{"count":2329,"next":"https://api-test.medunigraz.at/v1/research/project/?format=json&limit=20&offset=920&ordering=end_planned","previous":"https://api-test.medunigraz.at/v1/research/project/?format=json&limit=20&offset=880&ordering=end_planned","results":[{"id":3417,"title":{"de":"Die Rolle von NkG2D als Onkoprotein in der Krebsstammzelldifferenzierung","en":"CO-OPTION OF THE NKG2D LYMPHOCYTE RECEPTOR AS AN ONCOPROTEIN PROMOTING CANCER STEM CELL TRANSDIFFERENTIATION AND CANCER AUTONOMY"},"short":"NKG2D","url":null,"abstract":{"de":null,"en":null},"begin_planned":"2013-04-01T02:00:00+02:00","begin_effective":"2014-01-01T01:00:00+01:00","end_planned":"2016-03-31T02:00:00+02:00","end_effective":"2017-12-31T01:00:00+01:00","assignment":"2013-11-04T14:01:39+01:00","program":24,"subprogram":null,"organization":14022,"category":10,"type":10,"partner_function":4,"manager":60706,"contact":60706,"status":2,"research":1,"grant":10,"event":null,"study":null,"language":null,"funders":[10],"funder_projectcode":"331255","ethics_committee":null,"edudract_number":null,"persons":["3417-50777-12","3417-60706-10"]},{"id":3652,"title":{"de":"Molekulargenetische Tumoranalyse als Grundlage einer gezielten  Therapieauswahl","en":"Molecular tumor analysis as a basis for targeted therapy"},"short":"HTI-Tumortherapie","url":null,"abstract":{"de":null,"en":null},"begin_planned":"2014-05-01T02:00:00+02:00","begin_effective":"2014-07-01T02:00:00+02:00","end_planned":"2016-04-30T02:00:00+02:00","end_effective":"2016-09-30T02:00:00+02:00","assignment":"2014-05-06T13:06:44+02:00","program":75,"subprogram":"HTI Tech for Med","organization":14020,"category":10,"type":10,"partner_function":3,"manager":57386,"contact":null,"status":2,"research":2,"grant":10,"event":null,"study":null,"language":null,"funders":[135],"funder_projectcode":null,"ethics_committee":null,"edudract_number":null,"persons":["3652-57386-10"]},{"id":3178,"title":{"de":"Physikalische, chemische und molekulare Mechanismen der Insulinwirkung auf implantierte Glukose-Sensor-Systeme für die künstliche Bauchspeicheldrüse","en":"Physikalische, chemische und molekulare Mechanismen der Insulinwirkung auf implantierte Glukose-Sensor-Systeme für die künstliche Bauchspeicheldrüse"},"short":"DSZ-Projekt","url":null,"abstract":{"de":null,"en":null},"begin_planned":"2012-10-01T02:00:00+02:00","begin_effective":"2012-10-01T02:00:00+02:00","end_planned":"2016-04-30T02:00:00+02:00","end_effective":"2016-09-30T02:00:00+02:00","assignment":"2013-02-19T10:48:16+01:00","program":103,"subprogram":"Hans L. Merkle Stiftung Hans L. Merkle Program for Excellency in Science and Technology","organization":14080,"category":10,"type":10,"partner_function":4,"manager":51831,"contact":null,"status":2,"research":1,"grant":10,"event":null,"study":null,"language":null,"funders":[1388],"funder_projectcode":null,"ethics_committee":null,"edudract_number":null,"persons":["3178-51831-10"]},{"id":5008,"title":{"de":"Zonulin bei Anorexia nervosa","en":"Zonulin in anorexia nervosa"},"short":"Zonulin","url":null,"abstract":{"de":null,"en":null},"begin_planned":"2016-12-01T01:00:00+01:00","begin_effective":"2017-09-01T02:00:00+02:00","end_planned":"2016-05-01T02:00:00+02:00","end_effective":"2018-08-31T02:00:00+02:00","assignment":"2017-07-11T12:21:24+02:00","program":null,"subprogram":null,"organization":29444,"category":10,"type":10,"partner_function":4,"manager":84449,"contact":null,"status":2,"research":1,"grant":10,"event":null,"study":null,"language":null,"funders":[457],"funder_projectcode":null,"ethics_committee":null,"edudract_number":null,"persons":["5008-84449-10"]},{"id":3222,"title":{"de":"GPR55 in der Entwicklung des Kolonkarzinoms","en":"GPR55 in tumorigenesis and metastasis of colon cancer"},"short":null,"url":null,"abstract":{"de":"GPR55 in der