{"count":2329,"next":"https://api-test.medunigraz.at/v1/research/project/?format=json&limit=20&offset=2000&ordering=-end_planned","previous":"https://api-test.medunigraz.at/v1/research/project/?format=json&limit=20&offset=1960&ordering=-end_planned","results":[{"id":2220,"title":{"de":"Stratifizierung genetischer Veränderungen von malignen Kindertumoren - Grundlage für eine personalisierte Therapie","en":"Stratifizierung genetischer Veränderungen von malignen Kindertumoren - Grundlage für eine personalisierte Therapie"},"short":"MALIGNE KINDERTUMORE","url":null,"abstract":{"de":null,"en":null},"begin_planned":"2010-01-01T01:00:00+01:00","begin_effective":"2010-07-01T02:00:00+02:00","end_planned":"2010-12-31T01:00:00+01:00","end_effective":"2012-12-31T01:00:00+01:00","assignment":"2010-06-09T10:58:03+02:00","program":null,"subprogram":"MAE: IANr. eingetragen (01.06.2010)","organization":14020,"category":10,"type":10,"partner_function":4,"manager":52569,"contact":52569,"status":2,"research":2,"grant":10,"event":null,"study":null,"language":null,"funders":[135],"funder_projectcode":null,"ethics_committee":null,"edudract_number":null,"persons":["2220-52569-10"]},{"id":1702,"title":{"de":"Identification of genes associated with autism spectrum disorder","en":"Identification of genes associated with autism spectrum disorder"},"short":"AUTISM SPECTRUM DISORDER","url":null,"abstract":{"de":"Das \"Autismus-Spektrum\" umfasst insbesondere den frühkindlichen Autismus, den atypischen Autismus und das Asperger-Syndrom. Aufgrund der hohen Konkordanzraten eineiiger Zwillinge geht die Forschung in der Zwischenzeit davon aus, dass Autismus wesentlich auf genetische Ursachen zurückzuführen ist. Durch die in den letzten jahren erfolgte Entwicklung der \"vergleichenden genomischen Hybridisierung (CGH)\" und der sogenannten \"Microarray Analyse\" wird statt nach einzelnen veränderten Bausteinen im Erbgut der Probanden zu suchen, nach ganzen Abschnitten gefahndet, die entweder vollständig fehlen oder aber in doppelter Ausführung vorliegen. Dieser als CNV-Methode (Variationen in der Kopienzahl) bezeichnete Ansatz führte in den letzten beiden Jahren zu ungeahnten Variationen im menschlichen Genom. Unser Konzept im vorliegenden Forschungsantrag sieht vor, 70 bereits gut diagnostizierte Autismus PatientInnen mittels \"state-of-the-art\" Methoden auf Phänotyp-spezifische CNVs zu untersuchen.","en":"Das \"Autismus-Spektrum\" umfasst insbesondere den frühkindlichen Autismus, den atypischen Autismus und das Asperger-Syndrom. Aufgrund der hohen Konkordanzraten eineiiger Zwillinge geht die Forschung in der Zwischenzeit davon aus, dass Autismus wesentlich auf genetische Ursachen zurückzuführen ist. Durch die in den letzten jahren erfolgte Entwicklung der \"vergleichenden genomischen Hybridisierung (CGH)\" und der sogenannten \"Microarray Analyse\" wird statt nach einzelnen veränderten Bausteinen im Erbgut der Probanden zu suchen, nach ganzen Abschnitten gefahndet, die entweder vollständig fehlen oder aber in doppelter Ausführung vorliegen. Dieser als CNV-Methode (Variationen in der Kopienzahl) bezeichnete Ansatz führte in den letzten beiden Jahren zu ungeahnten Variationen im menschlichen Genom. Unser Konzept im vorliegenden Forschungsantrag sieht vor, 70 bereits gut diagnostizierte Autismus PatientInnen mittels \"state-of-the-art\" Methoden auf Phänotyp-spezifische CNVs zu untersuchen."