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year:gt,gte,lt,ltesci:iexact,contains,icontains,startswith,istartswithpubmed:iexact,contains,icontains,startswith,istartswithdoi:iexact,contains,icontains,startswith,istartswithpmc:iexact,contains,icontains,startswith,istartswithorganization_authorship:inimpact:isnull,gt,gte,lt,lteimported:isnull,gt,gte,lt,lte,date
GET /v1/research/publication/?format=api&offset=148860&ordering=year
{ "count": 157925, "next": "https://api-test.medunigraz.at/v1/research/publication/?format=api&limit=20&offset=148880&ordering=year", "previous": "https://api-test.medunigraz.at/v1/research/publication/?format=api&limit=20&offset=148840&ordering=year", "results": [ { "id": 210339, "title": "Pulmonary arterial wedge pressure in healthy subjects: a meta-analysis.", "abstract": null, "authors": [ "Zeder, K", "Avian, A", "Mak, S", "Giannakoulas, G", "Kawut, SM", "Maron, BA", "Humbert, M", "Olschewski, H", "Kovacs, G" ], "year": 2024, "source": "Eur Respir J. 2024; 64(2):", "category": 1, "document_type": 2, "sci": "ISI:001381674700006", "pubmed": "38964777", "doi": "10.1183/13993003.00967-2024", "pmc": "PMC11325264", "organizations": [ "210339-14026", "210339-14087" ], "persons": [ "210339-104780-1", "210339-59238-6", "210339-67207-6" ], "imported": "2024-07-05T02:00:00+02:00", "journal": "Eur Respir J", "issn": "0903-1936", "collection_publisher": null, "collection_title": null, "edition": null, "university": null, "country": null, "case_report": false, "impactfactor": 21.2, "impactfactor_year": 2024, "impactfactor_norm": 0.985, "impactfactor_norm_year": 2024, "impactfactor_norm_category": "RESPIRATORY SYSTEM-SCIE", "impactfactor_norm_super": 0.985, "impactfactor_norm_super_year": 2024, "impactfactor_norm_super_category": "RESPIRATORY SYSTEM-SCIE", "citations": true, "conference_name": null, "conference_place": null, "conference_international": false, "scientific_event": false, "invited_lecture": false, "keynote_speaker": false, "selected_presentation": false, "biobank_use": false, "bmf_use": false, "zmf_use": true, "local_affiliation": true }, { "id": 209622, "title": "Evaluation of spectral-domain optical coherence tomography for analysis of progression of atrophy secondary to Stargardt disease typ IV", "abstract": "Purpose: To investigate changes in retinal layer thickness and intact retinal area in patients with molecularly confirmed PROM1-associated retinal degeneration (RD) over a 24-month period, utilizing spectral-domain optical coherence tomography (SD-OCT). Retinal layer thickness and intact area are crucial markers of retinal health, particularly in conditions like Stargardt disease, and SD-OCT offers precise imaging for detecting subtle alterations in these parameters.\r\n\r\nDesign: international, multicenter, prospective case series\r\n\r\nMethods: Thirteen eyes from 13 patients affected by PROM1-associated RD were enrolled at five sites, with SD-OCT images captured at baseline and after 24 months. Mean thickness (MT) loss and intact area were estimated through semi-automated segmentation for various individual retinal layers within the central subfield (CS), inner ring, and outer ring of the early treatment diabetic retinopathy grid (ETDRS): retinal pigment epithelium (RPE), outer segments (OS), inner segments (IS), outer nuclear layer (ONL), inner retina (IR), and total retina (TR). Changes in mean thickness and intact area of individual retinal layers were analyzed as yearly rate differences and progression patterns.