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Culprit of Fetal Adverse Outcome","en":"Disturbed Lipid Metabolism in Gestational Diabetes - Culprit of Fetal Adverse Outcome"},"short":"DISTURBED LIPID METABOLISM","url":null,"abstract":{"de":null,"en":null},"begin_planned":"2010-01-01T01:00:00+01:00","begin_effective":"2010-01-01T01:00:00+01:00","end_planned":"2011-12-31T01:00:00+01:00","end_effective":"2017-12-31T01:00:00+01:00","assignment":"2009-11-30T14:36:35+01:00","program":null,"subprogram":null,"organization":14020,"category":10,"type":10,"partner_function":4,"manager":52569,"contact":52569,"status":2,"research":2,"grant":10,"event":null,"study":null,"language":null,"funders":[151],"funder_projectcode":null,"ethics_committee":null,"edudract_number":null,"persons":["1996-52569-10"]},{"id":4050,"title":{"de":"Der Beitrag von I(f) und I(K1) zur ektopen Fokusbildung im linken und rechten Atrium bei Vorhofflimmern","en":"Interatrial gradients in I(f) and I(K1) and their contribution to focal activity in atrial fibrillation"},"short":null,"url":null,"abstract":{"de":"Vorhofflimmern (VHF) ist eine der häufigsten Rhythmusstörungen und ist mit einer hohen Morbidität und Mortalität assoziiert. Veränderungen der Ionenkanalfunktion werden unter anderem für die Generierung der Arrhythmien verantwortlich gemacht. Neben Arealen im Bereich der Eintrittsstellen der Pulmonalvenen in den linken Vorhof spielen dabei sowohl das linke als auch das rechte Herzohr eine Rolle. Das Ziel der Studie ist die Erforschung der Rolle des Schrittmacherstromes  If – potentiell verantwortlich für ektope Aktivitäten, und die Erforschung des einwärts gleichrichtenden Kaliumstromes IK1 – verantwortlich für ein stabiles Ruhemembranpotential bei der Generierung abnormer Automatie bei VHF. Ein spezieller Fokus wird der Vergleich interatrialer Unterschiede bei Patienten mit und ohne VHF sein. Zusätzlich werden die experimentellen Untersuchungen in ein dreidimensionales Computermodell integriert, wodurch ein Beitrag zum besseren Verständnis der Bedeutung von If- und IK1 bei der Entstehung von VHF geleistet werden soll. Darüberhinaus könnten diese Ergebnisse zu einer verbesserten Behandlung des VHF beitragen.","en":"Atrial fibrillation (AF) is the most common arrhythmia tightly associated with an increased morbidity and mortality. Alterations in ion channel function are pivotal for the generation of arrhythmias. Besides the pulmonary veins, the left atrial appendage is increasingly recognized as an important source of focal ectopic activity. This study aims to investigate the role of the pacemaker current If – a potential contributor to ectopic activity, and the inward rectifier potassium current IK1 – a key determinant for a stable resting membrane potential in the generation of abnormal automaticity in AF. Special focus is given to interatrial differences in human AF patients. The experimental results will be implemented in a 3D computational model of the atria in order to assess the contribution of If and IK1 to focal activity in AF. Findings obtained in this study will lead to a better understanding of the mechanisms underlying AF and thereby provide important information for treatment of AF. \r\n\r\n"},"begin_planned":"2015-09-01T02:00:00+02:00","begin_effective":"2015-09-01T02:00:00+02:00","end_planned":"2017-08-31T02:00:00+02:00","end_effective":"2017-12-31T01:00:00+01:00","assignment":"2015-07-08T16:46:47+02:00","program":79,"subprogram":null,"organization":14011,"category":10,"type":10,"partner_function":4,"manager":50615,"contact":null,"status":2,"research":5,"grant":10,"event":null,"study":null,"language":null,"funders":[12],"funder_projectcode":null,"ethics_committee":null,"edudract_number":null,"persons":["4050-50615-10","4050-50840-12","4050-50966-12","4050-50969-12","4050-50990-12","4050-51592-12"]},{"id":4759,"title":{"de":"Die Rolle langer, nicht-kodierender RNS in Tumorstammzellen des Nierenzellkarzinoms.","en":"Role of long non-coding RNAs in renal cancer stem cells."},"short":"longncRNA in 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Detection."