{"count":2329,"next":"https://api-test.medunigraz.at/v1/research/project/?format=json&limit=20&offset=220&ordering=end_planned","previous":"https://api-test.medunigraz.at/v1/research/project/?format=json&limit=20&offset=180&ordering=end_planned","results":[{"id":671,"title":{"de":"DISMAL: Molecular signatures as diagnostic and therapeutic targets for disseminated epithelial malignancies","en":"DISMAL: Molecular signatures as diagnostic and therapeutic targets for disseminated epithelial malignancies"},"short":"DISMAL","url":null,"abstract":{"de":"Disseminated tumour cells (DTC) occur at very low numbers and can be detected using sensitive immunostaining and PCR methods. However, sensitivity and in particular specificity of this approach need to be improved. Combining the expertise of 11 academic partners with long-term expertise in mi-crometastasis research the DISMAL-project will establish an improved platform for DTC detection with an increased sensitivity and – in particular – with a largely improved specificity. Besides DTC detection also analysis of circulating tumour DNA and RNA, and expression profiling of tumours are being ex-plored for assessment of minimal disease. We will focus on epithelial tumours as the most common types of solid tumours in the EU, investigating the carcinoma types that display different modes of metastatic spread. Dissemination via the blood circulation will be analyzed, using bone marrow as an important indicator organ to which epithelial tumour cells home. Using genomics-based approaches, novel diagnos-tic target molecules will be identified and validated in functional models. We will complement immuno-cytochemical DTC detection by additional genotypic and phenotypic markers relevant for metastatic progression. To further increase diagnostic precision we will analyze whether this improved platform can be combined with analysis of tumour characteristics that were revealed by the microarray analysis, and with evaluation of circulating tumour-associated DNA or RNA. Besides the primary focus on improve-ment of DTC-based diagnostic platforms, it is important to realize that these cells are the target cells for adjuvant chemotherapy and radiotherapy. In innovative DTC models, the efficacy of DTC treatment will therefore be analyzed and potential improvements studied. The translation of scientific knowledge into commercial products will be ensured by 3 SMEs with unique technological capabilities.","en":"Disseminated tumour cells (DTC) occur at very low numbers and can be detected using sensitive immunostaining and PCR methods. However, sensitivity and in particular specificity of this approach need to be improved. Combining the expertise of 11 academic partners with long-term expertise in mi-crometastasis research the DISMAL-project will establish an improved platform for DTC detection with an increased sensitivity and – in particular – with a largely improved specificity. Besides DTC detection also analysis of circulating tumour DNA and RNA, and expression profiling of tumours are being ex-plored for assessment of minimal disease. We will focus on epithelial tumours as the most common types of solid tumours in the EU, investigating the carcinoma types that display different modes of metastatic spread. Dissemination via the blood circulation will be analyzed, using bone marrow as an important indicator organ to which epithelial tumour cells home. Using genomics-based approaches, novel diagnos-tic target molecules will be identified and validated in functional models. We will complement immuno-cytochemical DTC detection by additional genotypic and phenotypic markers relevant for metastatic progression. To further increase diagnostic precision we will analyze whether this improved platform can be combined with analysis of tumour characteristics that were revealed by the microarray analysis, and with evaluation of circulating tumour-associated DNA or RNA. Besides the primary focus on improve-ment of DTC-based diagnostic platforms, it is important to realize that these cells are the target cells for adjuvant chemotherapy and radiotherapy. In innovative DTC models, the efficacy of DTC treatment will therefore be analyzed and potential improvements studied. The translation of scientific knowledge into commercial products will be ensured by 3 SMEs with unique technological capabilities."},"begin_planned":"2006-01-01T01:00:00+01:00","begin_effective":"2006-02-01T01:00:00+01:00","end_planned":"2008-10-31T01:00:00+01:00","end_effective":"2009-04-30T02:00:00+02:00","assignment":"2006-01-21T19:45:22+01:00","program":21,"subprogram":"Biowissenschaften","organization":14021,"category":10,"type":10,"partner_function":2,"manager":null,"contact":null,"status":2,"research":2,"grant":10,"event":null,"study":null,"language":null,"funders":[10],"funder_projectcode":null,"ethics_committee":null,"edudract_number":null,"persons":[]},{"id":949,"title":{"de":"UNICAFE: Survey of the University Career of Female Scientists at Life Sciences versus Technical Universities","en":"UNICAFE: Survey of the University Career of Female Scientists at Life Sciences versus Technical Universities"},"short":"UNICAFE","url":null,"abstract":{"de":"The aim of the project is to carry out an innovative pilot survey to enhance existing knowledge\r\non career patterns of women in universities. The project will open up new perspectives for\r\nfurther in-depth work in the field by mapping the situation of female researchers in\r\nengineering and life sciences in eight universities in six countries in Europe with special\r\nregard to gender differences in research careers, critical areas where women are\r\nunderrepresented, leading university positions, access to funding, mobility and work-life balance.\r\nWomen face great difficulties in developing professional careers in equal opportunities to those\r\nof men in these sectors, especially regarding their proportion on the higher levels of the\r\nhierarchical ladder. The project will examine and compare the situtation of female researchers\r\nand decision makers. A methodology to map careers in university will be designed and tested\r\nin the partner institutions. The survey will involve PhD students, researchers and decision\r\nmakers as well. Besides the collection of detailed statistics – which is missing at almost all\r\ninvolved universities – the consortium will conduct interviews with those female researchers\r\nwho succeeded in doing a career in these areas of science in spite of the difficulties. The project\r\nwill map not only the good practices but the bad ones as well in order to determine how the\r\ncareer of female researchers is set back in these areas. Furthermore it is one of the objectives of\r\nthe project to draw the attention of the university managements to the importance of equal\r\nopportunities of women and men and the practice of gender mainstreaming as a policy of the\r\nEuropean Union. The partner countries include two new member states (Hungary and\r\nEstonia), three old member states (Austria, Finland and Italy) and a candidate country (Turkey),\r\nso they provide an ideal coverage of circumstances available throughout Europe.","en":"The aim of the project is to carry out an innovative pilot survey to enhance existing knowledge\r\non career patterns of women in universities. The project will open up new perspectives for\r\nfurther in-depth work in the field by mapping the situation of female researchers in\r\nengineering and life sciences in eight universities in six countries in Europe with special\r\nregard to gender differences in research careers, critical areas where women are\r\nunderrepresented, leading university positions, access to funding, mobility and work-life balance.