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GET /v1/research/publication/?format=api&offset=150000&ordering=year
{ "count": 157186, "next": "https://api-test.medunigraz.at/v1/research/publication/?format=api&limit=20&offset=150020&ordering=year", "previous": "https://api-test.medunigraz.at/v1/research/publication/?format=api&limit=20&offset=149980&ordering=year", "results": [ { "id": 209461, "title": "The effect of the polyamine spermidine on heart function assessed by echocardiography", "abstract": "Background and Aim: Arterial hypertension is the main risk factor for cardiovascular diseases (CVDs) and deaths with increasing incidence. In an animal study, it could already be proven that the supplementation with the polyamine spermidine led to lower blood pressure levels in mice. This thesis aims to give further insights into the possible cardioprotective effects of spermidine on heart function in patients with hypertension disease assessed by both conventional echocardiographic and strain parameters.\r\nMaterial and Methods: This work was based on retrospective data analysis of echocardiographic loops of 20 patients with arterial hypertension from the SMARTEST trial at four points in time (weeks 0, 8, 12, and 20). The subjects received 4mg spermidine per day and a placebo for each eight weeks with a washout interval of four weeks in between in a crossover design. Standard echocardiographic and strain parameters of visit 1 and visit 4 were statistically evaluated and compared with each other to assess cardiac function.\r\nResults: The results of this study showed no significant changes in left ventricular (LV) function and volumes, right ventricular (RV) function and diameter, left atrial (LA) function and diameter, and diastolic function between visit 1 and visit 4. Regarding strain analyses, a strong positive correlation between LV Endo global longitudinal strain (GLS) and LV AutoStrain (r = 0.651) as well as a strong negative correlation between biplane left ventricular ejection fraction (LVEF) and Endo GLS (r = -0.593) were determined on visit 4.\r\nConclusion: The administration of spermidine in hypertensive patients did not lead to any significant echocardiographic changes in volume, linear, and strain parameters. Nevertheless, this work could show the safety of oral spermidine supplementation on cardiac function in hypertensive patients evaluated by echocardiography. Further clinical research is necessary for the proof of the possible cardioprotective effects of spermidine and the understanding of the importance of GLS in hypertension disease.", "authors": [ "Waltl, K" ], "year": 2024, "source": "Humanmedizin; [ Diplomarbeit ] Medizinische Universität Graz; 2024. pp. 78", "category": 5, "document_type": 15, "sci": null, "pubmed": null, "doi": null, "pmc": null, "organizations": [], "persons": [], "imported": "2024-05-06T12:32:46+02:00", "journal": null, "issn": null, "collection_publisher": null, "collection_title": null, "edition": null, "university": "Medizinische Universität Graz", "country": "40", "case_report": false, "impactfactor": null, "impactfactor_year": null, "impactfactor_norm": null, "impactfactor_norm_year": null, "impactfactor_norm_category": null, "impactfactor_norm_super": null, "impactfactor_norm_super_year": null, "impactfactor_norm_super_category": null, "citations": null, "conference_name": null, "conference_place": null, "conference_international": false, "scientific_event": false, "invited_lecture": false, "keynote_speaker": false, "selected_presentation": false, "biobank_use": false, "bmf_use": false, "zmf_use": false, "local_affiliation": false }, { "id": 209462, "title": "Der Reducer: Eine neue Therapieform der refraktären Angina pectoris - Eine Diplomarbeit im Zuge einer retrospektiven klinischen Studie und der klinischen Praxis", "abstract": "Hintergrund: Schätzungen zufolge leiden bis zu 10% der KHK-Patient:innen an refraktärer Angina pectoris, trotz Ausschöpfung aller medikamentöser und interventioneller Therapiemöglichkeiten. Der Reducer, ein sanduhrförmiger Stent, stellt eine neue, symptomatische Therapieform für diese Patient:innen dar. Das Ziel dieser Arbeit ist, die Auswirkungen der Reducer-Therapie auf die Angina pectoris Symptomatik durch den Vergleich verschiedener Parameter vor und nach der Implantation zu untersuchen.