Entwicklung des Kolonkarzinoms\r\nG Protein gekoppelte Rezeptoren spielen eine wichtige Rolle im Tumorwachstum und in der Metastasierung von Krebszellen und stellen somit ein wichtiges pharmakologisches Target für die Krebstherapie dar. Auf Grund seiner fördernden Wirkung in der Proliferation und Invasion von Tumorzellen, aber auch in der Angiogenese, ist der G Protein gekoppelte Rezeptor 55 (GPR55) in jüngster Zeit als ein mögliches neues Target in Erscheinung getreten. Das bioaktive Phospholipid Lysophosphatidylinositol (LPI) ist seit längerem als der endogene Ligand des GPR55 Rezeptors bekannt. Erhöhte LPI Werte wurden im Ovarialkarzinom nachgewiesen und lassen auf einen Zusammenhang zwischen der LPI/GPR55 Achse und Krebswachstum schließen.\r\nGPR55 ist auch in Epithelzellen des Darmtrakts vorhanden, was auf eine mögliche Rolle in der Entwicklung des Kolonkarzinoms vermuten läßt. Im vorliegenden Projekt untersuchen wir die Funktion von GPR55 und LPI in der Tumorgenese und in der Metastasierung des Kolonkarzinoms zuerst an Hand der Kolonkarzinom Zelllinien HCT116 und SW480. Dabei werden Proliferations-, Apoptose-, Migration- und Invasionsassays verwendet ebenso wie molekularbiologische Methoden, um LPI-induzierte Signaltransduktionswege zu untersuchen. In einem Kolitis-assoziierten Kolonkarzinom Modell der Maus soll die Bedeutung von GPR55 in der Tumorentstehung in vivo untersucht werden, insbesondere ob GPR55 an der Proliferation von malignen Zellen und der Expression von onkogenen Transkriptionsfaktoren, wie NF-kappa B und STAT3, beteiligt ist.  Die Rolle von GPR55 in der Verbreitung der Kolonkarzinomzellen in Sekundärorgane soll in einem in vivo Metastasierungsmodell untersucht werden. An Hand von histologischen Schnitten und Biopsien von humanem Kolonkarzinomgewebe wollen wir schließlich noch die Bedeutung von GPR55 und LPI in der Entstehung des Kolonkarzinoms beim Menschen untersuchen. Das Projekt sollte wesentliche Aussagen bezüglich einer möglichen pharmakologischen Therapie gegen Dickdarmkrebs basierend auf GPR55 geben. Weiters soll es eine Aussage liefern, ob LPI als möglicher Biomarker bei Dickdarmkrebs Verwendung finden könnte. \r\n","en":null},"begin_planned":"2013-06-01T02:00:00+02:00","begin_effective":"2013-04-01T02:00:00+02:00","end_planned":"2016-05-31T02:00:00+02:00","end_effective":"2016-10-31T01:00:00+01:00","assignment":"2013-03-26T10:24:55+01:00","program":72,"subprogram":null,"organization":14022,"category":10,"type":10,"partner_function":4,"manager":56687,"contact":null,"status":2,"research":1,"grant":10,"event":null,"study":null,"language":null,"funders":[9],"funder_projectcode":"P25633","ethics_committee":null,"edudract_number":null,"persons":["3222-56687-10"]},{"id":3994,"title":{"de":"Biobanking and the Cyprus Human Genome Project","en":"Biobanking and the Cyprus Human Genome Project"},"short":"CY-Biobank_Horizon","url":null,"abstract":{"de":null,"en":null},"begin_planned":"2015-06-01T02:00:00+02:00","begin_effective":"2015-06-01T02:00:00+02:00","end_planned":"2016-05-31T02:00:00+02:00","end_effective":"2016-05-31T02:00:00+02:00","assignment":"2015-05-04T13:54:16+02:00","program":109,"subprogram":"WIDESPREAD-2014-2015","organization":14020,"category":10,"type":10,"partner_function":2,"manager":51663,"contact":null,"status":2,"research":5,"grant":10,"event":null,"study":null,"language":null,"funders":[10],"funder_projectcode":"664561","ethics_committee":null,"edudract_number":null,"persons":["3994-51449-12","3994-51663-10"]},{"id":3992,"title":{"de":"Autophagie in humanen Chondrosarkomzellen","en":"Autophagy in humane chondrosarcoma cell