Publication List

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            "title": "Allergien Was steckt dahinter?",
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            "source": "Lange Nacht der Forschung; MAY 24, 2024; Graz, AUSTRIA. 2024. ",
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            "title": "Body fat composition and Liver Iron Concentration in patients with hemochromatosis: is there a correlation?",
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            "title": "Body fat composition and liver iron concentration: Unveiling the intricate correlation in hemochromatosis through advanced MRI techniques",
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            "source": "ESGAR 2024 – 35th ANNUAL MEETING AND\r\nPOSTGRADUATE COURSE; May 28-31, 2024; Gothenburg, SWEDEN. 2024. ",
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            "title": "Evaluierung von intravitrealen Injektionen als Risikofaktor für posteriore Kapselruptur während Kataraktchirurgie.",
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                "Haas, A",
                "Wedrich, A."
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            "source": "64. Jahrestagung der ÖOG - Österreichische Ophthalmologische Gesellschaft; MAY 9-11, 2024; Schladming, AUSTRIA. 2024. ",
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            "source": "Simulation Research Conference, Children's Hospital of Philadelphia (CHOP); JUN 4, 2024; Philadelphia, USA. 2024. ",
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            "title": "Symptom: Zungenbrennen.",
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            "authors": [
                "Thurnher, D"
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            "year": 2024,
            "source": "Salzburger HNO Gespräche 2024, Erkrankungen der Mundschleimhaut - interdisziplinär; APR 20, 2024; Salzburg, AUSTRIA. 2024. ",
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            "id": 209862,
            "title": "Effekt von nahrungsergänzenden Präparaten auf Stürze sowie sturzbedingte Folgen in der Akut- und Langzeitpflege − ein Rapid Review",
            "abstract": "Hintergrund: Stürze erwachsener Personen verursachen eine erhebliche Morbidität und Mortalität, sie bedeuten daher für das Gesundheitssystem eine enorme Belastung. Der Körper benötigt unterschiedliche Nährstoffe, um Funktionen aufrecht erhalten zu können. Da viele Sturzrisikofaktoren direkt oder indirekt mit der Nahrung/Ernährung in Verbindung stehen, lässt sich vermuten, dass auch die Einnahme nahrungsergänzender Präparate Auswirkungen auf Stürze und/oder Sturzfolgen haben. Ziel der vorliegenden Arbeit ist es, den Effekt von nahrungsergänzenden Präparaten auf Stürze und deren Folgen im Akut- und Langzeitpflegesetting darzustellen.  \r\n\r\nMethode: Zur Beantwortung der Forschungsfrage wurde ein Rapid Review, nach Empfehlungen des „Cochrane Review Guides“ durchgeführt. Es wurde eine systematische Literaturrecherche in diversen Datenbanken sowie eine Handsuche durchgeführt. Die Ergebnisse der Recherche, nach systematischen Übersichtsarbeiten von RCTs erforderten zwei Update-Recherchen nach RCTs zu spezifischen Nahrungsergänzungen. Die gefundenen Studien wurden nach vordefinierten Ein- und Ausschlusskriterien ausgewählt und mithilfe von kritischen Fragebögen bewertet. Bei statistisch ähnlichen Effektmaßen, wurden Metaanalysen durchgeführt.  \r\n\r\nErgebnisse: Die inkludierte Literatur, welche aus neun systematischen Reviews, bestehend aus 22 relevanten RCTs und sechs weiteren RCTs bestand, ermöglichte einen Vergleich hinsichtlich des Effekts der Supplemente in Bezug auf den Sturz und dessen Auswirkungen. Hinsichtlich der Interventionen handelte es sich um die Gabe von Supplementen wie Vitamin D, Kalzium sowie proteinreiche Präparate.  Ebenso wurde der Effekt in Bezug auf die Dosis der Präparate sowie die Kombination mit Sport und/oder Ernährungsanpassung untersucht. Die Ergebnisse zeigen, dass zum einen die Gabe von Kalzium und Vitamin D zu einer signifikanten Sturzreduktion führt (p < 0,0001; OR 0,72; 95 % CI 0.62,0.84), des Weiteren auch die Gabe von proteinreichen Präparaten in Kombination mit Vitamin D und Kalzium sowie einer Ernährungsanpassung (p < 0,00001; OR 0,78; 95 % CI 0.78, 0.86). Ebenso ist aufgrund der Kombination von Supplementen und körperlichem Training ein positiver Effekt hinsichtlich Stürze und deren Auswirkungen ersichtlich (p = 0,008).  \r\n\r\nSchlussfolgerung: Aus der aktuellen Literatur kann abgeleitet werden, dass zum einen die Gabe von proteinreichen Supplementen in Kombination mit körperlichem Training und einer Ernährungsanpassung sowie auch die Gabe von Kalzium mit Vitamin D signifikante Reduktion von Stürzen/Verletzungen erzielen. Um Empfehlungen aussprechen zu können, bedarf es weiterer Forschung mit dem Fokus auf Sturz und dessen Folgen, besonders im Hinblick auf die Kombination von Präparaten, Dosierung sowie weiterer Nährstoffpräparate, welche zur Sturzprävention dienen könnten.",