\r\n\r\nResults: Six male and seven female patients, with a mean age of 38.2±14.2 years at baseline and symptom onset at 30.3±16.3 years (available for twelve patients) were enrolled. Mean best-corrected visual acuity at baseline was 0.51±0.53 LogMAR. Statistically significant thickness losses were observed in the RPE and TR in the CS and inner ring, and in the ONL and IS in the outer ring (all p<0.05). Additionally, a significant decrease in intact area of the RPE and IS was noted in the inner ring, and of the ONL in the outer ring (all p<0.05). Trends of decline were observed in MT and intact area of the other layers over the 24-month observational period.\r\n\r\nConclusions: Significant thickness losses in outer retinal layers were detected by SD-OCT over 24 months in patients with PROM1-associated RD. Effective treatments to halt or reverse maculopathy in Stargardt's disease are currently lacking. Loss of thickness and/or intact area in these layers may serve as potential endpoints for clinical trials aiming to slow down the disease progression of PROM1-associated RD.", "authors": [ "Grosspoetzl, M" ], "year": 2024, "source": "Doktoratsstudium der Medizinischen Wissenschaft; Humanmedizin; [ Dissertation ] Medizinische Universität Graz; 2024. pp. 83", "category": 5, "document_type": 16, "sci": null, "pubmed": null, "doi": null, "pmc": null, "organizations": [], "persons": [], "imported": "2024-05-21T14:04:09+02:00", "journal": null, "issn": null, "collection_publisher": null, "collection_title": null, "edition": null, "university": "Medizinische Universität Graz", "country": "40", "case_report": false, "impactfactor": null, "impactfactor_year": null, "impactfactor_norm": null, "impactfactor_norm_year": null, "impactfactor_norm_category": null, "impactfactor_norm_super": null, "impactfactor_norm_super_year": null, "impactfactor_norm_super_category": null, "citations": null, "conference_name": null, "conference_place": null, "conference_international": false, "scientific_event": false, "invited_lecture": false, "keynote_speaker": false, "selected_presentation": false, "biobank_use": false, "bmf_use": false, "zmf_use": false, "local_affiliation": false }, { "id": 210578, "title": "Hepatectomy versus systemic therapy for liver-limited BRAF V600E-mutated colorectal liver metastases: multicentre retrospective study.", "abstract": null, "authors": [ "Margonis, GA", "Wang, JJ", "Boerner, T", "Moretto, R", "Buettner, S", "Andreatos, N", "Gagnière, J", "Wagner, D", "Løes, IM", "Bergamo, F", "Pietrantonio, F", "Scartozzi, M", "Spallanzani, A", "Vincenzi, B", "Antoniou, E", "Pikoulis, E", "Sartore-Bianchi, A", "Stasinos, G", "Sasaki, K", "Pawlik, TM", "Orlandi, A", "Pella, N", "Fitschek, F", "Kaczirek, K", "Dupré, A", "Pozios, I", "Beyer, K", "Kornprat, P", "Aucejo, FN", "Burkhart, R", "Weiss, MJ", "Lønning, PE", "Poultsides, G", "Cremolini, C", "Kreis, ME", "D'Angelica, M" ], "year": 2024, "source": "Br J Surg. 2024; 111(7):", "category": 1, "document_type": 1, "sci": "ISI:001276290500002", "pubmed": "39051667", "doi": "10.1093/bjs/znae176", "pmc": "PMC11270119", "organizations": [ "210578-14073" ], "persons": [ "210578-50039-6", "210578-59327-6" ], "imported": "2024-07-30T02:00:00+02:00", "journal": "Br J Surg", "issn": "0007-1323", "collection_publisher": null, "collection_title": null, "edition": null, "university": null, "country": null, "case_report": false, "impactfactor": 8.8, "impactfactor_year": 2024, "impactfactor_norm": 