\r\nWomen face great difficulties in developing professional careers in equal opportunities to those\r\nof men in these sectors, especially regarding their proportion on the higher levels of the\r\nhierarchical ladder. The project will examine and compare the situtation of female researchers\r\nand decision makers. A methodology to map careers in university will be designed and tested\r\nin the partner institutions. The survey will involve PhD students, researchers and decision\r\nmakers as well. Besides the collection of detailed statistics – which is missing at almost all\r\ninvolved universities – the consortium will conduct interviews with those female researchers\r\nwho succeeded in doing a career in these areas of science in spite of the difficulties. The project\r\nwill map not only the good practices but the bad ones as well in order to determine how the\r\ncareer of female researchers is set back in these areas. Furthermore it is one of the objectives of\r\nthe project to draw the attention of the university managements to the importance of equal\r\nopportunities of women and men and the practice of gender mainstreaming as a policy of the\r\nEuropean Union. The partner countries include two new member states (Hungary and\r\nEstonia), three old member states (Austria, Finland and Italy) and a candidate country (Turkey),\r\nso they provide an ideal coverage of circumstances available throughout Europe."},"begin_planned":"2006-11-01T01:00:00+01:00","begin_effective":"2006-11-01T01:00:00+01:00","end_planned":"2008-10-31T01:00:00+01:00","end_effective":"2008-10-31T01:00:00+01:00","assignment":"2006-11-27T17:52:14+01:00","program":21,"subprogram":"Science and Society: call identifier FP6-2005-Science-and-society-17, Woman and Science call, line 4.3.5.2.c \"Deepening and broadening the quantitative knowledge base on woman and science in Europe\"","organization":23646,"category":10,"type":10,"partner_function":2,"manager":50095,"contact":50095,"status":2,"research":5,"grant":10,"event":null,"study":null,"language":null,"funders":[10],"funder_projectcode":null,"ethics_committee":null,"edudract_number":null,"persons":["949-50095-10"]},{"id":642,"title":{"de":"GOLD II -Genomics Of Lipid-associated Disorders II","en":"GOLD II -Genomics Of Lipid-associated Disorders II"},"short":"GOLD II","url":null,"abstract":{"de":"This component focuses on a genome-wide search for as yet unknown genes that are involved in cellular cholesterol metabolism, including its biosynthesis, absorption, mobilization and trafficking. We aim at identifying all cholesteryl ester hydrolases in the mouse and human genome as well as target genes of nuclear receptors as potential therapeutic targets for the treatment of cholesterol and bile acid disorders. Studies will be performed mainly in cells form intestine, macrophages and liver utilizing microarray hybridization and ChIP on chip experiments, inhibitor screening, and in silico search for homologues. ","en":"This component focuses on a genome-wide search for as yet unknown genes that are involved in cellular cholesterol metabolism, including its biosynthesis, absorption, mobilization and trafficking. We aim at identifying all cholesteryl ester hydrolases in the mouse and human genome as well as target genes of nuclear receptors as potential therapeutic targets for the treatment of cholesterol and bile acid disorders. Studies will be performed mainly in cells form intestine, macrophages and liver utilizing microarray hybridization and ChIP on chip experiments, inhibitor screening, and in silico search for homologues. "},"begin_planned":"2005-12-01T01:00:00+01:00","begin_effective":"2005-12-01T01:00:00+01:00","end_planned":"2008-11-01T01:00:00+01:00","end_effective":"2008-11-30T01:00:00+01:00","assignment":"2005-12-01T11:45:37+01:00","program":73,"subprogram":null,"organization":14013,"category":10,"type":10,"partner_function":2,"manager":51669,"contact":null,"status":2,"research":1,"grant":10,"event":null,"study":null,"language":null,"funders":[152],"funder_projectcode":null,"ethics_committee":null,"edudract_number":null,"persons":["642-51974-11","642-51904-10","642-51669-10"]},{"id":1447,"title":{"de":"Primäre und sekundäre Hautkrebsprävention in Schulen und an Arbeitsplätzen in der Steiermark","en":"Primäre und sekundäre Hautkrebsprävention in Schulen und an Arbeitsplätzen in der Steiermark"},"short":"HAUTKREBSPRAEVENTION_STMK","url":null,"abstract":{"de":"Das maligne Melanom gehört zu den weltweit am raschest ansteigenden Krebsentitäten und wird auch in der Steiermark immer häufiger. \r\nEntscheidend für die Prognose ist die frühe Entdeckung dieser Krebsart, was auf Grund der Lokalisation (Haut) auch gut, leicht und schmerzfrei möglich ist.\r\nEin früh erkanntes Melanom ist durch eine einfache Operation (Kosten: € 125,40) heilbar, während z. B. für eine immunstimulierende Behandlung in einem weiter fortgeschrittenen Stadium bereits € 44.639,40 pro Jahr ausgegeben werden müssen. \r\n\r\nDadurch wird primäre Prävention (Schulung, Aufklärung) und sekundäre Prävention (Vorsorgeuntersuchungen) immer wichtiger. Schulung im Umgang mit der Sonne und erste barrierefreie Vorsorgeuntersuchungen sind besonders in den jungen Lebensjahren wichtig, aber auch in den Jahren der Erwerbstätigkeit, in denen meist keine Zeit für Vorsorgeuntersuchungen bleibt und oft aus Unkenntnis über die Warnsignale der Haut oder Zeitmangel der Weg zum Arzt zu spät aufgesucht wird.\r\nEine solche Schulung/Untersuchung - Kombination wird seit Jahren in der Steiermark erfolgreich im vom Land Steiermark unterstützten Projekt .sun.watch. (Unterlage beiliegend) in den steirischen Bädern umgesetzt.\r\n\r\nUnser Projekt umfasst nun\r\n1) die Schulung von Kindern und Erwerbstätigen und\r\n2) die Untersuchungen von Kindern und Erwerbstätigen in der Schule bzw an ihren Arbeitsplätzen.\r\n","en":"Das maligne Melanom gehört zu den weltweit am raschest ansteigenden Krebsentitäten und wird auch in der Steiermark immer häufiger. \r\nEntscheidend für die Prognose ist die frühe Entdeckung dieser Krebsart, was auf Grund der Lokalisation (Haut) auch gut, leicht und schmerzfrei möglich ist.\r\nEin früh erkanntes Melanom ist durch eine einfache Operation (Kosten: € 125,40) heilbar, während z. B. für eine immunstimulierende Behandlung in einem weiter fortgeschrittenen Stadium bereits € 44.639,40 pro Jahr ausgegeben werden müssen. \r\n\r\nDadurch wird primäre Prävention (Schulung, Aufklärung) und sekundäre Prävention (Vorsorgeuntersuchungen) immer wichtiger. Schulung im Umgang mit der Sonne und erste barrierefreie Vorsorgeuntersuchungen sind besonders in den jungen Lebensjahren wichtig, aber auch in den Jahren der Erwerbstätigkeit, in denen meist keine Zeit für Vorsorgeuntersuchungen bleibt und oft aus Unkenntnis über die Warnsignale der Haut oder Zeitmangel der Weg zum Arzt zu spät aufgesucht wird.\r\nEine solche Schulung/Untersuchung - Kombination wird seit Jahren in der Steiermark erfolgreich im vom Land Steiermark unterstützten Projekt .sun.watch. (Unterlage beiliegend) in den steirischen Bädern umgesetzt.\r\n\r\nUnser Projekt umfasst nun\r\n1) die Schulung von Kindern und Erwerbstätigen und\r\n2) die Untersuchungen von Kindern und Erwerbstätigen in der Schule bzw an ihren Arbeitsplätzen.\r\n"},"begin_planned":"2007-12-01T01:00:00+01:00","begin_effective":"2007-12-01T01:00:00+01:00","end_planned":"2008-11-30T01:00:00+01:00","end_effective":"2009-08-31T02:00:00+02:00","assignment":"2008-01-16T09:55:50+01:00","program":null,"subprogram":null,"organization":14047,"category":10,"type":10,"partner_function":4,"manager":52274,"contact":52274,"status":2,"research":2,"grant":10,"event":null,"study":null,"language":null,"funders":[135],"funder_projectcode":null,"ethics_committee":null,"edudract_number":null,"persons":["1447-52274-10"]},{"id":1432,"title":{"de":"Visuelle Rehabilitation im AVC","en":"Visuelle Rehabilitation im AVC"},"short":"AVC","url":null,"abstract":{"de":"Für Erblindete mit einer speziellen Netzhauterkrankung (Retinopathia pigmentosa) für die es bislang keine Heilung gab, wurde ein elektronisches hochtechnologisches Augenimplantat entwickelt, das einen Teil der Sehfähigkeit wieder herstellen soll. Die elektrische Reizung der Netzhaut aber stellt einen neuartigen Reiz für das Gehirn dar. Das Gehirn muss erst lernen, diese Reize zu einem sinnvollen Bild zusammenzufügen (neues Sehen). Ähnlich wie bei einem Cochlea-Implantat wird der Erfolg mit dem Implantat maßgeblich von der Intensität und Qualität des Trainings bestimmt werden. Das Ausmaß dieses Lernprozesses wird demnach von einem entsprechendem Rehabilitationsprogramm abhängen. Der Inhalt dieses Projektes ist es, diese entsprechenden Maßnahmen zu entwickeln, wissenschaftlich exakt zu evaluieren und zu erproben.