{"count":2329,"next":"https://api-test.medunigraz.at/v1/research/project/?format=json&limit=20&offset=440&ordering=end_planned","previous":"https://api-test.medunigraz.at/v1/research/project/?format=json&limit=20&offset=400&ordering=end_planned","results":[{"id":2403,"title":{"de":"Maßgeschneiderte Therapien für Chordome: Bietet IGF-IR-Targeting neue Behandlungsoptionen?","en":"Targeted Therapies for Chordomas: Does IGF-IR-Targeting Provide New Treatment Options?"},"short":"Chordoma Targeted Therapies","url":null,"abstract":{"de":null,"en":null},"begin_planned":"2010-11-01T01:00:00+01:00","begin_effective":"2010-11-01T01:00:00+01:00","end_planned":"2011-11-01T01:00:00+01:00","end_effective":"2013-12-31T01:00:00+01:00","assignment":"2011-02-09T14:17:52+01:00","program":null,"subprogram":null,"organization":14052,"category":10,"type":10,"partner_function":1,"manager":50448,"contact":50448,"status":2,"research":1,"grant":10,"event":null,"study":null,"language":null,"funders":[1091],"funder_projectcode":null,"ethics_committee":null,"edudract_number":null,"persons":["2403-50448-10"]},{"id":2504,"title":{"de":"Subtyp-spezifische, nicht kompetitive metabotrope Glutamatrezeptor-1 Antoagonisten als neuer alternativer Therapieansatz bei neuroendokrinen Tumoren","en":"Subtype-specific, non competitive metabotropic glutamatereceptor-1 antagonists as novel alternative therapeutic option for neuroendocrine tumors"},"short":"glutamate-receptor-1 antagonists","url":null,"abstract":{"de":null,"en":null},"begin_planned":"2011-07-01T02:00:00+02:00","begin_effective":"2011-07-01T02:00:00+02:00","end_planned":"2011-11-30T01:00:00+01:00","end_effective":"2012-01-31T01:00:00+01:00","assignment":"2011-06-21T11:36:12+02:00","program":null,"subprogram":null,"organization":14014,"category":10,"type":10,"partner_function":4,"manager":null,"contact":null,"status":2,"research":1,"grant":10,"event":null,"study":null,"language":null,"funders":[135],"funder_projectcode":null,"ethics_committee":null,"edudract_number":null,"persons":[]},{"id":2568,"title":{"de":"Akustisches Interface zur Tremoranalyse","en":"Acoustic interface for tremoranalysis"},"short":"ACOUSTIC INTERFACE TREMORANALYSIS","url":null,"abstract":{"de":null,"en":null},"begin_planned":"2011-09-01T02:00:00+02:00","begin_effective":"2011-09-01T02:00:00+02:00","end_planned":"2011-11-30T01:00:00+01:00","end_effective":"2012-10-31T01:00:00+01:00","assignment":"2011-09-06T12:41:59+02:00","program":null,"subprogram":"Forschung Steiermark - Planung, Steuerung, Impulse\r\nHTI","organization":14051,"category":10,"type":10,"partner_function":4,"manager":null,"contact":null,"status":2,"research":2,"grant":10,"event":null,"study":null,"language":null,"funders":[135],"funder_projectcode":null,"ethics_committee":null,"edudract_number":null,"persons":[]},{"id":1714,"title":{"de":"GOLD3 - Genomics Of Lipid Droplet Biology, Component 5: Discovery of lipolytic activities by in vivo proteomic profiling","en":"GOLD3 - Genomics Of Lipid Droplet Biology, Component 5: Discovery of lipolytic activities by in vivo proteomic profiling"},"short":"GOLD3_BIRNER_GRUENBERGER","url":null,"abstract":{"de":"Lipid-associated disorders constitute a major health treat wordlwide. Currently more than one billion individuals are overweight or obese and it is estimated that by 2010 more than 300 million patients will be affected by insulin resistance and type-II diabetes.\r\nThe general aim of GOLD 3 is to elucidate processes that govern the biology of lipid droplets (LD), their synthesis and mobilization under normal and pathological conditions.\r\nThe proposed project will discover genes, proteins, and metabolites involved in the generation and catabolsim of LD in human cells. The characterization of their biochemical function, regulation od their expression, and 3-D structure will reveal currently unknown mechanisms and pathways that control the generation of lipid signalling molecules, energy substrates and membrane components affecting cell tissue function as well as energy homeostasis.","en":"Lipid-associated disorders constitute a major health treat wordlwide. Currently more than one billion individuals are overweight or obese and it is estimated that by 2010 more than 300 million patients will be affected by insulin resistance and type-II diabetes.