            "authors": [
                "Winkler, F"
            ],
            "year": 2024,
            "source": "Masterstudium; Interprofessionelle Gesundheitswissenschaften; [ Masterarbeit ] Medizinische Universität Graz; 2024. pp. 92",
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            "country": "40",
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        {
            "id": 209863,
            "title": "Veränderung der retinalen Gefäßdichte bei Retinitis pigmentosa",
            "abstract": "Zusammenfassung\r\n\r\nZiel dieser Studie ist es, die retinale Gefäßdichte bei Patient*innen mit Retinitis pigmentosa mit einer Kontrollgruppe zu vergleichen.\r\n\r\nEinleitung\r\n\r\nIn der Vergangenheit konnte durch Studien mit geringeren Fallzahlen bereits gezeigt werden, dass es bei der Retinitis pigmentosa zu einer Abnahme der Netzhautgefäßdichte kommt. Ziel war es daher, diese Abnahme der Netzhautgefäßdichte bei einer größeren Gruppe von Retinitis pigmentosa Patient*innen zu zeigen. \r\n\r\nMethoden und Patient*innen\r\n\r\nIn einer retrospektiven Studie wurde mittels optischer Kohärenztomografie-Angiografie (OCT-A) die Veränderung der retinalen Gefäßdichte von 44 Patient*innen mit klinisch diagnostizierter Retinitis pigmentosa untersucht und einer Gruppe von 61 Patient*innen ohne Netzhauterkrankung gegenübergestellt. Mangelhafte Bildaufnahmen wurden dabei verworfen und nicht näher untersucht.\r\n\r\nAn der Studie nahmen insgesamt 105 Patient*innen (210 Augen) teil. Davon entfielen 44 Patient*innen (88 Augen; 41,9%) auf die Fallgruppe mit bestätigter Retinitis pigmentosa und 61 Patient*innen (122 Augen; 58,1%) auf die Kontrollgruppe der Netzhautgesunden. \r\n\r\nErgebnisse \r\n\r\nDie Patientengruppe und Kontrollgruppe waren ähnlich in Bezug auf Vorerkrankungen und Geschlecht, jedoch waren Retinitis pigmentosa Patient*innen signifikant älter (50 Jahre ± 17) als die Patient*innen der Kontrollgruppe (42.2 ± 12; p=0,02). Die Gefäßdichte im Bereich des oberflächlichen retinalen Plexus war in der Patientengruppe (Median 38%; Q1-Q3 34-42%) signifikant geringer als in der Kontrollgruppe (48%; 46-50%) (p<0,0001). Im fovealen Bereich des oberflächlichen Plexus war die Dichte zwischen Patientengruppe (19%; 12 – 27%) und Kontrollgruppe (22%; 18-27%) ebenso verringert (p=0,017). Ähnliches konnte im tiefen retinalen Gefäßplexus festgestellt werden. Hier lag die Dichte für Patient*innen bei 41% (37- 45%) und für die Kontrollgruppe bei 49% (46-52%; p<0,0001). Die foveale Gefäßdichte in jenem Bereich unterschied sich ebenfalls signifikant (Patientengruppe 31%, 24-38%; Kontrollgruppe 38%, 34-44%; p<0,0001). Die Variablen blieben signifikant nach Adjustierung für das Alter. Die Größe der FAZ war im Median bei Patient*innen mit RP (0,2mm2; 0,15-0,35mm2) und in der Kontrollgruppe 0,22mm2 (0,14-0,31mm2). Es ergab sich kein signifikanter Unterschied zwischen den beiden Gruppen. (p=0,413).\r\n\r\nConclusio\r\n\r\nSowohl im oberflächlichen als auch im tiefen Plexus zeigte sich bei Retinitis pigmentosa eine Abnahme der Gefäßdichte im Vergleich zur Kontrollgruppe im Verlauf der Erkrankung. Eine signifikante Vergrößerung der fovealen avaskulären Zone (FAZ) bei den Betroffenen im Vergleich zur Kontrollgruppe konnte nicht festgestellt werden.",
            "authors": [
                "Kloeckl, L"
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            "year": 2024,
            "source": "Humanmedizin; [ Diplomarbeit ] Medizinische Universität Graz; 2024. pp. 63",
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        {
            "id": 209864,
            "title": "Die zementierte Fixation der Dual Mobility Pfanne in eine bereits existierende stabile Pfanne während der Revision von Hüfttotalendoprothesen",
            "abstract": "Hintergrund \r\n\r\nDie „double socket“ Technik ist ein vielversprechendes Verfahren in der Revisionschirurgie der Hüfte, welches postoperativer Instabilität und Luxationen der Prothese entgegenwirken und der Notwendigkeit einer Minimierung der intraoperativen Belastung alter und gebrechlicher Patient*innen Rechnung tragen soll. Während die „double socket“ Technik bei Anwendung mit konventionellen Inlays aus Polyethylen oder gekoppelten Inlays mit hohen Luxationsraten von bis zu 22 bzw. 42 Prozent assoziiert ist, hat sich das Einzementieren eines Dual Mobility Cups (DMC) in eine präexistente, stabil fixierte Pfanne bisher als gute, funktionelle Option mit geringen Luxations- und Dislokationsraten erwiesen. Diese Arbeit soll die „double socket“ Technik mit DMCs evaluieren und über die klinischen und radiologischen Ergebnisse sowie die intraoperative Belastung berichten.