\r\nMaterial und Methoden: In dieser retrospektiven Datenanalyse wurden die Daten von zehn Patient:innen, die an der Klinischen Abteilung für Kardiologie am LKH Univ. Klinikum Graz einen Reducer implantiert bekommen hatten, vor der Reducer-Implantation, sowie sechs und zwölf Monate nach der Implantation ausgewertet und verglichen. Die zur Auswertung verwendeten Parameter waren die Canadian-Cardiovascular-Society-Klassifikation (CCS), der 6-Minuten-Gehtest, der Seattle Angina Questionnaire (SAQ), der EQ-5D-5L und der EQ-VAS. Es erfolgte ein Vergleich der Variablen zwischen Baseline (vor der Implantation) und 6-Monats-Visite nach der Implantation, sowie zwischen 6- und 12-Monats-Visite. Die statistische Auswertung wurde mit dem Programm IBM SPSS Statistics 29.0 ® durchgeführt. Die Datenanalyse erfolgte mittels deskriptiver Statistik und die möglichen Veränderungen zwischen den drei Zeitpunkten wurden mittels Wilcoxon-Test bei gepaarten Stichproben mit einem Signifikanzniveau von p = 0,05 ermittelt.\r\nErgebnisse: Sechs Monate nach der Reducer-Implantation zeigte sich eine signifikante Reduktion von mindestens einer CCS-Klasse bei sieben Patient:innen (70%). Die mittlere CCS-Klasse betrug zum Zeitpunkt der Baseline 2,6 ± 0,5 (p < 0,05) , zum Zeitpunkt der 6-Monats-Visite 1,7 ± 0,7 (p < 0,05).\r\nWeiters konnte eine signifikante Steigerung im Teilbereich Lebensfreude des Seattle Angina Questionnaire veranschaulicht werden. Bei der Baseline-Untersuchung wurden durchschnittlich 49,2 ± 14,94 Punkte von den Teilnehmer:innen vergeben, sechs Monate später verbesserte sich die mittlere vergebene Punktezahl auf 66,7 ± 27,5 Punkte (p < 0,05).\r\nFazit: Diese retrospektive Datenanalyse zeigte bei 70% der Teilnehmer:innen ein Ansprechen auf die Reducer-Therapie, das sich durch eine Reduktion der Angina pectoris in der CCS-Klassifikation und eine Steigerung der Lebensfreude im SAQ darstellen lässt. Dieses Ergebnis entspricht anderen, ähnlich aufgebauten, Studien zur Reducer-Therapie. Warum es bei einigen Patient:innen zu keinem Therapieansprechen kam, wurde diskutiert, ist aber noch ein Bereich für weitere Forschung und kann im Rahmen dieser Diplomarbeit nicht ausreichend beantwortet werden.", "authors": [ "Fallent, A" ], "year": 2024, "source": "Humanmedizin; [ Diplomarbeit ] Medizinische Universität Graz; 2024. pp. 74", "category": 5, "document_type": 15, "sci": null, "pubmed": null, "doi": null, "pmc": null, "organizations": [], "persons": [], "imported": "2024-05-06T12:32:46+02:00", "journal": null, "issn": null, "collection_publisher": null, "collection_title": null, "edition": null, "university": "Medizinische Universität Graz", "country": "40", "case_report": false, "impactfactor": null, "impactfactor_year": null, "impactfactor_norm": null, "impactfactor_norm_year": null, "impactfactor_norm_category": null, "impactfactor_norm_super": null, "impactfactor_norm_super_year": null, "impactfactor_norm_super_category": null, "citations": null, "conference_name": null, "conference_place": null, "conference_international": false, "scientific_event": false, "invited_lecture": false, "keynote_speaker": false, "selected_presentation": false, "biobank_use": false, "bmf_use": false, "zmf_use": false, "local_affiliation": false }, { "id": 209463, "title": "Analyse der Häufigkeit von Nicht- Kontakt- Verletzungen der unteren Extremität in Abhängigkeit von Fähigkeiten in Maximalkraft, Sprungkraft und dynamischem Gleichgewicht - Lässt sich anhand ausgewählter Tests das Risiko für zukünftige Verletzungen bestimmen?", "abstract": "Verletzungen stellen ein großes und häufiges Problem im Sport dar. Trotz umfangreicher bis dato durchgeführter Forschungsarbeit gibt es bis heute keine eindeutigen, generellen Empfehlungen für bestimmte Parameter oder Screeningverfahren zur Identifikation von Sportlerinnen und Sportlern mit erhöhtem Verletzungsrisiko. Diesbezüglich wurde im Rahmen dieser Pilotstudie eine Testbatterie entwickelt, um Defizite in den motorischen Grundeigenschaften dynamisches Gleichgewicht, Maximalkraft und Sprungkraft festzustellen. Durchgeführt wurden der Y- Balance- Test (YBT), isometrische Maximalkraftmessungen des Musculus quadriceps femoris und der ischiocruralen Muskulatur sowie der Single Hop for distance und