\r\nThe general aim of GOLD 3 is to elucidate processes that govern the biology of lipid droplets (LD), their synthesis and mobilization under normal and pathological conditions.\r\nThe proposed project will discover genes, proteins, and metabolites involved in the generation and catabolsim of LD in human cells. The characterization of their biochemical function, regulation od their expression, and 3-D structure will reveal currently unknown mechanisms and pathways that control the generation of lipid signalling molecules, energy substrates and membrane components affecting cell tissue function as well as energy homeostasis."},"begin_planned":"2008-12-01T01:00:00+01:00","begin_effective":"2009-02-01T01:00:00+01:00","end_planned":"2011-11-30T01:00:00+01:00","end_effective":"2012-04-30T02:00:00+02:00","assignment":"2009-01-14T12:15:11+01:00","program":73,"subprogram":null,"organization":28394,"category":10,"type":10,"partner_function":2,"manager":58794,"contact":58794,"status":2,"research":2,"grant":10,"event":null,"study":null,"language":null,"funders":[152],"funder_projectcode":null,"ethics_committee":null,"edudract_number":null,"persons":["1714-58794-10"]},{"id":2496,"title":{"de":"Einfluss mechanischer Belastung auf die Expression von Matrix Metalloproteasen in Knorpelzellen aus der kindlichen Wachstumsfuge","en":"Influence of mechanical strain on the expression of Matrix Metalloproteases in chondrocytes from the infant growth plate"},"short":"KINDLICHE WACHSTUMSFUGE","url":null,"abstract":{"de":null,"en":null},"begin_planned":"2011-06-01T02:00:00+02:00","begin_effective":"2011-06-01T02:00:00+02:00","end_planned":"2011-11-30T01:00:00+01:00","end_effective":"2012-02-28T01:00:00+01:00","assignment":"2011-06-10T12:21:53+02:00","program":null,"subprogram":null,"organization":14049,"category":10,"type":10,"partner_function":4,"manager":null,"contact":null,"status":2,"research":1,"grant":10,"event":null,"study":null,"language":null,"funders":[135],"funder_projectcode":null,"ethics_committee":null,"edudract_number":null,"persons":[]},{"id":1735,"title":{"de":"GOLD3 - Genomics Of Lipid Droplet Biology, Component 8: Lipid droplet-associated proteins regulating lipid storage and release in macrophages and foam cells","en":"GOLD3 - Genomics Of Lipid Droplet Biology, Component 8: Lipid droplet-associated proteins regulating lipid storage and release in macrophages and foam cells"},"short":"GOLD3_KRATKY","url":null,"abstract":{"de":"Lipid-associated disorders constitute a major health treat wordlwide. Currently more than one billion individuals are overweight or obese and it is estimated that by 2010 more than 300 million patients will be affected by insulin resistance and type-II diabetes.\r\nThe general aim of GOLD 3 is to elucidate processes that govern the biology of lipid droplets (LD), their synthesis and mobilization under normal and pathological conditions.\r\nThe proposed project will discover genes, proteins, and metabolites involved in the generation and catabolsim of LD in human cells. The characterization of their biochemical function, regulation od their expression, and 3-D structure will reveal currently unknown mechanisms and pathways that control the generation of lipid signalling molecules, energy substrates and membrane components affecting cell tissue function as well as energy homeostasis.","en":"Lipid-associated disorders constitute a major health treat wordlwide. Currently more than one billion individuals are overweight or obese and it is estimated that by 2010 more than 300 million patients will be affected by insulin resistance and type-II diabetes.\r\nThe general aim of GOLD 3 is to elucidate processes that govern the biology of lipid droplets (LD), their synthesis and mobilization under normal and pathological conditions.