},"begin_planned":"2009-01-01T01:00:00+01:00","begin_effective":"2009-01-01T01:00:00+01:00","end_planned":"2010-12-31T01:00:00+01:00","end_effective":"2011-06-30T02:00:00+02:00","assignment":"2008-12-15T15:19:50+01:00","program":79,"subprogram":null,"organization":14021,"category":10,"type":10,"partner_function":4,"manager":51996,"contact":null,"status":2,"research":1,"grant":10,"event":null,"study":null,"language":null,"funders":[12],"funder_projectcode":null,"ethics_committee":null,"edudract_number":null,"persons":["1702-51996-10"]},{"id":2249,"title":{"de":"Die Rolle des Enzymes Phosphatidylethanolamin -N- Methyltransferase (PEMT) bei der Sekretion von Chylomikronen","en":"Role of the enzyme Phosphatidylethanolamine-N-methyltransferase (PEMT) during secretion of chylomicrons"},"short":"PEMT_CHYLOMICRONS","url":null,"abstract":{"de":null,"en":null},"begin_planned":"2010-04-01T02:00:00+02:00","begin_effective":"2010-04-01T02:00:00+02:00","end_planned":"2010-12-31T01:00:00+01:00","end_effective":"2010-12-31T01:00:00+01:00","assignment":"2010-07-12T11:48:26+02:00","program":null,"subprogram":null,"organization":14013,"category":10,"type":10,"partner_function":4,"manager":null,"contact":null,"status":2,"research":1,"grant":10,"event":null,"study":null,"language":null,"funders":[530],"funder_projectcode":null,"ethics_committee":null,"edudract_number":null,"persons":[]},{"id":979,"title":{"de":"SFB LIPOTOXICITY - Part 04: Lipasen und lipotoxische Lipide in Makrophagen: Rolle in der Atherogenese","en":"SFB LIPOTOXICITY - P04: Lipases and lipotoxic lipids in macrophages: Role in atherogenesis"},"short":"LIPOTOXICITY P04","url":null,"abstract":{"de":"Das Ziel des SFB-LIPOTOX ist die Zusammenführung relevanter Forschungsgruppen um gemeinsam ein zentrales Thema zu bearbeiten, Lipotoxizität. Unter Lipotoxizität versteht man die fehlgesteuerte Aufnahme bzw. Produktion von Fettsäuren und Lipiden, die zur Bildung (lipo)toxischer Substanzen führen, die Dysfunktion von Zellen und Geweben bewirken und im Zelltod enden können. Wir wollen jene metabolischen Vorgänge und molekularen Mechanismen untersuchen, die durch lipotoxische Effektoren ausgelöst werden und die pathologische Basis prävalenter Erkrankungen, wie z.B. dem Metabolischen Syndrom, Typ-2 Diabetes und Atherosklerose darstellen. Dieses hochgesteckte Ziel ist nur durch eine gemeinsame Anstrengung innerhalb eines dynamischen und interaktiven Konsortiums, die weit über die Möglichkeiten innerhalb von Einzelprojektförderungen  hinausgeht, zu erreichen. Durch Einsatz aktueller genomischer, proteomischer und lipidomischer Methoden sollen neue lipotoxische Stoffwechselwege entdeckt werden. Durch Einsatz mutanter Maus- und Hefemodelle werden jene molekulare Mechanismen untersucht, durch die zelluläre Dysfunktion und Zelltod bewirkt werden. Die gewonnenen Erkenntnisse können somit einen wichtigen Beitrag zur Auffindung neuartiger Diagnose- und Behandlungsmethoden leisten.","en":"Das Ziel des SFB-LIPOTOX ist die Zusammenführung relevanter Forschungsgruppen um gemeinsam ein zentrales Thema zu bearbeiten, Lipotoxizität. Unter Lipotoxizität versteht man die fehlgesteuerte Aufnahme bzw. Produktion von Fettsäuren und Lipiden, die zur Bildung (lipo)toxischer Substanzen führen, die Dysfunktion von Zellen und Geweben bewirken und im Zelltod enden können. Wir wollen jene metabolischen Vorgänge und molekularen Mechanismen untersuchen, die durch lipotoxische Effektoren ausgelöst werden und die pathologische Basis prävalenter Erkrankungen, wie z.B. dem Metabolischen Syndrom, Typ-2 Diabetes und Atherosklerose darstellen. Dieses hochgesteckte Ziel ist nur durch eine gemeinsame Anstrengung innerhalb eines dynamischen und interaktiven Konsortiums, die weit über die Möglichkeiten innerhalb von Einzelprojektförderungen  hinausgeht, zu erreichen. Durch Einsatz aktueller genomischer, proteomischer und lipidomischer Methoden sollen neue lipotoxische Stoffwechselwege entdeckt werden. Durch Einsatz mutanter Maus- und Hefemodelle werden jene molekulare Mechanismen untersucht, durch die zelluläre Dysfunktion und Zelltod bewirkt werden. Die gewonnenen Erkenntnisse können somit einen wichtigen Beitrag zur Auffindung neuartiger Diagnose- und Behandlungsmethoden leisten."