\r\nErstmalig gibt dieses Projekt die Möglichkeit diesen neuen Sehprozess direkt zu unterschen und daraus fundierte Grundlagen abzuleiten, die dem Grazer Team dessen Weiterentwicklung ermöglichen.\r\nInsgesamt sollen diese Maßnahmen dazu führen, die Wahrnehmung Erblindeter durch das Erkennen von Umrissen und Bewegungen erheblich zu erweitern: Mit diesen völlig neuen Perspektiven wird die Lebensqualität und Selbstständigkeit entschieden verbessert.","en":"Für Erblindete mit einer speziellen Netzhauterkrankung (Retinopathia pigmentosa) für die es bislang keine Heilung gab, wurde ein elektronisches hochtechnologisches Augenimplantat entwickelt, das einen Teil der Sehfähigkeit wieder herstellen soll. Die elektrische Reizung der Netzhaut aber stellt einen neuartigen Reiz für das Gehirn dar. Das Gehirn muss erst lernen, diese Reize zu einem sinnvollen Bild zusammenzufügen (neues Sehen). Ähnlich wie bei einem Cochlea-Implantat wird der Erfolg mit dem Implantat maßgeblich von der Intensität und Qualität des Trainings bestimmt werden. Das Ausmaß dieses Lernprozesses wird demnach von einem entsprechendem Rehabilitationsprogramm abhängen. Der Inhalt dieses Projektes ist es, diese entsprechenden Maßnahmen zu entwickeln, wissenschaftlich exakt zu evaluieren und zu erproben.\r\nErstmalig gibt dieses Projekt die Möglichkeit diesen neuen Sehprozess direkt zu unterschen und daraus fundierte Grundlagen abzuleiten, die dem Grazer Team dessen Weiterentwicklung ermöglichen.\r\nInsgesamt sollen diese Maßnahmen dazu führen, die Wahrnehmung Erblindeter durch das Erkennen von Umrissen und Bewegungen erheblich zu erweitern: Mit diesen völlig neuen Perspektiven wird die Lebensqualität und Selbstständigkeit entschieden verbessert."},"begin_planned":"2007-07-01T02:00:00+02:00","begin_effective":"2007-07-01T02:00:00+02:00","end_planned":"2008-11-30T01:00:00+01:00","end_effective":"2009-08-31T02:00:00+02:00","assignment":"2007-12-20T16:36:28+01:00","program":null,"subprogram":null,"organization":14043,"category":10,"type":10,"partner_function":4,"manager":null,"contact":null,"status":2,"research":4,"grant":10,"event":null,"study":null,"language":null,"funders":[135],"funder_projectcode":null,"ethics_committee":null,"edudract_number":null,"persons":[]},{"id":1281,"title":{"de":"VIPEM, Visual Analytics for Personalized Medicine","en":"VIPEM, Visual Analytics for Personalized Medicine"},"short":"VIPEM_FWF_2","url":null,"abstract":{"de":"The analysis of huge inhomogenous datasets is one of the main challenges in personalized medicine, which aims at more specific diagnosis and treatment of disease. In personalized medicine, the disease of individual patients are characterized on the basis of several parameters including molecular data (e.g. genetic polymorphisms, gene expression or proteomics data) as well as a broad spectrum of medical data (e.g. laboratory parameters, clinical phenotypes or pathological alterations). \r\nCurrently no suitable tool is available to cope with the increasing demands of data integration in personalized medicine. To address this need, we propose the further development of a data analysis system (Visual Analytics for Personalized Medicine, VIPEM) which takes advantage of the high visual data analysis capacities of humans and is specifically designed to support medical experts and basic researchers in hypothesis-driven data mining. Therefore the proposed project comprises an interdisciplinary team of medical experts and computer scientists.","en":"The analysis of huge inhomogenous datasets is one of the main challenges in personalized medicine, which aims at more specific diagnosis and treatment of disease. In personalized medicine, the disease of individual patients are characterized on the basis of several parameters including molecular data (e.g. genetic polymorphisms, gene expression or proteomics data) as well as a broad spectrum of medical data (e.g. laboratory parameters, clinical phenotypes or pathological alterations). \r\nCurrently no suitable tool is available to cope with the increasing demands of data integration in personalized medicine. To address this need, we propose the further development of a data analysis system (Visual Analytics for Personalized Medicine, VIPEM) which takes advantage of the high visual data analysis capacities of humans and is specifically designed to support medical experts and basic researchers in hypothesis-driven data mining. Therefore the proposed project comprises an interdisciplinary team of medical experts and computer scientists."},"begin_planned":"2006-12-01T01:00:00+01:00","begin_effective":"2007-11-01T01:00:00+01:00","end_planned":"2008-11-30T01:00:00+01:00","end_effective":"2010-04-30T02:00:00+02:00","assignment":"2007-05-30T15:35:58+02:00","program":71,"subprogram":null,"organization":14020,"category":10,"type":10,"partner_function":4,"manager":51663,"contact":51663,"status":2,"research":2,"grant":10,"event":null,"study":null,"language":null,"funders":[9],"funder_projectcode":"L427","ethics_committee":null,"edudract_number":null,"persons":["1281-51449-12","1281-51663-10"]},{"id":484,"title":{"de":"Rolle des Endothelin-Systems bei pathologischen Schwangerschaften","en":"The endothelin/endothelin receptor system in early pregnany diseases with dysregulation of trophoblast proliferation and invasion"},"short":"Endothelin","url":null,"abstract":{"de":"Verschiedene Probleme in der Schwangerschaft beruhen auf einer gestörten Invasion des Mutterkuchens (Plazenta) in das umliegende Gewebe. Andere Pathologien sind das Ergebnis eines überschießenden Zellwachstums. Auf Grund vorangegangener Arbeiten unserer Gruppe an isolierten Zellen gibt es Hinweise darauf, dass das Endothelin- und Endothelin-Rezeptor-System in diesem Geschehen eine wichtige Rolle spielt. Inhalt des gegenständlichen Projektes ist, diese an Modellsystemen erarbeiteten Ergenisse an biologischem Material von Patienten zu bestätigen. Aus diesem Grund wird sowohl Plazentamaterial als auch Blut, Harn und Cervikalabstriche von Frauen mit gestörten und ungestörten Schwangerschaften zu Beginn der Schwangerschaft gesammelt und darin Endothelin und Endothelin-Rezeptormengen mit verschiedenen Methoden auf verschiedene Ebenen (Protein-, RNA-Ebene) untersucht. Als weiteres Vergleichsmaterial sollen als Paraffinmaterial gelagerte Proben anderer Fehlentwicklungen der Plazenta (Blasenmolen und Chorionkarzinome) herangezogen werden. Ziel ist es, neue diagnostische Parameter für die Früherkennung gestörter Schwangerschaften zu erhalten. ","en":"Verschiedene Probleme in der Schwangerschaft beruhen auf einer gestörten Invasion des Mutterkuchens (Plazenta) in das umliegende Gewebe. Andere Pathologien sind das Ergebnis eines überschießenden Zellwachstums. Auf Grund vorangegangener Arbeiten unserer Gruppe an isolierten Zellen gibt es Hinweise darauf, dass das Endothelin- und Endothelin-Rezeptor-System in diesem Geschehen eine wichtige Rolle spielt. Inhalt des gegenständlichen Projektes ist, diese an Modellsystemen erarbeiteten Ergenisse an biologischem Material von Patienten zu bestätigen. Aus diesem Grund wird sowohl Plazentamaterial als auch Blut, Harn und Cervikalabstriche von Frauen mit gestörten und ungestörten Schwangerschaften zu Beginn der Schwangerschaft gesammelt und darin Endothelin und Endothelin-Rezeptormengen mit verschiedenen Methoden auf verschiedene Ebenen (Protein-, RNA-Ebene) untersucht. Als weiteres Vergleichsmaterial sollen als Paraffinmaterial gelagerte Proben anderer Fehlentwicklungen der Plazenta (Blasenmolen und Chorionkarzinome) herangezogen werden. Ziel ist es, neue diagnostische Parameter für die Früherkennung gestörter Schwangerschaften zu erhalten. "},"begin_planned":"2005-08-13T02:00:00+02:00","begin_effective":"2005-08-13T02:00:00+02:00","end_planned":"2008-11-30T01:00:00+01:00","end_effective":"2008-11-30T01:00:00+01:00","assignment":"2005-10-26T02:00:00+02:00","program":79,"subprogram":null,"organization":14038,"category":10,"type":10,"partner_function":4,"manager":null,"contact":null,"status":2,"research":2,"grant":10,"event":null,"study":null,"language":null,"funders":[12],"funder_projectcode":null,"ethics_committee":null,"edudract_number":null,"persons":[]},{"id":737,"title":{"de":"GOLDII - Genomics of Lipid-associated Disorders","en":"GOLDII - Genomics of Lipid-associated Disorders"},"short":"GOLDII","url":null,"abstract":{"de":"Despite the general opinion, that obesity and other lipid-associated disorders are to a large extent the result of misbehaviour, it is evident that overeating in humans is mostly \"hard-wired\" and that adipose tissue mass is genetically determined. Numerous twin/adoption and family studies confirm a major contribution of genes to the development of obesity. This fact, combined with the \"Obesogenic environment\" that we face in developed countries, with adopting a sedentary life style and an abundance of high-fat, high-calorie food at low cost, results in the tremendous rate at which obesity and related disorders increase in today's world.