lines"},"short":null,"url":null,"abstract":{"de":null,"en":null},"begin_planned":"2015-06-01T02:00:00+02:00","begin_effective":"2015-06-01T02:00:00+02:00","end_planned":"2016-05-31T02:00:00+02:00","end_effective":"2016-05-31T02:00:00+02:00","assignment":"2015-04-30T11:34:28+02:00","program":null,"subprogram":null,"organization":14052,"category":10,"type":10,"partner_function":4,"manager":50696,"contact":null,"status":2,"research":1,"grant":10,"event":null,"study":null,"language":null,"funders":[457],"funder_projectcode":null,"ethics_committee":null,"edudract_number":null,"persons":["3992-50696-10","3992-59782-12","3992-61131-12"]},{"id":3647,"title":{"de":"Vascular endothelial dysfunction: The putative interface of emerging cardiovascular risk factors affecting populations living with and without HIV in Sub-Saharan Africa","en":"Vascular endothelial dysfunction: The putative interface of emerging cardiovascular risk factors affecting populations living with and without HIV in Sub-Saharan Africa"},"short":"ENDOAFRICA","url":null,"abstract":{"de":null,"en":null},"begin_planned":"2014-06-01T02:00:00+02:00","begin_effective":"2014-04-01T02:00:00+02:00","end_planned":"2016-05-31T02:00:00+02:00","end_effective":"2018-12-31T01:00:00+01:00","assignment":"2014-04-30T16:02:52+02:00","program":null,"subprogram":"ERAFRICA","organization":14010,"category":10,"type":10,"partner_function":4,"manager":57932,"contact":null,"status":2,"research":1,"grant":10,"event":null,"study":null,"language":null,"funders":[20],"funder_projectcode":null,"ethics_committee":null,"edudract_number":null,"persons":["3647-50514-12","3647-57932-10","3647-51812-12"]},{"id":3377,"title":{"de":"Pathophysiologie und Behandlung von Cholemischer Nephropathie","en":"Pathophysiology and Treatment of Cholemic Nephropathy"},"short":null,"url":null,"abstract":{"de":null,"en":null},"begin_planned":"2013-06-01T02:00:00+02:00","begin_effective":"2013-06-01T02:00:00+02:00","end_planned":"2016-05-31T02:00:00+02:00","end_effective":"2018-09-30T02:00:00+02:00","assignment":"2013-09-19T11:45:29+02:00","program":72,"subprogram":null,"organization":14081,"category":10,"type":10,"partner_function":4,"manager":52938,"contact":null,"status":2,"research":2,"grant":10,"event":null,"study":null,"language":null,"funders":[9],"funder_projectcode":"P25911","ethics_committee":null,"edudract_number":null,"persons":["3377-50626-12","3377-54247-12","3377-57377-12","3377-57596-12","3377-66436-12","3377-66467-12","3377-70622-12","3377-87214-12","3377-53167-12","3377-52938-10"]},{"id":2019,"title":{"de":"European Medicines Research Training Network","en":"European Medicines Research Training Network"},"short":"EMTRAIN","url":null,"abstract":{"de":null,"en":null},"begin_planned":"2009-06-01T02:00:00+02:00","begin_effective":"2009-10-01T02:00:00+02:00","end_planned":"2016-05-31T02:00:00+02:00","end_effective":"2014-09-30T02:00:00+02:00","assignment":"2009-12-15T11:35:26+01:00","program":24,"subprogram":"IMI Innovative Medicine Initiative Call 14","organization":14020,"category":10,"type":10,"partner_function":2,"manager":51663,"contact":51663,"status":2,"research":5,"grant":10,"event":null,"study":null,"language":null,"funders":[10],"funder_projectcode":null,"ethics_committee":null,"edudract_number":null,"persons":["2019-51663-10"]},{"id":4157,"title":{"de":"Investigating the role of IL-33/ST2 signaling pathway in the growth plate chondrocytes","en":"Investigating the role of IL-33/ST2 signaling pathway in the growth plate chondrocytes"},"short":null,"url":null,"abstract":{"de":null,"en":null},"begin_planned":"2016-01-01T01:00:00+01:00","begin_effective":"2016-01-01T01:00:00+01:00","end_planned":"2016-06-30T02:00:00+02:00","end_effective":"2016-06-30T02:00:00+02:00","assignment":"2015-11-18T14:25:00+01:00","program":null,"subprogram":null,"organization":14052,"category":10,"type":10,"partner_function":4,"manager":null,"contact":null,"status":2,"research":5,"grant":10,"event":null,"study":null,"language":null,"funders":[1565],"funder_projectcode":null,"ethics_committee":null,"edudract_number":null,"persons":[]},{"id":4005,"title":{"de":"In