0.981, "impactfactor_norm_year": 2024, "impactfactor_norm_category": "SURGERY-SCIE", "impactfactor_norm_super": 0.981, "impactfactor_norm_super_year": 2024, "impactfactor_norm_super_category": "SURGERY-SCIE", "citations": true, "conference_name": null, "conference_place": null, "conference_international": false, "scientific_event": false, "invited_lecture": false, "keynote_speaker": false, "selected_presentation": false, "biobank_use": false, "bmf_use": false, "zmf_use": false, "local_affiliation": true }, { "id": 210633, "title": "The dark side of random-start ovarian stimulation: ovarian hyperstimulation syndrome due to inadvertent pregnancy.", "abstract": null, "authors": [ "Semrl, N", "De, Vos, M", "Blockeel, C" ], "year": 2024, "source": "Reprod Biomed Online. 2024; 49(4):104121", "category": 1, "document_type": 1, "sci": "ISI:001285599700001", "pubmed": "39089166", "doi": "10.1016/j.rbmo.2024.104121", "pmc": null, "organizations": [ "210633-14064" ], "persons": [ "210633-111750-2" ], "imported": "2024-08-05T02:00:00+02:00", "journal": "Reprod Biomed Online", "issn": "1472-6483", "collection_publisher": null, "collection_title": null, "edition": null, "university": null, "country": null, "case_report": false, "impactfactor": 3.5, "impactfactor_year": 2024, "impactfactor_norm": 0.81, "impactfactor_norm_year": 2024, "impactfactor_norm_category": "OBSTETRICS & GYNECOLOGY-SCIE", "impactfactor_norm_super": 0.847, "impactfactor_norm_super_year": 2021, "impactfactor_norm_super_category": "OBSTETRICS + GYNECOLOGY-SCI", "citations": true, "conference_name": null, "conference_place": null, "conference_international": false, "scientific_event": false, "invited_lecture": false, "keynote_speaker": false, "selected_presentation": false, "biobank_use": false, "bmf_use": false, "zmf_use": false, "local_affiliation": true }, { "id": 210732, "title": "Cerebral oxygenation during immediate fetal-to-neonatal transition and fidgety movements between six to 20 weeks of corrected age: An ancillary study to the COSGOD III trial.", "abstract": null, "authors": [ "Wolfsberger, CH", "Schwaberger, B", "Urlesberger, B", "Scheuchenegger, A", "Avian, A", "Hammerl, M", "Kiechl-Kohlendorfer, U", "Griesmaier, E", "Pichler, G" ], "year": 2024, "source": "Eur J Pediatr. 2024; 183(10):4425-4433", "category": 1, "document_type": 1, "sci": "ISI:001287974000001", "pubmed": "39126518", "doi": "10.1007/s00431-024-05711-3", "pmc": "PMC11413120", "organizations": [ "210732-14094", "210732-14026" ], "persons": [ "210732-79516-6", "210732-82050-1", "210732-67207-6", "210732-83581-6", "210732-50907-4" ], "imported": "2024-08-11T02:00:00+02:00", "journal": "Eur J Pediatr", "issn": "0340-6199", "collection_publisher": null, "collection_title": null, "edition": null, "university": null, "country": null, "case_report": false, "impactfactor": 2.6, "impactfactor_year": 2024, "impactfactor_norm": 0.767, "impactfactor_norm_year": 2024, "impactfactor_norm_category": "PEDIATRICS-SCIE", "impactfactor_norm_super": 0.831, "impactfactor_norm_super_year": 2023, "impactfactor_norm_super_category": "PEDIATRICS-SCIE", "citations": true, "conference_name": null, "conference_place": null, "conference_international": false, "scientific_event": false, "invited_lecture": false, "keynote_speaker": false, "selected_presentation": false, "biobank_use": false, "bmf_use": false, "zmf_use": false, "local_affiliation": true }, { "id": 210926, "title": "The Lipidomics Reporting Checklist A framework for transparency of lipidomic