der Cross Hop for distance. An der Studie nahmen 156 Sportlerinnen und Sportler aus den Sportarten Schi Alpin, Handball und Fußball teil. Weiters erfolgte im Rahmen der Durchführung der Tests eine ausführliche Verletzungsanamnese der letzten 12 Monate (zur retrospektiven Analyse). Für die Studie waren Nichtkontaktverletzungen der unteren Extremität von Relevanz. Von 45 Sportlerinnen und Sportlern wurde zudem nach einem Jahr eine weitere anamnestische Erhebung entsprechender Verletzungen durchgeführt (zur prospektiven Analyse). \r\nDie Leistungsparameter der Studienteilnehmerinnen und -teilnehmer wurden einerseits zur Etablierung von Normwerten herangezogen. Andererseits erfolgte anhand von in der Literatur definierten Cutoff- Werten eine Einteilung in zwei Gruppen. Gruppe A repräsentierte jene Sportlerinnen und Sportler, welche die Cutoff- Werte erreichten, Gruppe B repräsentierte jene, welche die Cutoff- Werte nicht erreichen konnten. Folgende Parameter und Cutoff- Werte wurden für die Gruppeneinteilung herangezogen:\r\n1.YBT anteriore Asymmetrie: Gruppe A < 4cm; Gruppe B ≥ 4cm\r\n2.YBT Composite Score: Gruppe A > 94%; Gruppe B ≤ 94%\r\n3.LSI der Maximalkraftmessungen und Hop- Tests: Gruppe A ≥ 90%; Gruppe B < 90%\r\nUm nun festzustellen, ob die Zugehörigkeit zur Gruppe B mit einem höheren Risiko für Verletzungen verbunden ist, wurde zunächst ein Vergleich der Mittelwerte beider Gruppen durchgeführt. Es zeigten sich, mit Ausnahme des Cross Hop for distance bei den Mädchen, keine signifikanten Unterschiede in den Durchschnittswerten zwischen den Gruppen A und B. Weiters erfolgte die Analyse des Zusammenhanges zwischen höheren Seitenasymmetrien bzw. schlechterem Gesamtscore des YBT und Verletzungen. In der retrospektiven Analyse zeigte sich kein signifikanter Zusammenhang mit Nichtkontaktverletzungen der vergangenen 12 Monate. In der prospektiven Analyse zeigte sich lediglich für den Single Hop for distance ein signifikanter Zusammenhang mit Nichtkontaktverletzungen der folgenden 12 Monate. \r\nZusammenfassend kann auch anhand dieser Pilotstudie keine eindeutige Empfehlung für eine Testbatterie bzw. bestimmte Parameter zur Identifikation von Sportlerinnen und Sportlern mit erhöhtem Verletzungsrisiko gegeben werden. Die anteriore Asymmetrie des YBT, der Composite Score des YBT, der LSI der Maximalkraftmessungen des Musculus quadriceps femoris und der ischiocruralen Muskulatur sowie der LSI des Cross Hop for distance können somit in dieser Studienpopulation nicht als Screeningverfahren für Verletzungen herangezogen werden. Einzig Seitendifferenzen im Single Hop for distance > 10% zeigten einen signifikanten Zusammenhang mit folgenden Nichtkontaktverletzungen der unteren Extremität. Aufgrund der geringen Fallzahlen ist es jedoch in weiterer Folge notwendig, diese Erkenntnis in weiterführenden Studien genauer zu überprüfen.", "authors": [ "Holzerbauer, A" ], "year": 2024, "source": "Humanmedizin; [ Diplomarbeit ] Medizinische Universität Graz; 2024. pp. 82", "category": 5, "document_type": 15, "sci": null, "pubmed": null, "doi": null, "pmc": null, "organizations": [], "persons": [], "imported": "2024-05-06T12:32:46+02:00", "journal": null, "issn": null, "collection_publisher": null, "collection_title": null, "edition": null, "university": "Medizinische Universität Graz", "country": "40", "case_report": false, "impactfactor": null, "impactfactor_year": null, "impactfactor_norm": null, "impactfactor_norm_year": null, "impactfactor_norm_category": null, "impactfactor_norm_super": null, "impactfactor_norm_super_year": null, "impactfactor_norm_super_category": null, "citations": null, "conference_name": null, "conference_place": null, "conference_international": false, "scientific_event": false, "invited_lecture": false, "keynote_speaker": false, "selected_presentation": false, "biobank_use": false, "bmf_use": false, "zmf_use": false, "local_affiliation": false }, { "id": 209465, "title": "Cardiac specific auto-antibodies in serum and tissue from coronary artery disease to ischaemic heart failure", "abstract": null, "authors": [ "Sattler, S" ], "year": 2024, "source": "31st ANNUAL MEETING - AAS of the Austrian Atherosclerosis Society; May 2 – 4, 2024; St. Gilgen, Austria. 