Interventional Radiology. 2024; 35(1):e7-e7.-International Symposium on Endovascular Therapy (ISET) 2024; JAN 22-25, 2024; Miami, USA. ", "category": 2, "document_type": 9, "sci": null, "pubmed": null, "doi": null, "pmc": null, "organizations": [ "210031-14045", "210031-14074" ], "persons": [ "210031-50860", "210031-51880", "210031-82944" ], "imported": "2024-06-17T13:47:53+02:00", "journal": null, "issn": "ISSN: 1051-0443", "collection_publisher": null, "collection_title": null, "edition": null, "university": null, "country": null, "case_report": false, "impactfactor": null, "impactfactor_year": null, "impactfactor_norm": null, "impactfactor_norm_year": null, "impactfactor_norm_category": null, "impactfactor_norm_super": null, "impactfactor_norm_super_year": null, "impactfactor_norm_super_category": null, "citations": null, "conference_name": true, "conference_place": true, "conference_international": true, "scientific_event": true, "invited_lecture": false, "keynote_speaker": false, "selected_presentation": true, "biobank_use": false, "bmf_use": false, "zmf_use": false, "local_affiliation": true }, { "id": 210034, "title": "Chirurgie des Zwerchfells.", "abstract": null, "authors": [ "Lindenmann, J" ], "year": 2024, "source": "Ausbildung zur Operationstechnischen Assistenz (OTA); JUN 19, 2024; Graz, AUSTRIA. 2024. ", "category": 20, "document_type": null, "sci": null, "pubmed": null, "doi": null, "pmc": null, "organizations": [ "210034-14077" ], "persons": [ "210034-50145" ], "imported": "2024-06-17T16:25:38+02:00", "journal": null, "issn": null, "collection_publisher": null, "collection_title": null, "edition": null, "university": null, "country": null, "case_report": false, "impactfactor": null, "impactfactor_year": null, "impactfactor_norm": null, "impactfactor_norm_year": null, "impactfactor_norm_category": null, "impactfactor_norm_super": null, "impactfactor_norm_super_year": null, "impactfactor_norm_super_category": null, "citations": null, "conference_name": true, "conference_place": true, "conference_international": false, "scientific_event": false, "invited_lecture": false, "keynote_speaker": false, "selected_presentation": false, "biobank_use": false, "bmf_use": false, "zmf_use": false, "local_affiliation": false }, { "id": 210035, "title": "Ösophaguschirurgie.", "abstract": null, "authors": [ "Lindenmann, J" ], "year": 2024, "source": "Ausbildung zur Operationstechnischen Assistenz (OTA); JUN 3, 2024; Graz, AUSTRIA. 2024. ", "category": 20, "document_type": null, "sci": null, "pubmed": null, "doi": null, "pmc": null, "organizations": [ "210035-14077" ], "persons": [ "210035-50145" ], "imported": "2024-06-17T16:26:44+02:00", "journal": null, "issn": null, "collection_publisher": null, "collection_title": null, "edition": null, "university": null, "country": null, "case_report": false, "impactfactor": null, "impactfactor_year": null, "impactfactor_norm": null, "impactfactor_norm_year": null, "impactfactor_norm_category": null, "impactfactor_norm_super": null, "impactfactor_norm_super_year": null, "impactfactor_norm_super_category": null, "citations": null, "conference_name": true, "conference_place": true, "conference_international": false, "scientific_event": false, "invited_lecture": false, "keynote_speaker": false, "selected_presentation": false, "biobank_use": false, "bmf_use": false, "zmf_use": false, "local_affiliation": false }, { "id": 210037, "title": "Ösophaguschirurgie.", "abstract": null, "authors": [ "Lindenmann, J" ], "year": 2024, "source": "Universitätslehrgang Sonderausbildung in der Intensivpflege; MAR 28, 2024; Graz, AUSTRIA. 