\r\n\r\nThis project will identify subsets of genes that are involved in the development of adipocytes, the regulation of lipid deposition and lipid mobilization, and the maintenance of cellular cholesterol homeostasis.\r\nWe expect to discover important components of the eukaryotic proteo-lipidome. Our results will significantly advance the understanding of lipid and energy metabolism and may provide novel durg targets for the treatment of metabolic diseases.","en":"Despite the general opinion, that obesity and other lipid-associated disorders are to a large extent the result of misbehaviour, it is evident that overeating in humans is mostly \"hard-wired\" and that adipose tissue mass is genetically determined. Numerous twin/adoption and family studies confirm a major contribution of genes to the development of obesity. This fact, combined with the \"Obesogenic environment\" that we face in developed countries, with adopting a sedentary life style and an abundance of high-fat, high-calorie food at low cost, results in the tremendous rate at which obesity and related disorders increase in today's world.\r\n\r\nThis project will identify subsets of genes that are involved in the development of adipocytes, the regulation of lipid deposition and lipid mobilization, and the maintenance of cellular cholesterol homeostasis.\r\nWe expect to discover important components of the eukaryotic proteo-lipidome. Our results will significantly advance the understanding of lipid and energy metabolism and may provide novel durg targets for the treatment of metabolic diseases."},"begin_planned":"2005-12-01T01:00:00+01:00","begin_effective":"2006-02-01T01:00:00+01:00","end_planned":"2008-11-30T01:00:00+01:00","end_effective":"2008-11-30T01:00:00+01:00","assignment":"2006-03-02T10:14:41+01:00","program":73,"subprogram":null,"organization":14019,"category":10,"type":10,"partner_function":2,"manager":51974,"contact":51974,"status":2,"research":1,"grant":10,"event":null,"study":null,"language":null,"funders":[152],"funder_projectcode":null,"ethics_committee":null,"edudract_number":null,"persons":["737-51974-10"]},{"id":287,"title":{"de":"PEROXISOMES: Integrated Project to decipher the biological function of peroxisomes in health and disease","en":"PEROXISOMES: Integrated Project to decipher the biological function of peroxisomes in health and disease"},"short":"Peroxisomes","url":null,"abstract":{"de":"Although peroxisomes are essential for life, the various functions and dynamics of this organelle in health and disease are only poorly understood. Most inherited peroxisomal disorders in humans have a low incidence but collectively they represent an enormous burden on affected individuals, families and society. A detailed understanding of biogenesis and function of this organelle is required for developing therapeutic strategies. To bridge the gap between the scarce knowledge about peroxisomes and their importance for living organisms, we will establish genomic, proteomic and metabolomic platforms focussed on peroxisomes. We will identify novel peroxisomal matrix and membrane proteins and gather comprehensive knowledge about their functions. Using this information, we should be able to decipher the molecular mechanism of so far uncharacterised peroxisomal disorders and open up novel diagnostic and therapeutic opportunities. Genome-wide gene expression and biochemical analyses of 14 different mouse models of  peroxisomal deficiencies will reveal why differing phenotypes occur even when the same metabolic pathway is disturbed. Mouse genetics will be used to evaluate the role of peroxisomes in different cell types during development and in adulthood. Because evidence is emerging for a role of peroxisomes as modulators in diseases of complex inheritance, such as arteriosclerosis, cancer and Alzheimer's disease, we will screen appropriate databases to detect dysregulation of genes encoding peroxisomal proteins. Tissue microarray analysis, cDNA chip and quantitative RT-PCR analysis will be used to verify the results with the final goal to develop diagnostic tools. The role of peroxisomes in Alzheimer's disease and in chronic metabolic liver diseases will be analysed and the biogenesis and dynamics of this organelle deciphered. Only with this integrated EU project will we be able to elucidate the role of peroxisomes in living organisms in the near future.","en":"Although peroxisomes are essential for life, the various functions and dynamics of this organelle in health and disease are only poorly understood. Most inherited peroxisomal disorders in humans have a low incidence but collectively they represent an enormous burden on affected individuals, families and society. A detailed understanding of biogenesis and function of this organelle is required for developing therapeutic strategies. To bridge the gap between the scarce knowledge about peroxisomes and their importance for living organisms, we will establish genomic, proteomic and metabolomic platforms focussed on peroxisomes. We will identify novel peroxisomal matrix and membrane proteins and gather comprehensive knowledge about their functions. Using this information, we should be able to decipher the molecular mechanism of so far uncharacterised peroxisomal disorders and open up novel diagnostic and therapeutic opportunities. Genome-wide gene expression and biochemical analyses of 14 different mouse models of  peroxisomal deficiencies will reveal why differing phenotypes occur even when the same metabolic pathway is disturbed. Mouse genetics will be used to evaluate the role of peroxisomes in different cell types during development and in adulthood. Because evidence is emerging for a role of peroxisomes as modulators in diseases of complex inheritance, such as arteriosclerosis, cancer and Alzheimer's disease, we will screen appropriate databases to detect dysregulation of genes encoding peroxisomal proteins. Tissue microarray analysis, cDNA chip and quantitative RT-PCR analysis will be used to verify the results with the final goal to develop diagnostic tools. The role of peroxisomes in Alzheimer's disease and in chronic metabolic liver diseases will be analysed and the biogenesis and dynamics of this organelle deciphered. Only with this integrated EU project will we be able to elucidate the role of peroxisomes in living organisms in the near future."