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Es wird seit langem darüber diskutiert, welches Dialyseverfahren – Hämodialyse oder Peritonealdialyse – die bessere Methode in Bezug auf Morbidität und Mortalität ist. Niedrige Konzentrationen von high-density lipoprotein (HDL), wie sie in Nierenpatienten vorkommen, korrelieren mit einem erhöhten Risiko von atherosklerotischen Gefäßerkrankungen. Kürzlich zeigte sich, dass neben der Menge an HDL dessen Funktionalität von entscheidender Bedeutung ist in Hinblick auf Herz-Kreislauf-Erkrankungen. Wir und andere haben in vorangegangenen Publikationen gezeigt das HDL seine Funktionalität in Patienten mit Niereninsuffizienz verlieren kann, und dadurch dysfunktional wird. Jedoch fehlen bis heute wichtige Daten über die Auswirkung unterschiedlicher Dialysemethoden auf HDL. Wir postulieren daher, dass Hämodialyse und Peritonealdialyse die Zusammensetzung und Funktion von HDL unterschiedlich beeinflussen und dadurch - zumindest in Teilen – zu den Unterschieden in der Mortalität führen.","en":"The survival of individuals with end stage renal disease (ESRD) compared to the general population is dramatically reduced. There is much debate over which dialysis modality – hemodialysis (HD) or peritoneal dialysis (PD) – is better in terms of morbidity and mortality. Low levels of high-density lipoprotein (HDL), such as found in renal patients, correlate with an increased risk of atherosclerotic vascular disease. Recently, it became evident that besides HDL cholesterol the functionality of HDL is of crucial importance in regard to cardiovascular protection. A recent clinical study has provided compelling evidence that cholesterol efflux capability of HDL, a functional measure of HDL, is a better predictor or cardiovascular mortality than LDL- or HDL-cholesterol levels. We and others have provided consistent evidence that HDL composition is altered in uremic patients leading to the formation of dysfunctional HDL.  However, data on the effect of dialysis on HDL composition and function are very limited for HD and entirely absent for PD. We, hypothesize that HD and PD differentially affect HDL composition and function, which might explain - at least in part - differences in cardiovascular outcomes.\r\n"},"begin_planned":"2014-08-01T02:00:00+02:00","begin_effective":"2014-08-01T02:00:00+02:00","end_planned":"2016-07-31T02:00:00+02:00","end_effective":"2016-09-30T02:00:00+02:00","assignment":"2014-07-01T13:12:22+02:00","program":79,"subprogram":null,"organization":14022,"category":10,"type":10,"partner_function":4,"manager":62749,"contact":null,"status":2,"research":1,"grant":10,"event":null,"study":null,"language":null,"funders":[12],"funder_projectcode":null,"ethics_committee":null,"edudract_number":null,"persons":["3696-51163-12","3696-62749-10"]},{"id":3700,"title":{"de":"Zukunftsgeneration in Medizin und Technik","en":"Future generation in medicine and technique"},"short":"Biobanking in future","url":null,"abstract":{"de":null,"en":null},"begin_planned":"2014-08-01T02:00:00+02:00","begin_effective":"2014-08-01T02:00:00+02:00","end_planned":"2015-07-31T02:00:00+02:00","end_effective":"2016-01-31T01:00:00+01:00","assignment":"2014-07-03T14:39:49+02:00","program":null,"subprogram":"FFG Talente Praktika für Schülerinnen und Schüler","organization":28392,"category":10,"type":10,"partner_function":4,"manager":54033,"contact":null,"status":2,"research":5,"grant":10,"event":null,"study":null,"language":null,"funders":[416],"funder_projectcode":"844692","ethics_committee":null,"edudract_number":null,"persons":["3700-92543-12","3700-50910-12","3700-54033-10","3700-93683-12"]},{"id":3691,"title":{"de":"Placenta Perfusion Studio","en":"Placenta Perfusion Studio"},"short":"Plazentatox","url":null,"abstract":{"de":null,"en":null},"begin_planned":"2014-09-01T02:00:00+02:00","begin_effective":"2014-09-01T02:00:00+02:00","end_planned":"2018-08-30T02:00:00+02:00","end_effective":"2019-02-28T01:00:00+01:00","assignment":"2014-06-26T13:30:26+02:00","program":107,"subprogram":null,"organization":14038,"category":10,"type":10,"partner_function":4,"manager":50442,"contact":null,"status":2,"research":2,"grant":10,"event":null,"study":null,"language":null,"funders":[416],"funder_projectcode":"844741","ethics_committee":null,"edudract_number":null,"persons":["3691-88993-12","3691-50442-10","3691-56938-12","3691-83661-12","3691-89898-12","3691-90214-12","3691-51632-12","3691-100813-12"]},{"id":3789,"title":{"de":"Diagnostische Klebsielle oxytoca PCR","en":"Diagnostic Klebsielle oxytoca PCR"},"short":"K.oxy PCR","url":null,"abstract":{"de":null,"en":null},"begin_planned":"2014-09-01T02:00:00+02:00","begin_effective":"2014-10-01T02:00:00+02:00","end_planned":"2015-09-01T02:00:00+02:00","end_effective":"2015-12-31T01:00:00+01:00","assignment":"2014-10-16T12:31:56+02:00","program":null,"subprogram":null,"organization":14023,"category":10,"type":10,"partner_function":4,"manager":50527,"contact":null,"status":2,"research":2,"grant":10,"event":null,"study":null,"language":null,"funders":[457],"funder_projectcode":null,"ethics_committee":null,"edudract_number":null,"persons":["3789-50527-10"]},{"id":3712,"title":{"de":"Domäneninteraktion zur Kontrolle der STIM1 Aktivierung von Orai1 Kanälen","en":"Domain interactions controlling STIM1 activation  of Orai1 channels "},"short":null,"url":null,"abstract":{"de":null,"en":null},"begin_planned":"2014-10-01T02:00:00+02:00","begin_effective":"2014-10-01T02:00:00+02:00","end_planned":"2017-10-01T02:00:00+02:00","end_effective":"2019-03-31T01:00:00+01:00","assignment":"2014-07-17T13:01:43+02:00","program":72,"subprogram":null,"organization":14011,"category":10,"type":10,"partner_function":2,"manager":78591,"contact":null,"status":2,"research":1,"grant":10,"event":null,"study":null,"language":null,"funders":[9],"funder_projectcode":"P27263","ethics_committee":null,"edudract_number":null,"persons":["3712-78591-10"]},{"id":3695,"title":{"de":"Ultrakonservierte Gene und deren Rolle im Metastasierungsprozeß bei Nierenkrebs","en":"Metastases-associated ultraconserved genes in renal cell carcinoma patients"},"short":"Ultraconserved genes in mRCC","url":null,"abstract":{"de":null,"en":null},"begin_planned":"2014-10-01T02:00:00+02:00","begin_effective":"2014-10-01T02:00:00+02:00","end_planned":"2016-09-30T02:00:00+02:00","end_effective":"2018-02-28T01:00:00+01:00","assignment":"2014-07-01T13:10:13+02:00","program":79,"subprogram":null,"organization":14056,"category":10,"type":10,"partner_function":4,"manager":50839,"contact":null,"status":2,"research":1,"grant":10,"event":null,"study":null,"language":null,"funders":[12],"funder_projectcode":null,"ethics_committee":null,"edudract_number":null,"persons":["3695-110608-12","3695-100192-12","3695-50229-12","3695-50839-10"]}]}