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Trotz wachsender Erkenntnisse über seine Funktion bleibt unklar, wie NR4A1 die Immunantwort moduliert und das Wachstum von Lymphomzellen beeinflusst. In dieser Studie untersuchen wir die Auswirkungen von NR4A1 auf Immunzellen, insbesondere auf T-Zellen und Makrophagen, sowie auf die zellulären und molekularen Mechanismen, die zur Tumorprogression beitragen. Mithilfe modernster Einzelzell-RNA-Sequenzierung und funktioneller Immunanalysen analysieren wir die NR4A1-vermittelten Signalwege in der TME. Unsere Ergebnisse könnten neue therapeutische Ansätze zur gezielten Beeinflussung von NR4A1 in der Immunmodulation und Lymphombehandlung ermöglichen.","en":"NR4A1 is a nuclear receptor that plays a key role in regulating the tumor microenvironment (TME) and interactions between immune and lymphoma cells in aggressive lymphomas. Despite growing insights into its function, how NR4A1 modulates immune responses and influences lymphoma cell growth remains unclear. In this study, we investigate the impact of NR4A1 on immune cells, particularly T cells and macrophages, as well as the cellular and molecular mechanisms contributing to tumor progression. Using advanced single-cell RNA sequencing and functional immune analyses, we analyze NR4A1-mediated signaling pathways in the TME. Our findings may pave the way for novel therapeutic approaches targeting NR4A1 in immune modulation and lymphoma treatment."},"begin_planned":"2024-04-01T02:00:00+02:00","begin_effective":"2024-06-01T02:00:00+02:00","end_planned":"2027-04-01T02:00:00+02:00","end_effective":"2027-05-31T02:00:00+02:00","assignment":"2024-10-03T12:57:24+02:00","program":null,"subprogram":null,"organization":14082,"category":10,"type":10,"partner_function":4,"manager":85928,"contact":null,"status":2,"research":1,"grant":10,"event":null,"study":null,"language":null,"funders":[457],"funder_projectcode":null,"ethics_committee":null,"edudract_number":null,"persons":["8414-85928-10"]},{"id":8787,"title":{"de":"Eine neuartige Zytokin basierte Therapieoption zur Behandlung der akuten \r\nmyeloischen Leukämie","en":"A novel cytokine based therapeutic strategy for treating acute myeloid 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