experiments and repurposing resource data.", "abstract": null, "authors": [ "Kopczynski, D", "Ejsing, CS", "McDonald, JG", "Bamba, T", "Baker, ES", "Bertrand-Michel, J", "Brügger, B", "Coman, C", "Ellis, SR", "Garrett, TJ", "Griffiths, WJ", "Guan, XL", "Han, X", "Höring, M", "Holčapek, M", "Hoffmann, N", "Huynh, K", "Lehmann, R", "Jones, JW", "Kaddurah-Daouk, R", "Köfeler, HC", "Meikle, PJ", "Metz, TO", "O'Donnell, VB", "Saigusa, D", "Schwudke, D", "Shevchenko, A", "Torta, F", "Vizcaíno, JA", "Welti, R", "Wenk, MR", "Wolrab, D", "Xia, Y", "Ekroos, K", "Ahrends, R", "Liebisch, G" ], "year": 2024, "source": "J Lipid Res. 2024; 100621", "category": 1, "document_type": 1, "sci": "ISI:001367437400001", "pubmed": "39151590", "doi": "10.1016/j.jlr.2024.100621", "pmc": "PMC11417233", "organizations": [ "210926-17225" ], "persons": [ "210926-58455-6" ], "imported": "2024-09-03T02:00:00+02:00", "journal": "J Lipid Res", "issn": "0022-2275", "collection_publisher": null, "collection_title": null, "edition": null, "university": null, "country": null, "case_report": false, "impactfactor": 4.1, "impactfactor_year": 2024, "impactfactor_norm": 0.671, "impactfactor_norm_year": 2024, "impactfactor_norm_category": "BIOCHEMISTRY & MOLECULAR BIOLOGY-SCIE", "impactfactor_norm_super": 0.821, "impactfactor_norm_super_year": 2022, "impactfactor_norm_super_category": "BIOCHEMISTRY + MOLECULAR BIOLOGY-SCIE", "citations": true, "conference_name": null, "conference_place": null, "conference_international": false, "scientific_event": false, "invited_lecture": false, "keynote_speaker": false, "selected_presentation": false, "biobank_use": false, "bmf_use": false, "zmf_use": true, "local_affiliation": true }, { "id": 210950, "title": "ERBB2/ ERBB3-mutated S100/ SOX10-positive unclassified high-grade uterine sarcoma: first detailed description of a novel entity.", "abstract": null, "authors": [ "Agaimy, A", "Dermawan, JK", "Haller, F", "Semrau, S", "Meidenbauer, N", "Stoehr, R", "Lax, S", "Hartmann, A", "Zou, YS", "Xing, D", "Tögel, L", "Gross, JM", "Michal, M" ], "year": 2024, "source": "Virchows Arch. 2024; ", "category": 1, "document_type": 1, "sci": "ISI:001303676200001", "pubmed": "39196362", "doi": "10.1007/s00428-024-03908-3", "pmc": "PMC11564289", "organizations": [ "210950-14020" ], "persons": [ "210950-52442-6" ], "imported": "2024-09-03T02:00:00+02:00", "journal": "Virchows Arch", "issn": "0945-6317", "collection_publisher": null, "collection_title": null, "edition": null, "university": null, "country": null, "case_report": false, "impactfactor": 3.1, "impactfactor_year": 2024, "impactfactor_norm": 0.684, "impactfactor_norm_year": 2024, "impactfactor_norm_category": "PATHOLOGY-SCIE", "impactfactor_norm_super": 0.74, "impactfactor_norm_super_year": 2021, "impactfactor_norm_super_category": "PATHOLOGY-SCI", "citations": true, "conference_name": null, "conference_place": null, "conference_international": false, "scientific_event": false, "invited_lecture": false, "keynote_speaker": false, "selected_presentation": false, "biobank_use": false, "bmf_use": false, "zmf_use": false, "local_affiliation": true }, { "id": 210963, "title": "Finerenone in Heart Failure with Mildly Reduced or Preserved Ejection Fraction.", "abstract": null, "authors": [ "Solomon, SD", "McMurray, JJV", "Vaduganathan, M", "Claggett, B", "Jhund, PS", "Desai, AS", "Henderson, AD", "Lam, CSP", "Pitt, B", "Senni, M", "Shah, SJ", "Voors, AA", "Zannad, F", "Abidin, IZ", "Alcocer-Gamba, MA", "Atherton, JJ", "Bauersachs, J", "Chang-Sheng, M", "Chiang, CE", "Chioncel, O", "Chopra, V", "Comin-Colet, J", "Filippatos, G", "Fonseca, C", "Gajos, G", "Goland, S", "Goncalvesova, E", "Kang, S", "Katova, T", "Kosiborod, MN", "Latkovskis, G", "Lee, AP", "Linssen, GCM", "Llamas-Esperón, G", "Mareev, V", "Martinez, FA", "Melenovský, V", "Merkely, B", "Nodari, S", "Petrie, MC", "Saldarriaga, CI", "Saraiva, JFK", "Sato, N", "Schou, M", "Sharma, K", "Troughton, R", "Udell, JA", "Ukkonen, H", "Vardeny, O", "Verma, S", "von, Lewinski, D", "Voronkov, L", "Yilmaz, MB", "Zieroth, S", "Lay-Flurrie, J", "van, Gameren, I", "Amarante, F", "Kolkhof, P", "Viswanathan, P" ], "year": 2024, "source": "N Engl J Med. 2024; 391(16):1475-1485", "category": 1, "document_type": 1, "sci": "ISI:001302089300001", "pubmed": "39225278", "doi": "10.1056/NEJMoa2407107", "pmc": null, "organizations": [ "210963-14083" ], "persons": [ "210963-59317-6" ], "imported": "2024-09-04T02:00:00+02:00", "journal": "N Engl J Med", "issn": "0028-4793", "collection_publisher": null, "collection_title": null, "edition": null, "university": null, "country": null, "case_report": false, "impactfactor": 78.5, "impactfactor_year": 2024, "impactfactor_norm": 0.994, "impactfactor_norm_year": 2024, "impactfactor_norm_category": "MEDICINE, GENERAL & INTERNAL-SCIE", "impactfactor_norm_super": 0.994, "impactfactor_norm_super_year": 2024, "impactfactor_norm_super_category": "MEDICINE, GENERAL + INTERNAL-SCIE", "citations": true, "conference_name": null, "conference_place": null, "conference_international": false, "scientific_event": false, "invited_lecture": false, "keynote_speaker": false, "selected_presentation": false, "biobank_use": false, "bmf_use": false, "zmf_use": false, "local_affiliation": true }, { "id": 211033, "title": "Information needs of people who have suffered a stroke or TIA and their preferred approaches of receiving health information: A scoping review.", "abstract": null, "authors": [ "Helbach, J", "Hoffmann, F", "Hecht, N", "Heesen, C", "Thomalla, G", "Wilfling, D", "Rahn, AC" ], "year": 2024, "source": "Eur Stroke J. 2024; 23969873241272744", "category": 1, "document_type": 3, "sci": "ISI:001298490400001", "pubmed": "39188106", "doi": "10.1177/23969873241272744", "pmc": "PMC11569532", "organizations": [], "persons": [ "211033-125094-6" ], "imported": "2024-09-09T02:00:00+02:00", "journal": "Eur Stroke J", "issn": "2396-9881", "collection_publisher": null, "collection_title": null, "edition": null, "university": null, "country": null, "case_report": false, "impactfactor": 4.5, "impactfactor_year": 2024, "impactfactor_norm": 0.821, "impactfactor_norm_year": 2024, "impactfactor_norm_category": "CLINICAL NEUROLOGY-SCIE", "impactfactor_norm_super": 0.892, "impactfactor_norm_super_year": 2023, "impactfactor_norm_super_category": "CLINICAL NEUROLOGY-SCIE", "citations": true, "conference_name": null, "conference_place": null, "conference_international": false, "scientific_event": false, "invited_lecture": false, "keynote_speaker": false, "selected_presentation": false, "biobank_use": false, "bmf_use": false, "zmf_use": false, "local_affiliation": false }, { "id": 211199, "title": "Unlocking biomedical data sharing: A structured approach with digital twins and artificial intelligence (AI) for open health sciences", "abstract": null, "authors": [ "Jean-Quartier, C", "Stryeck, S", "Thien, A", "Vrella, B", "Kleinschuster, J", "Spreitzer, E", "Wali, M", "Mueller, H", "Holzinger, A", "Jeanquartier, F" ], "year": 2024, "source": "DIGIT HEALTH. 