\r\nThe proposed project will discover genes, proteins, and metabolites involved in the generation and catabolsim of LD in human cells. The characterization of their biochemical function, regulation od their expression, and 3-D structure will reveal currently unknown mechanisms and pathways that control the generation of lipid signalling molecules, energy substrates and membrane components affecting cell tissue function as well as energy homeostasis."},"begin_planned":"2008-12-01T01:00:00+01:00","begin_effective":"2009-02-01T01:00:00+01:00","end_planned":"2011-11-30T01:00:00+01:00","end_effective":"2012-04-30T02:00:00+02:00","assignment":"2009-01-22T11:56:26+01:00","program":73,"subprogram":null,"organization":14013,"category":10,"type":10,"partner_function":2,"manager":51904,"contact":null,"status":2,"research":1,"grant":10,"event":null,"study":null,"language":null,"funders":[152],"funder_projectcode":null,"ethics_committee":null,"edudract_number":null,"persons":["1735-51904-10","1735-58794-11"]},{"id":2607,"title":{"de":"Die Rolle der Phospholipid-Scramblase 1 (PLSCR1) in der Differenzierung und Fusion von humanen Trophoblasten ","en":"The role of Phospholipid-Scramblase 1 (PLSCR1) in human trophoblast differentiation and fusion"},"short":null,"url":null,"abstract":{"de":null,"en":null},"begin_planned":"2011-05-13T02:00:00+02:00","begin_effective":"2011-05-13T02:00:00+02:00","end_planned":"2011-11-30T01:00:00+01:00","end_effective":"2011-11-30T01:00:00+01:00","assignment":"2011-10-05T11:53:24+02:00","program":null,"subprogram":null,"organization":14017,"category":10,"type":10,"partner_function":4,"manager":53232,"contact":null,"status":2,"research":1,"grant":10,"event":null,"study":null,"language":null,"funders":[530],"funder_projectcode":null,"ethics_committee":null,"edudract_number":null,"persons":["2607-53232-10"]},{"id":2438,"title":{"de":"Genvarianten in den RAD51-, XRCC2-, XRCC3-, XPD- und XPG-Genen als Prädiktionsfaktoren für Metastasierung bei PatientInnen mit Weichteilsarkomen","en":"Genetic variants in the RAD51, XRCC2, XRCC3, XPD and XPG genes as predictors of outcome in soft tissue sarcoma patients"},"short":"SOFT TISSUE SARCOMA PATIENTS","url":null,"abstract":{"de":null,"en":null},"begin_planned":"2010-12-01T01:00:00+01:00","begin_effective":"2011-04-01T02:00:00+02:00","end_planned":"2011-12-01T01:00:00+01:00","end_effective":"2012-03-30T02:00:00+02:00","assignment":"2011-03-03T12:10:08+01:00","program":null,"subprogram":null,"organization":14085,"category":10,"type":10,"partner_function":4,"manager":69234,"contact":69234,"status":2,"research":5,"grant":10,"event":null,"study":null,"language":null,"funders":[135],"funder_projectcode":null,"ethics_committee":null,"edudract_number":null,"persons":["2438-69234-10","2438-58814-12"]},{"id":2457,"title":{"de":"INTEROCEPTION AND ARTERIAL STIFFNESS","en":"INTEROCEPTION AND ARTERIAL STIFFNESS"},"short":"STRESS HYPOXIC CONDITIONS","url":null,"abstract":{"de":null,"en":null},"begin_planned":"2011-04-01T02:00:00+02:00","begin_effective":"2011-03-28T02:00:00+02:00","end_planned":"2011-12-30T01:00:00+01:00","end_effective":"2011-12-30T01:00:00+01:00","assignment":"2011-03-29T11:56:04+02:00","program":null,"subprogram":null,"organization":29447,"category":10,"type":10,"partner_function":4,"manager":60040,"contact":60040,"status":2,"research":1,"grant":10,"event":null,"study":null,"language":null,"funders":[135],"funder_projectcode":null,"ethics_committee":null,"edudract_number":null,"persons":["2457-60040-10"]},{"id":1716,"title":{"de":"Nano-Health: Nano-structured materials for drug targeting, release and imaging","en":"Nano-Health: Nano-structured materials for drug targeting, release and imaging"},"short":"NANO-HEALTH","url":null,"abstract":{"de":"The increasing incidence of cancer and of degenerative diseases, the latter uncreasingly in relatively young patients, calls for a new healthcare model that is more proactive (detects asymptomatic disease when it is more amenable to treatment), more personalised (based on the growing knowledge about the molecular mechanisms underlying disease), less traumatic and more targeted (non/minimally invasively and specifically treats the affected tissue or organ(s)) and that allows more informed interventions (following of the progress of therapy and disease reoccurrence in as close to real time as possible).