\r\n\r\nMaterial und Methode\r\n\r\nIm Rahmen einer retrospektiven Datenerhebung wurden 17 Patient*innen analysiert, welche sich zwischen 2018 und 2022 am Standort Stolzalpe des LKH Murtals einer Hüft-Revisionsoperation mit Einzementieren eines DMCs in eine vorbestehende, stabil fixierte Hüftpfanne im Sinne einer „double socket“ Technik unterzogen hatten. Eine Patientin wurde aufgrund einer traumatischen periprothetischen Fraktur ausgeschlossen. Zur Ermittlung des klinischen und funktionellen Outcomes wurden Röntgen-Aufnahmen sowie klinische Untersuchungen verwendet. Der Harris Hip Score (HHS) wurde verwendet, um auf die patient*innenbezogenen Ergebnisse rückschließen zu können. Hauptzielgröße war die Anzahl der beobachteten Luxationen der DMC-Prothese im Rahmen des Follow-ups. Nebenzielgrößen waren die Anzahl der Reoperationen und Lockerungen des zementierten Konstruktes, die Operationszeit sowie der postoperative Hämoglobinabfall. Die Survival-Analyse wurde mithilfe der Kaplan-Meier-Methode durchgeführt.\r\n\r\nErgebnisse\r\n\r\nNach einem durchschnittlichen Follow-up von 382 ± 357 (23 – 1218) Tagen  verbesserte sich der präoperative HHS von durchschnittlich 32,1 ± 19,9 (4 - 68) signifikant auf einen durchschnittlichen postoperativ erhobenen HHS von 65,4 ±14,9 (39 – 94) (p < ,001). Zum Zeitpunkt der Operation betrug das durchschnittliche Alter der Patient*innen 74,76 (53,25 – 93,71) Jahre. Die Operationszeit der Revisions-OP lag im Durchschnitt bei 179,3 ± 69,3 (82,1 – 303,2) Minuten und der durchschnittliche postoperative Hämoglobin-Abfall betrug 2,43 ± 1,78 (-1,00 – 5,84) g/dl. Es traten keinerlei Dislokationen oder Dissoziationen des DMC-Konstruktes oder aseptische Lockerungen der Metallpfanne auf. Des Weiteren kam es zu keinen Reoperationen oder Re-Revisionen des Konstrukts.\r\nSchlussfolgerungen\r\nDie „double socket“ Technik mit Einzementieren eines DMCs in eine vorbestehende, stabile Metallpfanne erscheint als sicheres Revisionsverfahren in der Hüftchirurgie, vor allem bei einer potenziellen Instabilität. Der Wechsel der gut implantierten Metallpfanne wird vermieden, dadurch wird das Operationsrisiko gesenkt. Vor allem ältere und vorerkrankte Patient*innen scheinen von dieser Reduktion der intraoperativen Belastung zu profitieren. Die Luxationsrate wirkt reduziert im Vergleich zu einem isolierten Inlay-Wechsel oder einer „double socket“ Technik mit konventionellen oder gekoppelten Inlays. Weitere, prospektive Studien mit längerem Follow-up werden benötigt, um diese guten ersten Ergebnisse zu überprüfen.\r\n\r\n\r\n ",
            "authors": [
                "Ziegler, M"
            ],
            "year": 2024,
            "source": "Humanmedizin; [ Diplomarbeit ] Medizinische Universität Graz; 2024. pp. 64",
            "category": 5,
            "document_type": 15,
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            "university": "Medizinische Universität Graz",
            "country": "40",
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        },
        {
            "id": 209865,
            "title": "Alkoholabhängigkeit und E-Health-Interventionen: \r\nEine systematische Übersichtsarbeit über die aktuelle Literatur",
            "abstract": "Zusammenfassung\r\nEinleitung: Alkoholabhängigkeit ist eine weit verbreitete, folgenschwere Erkrankung. E-Health-Interventionen haben eine gute Verfügbarkeit und Kosteneffizienz gezeigt. In dieser systematischen Übersichtsarbeit wird dargelegt, welche E – Health - Interventionen es für Personen mit Alkoholabhängigkeit gibt und welche Auswirkungen sie auf den Alkoholkonsum haben. \r\nMethodik: Die Suche für diese systematische Übersichtsarbeit wurde in der Datenbank PubMed mit den zuvor festgelegten Schlagwörtern „(web - based OR online OR internet OR text OR eHealth OR telemedicine OR mobile) AND alcohol“ durchgeführt. Es wurden randomisierte, kontrollierte Studien ausgewählt. Einschlusskriterien sind, dass eine E-Health-Intervention mit der Absicht, die Alkoholabhängigkeit zu behandeln oder den bisher erreichten Therapieerfolg zu erhalten, durchgeführt wurde, dass alle Teilnehmer*innen eine Alkoholabhängigkeit, nach ICD - 10-Kriterien, DSM - IV-Kriterien oder einer Alkoholkonsumstörung nach DSM - 5 von mindestens mittlerem Schweregrad haben und dass Zielvariablen die Auswirkungen der E - Health - Intervention im Vergleich zwischen mindestens einer Interventionsgruppe und einer Kontrollgruppe sind.\r\nErgebnisse: Von den 1051 Suchergebnissen werden nach Berücksichtigung der Ein- und Ausschlusskriterien acht Studien berücksichtigt und weiter analysiert. Als E-Health-Interventionen werden drei web-basierte Programme, drei App - basierte Produkte, telefonisches Monitoring und Textnachrichten verwendet. Sechs der Studien setzten die E-Health-Interventionen in der Interventionsgruppe als Ergänzung zur Standardtherapie ein und die Kontrollgruppe erhält nur die Standardtherapie. In zwei Studien erfolgt keine begleitende Therapie. Im Alkoholkonsumverhalten ergeben vier E-Health-Produkte signifikante und nicht signifikante Ergebnisse. Signifikante Gruppenunterschiede zeigt die App A - CHESS in einer Reduktion der riskanten Trinktage und einer höheren Abstinenz, internet - basierte kognitive Verhaltenstherapie in einem geringeren Alkoholkonsum nach zwölf Monaten und mehr alkoholfreien Tagen, telefonisches Monitoring mit Beratung in einer Reduktion der Trinktage und Textnachrichten in einer Reduktion der Standardgetränke pro Trinktag. In zwei Studien wurden keine signifikanten Auswirkungen auf das Alkoholkonsumverhalten gefunden. In der Studie zur DynamiCare Health App wurde aufgrund fehlender Daten keine Auswertung des Alkoholkonsumverhaltens vorgenommen.