2024; 10: 20552076241271769", "category": 1, "document_type": 1, "sci": "ISI:001307707100001", "pubmed": "39281045", "doi": "10.1177/20552076241271769", "pmc": "PMC11394355", "organizations": [ "211199-14013", "211199-14026", "211199-14020" ], "persons": [ "211199-101038-6", "211199-51050-6", "211199-51449-6" ], "imported": "2024-09-24T09:05:26+02:00", "journal": "DIGIT HEALTH", "issn": "2055-2076", "collection_publisher": null, "collection_title": "DIGITAL HEALTH; ", "edition": null, "university": null, "country": null, "case_report": false, "impactfactor": 3.3, "impactfactor_year": 2024, "impactfactor_norm": 0.852, "impactfactor_norm_year": 2024, "impactfactor_norm_category": "HEALTH POLICY & SERVICES-SSCI", "impactfactor_norm_super": 0.875, "impactfactor_norm_super_year": 2021, "impactfactor_norm_super_category": "HEALTH POLICY + SERVICES-SSCI", "citations": true, "conference_name": null, "conference_place": null, "conference_international": false, "scientific_event": false, "invited_lecture": false, "keynote_speaker": false, "selected_presentation": false, "biobank_use": false, "bmf_use": false, "zmf_use": false, "local_affiliation": true }, { "id": 211214, "title": "Postoperative Pain Management in children: guidance from the Pain Committee of the European Society for Paediatric Anaesthesiology (ESPA Pain Management Ladder Initiative) Part II.", "abstract": null, "authors": [ "Vittinghoff, M", "Lönnqvist, PA", "Mossetti, V", "Heschl, S", "Simic, D", "Colovic, V", "Hözle, M", "Zielinska, M", "Maria, BJ", "Oppitz, F", "Butkovic, D", "Morton, NS" ], "year": 2024, "source": "Anaesth Crit Care Pain Med. 2024; 43(6):101427", "category": 1, "document_type": 30, "sci": "ISI:001355229600001", "pubmed": "39299468", "doi": "10.1016/j.accpm.2024.101427", "pmc": null, "organizations": [ "211214-14070" ], "persons": [ "211214-57034-2", "211214-67711-6" ], "imported": "2024-09-24T02:00:00+02:00", "journal": "Anaesth Crit Care Pain Med", "issn": "2352-5568", "collection_publisher": null, "collection_title": null, "edition": null, "university": null, "country": null, "case_report": false, "impactfactor": 4.7, "impactfactor_year": 2024, "impactfactor_norm": 0.806, "impactfactor_norm_year": 2024, "impactfactor_norm_category": "ANESTHESIOLOGY-SCIE", "impactfactor_norm_super": null, "impactfactor_norm_super_year": null, "impactfactor_norm_super_category": null, "citations": true, "conference_name": null, "conference_place": null, "conference_international": false, "scientific_event": false, "invited_lecture": false, "keynote_speaker": false, "selected_presentation": false, "biobank_use": false, "bmf_use": false, "zmf_use": false, "local_affiliation": true }, { "id": 211216, "title": "Current and emerging technologies to develop Point-of-Care Diagnostics in medical mycology.", "abstract": null, "authors": [ "Matsuo, T", "Wurster, S", "Hoenigl, M", "Kontoyiannis, DP" ], "year": 2024, "source": "Expert Rev Mol Diagn. 2024; 24(9): 841-858. 