situ Mutationsdetektion von Subklonen von Tumorzellen in Kolonkarzinomgewebe","en":"In situ mutation detection of sub-clones of tumor cells in colon cancer tissue"},"short":null,"url":null,"abstract":{"de":null,"en":null},"begin_planned":"2015-01-01T01:00:00+01:00","begin_effective":"2015-01-01T01:00:00+01:00","end_planned":"2016-06-30T02:00:00+02:00","end_effective":"2016-06-30T02:00:00+02:00","assignment":"2015-05-11T15:44:32+02:00","program":null,"subprogram":null,"organization":14017,"category":10,"type":10,"partner_function":4,"manager":66435,"contact":null,"status":2,"research":2,"grant":10,"event":null,"study":null,"language":null,"funders":[894],"funder_projectcode":null,"ethics_committee":null,"edudract_number":null,"persons":["4005-66435-10"]},{"id":3323,"title":{"de":"Gealterte T Zellen und Knochenabbau bei Rheumatoider Arthritis und Osteoporose ","en":"T cells and bone loss in rheumatoid arthritis and primary osteoporosis"},"short":"T cell senescence and bone loss","url":null,"abstract":{"de":null,"en":null},"begin_planned":"2013-07-01T02:00:00+02:00","begin_effective":"2013-07-01T02:00:00+02:00","end_planned":"2016-06-30T02:00:00+02:00","end_effective":"2017-01-31T01:00:00+01:00","assignment":"2013-07-10T10:43:13+02:00","program":79,"subprogram":null,"organization":14086,"category":10,"type":10,"partner_function":4,"manager":66227,"contact":null,"status":2,"research":2,"grant":10,"event":null,"study":null,"language":null,"funders":[12],"funder_projectcode":null,"ethics_committee":null,"edudract_number":null,"persons":["3323-53560-12","3323-78952-12","3323-89855-12","3323-66227-10"]},{"id":8111,"title":{"de":"Voice Analysis & Pattern Recognition in Patients with Acute Speech Problems suspected to have a Brainstem Stroke","en":"Voice Analysis & Pattern Recognition in Patients with Acute Speech Problems suspected to have a Brainstem Stroke"},"short":null,"url":null,"abstract":{"de":null,"en":null},"begin_planned":"2015-07-01T02:00:00+02:00","begin_effective":"2015-07-14T02:00:00+02:00","end_planned":"2016-06-30T02:00:00+02:00","end_effective":"2017-01-10T01:00:00+01:00","assignment":"2024-03-22T13:59:30+01:00","program":null,"subprogram":null,"organization":14010,"category":10,"type":10,"partner_function":4,"manager":79651,"contact":null,"status":2,"research":1,"grant":10,"event":null,"study":null,"language":null,"funders":[2325],"funder_projectcode":null,"ethics_committee":null,"edudract_number":null,"persons":["8111-79651-10"]},{"id":3602,"title":{"de":"Imatinib als neues Prostaglandin freisetzendes Arzneimittel","en":"Imatinib as a novel prostaglandin releasing drug"},"short":null,"url":null,"abstract":{"de":null,"en":null},"begin_planned":"2013-07-01T02:00:00+02:00","begin_effective":"2014-04-01T02:00:00+02:00","end_planned":"2016-07-01T02:00:00+02:00","end_effective":"2019-09-30T02:00:00+02:00","assignment":"2014-03-11T09:48:51+01:00","program":72,"subprogram":null,"organization":14022,"category":10,"type":10,"partner_function":4,"manager":null,"contact":null,"status":2,"research":1,"grant":10,"event":null,"study":null,"language":null,"funders":[9],"funder_projectcode":"P 26185","ethics_committee":null,"edudract_number":null,"persons":[]},{"id":4232,"title":{"de":"Effekte von Akupunktur und Moxibustion auf die Herzratenvariabilität bei PatientInnen mit Burnout-Syndrom (Qi-Mangel)","en":"Effects of acupuncture and moxibustion on heart rate variability in patients with burnout syndrome (qi