2024. ", "category": 3, "document_type": null, "sci": null, "pubmed": null, "doi": null, "pmc": null, "organizations": [ "209465-14022", "209465-14083" ], "persons": [ "209465-114311" ], "imported": "2024-05-07T11:19:18+02:00", "journal": null, "issn": null, "collection_publisher": null, "collection_title": null, "edition": null, "university": null, "country": null, "case_report": false, "impactfactor": null, "impactfactor_year": null, "impactfactor_norm": null, "impactfactor_norm_year": null, "impactfactor_norm_category": null, "impactfactor_norm_super": null, "impactfactor_norm_super_year": null, "impactfactor_norm_super_category": null, "citations": null, "conference_name": true, "conference_place": true, "conference_international": false, "scientific_event": true, "invited_lecture": true, "keynote_speaker": false, "selected_presentation": true, "biobank_use": false, "bmf_use": false, "zmf_use": true, "local_affiliation": true }, { "id": 209466, "title": "The Role of PSG11 on Platelets during Pregnancy.", "abstract": "Pregnancy specific beta-1 glycoproteins (PSGs) are the most abundant trophoblast-derived proteins in the maternal blood stream during human pregnancy. Their expression is essential for a healthy placental and fetal development, as some studies indicate a crucial role of the PSGs in the regulation of the immune response, placental angiogenesis, and platelet activation. Proteomics data from preliminary experiments suggest that these pregnancy-specific glycoproteins accumulate in maternal platelets over the course of gestation. Therefore, the aim of this master thesis is to test whether PSG11 is selectively taken up by platelets and whether platelet priming is a crucial process during human pregnancy. Placental PSG11 from healthy first and third trimester as well as from preeclamptic tissue was characterized using immunohistochemistry, Western blot, and qPCR analysis. Platelets were isolated from whole blood samples either from healthy pregnant or non-pregnant women or male donors. Characterization of PSG11 in platelets was performed on protein level using immunocytochemistry, Western blot analysis and ELISA. Also, platelets from non-pregnant women were incubated with blood plasma of pregnant women in their third trimester of gestation, recombinant PSG11 or trophoblast-derived PSG11 and subsequently analyzed on protein level. Immunohistochemistry for PSG11 revealed positive signals in the villous syncytiotrophoblast of placental tissue from the first and third trimester of gestation as well as from preeclampsia patients. These results were verified on gene expression level via qPCR as well as on protein level via Western blot analysis. Our data showed an accumulation of PSG11 in platelets isolated from women in their third trimester of gestation compared to control groups, which were not pregnant. Furthermore, PSG11 was also detected in platelets from non-pregnant women after incubation with pregnant blood plasma. In conclusion, our data suggest that platelets sequester increased concentrations of PSG11 during human pregnancy, which leads us to speculate that platelet priming by placenta-derived factors is a common process.", "authors": [ "Nefischer, L" ], "year": 2024, "source": " [ Diplomarbeit/Master Thesis (UNI) ] Universität Graz; 2024. ", "category": 5, "document_type": 15, "sci": null, "pubmed": null, "doi": null, "pmc": null, "organizations": [], "persons": [], "imported": "2024-05-07T11:24:06+02:00", "journal": null, "issn": null, "collection_publisher": null, "collection_title": null, "edition": null, "university": "Universität Graz", "country": "40", "case_report": false, "impactfactor": null, "impactfactor_year": null, "impactfactor_norm": null, "impactfactor_norm_year": null, "impactfactor_norm_category": null, "impactfactor_norm_super": null, "impactfactor_norm_super_year": null, "impactfactor_norm_super_category": null, "citations": null, "conference_name": null, "conference_place": null, "conference_international": false, "scientific_event": false, "invited_lecture": false, "keynote_speaker": false, "selected_presentation": false, "biobank_use": false, "bmf_use": false, "zmf_use": false, "local_affiliation": false }, { "id": 209477, "title": "Der Einfluss einer PEO-Beschichtung auf die in vivo Degradation von \r\nresorbierbaren Mg-Schrauben für orthopädische Anwendungen", "abstract": null, "authors": [ "Marek, R", "Kaufmann, K", "Imwinkelried, T", "Honea, M", "Holweg, P", "Warchomicka, F", "Berger, L", "Weinberg, AM" ], "year": 2024, "source": "Technischen Fachtagung SGO-SST 2024 - Innovative Surfaces; May 7, 2024; Biel, Schweiz. 