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42(1): 615", "category": 1, "document_type": 1, "sci": "ISI:001346915900003", "pubmed": "39487858", "doi": "10.1007/s00345-024-05341-2", "pmc": "PMC11531415", "organizations": [], "persons": [ "212991-130518-6" ], "imported": "2025-01-10T01:00:00+01:00", "journal": "World J Urol", "issn": "1433-8726", "collection_publisher": null, "collection_title": null, "edition": null, "university": null, "country": null, "case_report": false, "impactfactor": 2.9, "impactfactor_year": 2024, "impactfactor_norm": 0.652, "impactfactor_norm_year": 2024, "impactfactor_norm_category": "UROLOGY & NEPHROLOGY-SCIE", "impactfactor_norm_super": 0.716, "impactfactor_norm_super_year": 2022, "impactfactor_norm_super_category": "UROLOGY + NEPHROLOGY-SCIE", "citations": true, "conference_name": null, "conference_place": null, "conference_international": false, "scientific_event": false, "invited_lecture": false, "keynote_speaker": false, "selected_presentation": false, "biobank_use": false, "bmf_use": false, "zmf_use": false, "local_affiliation": false }, { "id": 215730, "title": "The Immunomodulatory Effect of Different FLT3 Inhibitors on Dendritic Cells.", "abstract": null, "authors": [ "Schlaweck, S", "Radcke, A", "Kampmann, S", "Becker, BV", "Brossart, P", "Heine, A" ], "year": 2024, "source": "Cancers (Basel). 2024; 16(21):", "category": 1, "document_type": 1, "sci": "ISI:001351036000001", "pubmed": "39518156", "doi": "10.3390/cancers16213719", "pmc": "PMC11545830", "organizations": [], "persons": [ "215730-131437-4" ], "imported": "2025-04-18T02:00:00+02:00", "journal": "Cancers (Basel)", "issn": "2072-6694", "collection_publisher": null, "collection_title": null, "edition": null, "university": null, "country": null, "case_report": false, "impactfactor": 4.4, "impactfactor_year": 2024, "impactfactor_norm": 0.676, "impactfactor_norm_year": 2024, "impactfactor_norm_category": "ONCOLOGY-SCIE", "impactfactor_norm_super": 0.759, "impactfactor_norm_super_year": 2021, "impactfactor_norm_super_category": "ONCOLOGY-SCI", "citations": true, "conference_name": null, "conference_place": null, "conference_international": false, "scientific_event": false, "invited_lecture": false, "keynote_speaker": false, "selected_presentation": false, "biobank_use": false, "bmf_use": false, "zmf_use": false, "local_affiliation": false }, { "id": 209861, "title": "Neuroendokrine Pathomechanismen bei PCOS", "abstract": "Einleitung: Das Polyzystische Ovar-Syndrom (PCOS) ist eine Hormonveränderung mit einer Prävalenz von etwa 20%. Frauen mit PCOS weisen einen erhöhten Androgen-Spiegel, Oligo- oder Amenorrhö und/oder polyzystische Ovarien auf. Neben den reproduktiven Organen ist besonders der Stoffwechsel bei PCOS verändert. Das Gehirn als übergeordnetes Zentrum und Schaltstelle für Regelkreisläufe spielt bei der Verknüpfung der Reproduktionsfähigkeit mit dem Metabolismus eine wichtige Rolle. So zeigen Sexualhormone wie Androgene, aber auch Leptin und Adiponectin als metabolische Parameter bei PCOS-Frauen Unterschiede im Vergleich zu Frauen ohne PCOS. Eine Leptin/Adiponectin-Messung wurde als klinisch-praktischer Zugang zu diesem Thema mit aktuellen Daten in einer PCOS-Kohorte analysiert und mit aktuellen Hypothesen zur Neuroendokrinologie des PCOS dargestellt, um als Ausblick für weitere Forschung zu dienen. \r\n\r\nMethode: Der Literaturteil dieser Arbeit wurde in PubMed recherchiert. Im zweiten Teil wurden Leptin- und Adiponectin-Messungen mittels ELISAs in einer PCOS-Kohorte an 188 Proben von diagnostizierten PCOS-Patientinnen (EK-Nummer 18-066 ex 06/07) durchgeführt. Die Auswertung der Ergebnisse erfolgt mittels SPSS Version 27. \r\n\r\nErgebnisse: 188 Leptin- und Adiponectin-Messungen wurden durchgeführt und zeigten einen positiven Zusammenhang des Body-Mass-Index (BMI) mit Leptin, während Adiponectin und Sexualhormon-bindendes Globulin (SHGB) eine negative Korrelation aufwiesen (p<0,001; p<0,001; p<0,001). Bei erhöhtem Leptin und