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","en":"The actin cytoskeleton and transkriptionfactor NFkB as predictive factors for liver regeneration and hepatocellular carcinogenesis after hemihepatectomy."},"short":null,"url":null,"abstract":{"de":null,"en":null},"begin_planned":"2017-02-20T01:00:00+01:00","begin_effective":"2017-02-20T01:00:00+01:00","end_planned":"2020-12-31T01:00:00+01:00","end_effective":"2020-12-31T01:00:00+01:00","assignment":"2020-02-21T11:45:20+01:00","program":null,"subprogram":null,"organization":14108,"category":10,"type":10,"partner_function":2,"manager":98605,"contact":null,"status":2,"research":1,"grant":10,"event":null,"study":null,"language":null,"funders":[1170],"funder_projectcode":null,"ethics_committee":null,"edudract_number":null,"persons":["6064-98605-10"]},{"id":5639,"title":{"de":"Mikrobiomveränderungen als Indikator für einen steroid-refraktären Verlauf bei Colitis ulzerosa\r\n\r\n\r\n","en":"Study investigating if specific fecal microbiota alterations can predict a refractory disease course to standard steroid therapy in patients with active ulcerative colitis."},"short":null,"url":null,"abstract":{"de":null,"en":null},"begin_planned":"2019-01-01T01:00:00+01:00","begin_effective":"2019-01-01T01:00:00+01:00","end_planned":"2020-12-31T01:00:00+01:00","end_effective":"2021-05-31T02:00:00+02:00","assignment":"2019-01-24T09:45:52+01:00","program":null,"subprogram":null,"organization":14081,"category":10,"type":10,"partner_function":1,"manager":53167,"contact":null,"status":2,"research":4,"grant":10,"event":null,"study":null,"language":null,"funders":[12],"funder_projectcode":"17936","ethics_committee":null,"edudract_number":null,"persons":["5639-53167-10"]},{"id":5433,"title":{"de":"Health Literacy und Diversity für SchülerInnen der Sekundarstufe I ","en":"Health literacy and diversity for children in secondary school level I 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\r\n\r\n"},"short":"PITVIN","url":null,"abstract":{"de":null,"en":null},"begin_planned":"2018-08-01T02:00:00+02:00","begin_effective":"2018-02-01T01:00:00+01:00","end_planned":"2020-12-31T01:00:00+01:00","end_effective":"2021-06-30T02:00:00+02:00","assignment":"2018-01-31T11:57:04+01:00","program":null,"subprogram":null,"organization":14038,"category":10,"type":10,"partner_function":4,"manager":50853,"contact":null,"status":2,"research":4,"grant":10,"event":null,"study":null,"language":null,"funders":[],"funder_projectcode":null,"ethics_committee":null,"edudract_number":null,"persons":["5225-50853-10"]},{"id":5363,"title":{"de":"Evidenzbasierte Informationen zur Unterstützung von gesundheitskompetenten Entscheidungen","en":"Evidence-based Information As Support For Health Literate 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persons"},"short":null,"url":null,"abstract":{"de":null,"en":null},"begin_planned":"2019-01-01T01:00:00+01:00","begin_effective":"2019-01-01T01:00:00+01:00","end_planned":"2020-12-31T01:00:00+01:00","end_effective":"2022-02-28T01:00:00+01:00","assignment":"2019-03-28T14:37:22+01:00","program":null,"subprogram":null,"organization":14010,"category":10,"type":10,"partner_function":3,"manager":57932,"contact":null,"status":2,"research":1,"grant":10,"event":null,"study":null,"language":null,"funders":[20],"funder_projectcode":"ZA 05/2019","ethics_committee":null,"edudract_number":null,"persons":["5748-57932-10"]},{"id":5111,"title":{"de":"Erforschung des Reinke Ödems mittels Proteom-Analyse","en":"Exploring Reinke’s Edema by Proteomic Analysis"},"short":"Reinke Ödem","url":null,"abstract":{"de":"Das Reinke Ödem (RÖ) ist eine ein- oder beidseitige Schwellung der Stimmlippen, die vor allem bei Nikotinabusus und Stimm-Missbrauch auftritt. Das Reinke Ödem ist durch eine erniedrigten Stimmlage und schlechte Stimmqualität gekennzeichnet, was den beruflichen Alltag vor allem von Personen in Sprechberufen (Lehrer, Call Center Agenten etc.) deutlich erschwert. Bis dato gibt es keine kausale Therapie für das RÖ, auch der Goldstandard der Therapie, Stimmlippenchirurgie, bringt keine zufriedenstellenden Ergebnisse und stellt keine kausale Therapie dar.\r\nIm vorgestellten Projekt wollen wir die zellulären Ursachen des RÖ mittels Protein Analyse (Proteomics) erforschen. Damit werden erstmals die kausalen Ursachen dieser Krankheit erforscht. Aus Schleimhaut Biopsien die während Stimmlippen-OPs betroffener Patienten entnommen werden, sollen spezifische RÖ-Stimmlippenzellen kultiviert und für weitere Analysen und Versuche vorbereitet werden. Die Proteomics Analyse liefert eine Auflistung aller Proteine, die diese Zellen produzieren. Diese sollen mit den Proteinen aus Stimmlippenzellen aus gesundem Gewebe verglichen werden.\r\nIn darauffolgenden funktionellen Experimenten sollen bestimmte Proteine („Kandidaten-Proteine“), die vor allem von RÖ-Fibroblasten produziert werden, auf ihre biologische Relevanz überprüft werden. Mittels Verstärkung oder Blockierung dieser Kandidaten Proteine können wesentliche Rückschlüsse auf die Krankheitsmechanismen von RÖ gezogen werden, die den Weg zu neuen (nicht-chirurgischen) Therapieformen ebnen sollen.