},"begin_planned":"2005-01-01T01:00:00+01:00","begin_effective":"2005-01-01T01:00:00+01:00","end_planned":"2008-12-31T01:00:00+01:00","end_effective":"2008-12-31T01:00:00+01:00","assignment":"2005-10-26T02:00:00+02:00","program":21,"subprogram":"Life sciences, genomics and biotechnology for health","organization":14020,"category":10,"type":10,"partner_function":2,"manager":51691,"contact":51691,"status":2,"research":1,"grant":10,"event":null,"study":null,"language":null,"funders":[10],"funder_projectcode":null,"ethics_committee":null,"edudract_number":null,"persons":["287-51691-10"]},{"id":1748,"title":{"de":"Anbahnungsfinanzierung Healthcare integrated Biobanking RP7 Health 1. Stufe","en":"Anbahnungsfinanzierung Healthcare integrated Biobanking RP7 Health 1. Stufe"},"short":"HEALTHCARE_INTEGR_BIOBANKING","url":null,"abstract":{"de":null,"en":null},"begin_planned":"2008-09-03T02:00:00+02:00","begin_effective":"2008-09-03T02:00:00+02:00","end_planned":"2008-12-31T01:00:00+01:00","end_effective":"2008-12-31T01:00:00+01:00","assignment":"2009-02-17T13:36:04+01:00","program":54,"subprogram":null,"organization":14020,"category":10,"type":10,"partner_function":4,"manager":51663,"contact":51663,"status":2,"research":5,"grant":10,"event":null,"study":null,"language":null,"funders":[416],"funder_projectcode":"821139","ethics_committee":null,"edudract_number":null,"persons":["1748-51663-10"]},{"id":1435,"title":{"de":"STYJOBS - Interventionsoptimierung","en":"STYJOBS - Interventionsoptimierung"},"short":"STYJOBS_INTERVENT","url":null,"abstract":{"de":"Das Projekt STYJOBS (STYrian Juvenile OBesity Study) befasst sich mit der Prävention und Theragnostik von Atherosklerose und Adipositas assoziierten Folgeerkrankungen. Aufbauend auf den bisher durchgeführten Arbeiten soll STYJOBS zu einem besseren Verständnis des Zusammenhanges zwischen Adipositas, Ess-Sucht, Entzündungsreaktionen, oxidativem Stress, genetischer Disposition, Atherosklerose und den assoziierten metabolischen Veränderungen (z.B.:Typ 2 Diabetes mellitus) führen. Dies ist eine unabdingbare Voraussetzung für eine effiziente Vorbeugung von Herzinfarkt und Schlaganfall, den häufigsten Todesursachen in unserem Bundesland.\r\nEin integraler Bestandteil von STYJOBS ist die Durchführung und Verbesserung von Interventionsmaßnahmen bei Adipositas. Aufbauend auf eine im Jahr 2006 durchgeführte umfassend evaluierte Erstintervention wird derzeit eine weitere Intervention unter besonderer Addressierung des Suchtfaktors durchgeführt. Dabei werden unter anderem neue objektive Wege der bildgebenden noninvasiven Diagnostik von dopaminergen Regelkreisen zur Kontrolle des Sättigungsverhaltens beschritten. Mit den solcherart gewonnenen Erkenntnissen soll primär sucht-disponierten adipösen jungen Menschen in Zukunft effektiver geholfen werden.","en":"Das Projekt STYJOBS (STYrian Juvenile OBesity Study) befasst sich mit der Prävention und Theragnostik von Atherosklerose und Adipositas assoziierten Folgeerkrankungen. Aufbauend auf den bisher durchgeführten Arbeiten soll STYJOBS zu einem besseren Verständnis des Zusammenhanges zwischen Adipositas, Ess-Sucht, Entzündungsreaktionen, oxidativem Stress, genetischer Disposition, Atherosklerose und den assoziierten metabolischen Veränderungen (z.B.:Typ 2 Diabetes mellitus) führen. Dies ist eine unabdingbare Voraussetzung für eine effiziente Vorbeugung von Herzinfarkt und Schlaganfall, den häufigsten Todesursachen in unserem Bundesland.\r\nEin integraler Bestandteil von STYJOBS ist die Durchführung und Verbesserung von Interventionsmaßnahmen bei Adipositas. Aufbauend auf eine im Jahr 2006 durchgeführte umfassend evaluierte Erstintervention wird derzeit eine weitere Intervention unter besonderer Addressierung des Suchtfaktors durchgeführt. Dabei werden unter anderem neue objektive Wege der bildgebenden noninvasiven Diagnostik von dopaminergen Regelkreisen zur Kontrolle des Sättigungsverhaltens beschritten. Mit den solcherart gewonnenen Erkenntnissen soll primär sucht-disponierten adipösen jungen Menschen in Zukunft effektiver geholfen werden."},"begin_planned":"2007-05-01T02:00:00+02:00","begin_effective":"2007-05-01T02:00:00+02:00","end_planned":"2008-12-31T01:00:00+01:00","end_effective":"2008-12-31T01:00:00+01:00","assignment":"2008-01-07T13:23:48+01:00","program":null,"subprogram":null,"organization":14028,"category":10,"type":10,"partner_function":4,"manager":52854,"contact":52854,"status":2,"research":2,"grant":10,"event":null,"study":null,"language":null,"funders":[135],"funder_projectcode":null,"ethics_committee":null,"edudract_number":null,"persons":["1435-52854-10"]},{"id":1320,"title":{"de":"Mikrobiologische Untersuchungen in steirischen Weinkellern","en":"Mikrobiologische Untersuchungen in steirischen Weinkellern"},"short":"MIKROBIOLOG_STEIR_WEINKELLER","url":null,"abstract":{"de":"Im geplanten Forschungsprojekt sollte eine erste umfangreiche Evaluierung der steirischen Weinkeller im Hinblick auf das Vorkommen von unerwünschten Mikroorganismen (Schimmelpilzen und Bakterien) durchgeführt werden und die Beeinflussung von Bioaerosolen auf die Weinherstellung untersucht werden.\r\nÜber einen Zetruaum von zwei Jahren sollten dabei in der Steiermark 40 verschiedene Weinkeller (unter Berücksichtigung unterschiedlicher baulicher Parameter) untersucht werden. Anhand von quantitativen und qualitativen Analysen sollte untersucht werden, in welchem Ausmaß Mikroorganismen Kellerräume belasten und in Folge die Qualität des Weines beeinträchtigen könnten. \r\nDie Untersuchungen über die Menge und Zusammenstezung der Mikroflora in Weinkellern sind sowohl für den Weinherstellungsprozess als auch aus Gründen des Arbeitnehmerschutzes von großer Bedeutung.","en":"Im geplanten Forschungsprojekt sollte eine erste umfangreiche Evaluierung der steirischen Weinkeller im Hinblick auf das Vorkommen von unerwünschten Mikroorganismen (Schimmelpilzen und Bakterien) durchgeführt werden und die Beeinflussung von Bioaerosolen auf die Weinherstellung untersucht werden.\r\nÜber einen Zetruaum von zwei Jahren sollten dabei in der Steiermark 40 verschiedene Weinkeller (unter Berücksichtigung unterschiedlicher baulicher Parameter) untersucht werden. Anhand von quantitativen und qualitativen Analysen sollte untersucht werden, in welchem Ausmaß Mikroorganismen Kellerräume belasten und in Folge die Qualität des Weines beeinträchtigen könnten. \r\nDie Untersuchungen über die Menge und Zusammenstezung der Mikroflora in Weinkellern sind sowohl für den Weinherstellungsprozess als auch aus Gründen des Arbeitnehmerschutzes von großer Bedeutung."},"begin_planned":"2007-02-01T01:00:00+01:00","begin_effective":"2006-11-01T01:00:00+01:00","end_planned":"2008-12-31T01:00:00+01:00","end_effective":"2008-12-31T01:00:00+01:00","assignment":"2007-07-03T10:07:42+02:00","program":null,"subprogram":null,"organization":14023,"category":10,"type":10,"partner_function":4,"manager":51674,"contact":51674,"status":2,"research":2,"grant":10,"event":null,"study":null,"language":null,"funders":[135],"funder_projectcode":null,"ethics_committee":null,"edudract_number":null,"persons":["1320-51674-10"]},{"id":1506,"title":{"de":"PRIVILEGED","en":"PRIVILEGED"},"short":"PRIVILEGED","url":null,"abstract":{"de":"PRIVILEGED (Privacy in Law, Ethics and Genetic Data) will make recommendations for research practice and public policy-making, including regulatory options at the national and European level, to promote the optimal relation between research using genetic data and bio-banks and ethical interests in privacy. PRIVILEGED will identify, analyse and compare plural ethical, cultural and social concepts of legitimate privacy interest engaged by research using genetic database and bio-banks. It will articulate the relation between such concepts and the current regulation of research using genetic data and bio-banks.\r\nPRIVILEGED will bring together experts in medicine, public health, philosophy, ethics, sience and law from across the whole research area. A series of workshops, web-resources, national and comparaive papers will be co-ordinated through three centres (Lthuania, Portugal and the UK) to address points of both potential conflict and synergy within and between the interests of science and privacy, individual and groups, and diverse cultures and fundamental ethical principles.","en":"PRIVILEGED (Privacy in Law, Ethics and Genetic Data) will make recommendations for research practice and public policy-making, including regulatory options at the national and European level, to promote the optimal relation between research using genetic data and bio-banks and ethical interests in privacy. PRIVILEGED will identify, analyse and compare plural ethical, cultural and social concepts of legitimate privacy interest engaged by research using genetic database and bio-banks. It will articulate the relation between such concepts and the current regulation of research using genetic data and bio-banks.\r\nPRIVILEGED will bring together experts in medicine, public health, philosophy, ethics, sience and law from across the whole research area. A series of workshops, web-resources, national and comparaive papers will be co-ordinated through three centres (Lthuania, Portugal and the UK) to address points of both potential conflict and synergy within and between the interests of science and privacy, individual and groups, and diverse cultures and fundamental ethical principles."