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pathology"},"short":null,"url":null,"abstract":{"de":null,"en":null},"begin_planned":"2024-09-01T02:00:00+02:00","begin_effective":"2024-12-01T01:00:00+01:00","end_planned":"2026-08-31T02:00:00+02:00","end_effective":"2026-11-30T01:00:00+01:00","assignment":"2025-01-14T13:06:19+01:00","program":206,"subprogram":null,"organization":14020,"category":10,"type":10,"partner_function":4,"manager":104839,"contact":null,"status":2,"research":2,"grant":10,"event":null,"study":null,"language":null,"funders":[20],"funder_projectcode":null,"ethics_committee":null,"edudract_number":null,"persons":["8591-104839-10"]},{"id":9486,"title":{"de":"Gezielte Nanopartikel-Therapie zur Entzündungshemmung bei Sepsis","en":"Targeted nanoparticle therapy for inflammation reduction in sepsis"},"short":"nanoparticle 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ROS"},"short":null,"url":null,"abstract":{"de":null,"en":null},"begin_planned":"2022-12-01T01:00:00+01:00","begin_effective":"2022-12-01T01:00:00+01:00","end_planned":"2026-11-30T01:00:00+01:00","end_effective":"2026-11-30T01:00:00+01:00","assignment":"2022-10-31T13:29:37+01:00","program":72,"subprogram":null,"organization":14013,"category":10,"type":10,"partner_function":4,"manager":85069,"contact":null,"status":2,"research":1,"grant":10,"event":null,"study":null,"language":null,"funders":[9],"funder_projectcode":"P36591","ethics_committee":null,"edudract_number":null,"persons":["7238-85069-10","7238-93963-12","7238-104201-12","7238-111432-12","7238-112109-12","7238-116510-12","7238-117501-12","7238-121350-12","7238-119167-12"]},{"id":7906,"title":{"de":"INTERACT-EUROPE 100","en":"INTERACT-EUROPE 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Retrospektive, multizentrische Analyse des klinischen und onkologischen Outcomes in Österreich.","en":"Particle therapy in patients with sarcoma. Retrospective, multicentre study of clinical and oncological outcomes in Austria."},"short":null,"url":null,"abstract":{"de":null,"en":null},"begin_planned":"2025-06-01T02:00:00+02:00","begin_effective":"2025-06-01T02:00:00+02:00","end_planned":"2025-05-31T02:00:00+02:00","end_effective":"2026-11-30T01:00:00+01:00","assignment":"2025-05-28T10:29:07+02:00","program":null,"subprogram":null,"organization":14052,"category":10,"type":10,"partner_function":1,"manager":95171,"contact":null,"status":2,"research":2,"grant":10,"event":null,"study":null,"language":null,"funders":[1270],"funder_projectcode":null,"ethics_committee":null,"edudract_number":null,"persons":["8952-95171-10"]},{"id":6760,"title":{"de":"Apolipoprotein AI(apo-AI) Peptid-Lipid Komplexe","en":"Apolipoprotein AI(apo-AI) Mimetic Peptide Lipid Assemblies"},"short":"AAMLA","url":null,"abstract":{"de":null,"en":null},"begin_planned":"2022-01-01T01:00:00+01:00","begin_effective":"2022-01-01T01:00:00+01:00","end_planned":"2025-12-31T01:00:00+01:00","end_effective":"2026-11-30T01:00:00+01:00","assignment":"2021-10-22T11:40:29+02:00","program":111,"subprogram":null,"organization":14011,"category":10,"type":10,"partner_function":3,"manager":83104,"contact":null,"status":2,"research":1,"grant":10,"event":null,"study":null,"language":null,"funders":[9],"funder_projectcode":"I5703","ethics_committee":null,"edudract_number":null,"persons":["6760-83104-10","6760-83104-12","6760-107231-12"]},{"id":8530,"title":{"de":"Krebsbekämpfung mit digitaler Pathologie ","en":"Fighting cancer with digital pathology "},"short":null,"url":null,"abstract":{"de":null,"en":null},"begin_planned":"2024-12-01T01:00:00+01:00","begin_effective":"2024-12-01T01:00:00+01:00","end_planned":"2026-11-30T01:00:00+01:00","end_effective":"2026-11-30T01:00:00+01:00","assignment":"2024-11-26T10:47:29+01:00","program":206,"subprogram":null,"organization":14047,"category":10,"type":10,"partner_function":4,"manager":92422,"contact":null,"status":2,"research":10,"grant":10,"event":null,"study":null,"language":null,"funders":[20],"funder_projectcode":null,"ethics_committee":null,"edudract_number":null,"persons":["8530-92422-10"]},{"id":6787,"title":{"de":"Apolipoprotein AI (apo-AI) Mimetische \r\nPeptid-Lipid-Assemblies","en":"Apolipoprotein AI (apo-AI) Mimetic \r\nPeptide Lipid Assemblies"},"short":"AAMLA","url":null,"abstract":{"de":null,"en":null},"begin_planned":"2022-01-01T01:00:00+01:00","begin_effective":"2022-01-01T01:00:00+01:00","end_planned":"2025-12-31T01:00:00+01:00","end_effective":"2026-11-30T01:00:00+01:00","assignment":"2021-11-17T15:51:22+01:00","program":111,"subprogram":null,"organization":14022,"category":10,"type":10,"partner_function":2,"manager":53252,"contact":null,"status":2,"research":1,"grant":10,"event":null,"study":null,"language":null,"funders":[9],"funder_projectcode":"I5703","ethics_committee":null,"edudract_number":null,"persons":["6787-53252-10"]},{"id":9577,"title":{"de":"Er: YAG-Laser vs. rotierende Instrumente – Einfluss\r\nder Erfahrung auf Effizienz, Oberflächenqualität und\r\nPräferenz bei der Entfernung von Veneers","en":"Er: YAG laser vs. rotary instruments - influence\r\nof experience on efficiency, surface quality and\r\npreference when removing veneers"},"short":null,"url":null,"abstract":{"de":null,"en":null},"begin_planned":"2025-06-01T02:00:00+02:00","begin_effective":"2025-06-01T02:00:00+02:00","end_planned":"2026-12-01T01:00:00+01:00","end_effective":"2026-12-01T01:00:00+01:00","assignment":"2026-02-02T12:41:25+01:00","program":null,"subprogram":null,"organization":14111,"category":10,"type":10,"partner_function":1,"manager":126234,"contact":null,"status":2,"research":10,"grant":10,"event":null,"study":null,"language":null,"funders":[2591],"funder_projectcode":null,"ethics_committee":null,"edudract_number":null,"persons":["9577-126234-10"]},{"id":6155,"title":{"de":"Identifizierung von Interaktionen akuter Leukämiezellen mit der Knochenmarksnische.","en":"Identification of leukemic niche interactions in acute myeloid leukemia"},"short":null,"url":null,"abstract":{"de":null,"en":null},"begin_planned":"2020-04-01T02:00:00+02:00","begin_effective":"2020-07-01T02:00:00+02:00","end_planned":"2022-03-31T02:00:00+02:00","end_effective":"2026-12-30T01:00:00+01:00","assignment":"2020-06-15T13:54:55+02:00","program":null,"subprogram":null,"organization":14082,"category":10,"type":10,"partner_function":4,"manager":50747,"contact":null,"status":2,"research":1,"grant":10,"event":null,"study":null,"language":null,"funders":[1743],"funder_projectcode":null,"ethics_committee":null,"edudract_number":null,"persons":["6155-50747-10"]},{"id":8645,"title":{"de":"Bile acids ameliorate obesogenic memory","en":"Bile acids ameliorate obesogenic memory"},"short":"BAOB","url":null,"abstract":{"de":null,"en":null},"begin_planned":"2025-01-01T01:00:00+01:00","begin_effective":"2025-01-01T01:00:00+01:00","end_planned":"2026-12-31T01:00:00+01:00","end_effective":"2026-12-31T01:00:00+01:00","assignment":"2025-02-10T15:52:55+01:00","program":null,"subprogram":null,"organization":14083,"category":10,"type":10,"partner_function":4,"manager":98847,"contact":null,"status":2,"research":1,"grant":10,"event":null,"study":null,"language":null,"funders":[894],"funder_projectcode":null,"ethics_committee":null,"edudract_number":null,"persons":["8645-98847-10"]},{"id":8879,"title":{"de":"Wirkung von Tirzepatid