\r\n","en":"Reinke’s edema (RE) is a uni- or bilateral swelling of the vocal folds, occurring in patients with nicotine and voice abuse. Voice of patients is characterized by decreased pitch and detrimental voice quality, making it often difficult for voice professionals who rely on their voices (teacher, call center agents etc.)\r\nSo far treatment is only symptomatic, still the gold standard of therapy, microsurgery of the vocal folds, is far from being satisfactory. \r\nIn the proposed project we seek to explore the cellular mechanisms of RE by protein analysis (proteomics), revealing the true pathophysiology of RE for the first time. During routine vocal fold surgery for RE we will take small mucosa specimens. From these we will extract vocal fold fibroblasts for subsequent analysis. Proteomic analysis will deliver a complete list of proteins produces specifically by these cells. These will be compared with vocal fold cells grown out of healthy laryngeal mucosa. In subsequent functional experiments we will explore certain proteins of interest (aka. candidate proteins) that are produced in a high number by RE fibroblasts for their biological relevance. By enhancing or blocking these candidate proteins we aim to draw conclusions on their role in the development of RE, which should pave to way to new (non-surgical) treatment options.\r\n"},"begin_planned":"2018-01-01T01:00:00+01:00","begin_effective":"2018-01-01T01:00:00+01:00","end_planned":"2020-12-31T01:00:00+01:00","end_effective":"2022-02-28T01:00:00+01:00","assignment":"2017-10-30T10:42:53+01:00","program":72,"subprogram":null,"organization":14068,"category":10,"type":10,"partner_function":4,"manager":50670,"contact":null,"status":2,"research":1,"grant":10,"event":null,"study":null,"language":null,"funders":[9],"funder_projectcode":"P30496","ethics_committee":null,"edudract_number":null,"persons":["5111-50670-10","5111-50698-12","5111-51047-12","5111-69755-12","5111-77116-12","5111-82902-12","5111-51982-12","5111-88652-12","5111-103118-12","5111-104099-12","5111-58794-12","5111-57544-12"]},{"id":4806,"title":{"de":"Mechanismen der Entstehung von Vorhofflimmern bei Hyperglykämie","en":"Mechanisms underlying the development of atrial fibrillation in hyperglycemia"},"short":"GlucoAF","url":null,"abstract":{"de":null,"en":null},"begin_planned":"2017-03-01T01:00:00+01:00","begin_effective":"2017-03-01T01:00:00+01:00","end_planned":"2020-12-31T01:00:00+01:00","end_effective":"2020-12-31T01:00:00+01:00","assignment":"2017-02-06T11:34:23+01:00","program":null,"subprogram":null,"organization":14083,"category":10,"type":10,"partner_function":4,"manager":63032,"contact":null,"status":2,"research":1,"grant":10,"event":null,"study":null,"language":null,"funders":[468],"funder_projectcode":null,"ethics_committee":null,"edudract_number":null,"persons":["4806-63032-10"]},{"id":4791,"title":{"de":"BioTechMed Leuchtturmprojekt Lipid Signaling","en":"BioTechMed Leuchtturmprojekt Lipid Signaling"},"short":null,"url":null,"abstract":{"de":null,"en":null},"begin_planned":"2017-01-01T01:00:00+01:00","begin_effective":"2017-01-01T01:00:00+01:00","end_planned":"2020-12-31T01:00:00+01:00","end_effective":"2017-12-31T01:00:00+01:00","assignment":"2017-01-02T11:25:35+01:00","program":90,"subprogram":null,"organization":14022,"category":10,"type":10,"partner_function":2,"manager":51756,"contact":null,"status":2,"research":1,"grant":10,"event":null,"study":null,"language":null,"funders":[2325],"funder_projectcode":null,"ethics_committee":null,"edudract_number":null,"persons":["4791-51756-10"]},{"id":5260,"title":{"de":"Entwicklung genetisch kodierter K+-Fluoreszenzsensoren","en":"Development of genetically encoded fluorescent K+ probes"},"short":"Shining Light on (sub)cellular K+ fluxes","url":null,"abstract":{"de":null,"en":null},"begin_planned":"2018-01-01T01:00:00+01:00","begin_effective":"2018-10-01T02:00:00+02:00","end_planned":"2020-12-31T01:00:00+01:00","end_effective":"2022-12-31T01:00:00+01:00","assignment":"2018-02-15T10:36:01+01:00","program":64,"subprogram":"I - Internationale Projekte - Joint Project - Austria/Germany","organization":14013,"category":10,"type":10,"partner_function":4,"manager":50810,"contact":null,"status":2,"research":1,"grant":10,"event":null,"study":null,"language":null,"funders":[9],"funder_projectcode":"3716-B27","ethics_committee":null,"edudract_number":null,"persons":["5260-50810-10"]},{"id":6353,"title":{"de":"Impact of UV on skin metabolome and lipidome","en":"Impact of UV on skin metabolome and lipidome"},"short":"UVmetabolome","url":null,"abstract":{"de":null,"en":null},"begin_planned":"2020-06-01T02:00:00+02:00","begin_effective":"2020-06-01T02:00:00+02:00","end_planned":"2020-12-31T01:00:00+01:00","end_effective":"2020-12-31T01:00:00+01:00","assignment":"2020-12-02T17:11:59+01:00","program":null,"subprogram":null,"organization":14047,"category":10,"type":10,"partner_function":4,"manager":87275,"contact":null,"status":2,"research":1,"grant":10,"event":null,"study":null,"language":null,"funders":[2471],"funder_projectcode":null,"ethics_committee":null,"edudract_number":null,"persons":["6353-87275-10"]}]}