},"begin_planned":"2006-01-01T01:00:00+01:00","begin_effective":"2006-01-01T01:00:00+01:00","end_planned":"2008-12-31T01:00:00+01:00","end_effective":"2008-12-31T01:00:00+01:00","assignment":"2008-04-03T17:43:24+02:00","program":21,"subprogram":null,"organization":14045,"category":10,"type":10,"partner_function":2,"manager":null,"contact":null,"status":2,"research":2,"grant":10,"event":null,"study":null,"language":null,"funders":[10],"funder_projectcode":null,"ethics_committee":null,"edudract_number":null,"persons":[]},{"id":999,"title":{"de":"Einfluss vom ET/ET Rezeptor System auf die Apoptose in Plazenten aus normalen und pathologischen Schwangerschaften","en":"Einfluss vom ET/ET Rezeptor System auf die Apoptose in Plazenten aus normalen und pathologischen Schwangerschaften"},"short":"APOPTOSE_PLAZENTE","url":null,"abstract":{"de":"Apoptose ist ein kontrollierter Prozess des natürlichen Zelltods, ein physiologisches und erwünschtes Geschehen. Leider, gibt es viele Krankheiten die mit einer abnormen Apoptose in verschiedenen Organen verbunden oder sogar durch sie verursacht sind. In Schwangerschaften die durch Diabetes, Präeklampsie und fetale Wachstumsretardierung kompliziert sind, wurde eine erhöhte Apoptose in der Plazenta nachgewiesen. Endotheline, besonders Endothelin-1, und ihre Rezeptoren: ETA und ETB, könnten in diesen pathologischen Umständen eine wichtige Rolle spielen. Wegen des starken Einflusses von Endothelin-1 auf Proliferation, Invasion und Apoptose bei Karzinomzellen, verbindet man diese Substanz immer mehr mit ähnlichen Zellprozessen bei Trophoblastzellen.\r\n In der Inneren Medizin versucht man schon erfolgreich dem unerwünschten Effekt der Endotheline mit ihren Rezeptor-Antagonisten vorzubeugen. \r\nDas Ziel dieser Studie ist die physiologische Darstellung der Rolle dieses Systems in der Apoptose der normalen Plazenta, und die Erforschung der Veränderungen des Systems bei den Krankheiten mit erhöhter Apoptose in der Plazenta, wie diabetischen, präeklamptischen Schwangerschaften und Schwangerschaften mit der fetalen Wachstumsretardierung.","en":"Apoptose ist ein kontrollierter Prozess des natürlichen Zelltods, ein physiologisches und erwünschtes Geschehen. Leider, gibt es viele Krankheiten die mit einer abnormen Apoptose in verschiedenen Organen verbunden oder sogar durch sie verursacht sind. In Schwangerschaften die durch Diabetes, Präeklampsie und fetale Wachstumsretardierung kompliziert sind, wurde eine erhöhte Apoptose in der Plazenta nachgewiesen. Endotheline, besonders Endothelin-1, und ihre Rezeptoren: ETA und ETB, könnten in diesen pathologischen Umständen eine wichtige Rolle spielen. Wegen des starken Einflusses von Endothelin-1 auf Proliferation, Invasion und Apoptose bei Karzinomzellen, verbindet man diese Substanz immer mehr mit ähnlichen Zellprozessen bei Trophoblastzellen.\r\n In der Inneren Medizin versucht man schon erfolgreich dem unerwünschten Effekt der Endotheline mit ihren Rezeptor-Antagonisten vorzubeugen. \r\nDas Ziel dieser Studie ist die physiologische Darstellung der Rolle dieses Systems in der Apoptose der normalen Plazenta, und die Erforschung der Veränderungen des Systems bei den Krankheiten mit erhöhter Apoptose in der Plazenta, wie diabetischen, präeklamptischen Schwangerschaften und Schwangerschaften mit der fetalen Wachstumsretardierung."},"begin_planned":"2007-01-01T01:00:00+01:00","begin_effective":"2007-01-01T01:00:00+01:00","end_planned":"2008-12-31T01:00:00+01:00","end_effective":"2009-12-31T01:00:00+01:00","assignment":"2007-01-15T14:20:10+01:00","program":null,"subprogram":null,"organization":14064,"category":10,"type":10,"partner_function":4,"manager":51978,"contact":51978,"status":2,"research":2,"grant":10,"event":null,"study":null,"language":null,"funders":[12],"funder_projectcode":null,"ethics_committee":null,"edudract_number":null,"persons":["999-51978-10"]},{"id":1004,"title":{"de":"Genetische Risikofaktoren von Plattenepithelkarzinomen und Plattenepithelpräkanzerosen des oberen Respiration- und Digestionstraktes","en":"Genetische Risikofaktoren von Plattenepithelkarzinomen und Plattenepithelpräkanzerosen des oberen Respiration- und Digestionstraktes"},"short":"GEN_PLATTENEPITHEL","url":null,"abstract":{"de":"Die weitaus häufigste Form bösartiger Neubildungen im HNO-Bereich stellt unabhängig von der anatomischen Lage mit über 90% das Plattenepithelkarzinom dar. Bisherige Diagnose- und Therapieverfahren stoßen durch die enorme Heterogenität, sowohl der Entstehung, als auch des weiteren Verlaufes maligner Erkrankungen an ihre Grenzen.\r\nZiel der Studie ist der Aufbau einer DNA- und Serumbank mit dem Ziel der Charakterisierung molekularer Polymorphismen und Blutparameter, die mit der Entstehung und der Tumorbiologie oraler Plattenepithelkarzinome und deren Vorläufern in Verbindung stehen. Des weiteren die Beschreibung neuer genetischer Varianten, die einen Zusammenhang mit der beschrebenen Neoplasie aufweisen.","en":"Die weitaus häufigste Form bösartiger Neubildungen im HNO-Bereich stellt unabhängig von der anatomischen Lage mit über 90% das Plattenepithelkarzinom dar. Bisherige Diagnose- und Therapieverfahren stoßen durch die enorme Heterogenität, sowohl der Entstehung, als auch des weiteren Verlaufes maligner Erkrankungen an ihre Grenzen.\r\nZiel der Studie ist der Aufbau einer DNA- und Serumbank mit dem Ziel der Charakterisierung molekularer Polymorphismen und Blutparameter, die mit der Entstehung und der Tumorbiologie oraler Plattenepithelkarzinome und deren Vorläufern in Verbindung stehen. Des weiteren die Beschreibung neuer genetischer Varianten, die einen Zusammenhang mit der beschrebenen Neoplasie aufweisen."},"begin_planned":"2006-01-01T01:00:00+01:00","begin_effective":"2006-07-01T02:00:00+02:00","end_planned":"2008-12-31T01:00:00+01:00","end_effective":"2008-12-31T01:00:00+01:00","assignment":"2007-01-15T14:23:09+01:00","program":null,"subprogram":null,"organization":14068,"category":10,"type":10,"partner_function":4,"manager":50670,"contact":50670,"status":2,"research":2,"grant":10,"event":null,"study":null,"language":null,"funders":[135],"funder_projectcode":null,"ethics_committee":null,"edudract_number":null,"persons":["1004-50670-10"]},{"id":585,"title":{"de":"Charakterisierung von kardiovaskulären TRPC3 Kanälen (Teilprojekt)","en":"Characterization of cardiovascular TRPC3 channels (Teilprojekt)"},"short":"Char. of cardiovascular TRPC3 channels","url":null,"abstract":{"de":"Over the past decade, evidence for a pivotal role of TRP (transient receptor potential) proteins in cellular Ca2+ signaling has accumulated, and the concept of TRP signaling complexes as a potential pharmacological target has emerged. TRPC proteins form cation channel complexes and are considered as highly versatile signal transduction molecules. Results obtained in heterologous expression systems suggest TRPC3 as a paradigm of multifunctional signal transduction. Due to its ability to form signalplexes with a variety of signaling partners, TRPC3 may serve cellular CA2+ signaling by multiple mechanisms and may control a variety of diestinct physiological functions. In the cardiovascular system, TRPC3 is a prominent TRPC species in endothelial cells and cardiac myocytes. The structure, regulation and functional role of cardiovascular TRPC3 channel complexes remain still elusive. Open questions that will be addressed in this project are: i) What are the pore-forming interaction partners of TRPC3 in native cardiovascular TRPC3 channel complexes, and what is the role of specific subunits as determinants of chanel function? ii) What is the physiological significance of interactions between TRPC3 and cardiovascular signaling molecules such as caveolin-1 and NCX1 in terms of channel gating and/or transduction of input stimuli into distinct Ca2+ signals? These topics will be investigated using native macro- and microvascular endothelial cell as well as cardiac myocytes. The employed methods comprise classical techniques for subcellular localization of signaling