deficiency)"},"short":null,"url":null,"abstract":{"de":null,"en":null},"begin_planned":"2015-08-01T02:00:00+02:00","begin_effective":"2015-09-01T02:00:00+02:00","end_planned":"2016-07-31T02:00:00+02:00","end_effective":"2016-07-31T02:00:00+02:00","assignment":"2016-01-15T12:26:52+01:00","program":null,"subprogram":null,"organization":14044,"category":10,"type":10,"partner_function":4,"manager":null,"contact":null,"status":2,"research":1,"grant":10,"event":null,"study":null,"language":null,"funders":[762],"funder_projectcode":"EPU 04/2015","ethics_committee":null,"edudract_number":null,"persons":[]},{"id":3321,"title":{"de":"Hormonale Regulation der Lipolyse","en":"Hormonal regulation of lipolysis"},"short":"Hormonal regulation of lipolysis","url":null,"abstract":{"de":"Lipasen, das sind Fett spaltende Enzyme, spielen eine wichtige Rolle im Energiestoffwechsel. Beeinträchtigungen ihrer Funktion verursachen Störungen in der Aufnahme, in der Mobilisierung und im Transport von Fetten, sog. Lipiden, und führen zu Lipid-assoziierten Krankheiten, z.B. Typ 2 Diabetes, Atherosklerose und Leberkrankheiten, aber auch Krebs. Die Kontrolle der Lipolyse ist wichtig für das Gleichgewicht des Energiehaushalts und die Verteilung der Fettdepots im Körper. Die Freisetzung von Fettsäuren ist abhängig von der Lipolyse von Triacylglyzeriden und wird neural und hormonal reguliert, um den Energiebedarf zu stillen. Die molekularen Mechanismen dieser Regulation sind noch nicht vollständig erforscht, aber posttranslationelle Proteinmodifikationen, Proteininteraktionen, Proteinlokalisierung und Zugang der Lipasen zu ihrem Substraten, den Lipiden, scheinen eine große Rolle zu spielen. Phosphorylierung der Hormonsensitiven Lipase, des Perilipins und der Adipose Triglyzerid Lipase wurde an verschiedenen Stellen durch verschiedene Kinasen beschrieben. Die Regulation und Funktion der Phosphorylierungsstellen wird aber ungenügend verstanden. Auch ist nichts über die Regulation anderer wichtiger Lipasen und Regulatoren, wie der Monoglyzerid Lipase, CGI-58 und G0/G1 Switch Gen 2, bekannt.\r\nWir haben eine analytische Plattform zur Detektion, vergleichenden Analyse und Visualisierung von Lipasen in lebenden Zellen und Geweben etabliert. In unseren Studien haben wir wiederholt Proteinisoformen der Lipasen detektiert. Außerdem haben wir kürzlich entdeckt, dass CGI-58 phosphoryliert wird. Zusammenfassend weisen unsere Studien, sowie die Studien anderer, auf die Existenz von Lipolyseproteinkomplexen hin, die über Phosphorylierung reguliert werden. Ziel des Projekts ist es daher, die Regulation des Lipidgleichgewichts besser zu verstehen. Dazu werden wir untersuchen, ob Lipasen und ihre Regulatoren phosphoryliert werden, ob und wie Lipolyseproteinkomplexe im Fettgewebe hormonell reguliert werden, und welche Funktionen neue Phosphorylierungsstellen und Proteininteraktionspartner von Lipasen und Regulatoren haben. Dadurch wird auch zum ersten Mal das lipolytische Proteom in humanen Fettgewebe direkt auf der Enzymaktivitätsebene erschlossen, was zum besseren Verständnis der Lipid-Mobilisierung in gesundem Gewebe führen wird, und so neue Therapieansätze für Lipid-assoziierte Krankheiten eröffnen wird.\r\n\r\n","en":"Lipases play a key role in regulation of whole body energy homeostasis. Control of lipolysis is important for energy partitioning and balance and maintains the size of fat depots in the body. Dysregulation of lipolytic activities affects lipid absorption, mobilization and transport, and is causative for lipid-related diseases. The release of free fatty acids is dependent on the lipolysis of stored triacylglycerol which is tightly controlled by neural regulation and several hormones to meet energy demands. Molecular mechanisms of this regulation are poorly understood but post-translational modification, protein interactions, protein localizations and access of lipases to their substrates appear to play a major role. Phosphorylation of hormone sensitive lipase, the lipolysis regulator perilipin 1 and more recently also adipose triglyceride lipase (ATGL) have been described on various sometimes controversial sites by different sometimes unknown kinases. Regulations and functions of described sites, however, are poorly understood. Moreover, no information is yet available on regulation of other important players, such as monoglyceride lipase or the ATGL regulators comparative gene identification 58 (CGI-58/ABHD-5) and G0/G1 switch gene 2.