2024. ", "category": 3, "document_type": null, "sci": null, "pubmed": null, "doi": null, "pmc": null, "organizations": [ "210037-14077" ], "persons": [ "210037-50145" ], "imported": "2024-06-17T16:33:28+02:00", "journal": null, "issn": null, "collection_publisher": null, "collection_title": null, "edition": null, "university": null, "country": null, "case_report": false, "impactfactor": null, "impactfactor_year": null, "impactfactor_norm": null, "impactfactor_norm_year": null, "impactfactor_norm_category": null, "impactfactor_norm_super": null, "impactfactor_norm_super_year": null, "impactfactor_norm_super_category": null, "citations": null, "conference_name": true, "conference_place": true, "conference_international": false, "scientific_event": false, "invited_lecture": true, "keynote_speaker": true, "selected_presentation": false, "biobank_use": false, "bmf_use": false, "zmf_use": false, "local_affiliation": true }, { "id": 210038, "title": "Gasbrand.", "abstract": null, "authors": [ "Porubsky, Ch" ], "year": 2024, "source": "Universitätslehrgang Sonderausbildung in der Intensivpflege; MAR 27, 2024; Graz, AUSTRIA. 2024. ", "category": 3, "document_type": null, "sci": null, "pubmed": null, "doi": null, "pmc": null, "organizations": [ "210038-14045" ], "persons": [ "210038-50477" ], "imported": "2024-06-17T16:34:39+02:00", "journal": null, "issn": null, "collection_publisher": null, "collection_title": null, "edition": null, "university": null, "country": null, "case_report": false, "impactfactor": null, "impactfactor_year": null, "impactfactor_norm": null, "impactfactor_norm_year": null, "impactfactor_norm_category": null, "impactfactor_norm_super": null, "impactfactor_norm_super_year": null, "impactfactor_norm_super_category": null, "citations": null, "conference_name": true, "conference_place": true, "conference_international": false, "scientific_event": false, "invited_lecture": true, "keynote_speaker": true, "selected_presentation": false, "biobank_use": false, "bmf_use": false, "zmf_use": false, "local_affiliation": true }, { "id": 210039, "title": "Lunge, Pleura, Mediastinum- Teil 2.", "abstract": null, "authors": [ "Strießnig, A" ], "year": 2024, "source": "Universitätslehrgang Sonderausbildung in der Intensivpflege; MAR 19, 2024; Graz, AUSTRIA. 2024. ", "category": 3, "document_type": null, "sci": null, "pubmed": null, "doi": null, "pmc": null, "organizations": [ "210039-14045" ], "persons": [], "imported": "2024-06-17T16:35:58+02:00", "journal": null, "issn": null, "collection_publisher": null, "collection_title": null, "edition": null, "university": null, "country": null, "case_report": false, "impactfactor": null, "impactfactor_year": null, "impactfactor_norm": null, "impactfactor_norm_year": null, "impactfactor_norm_category": null, "impactfactor_norm_super": null, "impactfactor_norm_super_year": null, "impactfactor_norm_super_category": null, "citations": null, "conference_name": true, "conference_place": true, "conference_international": false, "scientific_event": false, "invited_lecture": true, "keynote_speaker": true, "selected_presentation": false, "biobank_use": false, "bmf_use": false, "zmf_use": false, "local_affiliation": true }, { "id": 210040, "title": "Thoraxtrauma.", "abstract": null, "authors": [ "Porubsky, Ch" ], "year": 2024, "source": "Universitätslehrgang Sonderausbildung in der Intensivpflege; MAR 18, 2024; Graz, AUSTRIA. 2024. ", "category": 3, "document_type": null, "sci": null, "pubmed": null, "doi": null, "pmc": null, "organizations": [ "210040-14045" ], "persons": [ "210040-50477" ], "imported": "2024-06-17T16:36:56+02:00", "journal": null, "issn": null, "collection_publisher": null, "collection_title": null, "edition": null, "university": null, "country": null, "case_report": false, "impactfactor": null, "impactfactor_year": null, "impactfactor_norm": null, "impactfactor_norm_year": null, "impactfactor_norm_category": null, "impactfactor_norm_super": null, "impactfactor_norm_super_year": null, "impactfactor_norm_super_category": null, "citations": null, "conference_name": true, "conference_place": true, "conference_international": false, "scientific_event": false, "invited_lecture": true, "keynote_speaker": true, "selected_presentation": false, "biobank_use": false, "bmf_use": false, "zmf_use": false, "local_affiliation": true }, { "id": 210041, "title": "Lunge, Pleura, Mediastinum- Teil 1.", "abstract": null, "authors": [ "Strießnig, A" ], "year": 2024, "source": "Universitätslehrgang Sonderausbildung in der Intensivpflege; MAR 14, 2024; Graz, AUSTRIA. 