2024. ", "category": 3, "document_type": null, "sci": null, "pubmed": null, "doi": null, "pmc": null, "organizations": [ "209477-14052" ], "persons": [ "209477-50785" ], "imported": "2024-05-08T18:03:48+02:00", "journal": null, "issn": null, "collection_publisher": null, "collection_title": null, "edition": null, "university": null, "country": null, "case_report": false, "impactfactor": null, "impactfactor_year": null, "impactfactor_norm": null, "impactfactor_norm_year": null, "impactfactor_norm_category": null, "impactfactor_norm_super": null, "impactfactor_norm_super_year": null, "impactfactor_norm_super_category": null, "citations": null, "conference_name": true, "conference_place": true, "conference_international": true, "scientific_event": true, "invited_lecture": false, "keynote_speaker": false, "selected_presentation": true, "biobank_use": false, "bmf_use": false, "zmf_use": false, "local_affiliation": true }, { "id": 210361, "title": "HDL-based therapeutics: A promising frontier in combating viral and bacterial infections.", "abstract": null, "authors": [ "Rani, A", "Stadler, JT", "Marsche, G" ], "year": 2024, "source": "Pharmacol Ther. 2024; 260: 108684", "category": 1, "document_type": 3, "sci": "ISI:001267728200001", "pubmed": "38964560", "doi": "10.1016/j.pharmthera.2024.108684", "pmc": null, "organizations": [ "210361-14022" ], "persons": [ "210361-111769-1", "210361-53252-4", "210361-100799-6" ], "imported": "2024-07-08T02:00:00+02:00", "journal": "Pharmacol Ther", "issn": "0163-7258", "collection_publisher": null, "collection_title": null, "edition": null, "university": null, "country": null, "case_report": false, "impactfactor": 12.5, "impactfactor_year": 2024, "impactfactor_norm": 0.97, "impactfactor_norm_year": 2024, "impactfactor_norm_category": "PHARMACOLOGY & PHARMACY-SCIE", "impactfactor_norm_super": 0.978, "impactfactor_norm_super_year": 2022, "impactfactor_norm_super_category": "PHARMACOLOGY + PHARMACY-SCIE", "citations": true, "conference_name": null, "conference_place": null, "conference_international": false, "scientific_event": false, "invited_lecture": false, "keynote_speaker": false, "selected_presentation": false, "biobank_use": false, "bmf_use": true, "zmf_use": false, "local_affiliation": true }, { "id": 210305, "title": "Rivaroxaban vs Vitamin K Antagonist in Patients With Atrial Fibrillation and Advanced Chronic Kidney Disease.", "abstract": null, "authors": [ "Kreutz, R", "Deray, G", "Floege, J", "Gwechenberger, M", "Hahn, K", "Luft, AR", "Persson, P", "Axthelm, C", "Beer, JH", "Bergler-Klein, J", "Lellouche, N", "Taggeselle, J", "Coleman, CI", "Beyer-Westendorf, J, , XARENO, registry" ], "year": 2024, "source": "JACC Adv. 2024; 3(2): 100813", "category": 1, "document_type": 1, "sci": "ISI:001502701100011", "pubmed": "38939389", "doi": "10.1016/j.jacadv.2023.100813", "pmc": "PMC11198259", "organizations": [], "persons": [ "210305-50168-7" ], "imported": "2024-07-03T02:00:00+02:00", "journal": "JACC Adv", "issn": "2772-963X", "collection_publisher": null, "collection_title": null, "edition": null, "university": null, "country": null, "case_report": false, "impactfactor": null, "impactfactor_year": null, "impactfactor_norm": null, "impactfactor_norm_year": null, "impactfactor_norm_category": null, "impactfactor_norm_super": null, "impactfactor_norm_super_year": null, "impactfactor_norm_super_category": null, "citations": true, "conference_name": null, "conference_place": null, "conference_international": false, "scientific_event": false, "invited_lecture": false, "keynote_speaker": false, "selected_presentation": false, "biobank_use": false, "bmf_use": false, "zmf_use": false, "local_affiliation": false }, { "id": 209485, "title": "Investigating the influence of aging on metabolome and gene expression in Saccharomyces yeast.", "abstract": null, "authors": [ "Eigenfeld, M.", "Lupp, K.", "Schwaminger, S.P." ], "year": 2024, "source": "35th VH Yeast Conference; May 6-7, 2024; Berlin, Germany. 2024. 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