\r\nWe have established an analytical platform for activity-based discovery, detection, profiling and imaging of lipolytic enzymes in intact cells and tissues. In our activity-based proteomic screens we have repeatedly detected active isoforms of lipases suggesting that they are posttranslationally modified. Moreover, we have recently discovered a novel post translational modification of CGI-58 by protein kinase A. Previous work by others and us points thus towards the existence of lipolytic complexes and post translational modification of the involved proteins, warranting a comprehensive screen for novel regulators of lipolysis.\r\nThe major objective of the proposed project “Hormonal regulation of lipolysis” is to provide a better understanding of the regulation of lipid homeostasis. We will perform in vitro kinase assays to search for novel substrates of known kinases among known lipolytic proteins and protein regulators, investigate the (phospho)proteomic effects of hormonal regulation on lipolytic complexes in murine and human tissues, and functionally analyze selected novel potential regulators of lipolysis (i.e. novel phosphosites, including our novel CGI-58 phosphosite, and/or novel interacting proteins).\r\nAlthough many protein functions appear to be conserved in humans and mice there is growing evidence for important interspecies differences, especially in complex diseases caused by genetic and environmental factors, which cannot be easily reproduced in model organisms. While activity-based probes were already successfully employed to identify novel lipolytic enzymes in mouse liver and adipose tissue homogenates, this study will for the first time shed light on the lipolytic proteome of human adipose tissues in situ directly at enzymatic activity level. Combined with standard quantitative (phospho)proteomic profiling relevant regulators of lipolytic activities will be identified and might offer entry points for future therapies.\r\n\r\n\r\n"},"begin_planned":"2013-08-01T02:00:00+02:00","begin_effective":"2013-09-01T02:00:00+02:00","end_planned":"2016-07-31T02:00:00+02:00","end_effective":"2016-08-31T02:00:00+02:00","assignment":"2013-07-10T10:40:38+02:00","program":72,"subprogram":null,"organization":14020,"category":10,"type":10,"partner_function":4,"manager":58794,"contact":null,"status":2,"research":1,"grant":10,"event":null,"study":null,"language":null,"funders":[9],"funder_projectcode":"P26074","ethics_committee":null,"edudract_number":null,"persons":["3321-96765-12","3321-58794-10"]},{"id":3696,"title":{"de":"Einfluss der Dialysemethode auf die Funktion von HDL","en":"IMPACT OF DIALYSIS MODALITY ON HDL FUNCTION"},"short":null,"url":null,"abstract":{"de":"Die Mortalität von Patienten mit Nierenerkrankungen ist im Vergleich mit der Gesamtbevölkerung stark erhöht. Es wird seit langem darüber diskutiert, welches Dialyseverfahren – Hämodialyse oder Peritonealdialyse – die bessere Methode in Bezug auf Morbidität und Mortalität ist. Niedrige Konzentrationen von high-density lipoprotein (HDL), wie sie in Nierenpatienten vorkommen, korrelieren mit einem erhöhten Risiko von atherosklerotischen Gefäßerkrankungen. Kürzlich zeigte sich, dass neben der Menge an HDL dessen Funktionalität von entscheidender Bedeutung ist in Hinblick auf Herz-Kreislauf-Erkrankungen. Wir und andere haben in vorangegangenen Publikationen gezeigt das HDL seine Funktionalität in