2024. ", "category": 3, "document_type": null, "sci": null, "pubmed": null, "doi": null, "pmc": null, "organizations": [ "210041-14045" ], "persons": [], "imported": "2024-06-17T16:38:02+02:00", "journal": null, "issn": null, "collection_publisher": null, "collection_title": null, "edition": null, "university": null, "country": null, "case_report": false, "impactfactor": null, "impactfactor_year": null, "impactfactor_norm": null, "impactfactor_norm_year": null, "impactfactor_norm_category": null, "impactfactor_norm_super": null, "impactfactor_norm_super_year": null, "impactfactor_norm_super_category": null, "citations": null, "conference_name": true, "conference_place": true, "conference_international": false, "scientific_event": false, "invited_lecture": true, "keynote_speaker": true, "selected_presentation": false, "biobank_use": false, "bmf_use": false, "zmf_use": false, "local_affiliation": true }, { "id": 210042, "title": "Einleitung, Thoraxdrain.", "abstract": null, "authors": [ "Porubsky, Ch" ], "year": 2024, "source": "Universitätslehrgang Sonderausbildung in der Intensivpflege; MAR 12, 2024; Graz, AUSTRIA. 2024. ", "category": 3, "document_type": null, "sci": null, "pubmed": null, "doi": null, "pmc": null, "organizations": [ "210042-14045" ], "persons": [ "210042-50477" ], "imported": "2024-06-17T16:39:03+02:00", "journal": null, "issn": null, "collection_publisher": null, "collection_title": null, "edition": null, "university": null, "country": null, "case_report": false, "impactfactor": null, "impactfactor_year": null, "impactfactor_norm": null, "impactfactor_norm_year": null, "impactfactor_norm_category": null, "impactfactor_norm_super": null, "impactfactor_norm_super_year": null, "impactfactor_norm_super_category": null, "citations": null, "conference_name": true, "conference_place": true, "conference_international": false, "scientific_event": false, "invited_lecture": true, "keynote_speaker": true, "selected_presentation": false, "biobank_use": false, "bmf_use": false, "zmf_use": false, "local_affiliation": true }, { "id": 210046, "title": "Clinical impact of the registry results", "abstract": null, "authors": [ "Szkandera, J" ], "year": 2024, "source": "EMSOS; JUNE 12-14, 2024; Szczetin, POLAND. 2024. ", "category": 3, "document_type": null, "sci": null, "pubmed": null, "doi": null, "pmc": null, "organizations": [ "210046-14085" ], "persons": [ "210046-69234" ], "imported": "2024-06-18T12:01:18+02:00", "journal": null, "issn": null, "collection_publisher": null, "collection_title": null, "edition": null, "university": null, "country": null, "case_report": false, "impactfactor": null, "impactfactor_year": null, "impactfactor_norm": null, "impactfactor_norm_year": null, "impactfactor_norm_category": null, "impactfactor_norm_super": null, "impactfactor_norm_super_year": null, "impactfactor_norm_super_category": null, "citations": null, "conference_name": true, "conference_place": true, "conference_international": true, "scientific_event": true, "invited_lecture": true, "keynote_speaker": false, "selected_presentation": false, "biobank_use": false, "bmf_use": false, "zmf_use": false, "local_affiliation": true }, { "id": 210050, "title": "Post EAACI Highlights 2024", "abstract": null, "authors": [ "Schöffl, Clemens" ], "year": 2024, "source": "EAACI 2024 Kongress Highlights zum Hereditären Angioödem; JUN 14, 2024; München, DEUTSCHLAND. 2024. ", "category": 3, "document_type": null, "sci": null, "pubmed": null, "doi": null, "pmc": null, "organizations": [ "210050-14047" ], "persons": [ "210050-95463" ], "imported": "2024-06-18T15:48:24+02:00", "journal": null, "issn": null, "collection_publisher": null, "collection_title": null, "edition": null, "university": null, "country": null, "case_report": false, "impactfactor": null, "impactfactor_year": null, "impactfactor_norm": null, "impactfactor_norm_year": null, "impactfactor_norm_category": null, "impactfactor_norm_super": null, "impactfactor_norm_super_year": null, "impactfactor_norm_super_category": null, "citations": null, "conference_name": true, "conference_place": true, "conference_international": true, "scientific_event": true, "invited_lecture": true, "keynote_speaker": false, "selected_presentation": true, "biobank_use": false, "bmf_use": false, "zmf_use": false, "local_affiliation": true }, { "id": 210055, "title": "Effectiveness of simulation-based interprofessional education on teamwork and communication skills in neonatal resuscitation.", "abstract": null, "authors": [ "Mileder, LP" ], "year": 2024, "source": "Simulation Journal Club, Children's Hospital of Philadelphia (CHOP); JUN 18, 2024; Philadelphia, USA. 2024. ", "category": 3, "document_type": null, "sci": null, "pubmed": null, "doi": null, "pmc": null, "organizations": [ "210055-14094" ], "persons": [ "210055-68534" ], "imported": "2024-06-18T18:38:22+02:00", "journal": null, "issn": null, "collection_publisher": null, "collection_title": null, "edition": null, "university": null, "country": null, "case_report": false, "impactfactor": null, "impactfactor_year": null, "impactfactor_norm": null, "impactfactor_norm_year": null, "impactfactor_norm_category": null, "impactfactor_norm_super": null, "impactfactor_norm_super_year": null, "impactfactor_norm_super_category": null, "citations": null, "conference_name": true, "conference_place": true, "conference_international": true, "scientific_event": true, "invited_lecture": true, "keynote_speaker": true, "selected_presentation": false, "biobank_use": false, "bmf_use": false, "zmf_use": false, "local_affiliation": true }, { "id": 210058, "title": "The impact of different mitochondrial Ca2+ modulators on lifespan and health of C. elegans.", "abstract": "Aging is a highly complex and poorly understood process that makes the body vulnerable to age-related diseases such as cardiovascular and neurodegenerative diseases. As we live in an increasingly aging society, it is crucial to understand the molecular mechanisms behind aging and to find new therapeutic approaches to intervene and delay aging and associated diseases. Mitochondria are crucial to cellular metabolism as they are the production site of ATP and reactive oxygen species (ROS) and can trigger apoptosis. Calcium (Ca2+) is a key regulator of mitochondrial function and is able to enter the mitochondrial matrix through the mitochondrial Ca2+ ([Ca2+]mito) transporter (MCU). However, aging is often associated with mitochondrial dysfunction caused by disturbances in ROS, and Ca2+ homeostasis. We therefore set out to investigate how modulation of [Ca2+]mito homeostasis during aging affects life- and health span in the model organism Caenorhabditis elegans (C. elegans). In this study, we used lifespan analyses, [Ca2+]mito measurements, and motility assays to answer these questions. To modulate the Ca2+ homeostasis, we induced mcu-1 knockdown to the worms and used pharmacological inhibitors of the MCU complex, such as the anti-cancer drug mitoxantrone and the small molecule MCU-i11. Ca2+ measurements from mcu-1 worms revealed reduced basal [Ca2+]mito concentrations and matrix Ca2+ uptake compared to wild type worms. Lifespan analyses have shown that the knockdown of mcu-1 and its inhibition by treatment with mitoxantrone leads to an extension of the lifespan of C. elegans. Also, mcu-1 knockdown and mitoxantrone treatment led to increased motility in old age, thereby extending health span. The second MCU inhibitor, MCU-i11, improved survival in middle-age but had no effect on life expectancy in old age. Motility assays showed a similar result, with increased worm activity only present in middle-age. We suspect that the inhibitor is unable to prevent Ca2+ influx during high Ca2+ concentrations in old age. Based on the results of MCU knockdown and inhibition by mitoxantrone, we conclude that the impaired Ca2+ conditions in early life mechanisms might be related to longevity.", "authors": [ "Lederer, S" ], "year": 2024, "source": " [ Diplomarbeit/Master Thesis (UNI) ] Universität Graz; 2024. pp.43. 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