und Inkretinen auf den Stoffwechsel von Endothelzellen","en":"Effect of tirzepatide and incretins on endothelial cell metabolism"},"short":null,"url":null,"abstract":{"de":null,"en":null},"begin_planned":"2025-06-01T02:00:00+02:00","begin_effective":"2025-06-01T02:00:00+02:00","end_planned":"2026-12-31T01:00:00+01:00","end_effective":"2026-12-31T01:00:00+01:00","assignment":"2025-05-20T14:36:13+02:00","program":null,"subprogram":null,"organization":14010,"category":10,"type":10,"partner_function":4,"manager":77116,"contact":null,"status":2,"research":1,"grant":10,"event":null,"study":null,"language":null,"funders":[894],"funder_projectcode":null,"ethics_committee":null,"edudract_number":null,"persons":["8879-77116-10"]},{"id":8316,"title":{"de":"Uterine Trophoblasteninvasion: Ein mastrixbasiertes 3D-Gefäßmodel zur \r\nCharakterisierung schwangerschaftsassozierter Erkrankungen","en":"Uterine trophoblast invasion: A mastrix-based 3D vascular model for the characterization of pregnancy-associated diseases"},"short":null,"url":null,"abstract":{"de":null,"en":null},"begin_planned":"2025-01-01T01:00:00+01:00","begin_effective":"2025-01-01T01:00:00+01:00","end_planned":"2025-12-31T01:00:00+01:00","end_effective":"2026-12-31T01:00:00+01:00","assignment":"2024-07-29T15:26:52+02:00","program":null,"subprogram":null,"organization":14017,"category":10,"type":10,"partner_function":2,"manager":76930,"contact":null,"status":2,"research":3,"grant":10,"event":null,"study":null,"language":null,"funders":[135],"funder_projectcode":null,"ethics_committee":null,"edudract_number":null,"persons":["8316-76930-10","8316-97931-11"]},{"id":7959,"title":{"de":"Zusammensetzung und Funktion von Immunzellen bei Patient*innen mit und ohne steroidrefraktärer akuter und chronischer Graft-versus-Host-Krankheit nach allogener hämatopoetischer Zelltransplantation","en":"Immune cell composition and function in patients with and without steroid-refractory acute and chronic graft-versus-host disease after allogeneic hematopoietic cell transplantation"},"short":"Immune cell composition in GVHD","url":null,"abstract":{"de":null,"en":"One of the most serious life-threatening complications of allogeneic hematopoietic stem cell transplantation (allo-HCT) is acute and chronic graft-versus-host disease (GVHD). (1,2) The established first-line therapy of acute GVHD is methylprednisolone with an initial dose of 2 mg/kg body weight per day. But, only half of all patients respond to first-line therapy and the so-called steroid-refractory GVHD (SR-GVHD) is associated with a poor long-term prognosis. There is still an urgent need for biomarkers that predict response to glucocorticoid therapy. In a retrospective study we showed that cellular infiltrates of immune cells, like innate lymphoid cells (ILCs) and tissue-resident memory T cells (TRMs), differ at onset of gastrointestinal (GI) GVHD in patients who subsequently respond to glucocorticoid therapy compared to patients developing steroid-refractory disease. Based on these preliminary data, we hypothesize that GVHD affects the composition of immune cell populations in affected tissues, such as skin and GI tract, and cellular and molecular profiles of immune cells from peripheral blood (PB) and tissue biopsies, as well as the GI microbiome, may predict lack of response to glucocorticoid therapy. Furthermore, these cellular and molecular profiles may be prognostic for immune reconstitution after allo-HCT. Therefore, the aim of this study is to identify cellular and molecular profiles of GVHD in patients. \r\nFor this purpose, we will prospectively collect clinical data of patients undergoing allo-HCT