Patienten mit Niereninsuffizienz verlieren kann, und dadurch dysfunktional wird. Jedoch fehlen bis heute wichtige Daten über die Auswirkung unterschiedlicher Dialysemethoden auf HDL. Wir postulieren daher, dass Hämodialyse und Peritonealdialyse die Zusammensetzung und Funktion von HDL unterschiedlich beeinflussen und dadurch - zumindest in Teilen – zu den Unterschieden in der Mortalität führen.","en":"The survival of individuals with end stage renal disease (ESRD) compared to the general population is dramatically reduced. There is much debate over which dialysis modality – hemodialysis (HD) or peritoneal dialysis (PD) – is better in terms of morbidity and mortality. Low levels of high-density lipoprotein (HDL), such as found in renal patients, correlate with an increased risk of atherosclerotic vascular disease. Recently, it became evident that besides HDL cholesterol the functionality of HDL is of crucial importance in regard to cardiovascular protection. A recent clinical study has provided compelling evidence that cholesterol efflux capability of HDL, a functional measure of HDL, is a better predictor or cardiovascular mortality than LDL- or HDL-cholesterol levels. We and others have provided consistent evidence that HDL composition is altered in uremic patients leading to the formation of dysfunctional HDL.  However, data on the effect of dialysis on HDL composition and function are very limited for HD and entirely absent for PD. We, hypothesize that HD and PD differentially affect HDL composition and function, which might explain - at least in part - differences in cardiovascular outcomes.\r\n"},"begin_planned":"2014-08-01T02:00:00+02:00","begin_effective":"2014-08-01T02:00:00+02:00","end_planned":"2016-07-31T02:00:00+02:00","end_effective":"2016-09-30T02:00:00+02:00","assignment":"2014-07-01T13:12:22+02:00","program":79,"subprogram":null,"organization":14022,"category":10,"type":10,"partner_function":4,"manager":62749,"contact":null,"status":2,"research":1,"grant":10,"event":null,"study":null,"language":null,"funders":[12],"funder_projectcode":null,"ethics_committee":null,"edudract_number":null,"persons":["3696-51163-12","3696-62749-10"]},{"id":3522,"title":{"de":"Endotheliale Indolamin 2,3-dioxygenase-1 in der Regulation des plazentaren Gefäßtonus","en":"Endothelial indoleamine 2,3-dioxygenase-1 in the regulation of placental vascular tone"},"short":null,"url":null,"abstract":{"de":null,"en":null},"begin_planned":"2014-02-01T01:00:00+01:00","begin_effective":"2014-01-01T01:00:00+01:00","end_planned":"2016-07-31T02:00:00+02:00","end_effective":"2018-04-30T02:00:00+02:00","assignment":"2014-01-22T09:48:57+01:00","program":79,"subprogram":null,"organization":14017,"category":10,"type":10,"partner_function":4,"manager":null,"contact":null,"status":2,"research":1,"grant":10,"event":null,"study":null,"language":null,"funders":[12],"funder_projectcode":"15671","ethics_committee":null,"edudract_number":null,"persons":[]},{"id":4141,"title":{"de":"Verbesserung der Studiendesigns von Beobachtungsstudien bei Infektionskrankheiten mittels mathematischer Modelle","en":"Enhancing observational study designs of infectious disease surveys using mathematical modelling techniques"},"short":null,"url":null,"abstract":{"de":null,"en":null},"begin_planned":"2016-05-01T02:00:00+02:00","begin_effective":"2016-05-01T02:00:00+02:00","end_planned":"2016-07-31T02:00:00+02:00","end_effective":"2016-07-31T02:00:00+02:00","assignment":"2015-11-05T13:28:54+01:00","program":null,"subprogram":null,"organization":14026,"category":10,"type":10,"partner_function":4,"manager":83644,"contact":null,"status":2,"research":5,"grant":10,"event":null,"study":null,"language":null,"funders":[],"funder_projectcode":null,"ethics_committee":null,"edudract_number":null,"persons":["4141-83644-10"]}]}