erhöhtem freiem Testosteron war auch das Homeostatic Model Assessment of Insulin Resistance (HOMA-IR) deutlich erhöht (p<0,001; p<0,001). Adiponectin und SHBG zeigten ein inverses Bild (p<0,001; p<0,001). Leptin und freies Testosteron waren positiv korreliert, im Gegensatz zu Leptin und SHBG (p<0,001; p<0,001). Adiponectin war umgekehrt positiv mit SHBG und negativ mit freiem Testosteron korreliert (p<0,001; p<0,001). \r\n\r\nSchlussfolgerungen: In dieser Arbeit werden signifikante Zusammenhänge von Adipokinen, Androgenen und metabolischen Parametern dargestellt und Ergebnisse von bestehenden Studien bestätigt. Damit wird neuerlich die komplexe neuroendokrine Regulation von PCOS und zentralen Regulationen nachgewiesen und soll zu weiteren Forschungsprojekten anregen.", "authors": [ "Fellner, M" ], "year": 2024, "source": "Humanmedizin; [ Diplomarbeit ] Medizinische Universität Graz; 2024. pp. 84", "category": 5, "document_type": 15, "sci": null, "pubmed": null, "doi": null, "pmc": null, "organizations": [], "persons": [], "imported": "2024-06-05T09:18:40+02:00", "journal": null, "issn": null, "collection_publisher": null, "collection_title": null, "edition": null, "university": "Medizinische Universität Graz", "country": "40", "case_report": false, "impactfactor": null, "impactfactor_year": null, "impactfactor_norm": null, "impactfactor_norm_year": null, "impactfactor_norm_category": null, "impactfactor_norm_super": null, "impactfactor_norm_super_year": null, "impactfactor_norm_super_category": null, "citations": null, "conference_name": null, "conference_place": null, "conference_international": false, "scientific_event": false, "invited_lecture": false, "keynote_speaker": false, "selected_presentation": false, "biobank_use": false, "bmf_use": false, "zmf_use": false, "local_affiliation": false }, { "id": 214805, "title": "The TGF-β1 target WISP1 is highly expressed in liver cirrhosis and cirrhotic HCC microenvironment and involved in pro- and anti-tumorigenic effects.", "abstract": null, "authors": [ "Dropmann, A", "Alex, S", "Schorn, K", "Tong, C", "Caccamo, T", "Godoy, P", "Ilkavets, I", "Liebe, R", "Gonzalez, D", "Hengstler, JG", "Piiper, A", "Quagliata, L", "Matter, MS", "Waidmann, O", "Finkelmeier, F", "Feng, T", "Weiss, TS", "Rahbari, N", "Birgin, E", "Rasbach, E", "Roessler, S", "Breuhahn, K", "Tóth, M", "Ebert, MP", "Dooley, S", "Hammad, S", "Meindl-Beinker, NM" ], "year": 2024, "source": "Biochem Biophys Res Commun. 2024; 732: 150409", "category": 1, "document_type": 1, "sci": "ISI:001276864500001", "pubmed": "39033550", "doi": "10.1016/j.bbrc.2024.150409", "pmc": null, "organizations": [], "persons": [ "214805-130396-6" ], "imported": "2025-03-03T01:00:00+01:00", "journal": "Biochem Biophys Res Commun", "issn": "1090-2104", "collection_publisher": null, "collection_title": null, "edition": null, "university": null, "country": null, "case_report": false, "impactfactor": 2.2, "impactfactor_year": 2024, "impactfactor_norm": 0.319, "impactfactor_norm_year": 2024, "impactfactor_norm_category": "BIOPHYSICS-SCIE", "impactfactor_norm_super": 0.543, "impactfactor_norm_super_year": 2022, "impactfactor_norm_super_category": "BIOPHYSICS-SCIE", "citations": true, "conference_name": null, "conference_place": null, "conference_international": false, "scientific_event": false, "invited_lecture": false, "keynote_speaker": false, "selected_presentation": false, "biobank_use": false, "bmf_use": false, "zmf_use": false, "local_affiliation": false } ] }