},"begin_planned":"2007-01-01T01:00:00+01:00","begin_effective":"2007-01-01T01:00:00+01:00","end_planned":"2010-12-31T01:00:00+01:00","end_effective":"2011-03-31T02:00:00+02:00","assignment":"2006-12-27T14:28:13+01:00","program":67,"subprogram":null,"organization":14013,"category":10,"type":10,"partner_function":2,"manager":51904,"contact":51904,"status":2,"research":1,"grant":10,"event":null,"study":null,"language":null,"funders":[9],"funder_projectcode":"F30","ethics_committee":null,"edudract_number":null,"persons":["979-51904-10"]},{"id":1957,"title":{"de":"Genetics of the Dopaminergic System and Smoking Behavior","en":"Genetics of the Dopaminergic System and Smoking Behavior"},"short":"Genetics of the Dopaminergic System","url":null,"abstract":{"de":null,"en":null},"begin_planned":"2009-01-01T01:00:00+01:00","begin_effective":"2009-01-01T01:00:00+01:00","end_planned":"2010-12-30T01:00:00+01:00","end_effective":"2010-12-30T01:00:00+01:00","assignment":"2009-10-23T12:55:40+02:00","program":null,"subprogram":null,"organization":14028,"category":10,"type":10,"partner_function":4,"manager":50910,"contact":50910,"status":2,"research":2,"grant":10,"event":null,"study":null,"language":null,"funders":[135],"funder_projectcode":null,"ethics_committee":null,"edudract_number":null,"persons":["1957-50910-10"]},{"id":2258,"title":{"de":"3D-Densvermessung und Optimierung der OP-Technik mittels Virtual Surgery","en":"3D-morphometry of dens and improvement of surgical technique via virtual surgery"},"short":"3D-Densstudie","url":null,"abstract":{"de":null,"en":null},"begin_planned":"2010-05-01T02:00:00+02:00","begin_effective":"2010-08-01T02:00:00+02:00","end_planned":"2010-12-01T01:00:00+01:00","end_effective":"2011-07-31T02:00:00+02:00","assignment":"2010-07-29T15:54:41+02:00","program":null,"subprogram":null,"organization":14052,"category":10,"type":10,"partner_function":4,"manager":62925,"contact":62925,"status":2,"research":1,"grant":10,"event":null,"study":null,"language":null,"funders":[135],"funder_projectcode":null,"ethics_committee":null,"edudract_number":null,"persons":["2258-62925-10"]},{"id":1613,"title":{"de":"Glukose Monitoring bei der Hemodialyse","en":"Glucose monitoring in hemodialysis"},"short":"GLUCOSEMONITORING_BRIDGE08","url":null,"abstract":{"de":"Ziel des Projekts ist die Entwicklung eines Systems zur automatischen und kontinuierlichen Messung der Glukose bei der Hämodialyse und bei verwandten extrakorporalen Blutbehandlungsverfahren, sowie zur indirekten Bestimmung der Glukosekonzentration im Blut und davon abgeleiteter Größen.","en":"To develop a system for automatic and continuous glucose measurements during hemodialysis and other related extracorporeal blood treatments for indirect estimation of arterial blood glucose and related entities."},"begin_planned":"2008-10-01T02:00:00+02:00","begin_effective":"2008-10-01T02:00:00+02:00","end_planned":"2010-11-30T01:00:00+01:00","end_effective":"2011-03-31T02:00:00+02:00","assignment":"2008-09-02T18:21:16+02:00","program":60,"subprogram":null,"organization":14010,"category":10,"type":10,"partner_function":4,"manager":51834,"contact":51834,"status":2,"research":3,"grant":10,"event":null,"study":null,"language":null,"funders":[416],"funder_projectcode":"818127","ethics_committee":null,"edudract_number":null,"persons":["1613-50404-12","1613-51834-10"]},{"id":1442,"title":{"de":"Single-Molecule Measurements in Solution by FCS/FCCS:","en":"Single-Molecule Measurements in Solution by FCS/FCCS:"},"short":"FLUORESCENCE_CORRELATION_SPECTROSCOPY","url":null,"abstract":{"de":"FWF Austrian Science Fund Project