molecules and for analysis of protein-protein interactions as well as subunit stoichiometry such as immunocytochemistry, immunoprecipitation and GST-pulldown experiments as well as analysis of mutation-induced changes in channel properties. These classical methods will be complemented by detection of protein-protein interactions within TRPC signalplexes with FRET- and single molecule-microscopy and by proteomic aööroaches to identify novel signaling partners of TRPC3. The function of cardiovascular TRPC signalplexes will be analyzed by simultaneous measurement of membrane currents and intracellular ion concentrations. The proposed rigorous analysis of the molecular organization, function and physiological role of cardiovascular TRPC3 channels is suggested as an important step towards exploiting endothelial TRPC proteins as a therapeutic target. ","en":"Over the past decade, evidence for a pivotal role of TRP (transient receptor potential) proteins in cellular Ca2+ signaling has accumulated, and the concept of TRP signaling complexes as a potential pharmacological target has emerged. TRPC proteins form cation channel complexes and are considered as highly versatile signal transduction molecules. Results obtained in heterologous expression systems suggest TRPC3 as a paradigm of multifunctional signal transduction. Due to its ability to form signalplexes with a variety of signaling partners, TRPC3 may serve cellular CA2+ signaling by multiple mechanisms and may control a variety of diestinct physiological functions. In the cardiovascular system, TRPC3 is a prominent TRPC species in endothelial cells and cardiac myocytes. The structure, regulation and functional role of cardiovascular TRPC3 channel complexes remain still elusive. Open questions that will be addressed in this project are: i) What are the pore-forming interaction partners of TRPC3 in native cardiovascular TRPC3 channel complexes, and what is the role of specific subunits as determinants of chanel function? ii) What is the physiological significance of interactions between TRPC3 and cardiovascular signaling molecules such as caveolin-1 and NCX1 in terms of channel gating and/or transduction of input stimuli into distinct Ca2+ signals? These topics will be investigated using native macro- and microvascular endothelial cell as well as cardiac myocytes. The employed methods comprise classical techniques for subcellular localization of signaling molecules and for analysis of protein-protein interactions as well as subunit stoichiometry such as immunocytochemistry, immunoprecipitation and GST-pulldown experiments as well as analysis of mutation-induced changes in channel properties. These classical methods will be complemented by detection of protein-protein interactions within TRPC signalplexes with FRET- and single molecule-microscopy and by proteomic aööroaches to identify novel signaling partners of TRPC3. The function of cardiovascular TRPC signalplexes will be analyzed by simultaneous measurement of membrane currents and intracellular ion concentrations. The proposed rigorous analysis of the molecular organization, function and physiological role of cardiovascular TRPC3 channels is suggested as an important step towards exploiting endothelial TRPC proteins as a therapeutic target. "},"begin_planned":"2006-01-01T01:00:00+01:00","begin_effective":"2006-01-01T01:00:00+01:00","end_planned":"2008-12-31T01:00:00+01:00","end_effective":"2008-12-31T01:00:00+01:00","assignment":"2005-11-14T16:35:00+01:00","program":72,"subprogram":null,"organization":14013,"category":10,"type":10,"partner_function":2,"manager":51705,"contact":51705,"status":2,"research":1,"grant":10,"event":null,"study":null,"language":null,"funders":[9],"funder_projectcode":"P18280","ethics_committee":null,"edudract_number":null,"persons":["585-51705-10"]},{"id":1469,"title":{"de":"Evaluation of Neuroproteins as Biomarkers for Traumatic Brain Injury in Pediatric Patients","en":"Evaluation of Neuroproteins as Biomarkers for Traumatic Brain Injury in Pediatric Patients"},"short":"TRAUMATIC_BRAIN_INJURY","url":null,"abstract":{"de":"Berichte in der Literatur und eigene Untersuchungen lassen auf einen diagnostischen und ökonomischen Vorteil durch die Bestimmung von Neuroproteinen bei Patienten mit Schädel-Hirn-Trauma schließen. Bisher kann bei einem negativen Testergebnis eine signifikante Läsion mit Sicherheit ausgeschlossen, bei einem positiven aber nicht als bewiesen angesehen werden. Um nähere Erkenntnisse über Funktion und Regulation von S-100B, GFAP, MBP, NSE und CTP zu erhalten, sind Untersuchungen an einem großen pädiatrischen Kollektiv erforderlich. S-100B wurde bereits in einer groß angelegten Untersuchung durch die Antragsteller (n=300)evaluiert. Ziel dieser Untersuchung ist es, die anderen 4 Biomarker im selben Kollektiv zu analysieren. Weiters sollen Normwerte der untersuchten Marker für die kindliche Population anhand eines gesunden Kollektives aufgestellt werden, da diese bisher nur für Erwachsene bestimmt wurden und ein Rückschluss auf Kinder nicht unbedingt möglich ist.","en":"Berichte in der Literatur und eigene Untersuchungen lassen auf einen diagnostischen und ökonomischen Vorteil durch die Bestimmung von Neuroproteinen bei Patienten mit Schädel-Hirn-Trauma schließen. Bisher kann bei einem negativen Testergebnis eine signifikante Läsion mit Sicherheit ausgeschlossen, bei einem positiven aber nicht als bewiesen angesehen werden. Um nähere Erkenntnisse über Funktion und Regulation von S-100B, GFAP, MBP, NSE und CTP zu erhalten, sind Untersuchungen an einem großen pädiatrischen Kollektiv erforderlich. S-100B wurde bereits in einer groß angelegten Untersuchung durch die Antragsteller (n=300)evaluiert. Ziel dieser Untersuchung ist es, die anderen 4 Biomarker im selben Kollektiv zu analysieren. Weiters sollen Normwerte der untersuchten Marker für die kindliche Population anhand eines gesunden Kollektives aufgestellt werden, da diese bisher nur für Erwachsene bestimmt wurden und ein Rückschluss auf Kinder nicht unbedingt möglich ist."},"begin_planned":"2008-01-01T01:00:00+01:00","begin_effective":"2008-01-01T01:00:00+01:00","end_planned":"2008-12-31T01:00:00+01:00","end_effective":"2009-06-30T02:00:00+02:00","assignment":"2008-02-07T17:45:07+01:00","program":79,"subprogram":null,"organization":14049,"category":10,"type":10,"partner_function":4,"manager":50785,"contact":50785,"status":2,"research":2,"grant":10,"event":null,"study":null,"language":null,"funders":[12],"funder_projectcode":null,"ethics_committee":null,"edudract_number":null,"persons":["1469-50785-10","1469-51344-11","1469-58794-11"]},{"id":1313,"title":{"de":"GENOPTIKUM","en":"GENOPTIKUM"},"short":"GENOPTIKUM","url":null,"abstract":{"de":"GENOPTIKUM is an interactive data exploration system for the \"visualization of\" and \" navigation in\" molecular and clinical data in the field of personalized medicine. GENOPTIKUM addresses the essential but to date unsolved problem of how to identify connections between genetic variants and their corresponding diseases or the response to certain drugs and treatments, respectively. It is, therefore, necessary to connect gene data and clinical data in order to categorise specific subgroups of patients with certain disease features. The huge amount of data provided by molecular analytical methods (genetic polymorphisms, gene expression data, proteomics) can only be analysed by applying statistical methods and bioinformatics. However, even standard methods of statistics and bioinformatics fail when the data are inhomogeneous - as is the case with clinical data - and when data structures are obscured by noise and dominant patterns","en":"GENOPTIKUM is an interactive data exploration system for the \"visualization of\" and \" navigation in\" molecular and clinical data in the field of personalized medicine. GENOPTIKUM addresses the essential but to date unsolved problem of how to identify connections between genetic variants and their corresponding diseases or the response to certain drugs and treatments, respectively. It is, therefore, necessary to connect gene data and clinical data in order to categorise specific subgroups of patients with certain disease features. The huge amount