\r\nDiskussion: In den analysierten Studien werden acht E – Health - Interventionen für Personen mit Alkoholabhängigkeit beschrieben. Die vier Studien, die Auswirkungen auf das Alkoholkonsumverhalten zeigen, basieren auf Steigerung der Bewältigungskompetenz durch das Erkennen und Bewältigen von Risikosituationen, Selbstkontrolltraining mit positiven Lebensstiländerungen, Stärkung der Selbstwirksamkeit z.B. durch das Setzen erreichbarer Verhaltensziele und auf sozialer Unterstützung. Limitationen dieser Arbeit ergeben sich durch unterschiedliche Rahmenbedingungen, Komorbiditäten der Stichproben, Heterogenität der Outcome-Variablen und durch die Einschränkung auf randomisierte, kontrollierte Studien. Die insgesamt geringe Datenlage deutet auf eine leichte Überlegenheit in der Behandlung mit Zuhilfenahme von E – Health - Interventionen in Bezug auf das Alkoholkonsumverhalten hin.",
            "authors": [
                "Strunk, J"
            ],
            "year": 2024,
            "source": "Humanmedizin; [ Diplomarbeit ] Medizinische Universität Graz; 2024. pp. 62",
            "category": 5,
            "document_type": 15,
            "sci": null,
            "pubmed": null,
            "doi": null,
            "pmc": null,
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            "journal": null,
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            "edition": null,
            "university": "Medizinische Universität Graz",
            "country": "40",
            "case_report": false,
            "impactfactor": null,
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            "local_affiliation": false
        },
        {
            "id": 209866,
            "title": "Neutrophil function in pregnancy",
            "abstract": "Pregnancy represents a unique period during which the mother and fetus must co-exist. In the early stages of placental development, maternal immune cells located at the feto-maternal interface, or decidua basalis (DB), must facilitate the invasion of extravillous trophoblasts (EVTs) to ensure proper placental development. Immune cell function at the DB, particularly natural killer cells (NKs) and macrophages, has been described to have an important role in placental development, with their malfunction linked to the development of pregnancy complications. Additionally, neutrophils have been observed to enter the DB, stimulating regulatory T cells, and their depletion has been associated with abnormal placental development. However, their precise function during pregnancy remains to be thoroughly investigated.\r\nBuilding upon previous research, we hypothesized that neutrophils infiltrate the DB during the early stages of placental development, exhibiting a tissue-specific phenotype and function. Moreover, we aimed to investigate the impact of neutrophil granular protein release on EVTs function.\r\nIn this thesis, we initially evaluated immune infiltration in the DB compared with the EVT uninvaded part of the tissue, known as decidua parietalis (DP), demonstrating a substantial presence of neutrophils within the DB. Through a comprehensive analysis, we categorized the phenotype of tissue neutrophils and blood neutrophils, revealing that neutrophils alter their marker expression upon migration into the tissue. Furthermore, we identified three distinct subsets of neutrophils within the tissue and observed differential expression of numerous markers among these populations. Upon investigating the effect of neutrophil-derived myeloperoxidase (MPO) on EVTs, we found that MPO internalization promotes JEG-3 cell line migration and invasion, elucidating the crucial role of neutrophils invasion into the DB.\r\nOur study provides a comprehensive picture of the immune landscape and specific surface protein expression pattern on neutrophils at the feto-maternal interface. To the best of our knowledge, this is the first study that focuses on the specific subpopulation of neutrophil infiltrating the DB and their derived protein effects on EVTs.",
            "authors": [
                "Mihalic, Z"
            ],
            "year": 2024,
            "source": "PhD-Studium (Doctor of Philosophy); Humanmedizin; [ Dissertation ] Medizinische Universität Graz; 2024. pp. ",
            "category": 5,
            "document_type": 16,
            "sci": null,
            "pubmed": null,
            "doi": null,
            "pmc": null,
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            "imported": "2024-06-05T09:18:40+02:00",
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            "edition": null,
            "university": "Medizinische Universität Graz",
            "country": "40",
            "case_report": false,