at the Clinical Division of Hematology at the Medical University/University Hospital Graz, to create a database and compare patient’s clinical course with immune cell composition as well as function/activation state of the PB determined by flow cytometry and cytokine production, as we GI microbiome analysis and tissue samples (skin and GI) obtained from routine clinical biopsies using immunofluorescence, immunohistochemistry and High-Definition Spatial Transcriptomics (HDST). Results of blood and tissue immune cell analyses, cytokines and data from GI microbiome will be compared to the cli nical data on occurrence and severity of GVHD, response to GVHD therapy and patient outcome.\r\n"},"begin_planned":"2023-11-01T01:00:00+01:00","begin_effective":"2024-01-01T01:00:00+01:00","end_planned":"2025-10-31T01:00:00+01:00","end_effective":"2026-12-31T01:00:00+01:00","assignment":"2024-01-04T15:27:07+01:00","program":null,"subprogram":null,"organization":14082,"category":10,"type":10,"partner_function":4,"manager":82501,"contact":null,"status":2,"research":1,"grant":10,"event":null,"study":null,"language":null,"funders":[894,1743],"funder_projectcode":null,"ethics_committee":null,"edudract_number":null,"persons":["7959-100134-12","7959-59183-12","7959-82501-10","7959-111069-12"]},{"id":7932,"title":{"de":"European Viral Outbreak Response Alliance","en":"European Viral Outbreak Response Alliance"},"short":"EVORA","url":null,"abstract":{"de":null,"en":null},"begin_planned":"2023-09-01T02:00:00+02:00","begin_effective":"2024-01-01T01:00:00+01:00","end_planned":"2026-08-31T02:00:00+02:00","end_effective":"2026-12-31T01:00:00+01:00","assignment":"2023-12-15T12:05:57+01:00","program":210,"subprogram":null,"organization":14020,"category":10,"type":10,"partner_function":2,"manager":51663,"contact":null,"status":2,"research":10,"grant":10,"event":null,"study":null,"language":null,"funders":[10],"funder_projectcode":null,"ethics_committee":null,"edudract_number":null,"persons":["7932-51663-10"]},{"id":8107,"title":{"de":"Accelerating datafication for support of EU health priorities, greening of biobanks and integrated approach to “One Health”","en":"Accelerating datafication for support of EU health priorities, greening of biobanks and integrated approach to “One Health”"},"short":"EvolveBBMRI","url":null,"abstract":{"de":null,"en":null},"begin_planned":"2023-09-01T02:00:00+02:00","begin_effective":"2024-01-01T01:00:00+01:00","end_planned":"2026-08-31T02:00:00+02:00","end_effective":"2026-12-31T01:00:00+01:00","assignment":"2024-03-22T10:41:14+01:00","program":210,"subprogram":null,"organization":14020,"category":10,"type":10,"partner_function":2,"manager":51663,"contact":null,"status":2,"research":10,"grant":10,"event":null,"study":null,"language":null,"funders":[10],"funder_projectcode":null,"ethics_committee":null,"edudract_number":null,"persons":["8107-51663-10"]},{"id":7933,"title":{"de":"INTERnational Cooperation of high containment research infrastructures: from Epidemic Preparedness TO\r\nResponse","en":"INTERnational Cooperation of high containment research infrastructures: from Epidemic Preparedness TO\r\nResponse"},"short":"INTERCEPTOR","url":null,"abstract":{"de":null,"en":null},"begin_planned":"2023-09-01T02:00:00+02:00","begin_effective":"2024-01-01T01:00:00+01:00","end_planned":"2026-08-31T02:00:00+02:00","end_effective":"2026-12-31T01:00:00+01:00","assignment":"2023-12-15T12:06:13+01:00","program":210,"subprogram":null,"organization":14020,"category":10,"type":10,"partner_function":2,"manager":51663,"contact":null,"status":2,"research":10,"grant":10,"event":null,"study":null,"language":null,"funders":[10],"funder_projectcode":null,"ethics_committee":null,"edudract_number":null,"persons":["7933-51663-10"]},{"id":8140,"title":{"de":"Entschlüsselung