of data provided by molecular analytical methods (genetic polymorphisms, gene expression data, proteomics) can only be analysed by applying statistical methods and bioinformatics. However, even standard methods of statistics and bioinformatics fail when the data are inhomogeneous - as is the case with clinical data - and when data structures are obscured by noise and dominant patterns"},"begin_planned":"2007-01-01T01:00:00+01:00","begin_effective":"2007-08-01T02:00:00+02:00","end_planned":"2008-12-31T01:00:00+01:00","end_effective":"2010-04-30T02:00:00+02:00","assignment":"2007-06-26T15:39:42+02:00","program":null,"subprogram":"FFG-Programm: FIT-IT 5% des Gesamtprojektvolumens wird von der Fa. Oridis in CASH an Unis bezahlt.","organization":14020,"category":10,"type":10,"partner_function":2,"manager":51663,"contact":51663,"status":2,"research":2,"grant":10,"event":null,"study":null,"language":null,"funders":[416],"funder_projectcode":null,"ethics_committee":null,"edudract_number":null,"persons":["1313-51449-12","1313-51663-10"]},{"id":250,"title":{"de":"Translationale Neurogastroenterologie","en":"Translationale Neurogastroenterologie"},"short":"Translationale Neurogastroenterologie","url":null,"abstract":{"de":"Entzündliche und funktionelle Erkrankungen des Magen-Darmtrakts gehen mit einer defekten oder überaktiven Innervation einher. Ein typisches Symptom funktioneller Darmerkrankungen ist abdomineller Schmerz, ohne dass eine Organische Ursache nachweisbar wäre. Diese Symptomatik wird auf eine Überempfindlichkeit des afferenten Systems und auf stressinduzierte Störungen der zentralen Kommunikation zwischen Darm und Gehirn zurückgeführt. Angesichts der beschränkten Behandlungsmöglichkeiten und der Häufigkeit dieser Erkrankungen ist die Entwicklung  wirksamer Therapieoptionen dringend geboten. Das vorliegende Translationale Forschungsprojekt stellt sich dieser Herausforderung, indem es experimentelle Modelle entwickeln und validieren will, die typische Aspekte funktioneller Darmerkrankungen reproduzieren, neue Angriffspunkte für wirksame Medikamente identifizieren und deren quantitative Prüfung ermöglichen.","en":"Entzündliche und funktionelle Erkrankungen des Magen-Darmtrakts gehen mit einer defekten oder überaktiven Innervation einher. Ein typisches Symptom funktioneller Darmerkrankungen ist abdomineller Schmerz, ohne dass eine Organische Ursache nachweisbar wäre. Diese Symptomatik wird auf eine Überempfindlichkeit des afferenten Systems und auf stressinduzierte Störungen der zentralen Kommunikation zwischen Darm und Gehirn zurückgeführt. Angesichts der beschränkten Behandlungsmöglichkeiten und der Häufigkeit dieser Erkrankungen ist die Entwicklung  wirksamer Therapieoptionen dringend geboten. Das vorliegende Translationale Forschungsprojekt stellt sich dieser Herausforderung, indem es experimentelle Modelle entwickeln und validieren will, die typische Aspekte funktioneller Darmerkrankungen reproduzieren, neue Angriffspunkte für wirksame Medikamente identifizieren und deren quantitative Prüfung ermöglichen."},"begin_planned":"2005-03-01T01:00:00+01:00","begin_effective":"2005-03-01T01:00:00+01:00","end_planned":"2008-12-31T01:00:00+01:00","end_effective":"2008-12-31T01:00:00+01:00","assignment":"2005-10-26T02:00:00+02:00","program":71,"subprogram":null,"organization":14022,"category":10,"type":10,"partner_function":4,"manager":51529,"contact":51529,"status":2,"research":1,"grant":10,"event":null,"study":null,"language":null,"funders":[9],"funder_projectcode":"L25","ethics_committee":null,"edudract_number":null,"persons":["250-51529-10"]},{"id":917,"title":{"de":"MICRO-WEDGE","en":"MICRO-WEDGE"},"short":"MICRO-WEDGE","url":null,"abstract":{"de":"Several multicenter clinical trials have provided consistent evidence that implantable defibrillation therapy prolongs patient life. This convincing demonstration of the efficacy of defibrillation has led to a nearly exponential growth, over the last decade, in the number of patients receiving implantable devices. The current wide application of defibrillation raises new concerns regarding the safety and optimization of the therapy. Improved understanding of defibrillation mechanisms is therefore\r\nimperative to the development of better and safer strategies for prevention of sudden cardiac death. Despite the importance of this therapy, understanding of mechanisms by which electric shocks halt life-threatening arrhythmias remains incomplete. While recent experimental advances have provided new characterizations of tissue\r\nresponses to shocks, mechanistic inquiry into the success and failure of defibrillation is hampered by the inability of current experimental techniques to resolve, with sufficient accuracy, electrical behavior confined to the depth of the ventricles.\r\nThe overall objective of this research is, by employing realistic 3D computer simulations, to bring a new level of understanding of the post-shock events in the heart that lead to the failure of the shock. Current models do not incorporate anatomical microheterogeneities, which could play an important role. Specifically, this project proposes to examine, in bidomain models of cardiac micro-structure, mechanisms underlying the ``isoelectric window\", the quiescent period often preceding the first postshock activation following failed shocks. We hypothesize that the isoelectric window arises from small-scale shock-induced polarization, such as polarization of trabeculae and papillary muscle. Understanding the isoelectric window mechanisms could pave the way to new strategies for extending it indefinitely, and thus converting a failed shock into a successful one.","en":"Several multicenter clinical trials have provided consistent evidence that implantable defibrillation therapy prolongs patient life. This convincing demonstration of the efficacy of defibrillation has led to a nearly exponential growth, over the last decade, in the number of patients receiving implantable devices. The current wide application of defibrillation raises new concerns regarding the safety and optimization of the therapy. Improved understanding of defibrillation mechanisms is therefore\r\nimperative to the development of better and safer strategies for prevention of sudden cardiac death.\r\nDespite the importance of this therapy, understanding of mechanisms by which electric shocks halt life-threatening arrhythmias remains incomplete. While recent experimental advances have provided new characterizations of tissue\r\nresponses to shocks, mechanistic inquiry into the success and failure of defibrillation is hampered by the inability of current experimental techniques to resolve, with sufficient accuracy, electrical behavior confined to the depth of the ventricles.\r\nThe overall objective of this research is, by employing realistic 3D computer simulations, to bring a new level of understanding of the post-shock events in the heart that lead to the failure of the shock. Current models do not incorporate anatomical microheterogeneities, which could play an important role. Specifically, this project proposes to examine, in bidomain models of cardiac micro-structure, mechanisms underlying the ``isoelectric window\", the quiescent period often preceding the first postshock activation following failed shocks. We hypothesize that the isoelectric window arises from small-scale shock-induced polarization, such as polarization of trabeculae and papillary muscle. Understanding the isoelectric window mechanisms could pave the way to new strategies for extending it indefinitely, and thus converting a failed shock into a successful one."},"begin_planned":"2006-11-01T01:00:00+01:00","begin_effective":"2006-10-18T02:00:00+02:00","end_planned":"2009-01-31T01:00:00+01:00","end_effective":"2009-01-17T01:00:00+01:00","assignment":"2006-10-11T11:51:03+02:00","program":21,"subprogram":"Marie Curie (Outgoing International Fellowship)","organization":14011,"category":10,"type":10,"partner_function":4,"manager":50966,"contact":50966,"status":2,"research":1,"grant":10,"event":null,"study":null,"language":null,"funders":[10],"funder_projectcode":null,"ethics_committee":null,"edudract_number":null,"persons":["917-50966-10","917-51502-12"]}]}