            "impactfactor": null,
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            "local_affiliation": false
        },
        {
            "id": 209867,
            "title": "Adult Osteosarcoma: a retrospective study of single center cohort database",
            "abstract": "Introduction: Osteosarcoma, the most prevalent highly malignant tumor of bone, has a bimodal age distribution. At diagnosis, most patients are in their second and third decade of life with a second peak after the age of 40. After the invention of polychemotherapy regimes in addition to radical resection in the 1970s, no improvement regarding therapy modalities occurred in the last decades and the 5-year OS remains stable with around 60%. \r\nMaterial and methods: 79 adult patients with osteosarcoma diagnosed and treated between 2000 and 2020 at the Medical University Hospital of Graz, a reference center for soft tissue and bone tumors, were included. For each patient we registered age, gender, medical history, clinical appearance, radiological findings (location, affected side, number and size of lesion(s), joint involvement), histological type, tumor grading, treatment, occurrence of metastasis, recurrence, follow-up time and outcomes. These parameters were compared with the published literature. In addition, the comparison between the patients under and above the age of 50 years was performed.  \r\nResults: Out of 79 patients, 31 were male and 48 were female. The median age was 45.8 years (range from 18 to 93 years). At time of diagnosis, 48 (60.8%) patients were under the age of 50 and 31 (39.2%) patients were above 50. Localization included appendicular skeleton in 72 cases and axial skeleton in 7 cases. 56 (70.9%) patients had conventional osteosarcoma, eleven (13,9%) parosteal osteosarcoma, 6 (7.6%) low grade-central osteosarcoma, 2 (2.5%) high-grade surface osteosarcoma and secondary osteosarcoma was diagnosed in 4 (5.1%) patients. The mean time from onset of symptoms until diagnosis was 5.3 months (range from 0.5 to 60 months); 4 tumors were an incidental finding. 70 (88.6%) patients underwent surgery, 46 (58.2%) received chemotherapy, 35 (44.3%) were treated with neoadjuvant and adjuvant chemotherapy in addition to radical resection. 38 (48.1%) patients developed metastasis; local recurrence was seen in eight (10.1%) patients. Mean follow-up time was 50.7 months. 25 (31.6%) patients died of disease (mean time 32.2 months). \r\nConclusion: High grade conventional osteosarcoma is the most common subtype occurring in the adults, most frequently in the knee region. The limb-salvage surgery with implantation of tumor endoprosthesis is a standard treatment option for all patients, whereas the use of chemotherapy in the elderly patients remains low (especially in the group of patients over the age of 50). The older patients more commonly develop metastasis, have higher recurrence rate and time to death is shorter than in the younger age group. Considering increasing life span in the general population and therefore a probable higher incidence of osteosarcoma in the elderly, further studies in the geriatric population with osteosarcoma regarding possible treatment options are warrant.",
            "authors": [
                "Adunka, H"
            ],
            "year": 2024,
            "source": "Humanmedizin; [ Diplomarbeit ] Medizinische Universität Graz; 2024. pp. 88",
            "category": 5,
            "document_type": 15,
            "sci": null,
            "pubmed": null,
            "doi": null,
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            "university": "Medizinische Universität Graz",
            "country": "40",
            "case_report": false,
            "impactfactor": null,
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        },
        {
            "id": 213524,
            "title": "Neural network emulation of the human ventricular cardiomyocyte\r\naction potential: a promising tool for more efficient computations in\r\nquantitative systems pharmacology studies",
            "abstract": null,
            "authors": [
                "Grandits, T",
                "Augustin, C.M.",
                "Haase, G.",
                "Jost, N.",
                "Mirams, G.R.",
                "Niederer, S.A.",
                "Plank, G.",
                "Varró, A.",
                "Virág, L.",
                "Jung, A"
            ],
            "year": 2024,
            "source": "48th Annual Meeting of the ESC Working Group on Cardiac Cellular Electrophysiology; JUL 1-3, 2024; Graz, AUSTRIA. 2024. ",
            "category": 3,
            "document_type": null,
            "sci": null,
            "pubmed": null,
            "doi": null,
            "pmc": null,
            "organizations": [
                "213524-14011"
            ],
            "persons": [
                "213524-50966",
                "213524-79791",
                "213524-91352"
            ],
            "imported": "2025-01-29T12:11:39+01:00",