von Alzheimer: \r\nTRPC1 als zentrale Figur bei Protein-Entfaltung und Cholesterin-Biosynthese\r\n","en":"Deciphering Alzheimer's: \r\nTRPC1 as a central player in protein unfolding and cholesterol biosynthesis"},"short":null,"url":null,"abstract":{"de":"Hintergrund: Die Alzheimer-Krankheit (AD) ist eine irreversible und tödliche Form von Demenz, unterteilt in sporadische (SAD) und familiäre AD (FAD). FAD, mit frühem Beginn aufgrund spezifischer Genmutationen, steht im Gegensatz zu SAD, das einen späten Beginn und eine unklare Ursache aufweist. Die Ca2+-Homöostase- Hypothese von SAD legt nahe, dass eine frühzeitige Ca2+-Dysregulation mit der Fehlfaltung von Proteinen und der Anreicherung von Cholesterin einhergeht. Das endoplasmatische Retikulum (ER) ist entscheidend für die Regulation des intrazellulären Ca2+, die Verarbeitung von Proteinen und die Lipid-Biosynthese. Die Familie der transienten Rezeptorpotenzial-Kanäle (TRPC1-7) umfasst TRPC1, der im Hippocampus stark exprimiert wird. Während TRPC2-7 ausschließlich in der Plasmamembran gefunden werden, befindet sich TRPC1 auch in der ER- Membran.\r\nHypothese: TRPC1 könnte an der Regulation von Ca2+, der Synthese von Proteinen und Cholesterin im ER beteiligt sein.\r\nErgebnisse: Vorläufige Experimente zeigten, dass TRPC1 den Ca2+-Leck aus dem ER signifikant verstärkte, den Cholesterinspiegel in TRPC1-transfizierten HEK293-Zellen erhöhte, den Cholesterinspiegel in den Hippocampi transgener Mäuse im Alter veränderte und die Expression von Transkriptionsfaktoren beeinflusste, die an der Proteinfaltung beteiligt sind.\r\nFazit: Eine weitere Erforschung der Rolle von TRPC1 im ER könnte ihn als potenzielles pharmazeutisches Ziel in der AD-Behandlung etablieren.","en":"Background: Alzheimer’s disease (AD) is an irreversible and fatal form of dementia, divided into sporadic (SAD) and familial AD (FAD). FAD, with early onset due to specific gene mutations, contrasts SAD, with late onset and an unclear cause. The Ca2+ homeostasis hypothesis of SAD suggests early Ca2+ dyshomeostasis links to protein misfolding and cholesterol accumulation. The endoplasmic reticulum (ER) is crucial, managing intracellular Ca2+, protein processing, and lipid biosynthesis. The transient receptor potential canonical family (TRPC1-7) includes TRPC1, highly expressed in the hippocampus. While TRPC2-7 target the plasma membrane, TRPC1 is also found in the ER membrane.\r\nHypothesis: TRPC1 may be involved in Ca2+ handling, protein, and cholesterol synthesis in the ER.\r\nResults: Preliminary experiments showed TRPC1 increased Ca2+ leak from the ER, elevated cholesterol in TRPC1- transfected HEK293 cells, altered cholesterol levels in hippocampi from aged transgenic mice, and affected expression of transcription factors involved in protein folding.\r\nConclusion: Further exploring TRPC1 role in the ER could establish it as a potential pharmaceutical target in AD treatment."},"begin_planned":"2024-03-01T01:00:00+01:00","begin_effective":"2024-03-01T01:00:00+01:00","end_planned":"2025-02-28T01:00:00+01:00","end_effective":"2026-12-31T01:00:00+01:00","assignment":"2024-04-16T14:17:18+02:00","program":null,"subprogram":null,"organization":14011,"category":10,"type":10,"partner_function":4,"manager":90337,"contact":null,"status":2,"research":2,"grant":10,"event":null,"study":null,"language":null,"funders":[1743],"funder_projectcode":null,"ethics_committee":null,"edudract_number":null,"persons":["8140-90337-10","8140-116421-12","8140-122690-12"]}]}