P20454-N13: Stand-Alone Collaborative Research Project with visiting professorships (Forschungsprofessuren) in the USA, Japan and Cairo for about 27 months: dienstzuteilung aboard (im Ausland). \r\n\r\nThe work presented in this authorized and supported project program involves the development of a new analysis technique for single-molecule spectroscopy and imaging. For the first time, it is turned into a potential opportunity. The new concept of analysis of just one single molecule in solution over extended periods of time will make it possible to observe the single molecules without bias to the millisecond range in solution of freely diffusing molecules or to artificial immobilization on surfaces or hydrodynamic focusing. The following main idea is put forward: is it possible to statistically recognize the same molecule multiple times as it diffuses through a small confocal probe volume? If so, the detection time of an individual molecule freely diffusing in solution could be extended. For the new analysis approach, it is crucial to understand the balance between the time scale and the frequency that a single molecule reenters the confocal probe volume and the overall time necessary for the measurement. \r\nThe proposed research will provide with a better understanding of some of the theoretical and experimental backgrounds of these types of analyses and biological or medical applications. The originality and innovative nature of the proposal work reside in the strict coupling of latest microscopic and spectroscopic developments with physiological relevance. The new ideas are comprehensively presented and this relationship is a new concept at the time. Possible users for this concept are those working in biotechnological applications dealing with gene technology. Furthermore, the concept is of interest for a great number of medical, pharmaceutical and bio-chemical laboratories. It may serve as a foundation for further work in single-cell biology and immunology.\r\n\r\nURL: http://topics.scirus.com/Measurements_of_Single_Molecules_in_Solution_and_Live_Cell_at_Time_Scales_That_Are_Currently_Not_Available_Impact_on_Immunology.html","en":"FWF Austrian Science Fund Project P20454-N13: Stand-Alone Collaborative Research Project with visiting professorships (Forschungsprofessuren) in the USA, Japan and Cairo for about 27 months: dienstzuteilung aboard (im Ausland). \r\n\r\nThe work presented in this authorized and supported project program involves the development of a new analysis technique for single-molecule spectroscopy and imaging. For the first time, it is turned into a potential opportunity. The new concept of analysis of just one single molecule in solution over extended periods of time will make it possible to observe the single molecules without bias to the millisecond range in solution of freely diffusing molecules or to artificial immobilization on surfaces or hydrodynamic focusing. The following main idea is put forward: is it possible to statistically recognize the same molecule multiple times as it diffuses through a small confocal probe volume? If so, the detection time of an individual molecule freely diffusing in solution could be extended. For the new analysis approach, it is crucial to understand the balance between the time scale and the frequency that a single molecule reenters the confocal probe volume and the overall time necessary for the measurement. \r\nThe proposed research will provide with a better understanding of some of the theoretical and experimental backgrounds of these types of analyses and biological or medical applications. The originality and innovative nature of the proposal work reside in the strict coupling of latest microscopic and spectroscopic developments with physiological relevance. The new ideas are comprehensively presented and this relationship is a new concept at the time. Possible users for this concept are those working in biotechnological applications dealing with gene technology. Furthermore, the concept is of interest for a great number of medical, pharmaceutical and bio-chemical laboratories. It may serve as a foundation for further work in single-cell biology and immunology.