            "journal": null,
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            "local_affiliation": true
        },
        {
            "id": 213527,
            "title": "HPV positive tumors and the microbiome, HPV in Head and Neck Tumors II.",
            "abstract": null,
            "authors": [
                "Thurnher, D"
            ],
            "year": 2024,
            "source": "Czech Head and Neck Cancer Cooperative Group Annual Conference; OCT 3-5, 2024; Znojmo, CZECH REPUBLIC. 2024. ",
            "category": 3,
            "document_type": null,
            "sci": null,
            "pubmed": null,
            "doi": null,
            "pmc": null,
            "organizations": [
                "213527-14066"
            ],
            "persons": [
                "213527-91899"
            ],
            "imported": "2025-01-29T12:16:49+01:00",
            "journal": null,
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            "university": null,
            "country": null,
            "case_report": false,
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            "conference_name": true,
            "conference_place": true,
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            "local_affiliation": true
        },
        {
            "id": 209868,
            "title": "Conservation of β2-adrenergic signaling in rat and human cardiomyocytes during heart failure",
            "abstract": "Introduction: Beta-2 adrenergic (β2AR) signaling in heart failure remains an area of active investigation, presenting diverse insights. The dual nature of β2AR signaling, exhibiting both cardioprotective and cardiotoxic effects, remains incompletely understood. Moreover, the translational relevance of animal models to human data is yet to be fully established.\r\n\r\nMaterial and Methods: This thesis investigates the preservation of β2AR signaling in male rat and male and female human hearts during heart failure. To discern the intricacies of β2AR behavior, we utilized a hypertensive Dahl salt-sensitive rat model fed a high-salt-diet starting at 7 weeks (HSD, 8% NaCl) for 5 (early remodeling) and 10 to 12 (late remodeling) weeks. The control group comprised male Dahl salt-sensitive rats on a low-salt-diet (LSD, 0.3% NaCl). In addition, we had valuable access to donor and explanted human heart tissue with various degrees of cardiac remodeling. Phenotyping of rats as heart failure with Preserved Ejection Fraction (HFpEF) occurred through gravimetric analyses and echocardiography. Human subjects were categorized into HFpEF and heart failure with Reduced Ejection Fraction (HFrEF) groups based on echocardiography data provided by the Department of Cardiology. Cardiomyocytes were obtained through Langendorff isolation methods. Quantification of β2AR involved Immunocytochemistry (ICC), immunoblotting, and microarray techniques. Cells used for ICC were additionally stimulated with β-adrenergic agonist isoprenaline.\r\n\r\nResults: (1) Significant β2AR downregulation, particularly at a late remodeling time point, in the microarray and ICC analyses of the Dahl salt-sensitive rat model; (2) Conversely, rat immunoblots failed to reproduce this observation; (3) Comparable rates of β1AR and β2AR downregulation in rats in the ICC at a late remodeling timepoint; (4) Impaired rapid-ISO-induced β2AR downregulation in HSD Dahl salt-sensitive rats; (5) β2AR downregulation observed in human immunoblot for diastolic dysfunction, but not for dilated cardiomyopathy.\r\n\r\nDiscussion: We conclude that β2AR downregulation occurs at a comparable rate to β1AR during late-stage cardiac remodeling in rats with systemic hypertension heart failure. In humans, superior downregulation was evident in patients with diastolic dysfunction compared to dilated cardiomyopathy. These insights suggest a specific adrenergic expression pattern depending on heart failure type, stage, and etiology. Future experiments, including translation to human tissue and analysis of β2AR downstream targets, promise additional molecular insights into β2AR signaling in humans during the development and progression of heart failure. Such insights may inform novel treatment strategies tailored to specific heart failure types, stages, and etiologies, contributing to the paradigm of personalized medicine.",
            "authors": [
                "Fernandes Hollnagel, C"
            ],
            "year": 2024,
            "source": "Humanmedizin; [ Diplomarbeit ] Medizinische Universität Graz; 2024. pp. 115",
            "category": 5,
            "document_type": 15,
            "sci": null,
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            "university": "Medizinische Universität Graz",
            "country": "40",
            "case_report": false,
            "impactfactor": null,
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        },
        {
            "id": 209869,
            "title": "Nuclear and chemokine receptors are involved in lymphomagenesis",