},"short":null,"url":null,"abstract":{"de":null,"en":null},"begin_planned":"2013-01-01T01:00:00+01:00","begin_effective":"2013-01-01T01:00:00+01:00","end_planned":"2015-12-31T01:00:00+01:00","end_effective":"2018-01-01T01:00:00+01:00","assignment":"2012-10-16T16:56:43+02:00","program":72,"subprogram":null,"organization":14010,"category":10,"type":10,"partner_function":4,"manager":58883,"contact":58883,"status":2,"research":1,"grant":10,"event":null,"study":null,"language":null,"funders":[9],"funder_projectcode":"P25241","ethics_committee":null,"edudract_number":null,"persons":["3003-58883-10"]},{"id":4977,"title":{"de":"Stressinduzierte kardiovaskuläre Reaktivität bei Jugendlichen – Vergleich von Früh- zu Normalgeborenen.","en":"Stress-related cardiovascular reactivity in 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under the 7th Framework Programme for Research. The main objective of this project is to address more in depth prospects of improved diagnosis and treatment of atherosclerosis by means of nanotechnology. \r\n\r\nFacts & Figures\r\n- Total project volume: EUR 12.8 million \r\n- Project time: five years (1026 person-months)\r\n- Start of the project: 1 February 2013\r\n- 16 partners from 10 countries\r\n\r\nObjectives: \r\n\r\nNanoAthero aims to demonstrate initial clinical feasibility of nanosystems for targeted imaging and treatment of advanced atherosclerotic disease in humans. The nanosystems are assemblies of following components: nanocarrier, targeting, imaging agent/drug. They have proven safety records, and strong preliminary in vitro and in vivo proofs of efficacy are available. Partners have patented and provided evidence of efficacy of carriers and ligands. \r\nOver 5 years, NanoAthero will integrate GMP production, the initiation of clinical investigations in high-risk patients, including the preparation of regulatory dossiers, risk and ethical assessments, and the evaluation of the performance of optimized diagnostic and therapeutic compounds. NanoAthero offers a unique opportunity for combining in-depth knowledge of nanocarrier bioengineering and production with state-of the art expertise in imaging and treatment of cardiovascular patients providing a full bench-to-bedside framework within one collaborative consortium of 16 partners. \r\nNanoAthero gathers together leading chemists, engineers, pharmacists, biologists, toxicologists, clinicians, analysts, ethicists and key-opinion leaders in the field of cardiovascular medicine and early drug development, a European association, 3 SMEs and a large pharmaceutical company (i.e.Bracco). \r\nPhase I clinical trials targeting pivotal pathways in atherothrombosis will be performed with nanosystems for diagnosis and treatment of carotid atheroma and stroke. NanoAthero aims to complete phase I evaluation of two nanosystems: thrombus imaging and plaque stabilization in high-risk patients. Preclinical studies for two nanosystems (one to dissolve blood clots in stroke and one for plaque imaging) will be collaboratively completed and collection of clinical data will be launched. \r\n\r\n"},"begin_planned":"2013-01-01T01:00:00+01:00","begin_effective":"2013-02-01T01:00:00+01:00","end_planned":"2017-12-31T01:00:00+01:00","end_effective":"2018-01-31T01:00:00+01:00","assignment":"2013-01-21T11:07:13+01:00","program":24,"subprogram":"NMP.2012.1.2-2: Development and phase-I clinical trials of novel therapeutic nanotechnology-enabled systems for the diagnosis and treatment of atherosclerosis.","organization":14028,"category":10,"type":10,"partner_function":2,"manager":52854,"contact":52854,"status":2,"research":2,"grant":10,"event":null,"study":null,"language":null,"funders":[10],"funder_projectcode":"309820","ethics_committee":null,"edudract_number":null,"persons":["3144-50464-12","3144-52854-10","3144-56571-12","3144-88042-12"]},{"id":3483,"title":{"de":"Systembiologie zur Identifizierung neuer Targets in der Therapie von Gefässerkrankungen","en":"Systems Biology to Identify Molecular Targets for Vascular Disease Treatment"},"short":"SysVasc","url":null,"abstract":{"de":null,"en":null},"begin_planned":"2013-09-01T02:00:00+02:00","begin_effective":"2014-02-01T01:00:00+01:00","end_planned":"2018-09-01T02:00:00+02:00","end_effective":"2018-01-31T01:00:00+01:00","assignment":"2013-12-20T11:31:45+01:00","program":24,"subprogram":null,"organization":14083,"category":10,"type":10,"partner_function":3,"manager":59317,"contact":null,"status":2,"research":1,"grant":10,"event":null,"study":null,"language":null,"funders":[10],"funder_projectcode":"603288","ethics_committee":null,"edudract_number":null,"persons":["3483-59941-12","3483-91349-12"]},{"id":4800,"title":{"de":"Mitochondrien-Forschung: Je sanfter desto besser!\r\n","en":"Mitochondria-research"},"short":null,"url":null,"abstract":{"de":null,"en":null},"begin_planned":"2017-02-01T01:00:00+01:00","begin_effective":"2017-02-01T01:00:00+01:00","end_planned":"2018-01-31T01:00:00+01:00","end_effective":"2018-01-31T01:00:00+01:00","assignment":"2017-02-01T15:06:11+01:00","program":null,"subprogram":null,"organization":28392,"category":10,"type":10,"partner_function":4,"manager":null,"contact":null,"status":2,"research":1,"grant":10,"event":null,"study":null,"language":null,"funders":[1743],"funder_projectcode":"MEFO-02","ethics_committee":null,"edudract_number":null,"persons":[]}]}