\r\n\r\nURL: http://topics.scirus.com/Measurements_of_Single_Molecules_in_Solution_and_Live_Cell_at_Time_Scales_That_Are_Currently_Not_Available_Impact_on_Immunology.html"},"begin_planned":"2007-12-01T01:00:00+01:00","begin_effective":"2007-12-01T01:00:00+01:00","end_planned":"2010-11-30T01:00:00+01:00","end_effective":"2011-06-20T02:00:00+02:00","assignment":"2008-01-10T15:46:36+01:00","program":72,"subprogram":null,"organization":14046,"category":10,"type":10,"partner_function":2,"manager":null,"contact":null,"status":2,"research":1,"grant":10,"event":null,"study":null,"language":null,"funders":[9],"funder_projectcode":"P20454","ethics_committee":null,"edudract_number":null,"persons":[]},{"id":2318,"title":{"de":"Der Einfluss von molekulargenetischen Veränderungen in TGFß1 auf den Schweregrad von strahlentherapiebedingten Toxizitäten bei Prostatakarzinompatienten.","en":"The association between genetic variants in TGFß1 and radiation induced side effects in prostate cancer patients."},"short":"MOLECULAR GENETIC VARIANTS","url":null,"abstract":{"de":null,"en":null},"begin_planned":"2010-03-01T01:00:00+01:00","begin_effective":"2010-11-01T01:00:00+01:00","end_planned":"2010-11-30T01:00:00+01:00","end_effective":"2011-06-30T02:00:00+02:00","assignment":"2010-09-29T12:46:53+02:00","program":null,"subprogram":null,"organization":14060,"category":10,"type":10,"partner_function":4,"manager":50495,"contact":50495,"status":2,"research":1,"grant":10,"event":null,"study":null,"language":null,"funders":[135],"funder_projectcode":null,"ethics_committee":null,"edudract_number":null,"persons":["2318-50495-10"]},{"id":1505,"title":{"de":"Genetische Determinaten zerebraler Kleingefäßerkrankung","en":"Genetic determinants of cerebral small vessel disease"},"short":"CEREBRALVESSEL_FWF07","url":null,"abstract":{"de":"Die Kleingefäßerkrankung ist die zweithäufigste endemische Schädigung des alternden Gehirns nach Alzheimer Pathologie. Leukoaraiose und Lakunen sind die Hauptläsionen dieser Entität und können mittels Magnet Resonanz (MR) Tomografie des Gehirns dargestellt werden. Bis zu 90% aller Personen über dem 65.Lebensjahr zeigen Laukaraiose unterschiedlichen Schweregrades.\r\nDas Ziel unserer Studie ist die Komplexität der zerebralen Kleingefäßerkrankung auf genetischer Basis aufzutrennen, um ein besseres Verständnis des Pathomechanismus dieser Läsion zu erhalten. Im ersten Schritt werden wir eine genomweite Assoziationsstudie und ein Feinmapping der Kopplungsregionen auf Chromosom 4 und 17 in der Austrian Stroke Prevention Study Kohorte durchführen. Im zweiten Schritt werden wir Familien aus der Basiskohorte der Austrian Stroke Prevention Study rekrutieren. Die Familienmitglieder werden dem selben Studienprookoll unterzogen, wie die Probanden der Basiskohorte. In dieser Familienstudie werden wir Schätzungen zur Vererblichkeit der verschiedenen Läsionscharakteristika und  die genetische Korrelation zwischen diesen Läsionsmerkmalen und ihren Hauptrisikofaktoren berechnen. Das Spektrum möglicher Endophenotypen der zerebraler Kleingefäßerkrankung soll aufgezeigt werden. In der Familienstudie werden wir Gene verifizieren, die mit dieser Hirnschädigung in früheren Studien identifiziert wurden.