            "abstract": "In this first part of the thesis, the importance of studying the CXCR4/CXCL12 axis in diffuse large B cell lymphoma (DLBCL) is highlighted. In over 20 different cancers, the CXCR4-CXCL12 axis plays a crucial role in several key processes, including survival, tumor cell proliferation, migration metastasis, and invasion. However, research on the interplay of CXCR4 and CXCL12 in DLBCL is limited and inconsistent. To close this gap, we conducted a comprehensive study of the CXCR4-CXCL12 axis in our cohort of DLBCL patients. Additionally, we examined the impact of CXCR4 antagonists on lymphoma cell lines in vitro. In our study of DLBCL, we discovered a remarkable 140-fold upregulation in CXCR4 expression when compared to non-neoplastic controls. Moreover, elevated CXCR4 expression correlated with unfavorable clinical outcomes. Analysis of corresponding bone marrow biopsies revealed a correlation between CXCL12 expression and lymphoma infiltration rate. Further, we found a decrease in CXCR4 expression following treatment-induced remission of bone marrow involvement. In addition, we evaluated the effects of three CXCR4 antagonists in vitro: AMD3100 (Plerixafor), AMD070 (Mavorixafor), and WKI-a niacin derivative of AMD070 synthesized in our study. Notably, WK1 exhibited more potent pro-apoptotic effects compared to AMD070, inducing the expression of pro-apoptotic genes in CXCR4+ lymphoma cells. Interestingly, WK1 treatment led to decreased expression of genes associated with the ERK1/2, JNK, and NF-κB/BCR pathways. In summary, our findings indicate that the CXCR4-CXCL12 axis plays a substantial role in the development of DLBCL and presents a hopeful avenue for therapeutic intervention in aggressive lymphomas.\r\nThe second part of the thesis investigated the effect of Nr4a1 loss/deficiency on the tumor microenvironment (TME) and the immune response in a lymphoma mouse model. Transplantation of lymphoma cells with Nr4a1 loss into immunocompetent C57BL/6 wild-type mice resulted in increased splenic malignant B cell infiltration, decreased CD3+ T cell infiltration including subtypes of CD4+ T cells and CD8+ T cells, and an increased M2 macrophages- and Tregs-content, indicating immunosuppression and an immune cell depleted TME. Furthermore, a higher content of CD3+ T cells co-expressed of several immune checkpoint proteins in mice transplanted with lymphoma cells with Nr4a1 loss indicated an immunodepleted, exhausted TME. Co-culture assays revealed a decrease in T cell-mediated lymphoma cell lysis in the absence of Nr4a1, a phenomenon partially alleviated by Ctla4-/- OT-1 CD8+ T cells. These findings suggest Nr4a1's involvement in modulating T cell functionality. Nr4a1-deficiency resulted in increased phosphorylation of several kinases related with signaling pathways implicated in cell growth, apoptosis, and immune regulation. Collectively, our findings emphasize the immunoregulatory role of Nr4a1 in shaping the TME and immune checkpoint regulation in murine lymphomas.",
            "authors": [
                "Pansy, K"
            ],
            "year": 2024,
            "source": "PhD-Studium (Doctor of Philosophy); Humanmedizin; [ Dissertation ] Medizinische Universität Graz; 2024. pp. 140",
            "category": 5,
            "document_type": 16,
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            "country": "40",
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        },
        {
            "id": 213530,
            "title": "Long-Term Treatment for Brain Tumors: Sustained Drug Delivery with Iontronic Pumps.",
            "abstract": null,
            "authors": [
                "Handl, V",
                "Telebar-Žbulj, F",
                "Bogdan, I",
                "Bernacka Wojcik, I",
                ", Saarela, H",
                "Nowakowska-Desplantes, M",
                "Erschen, S",
                "Gorischek, A",
                "Tomin, T",
                "Arbring-Sjöström, T",
                "Bintinger, J",
                "Ropele, S",
                "Üçal, M",
                "Simon, D",
                "Schindl, R",
                "Waldherr, L"
            ],
            "year": 2024,
            "source": "https://www.nanoge.org/CyBioEl/home. 2024; -Conference on Bioelectronic Interfaces: Materials, Devices and Applications (CYBIOEL24); OCT 22-25, 2024; Limassol, CYPRUS. ",
            "category": 2,
            "document_type": 9,
            "sci": null,
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            "pmc": null,
            "organizations": [
                "213530-14011",
                "213530-14020",
                "213530-14050",
                "213530-14051"
            ],
            "persons": [
                "213530-107229",
                "213530-108352",
                "213530-51279",
                "213530-57129",
                "213530-98848",
                "213530-99703",
                "213530-105020",
                "213530-72095"
            ],