\r\nThis prolongation of NANO-HEALTH will build on the work done to date to develop new NM-based solutions for targeted drug delivery and imaging. The following topics will be pursued:\r\n*Further development of thiomers for oral delivery of active substances\r\n*An industrial production process for nano-thiomers\r\n*Development of targeted imaging for cancer using MRI\r\n*Stem cell tracking in vivo\r\n*Atherosclerotic plaque detection\r\n*Chronic nanotoxicity","en":"The increasing incidence of cancer and of degenerative diseases, the latter uncreasingly in relatively young patients, calls for a new healthcare model that is more proactive (detects asymptomatic disease when it is more amenable to treatment), more personalised (based on the growing knowledge about the molecular mechanisms underlying disease), less traumatic and more targeted (non/minimally invasively and specifically treats the affected tissue or organ(s)) and that allows more informed interventions (following of the progress of therapy and disease reoccurrence in as close to real time as possible).\r\nThis prolongation of NANO-HEALTH will build on the work done to date to develop new NM-based solutions for targeted drug delivery and imaging. The following topics will be pursued:\r\n*Further development of thiomers for oral delivery of active substances\r\n*An industrial production process for nano-thiomers\r\n*Development of targeted imaging for cancer using MRI\r\n*Stem cell tracking in vivo\r\n*Atherosclerotic plaque detection\r\n*Chronic nanotoxicity"},"begin_planned":"2009-01-01T01:00:00+01:00","begin_effective":"2009-03-01T01:00:00+01:00","end_planned":"2011-12-31T01:00:00+01:00","end_effective":"2012-02-28T01:00:00+01:00","assignment":"2009-01-14T14:15:30+01:00","program":null,"subprogram":"Nano-Initiative","organization":28392,"category":10,"type":10,"partner_function":2,"manager":54033,"contact":null,"status":2,"research":5,"grant":10,"event":null,"study":null,"language":null,"funders":[416],"funder_projectcode":null,"ethics_committee":null,"edudract_number":null,"persons":["1716-54033-10"]},{"id":2130,"title":{"de":"Kinder erzählen: Text- und Erzählkompetenz im Vorschulalter: eine Voraussetzung für den schulischen 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patients"},"short":"GENETIC_PROSTATE_CANCER_OeNB","url":null,"abstract":{"de":null,"en":null},"begin_planned":"2010-01-01T01:00:00+01:00","begin_effective":"2010-01-01T01:00:00+01:00","end_planned":"2011-12-31T01:00:00+01:00","end_effective":"2011-12-31T01:00:00+01:00","assignment":"2010-01-11T15:12:11+01:00","program":79,"subprogram":null,"organization":14060,"category":10,"type":10,"partner_function":4,"manager":50495,"contact":null,"status":2,"research":2,"grant":10,"event":null,"study":null,"language":null,"funders":[12],"funder_projectcode":null,"ethics_committee":null,"edudract_number":null,"persons":["2031-50495-10","2031-50910-12"]},{"id":2192,"title":{"de":"Akupressur-Stimulationsequipment zur emotionalen Entlastung von Menschen mit geistiger Behinderung","en":"Akupressur-Stimulationsequipment zur emotionalen Entlastung von Menschen mit geistiger Behinderung"},"short":"AKUPRESSUR_STIMULATION","url":null,"abstract":{"de":null,"en":null},"begin_planned":"2010-01-01T01:00:00+01:00","begin_effective":"2010-01-01T01:00:00+01:00","end_planned":"2011-12-31T01:00:00+01:00","end_effective":"2013-12-31T01:00:00+01:00","assignment":"2010-05-03T14:28:49+02:00","program":null,"subprogram":null,"organization":14044,"category":10,"type":10,"partner_function":4,"manager":51073,"contact":51073,"status":2,"research":4,"grant":10,"event":null,"study":null,"language":null,"funders":[135],"funder_projectcode":null,"ethics_committee":null,"edudract_number":null,"persons":["2192-51073-10"]},{"id":2495,"title":{"de":"Bipolar affektive Erkrankung und Schwangerschaft, Geburt und Postpartum","en":"Bipolar affektive Erkrankung und Schwangerschaft, Geburt und Postpartum"},"short":"Bipolar affektive 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