            "imported": "2025-01-29T12:30:59+01:00",
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        },
        {
            "id": 209871,
            "title": "Unraveling the complexity of intrinsically disordered protein regions: Investigating regulatory mechanisms governing structure, dynamics, and function.",
            "abstract": "Aberrant protein liquid-liquid phase separation (LLPS) is a vital and widespread phenomenon underlying the assembly of membraneless organelles (MLOs) in cells. The presence of missense mutations and defective nucleocytoplsmic transport of arginine- glycine(-glycine)-rich (RG/RGG) protein regions, which are highly abundant in RNA- binding proteins (RBPs), have been associated with misregulated LLPS and MLO formation, implying their contribution to the onset and progression of neurodegeneration. LLPS and MLO recruitment of these regions are intricately regulated by post-translational modifications, such as arginine methylation and phosphorylation, as well as binding to nuclear import receptors, such as transportin-1. An emerging evidence suggests that numerous RBPs harbor citrullination sites in their disordered arginine-rich regions. Protein citrullination, catalyzed by calcium-dependent protein arginine deiminases (PADs), converts peptidyl-arginine residues to peptidyl-citrullines, resulting in the loss of positive charge. Elevated levels of protein citrullination are frequently observed in patients suffering from multiple sclerosis and various autoimmune, neurodegenerative and cancer diseases.\r\nThe first part of this dissertation aimed at unravelling the effects of PAD4-mediated citrullination on model arginine-rich regions derived from FUS, G3BP1, and Nucleoprotein from SARS-CoV-2. Solution NMR data offers valuable insights into PAD4-mediated citrullination in vitro, facilitating residue-level assignment of modified sites, elucidation of citrullination kinetics and its modulation, and the derivation and comparison of structural and dynamic parameters for both an unmodified and citrullinated protein. Through a combination of solution NMR spectroscopy, ITC, DIC, and turbidity assays, it is demonstrated that citrullination of these regions reduces their RNA-induced LLPS, RNA- binding, and interaction with Transportin-1 in vitro. Furthermore, the obtained findings unveiled a reduced stress granules association of FUS upon its citrullination in semi- permeabilized cells. Additionally, the undertaken investigation revealed the lack of demethylation or citrullination of methylarginines by PAD4 in vitro. In conclusion, these results suggest that citrullination of disordered arginine-rich regions regulates their LLPS and transportin-1 mediated nuclear import.\r\nIn the second part of this work, I introduce OptoFluidic Force Induction (OF2i) technology as a novel tool for real-time monitoring of particle concentration, and temporal evolution.\r\nThis is motivated by our incomplete understanding of the molecular details underlying the transition of soluble single molecules into oligomeric complexes with liquid-like droplet properties, as well as the mechanisms regulating changes in the size distribution of nanoclusters formed by phase separating proteins. In this study, OF2i was utilized to monitor DTT-dependent aggregation of insulin, and investigate the role of RNA and salt concentration for RNA-mediated condensate formation of disordered regions from SARS- CoV-2 Nucleoprotein and FUS. In the summary, OF2i technology shows a promise as a tool to quantitatively characterize the size distribution and dynamics of condensates and protein aggregates.",
            "authors": [
                "Lenard, A"
            ],
            "year": 2024,
            "source": "PhD-Studium (Doctor of Philosophy); Humanmedizin; [ Dissertation ] Medizinische Universität Graz; 2024. pp. ",
            "category": 5,
            "document_type": 16,
            "sci": null,
            "pubmed": null,
            "doi": null,
            "pmc": null,
            "organizations": [],
            "persons": [],
            "imported": "2024-06-05T09:18:40+02:00",
            "journal": null,
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            "edition": null,
            "university": "Medizinische Universität Graz",
            "country": "40",
            "case_report": false,
            "impactfactor": null,
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        },
        {
            "id": 209874,
            "title": "SiMed an AI-based approach to safe medication",
            "abstract": null,
            "authors": [
                "Hoffmann, M",
                "Hava, N",
                ""
            ],
            "year": 2024,
            "source": "Austrian Life Science Day, Health Care Data; Juni 4, 2024; Graz, Austria . 2024. ",
            "category": 3,
            "document_type": null,
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                "209874-14076"
            ],
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}