\r\nDie gleichzeitige Verfügbarkeit einer Familien- und einer populationsbasierenden Kohorte mit identem Protokoll bietet die einmalige Gelegenheit zur Identifizierung relevanter Gene, da Kopplungs- und Assoziationsstudien in Kombination duchgeführt werden können. Die Identifizierung solcher Gene wird unser äußerst unvollständiges pathophysiologisches Verständnis über die zerebrale Kleingefäßerkrankung verbessern und die Entdeckung neuer therapeutischer Ziele ermöglichen.","en":"Cerebral small vessel disease is the second most common endemic entity of the ageing brain following Alzheimer pathology. Its hallmark lesions are leuko-araiosis and lacunar infarctions, which can be non-invasively depicted with brain magnetic resonance imaging. Up to 90% of persons above the age of 65 years present with leuko-araiosis. Lacunes occur less common with a frequency of 6% to 20%. Decreased mobility of the elderly due to disequilibrium and gait abnormalities, and progressive cognitive impairment up to dementia are frequent clinical sequelae of cerebral microangiopathy. Established risk factors are arterial hypertension and advancing age. There does not exist any established treatment yet which allows to modify the evolution of small vessel disease-related brain damage. \r\nThe heritability of leukoaraiosis volume ranges between 55% and 73%. There are no heritability estimates of other characteristics of white matter lesions such as type and progression are available. Similarly, the heritability of other components of small vessel disease such as lacunes, brain atrophy and microbleeds have not yet been investigated yet. Association studies indicated that the APOE, ACE, eNOS, MTHFR genes might be related to these pathologies. We found positive associations with APOE, PON1 as well as the AGT, with considerable evidence for a causal relationship for the latter. Very recently, the results of the first genome wide scan on white matter lesion volume have been reported by the Framingham Heart Study describing a significant LOD score on chromosome 4 and a suggestive LOD score for linkage on chromosome 17.\r\n \tThe aim of our study is to genetically dissect the complexity of cerebral small vessel disease in order to better understand the pathomechanisms leading to these lesions. First we will apply genome wide association as well as fine map the linkage regions on Chr 4 and 17 in the the Austrian Stroke Prevention Study cohort, which is one of the largest community-dwelling studies on cerebral small vessel disease and the study with the longest MRI follow up so far. Second, we will recruit families ascertained through participants of the Austrian Stroke Prevention Study. Family members will undergo the same study protocol including brain MRI as the probands in the population based cohort. In the family based cohort we will estimate heritability of and genetic correlation between different lesion characteristics of cerebral small vessel disease and its major risk factors. We aim to develop a spectrum of possible endophenotypes for cerebral small vessel disease. In the family based cohort we also aim to verify genes associated with cerebral small vessel disease in previous studies. \r\nThe co-existence of a family and a population based cohort characterized with identical study protocol will offer a unique and outstanding resource to identify genes by allowing for the combined use of linkage and association. Knowledge of genes involved in cerebral small vessel disease will improve our understanding of the pathogenesis of these lesions and will possibly facilitate the development of novel therapeutic targets.\r\n"},"begin_planned":"2007-11-01T01:00:00+01:00","begin_effective":"2008-05-01T02:00:00+02:00","end_planned":"2010-10-31T02:00:00+02:00","end_effective":"2012-12-31T01:00:00+01:00","assignment":"2008-03-31T18:04:38+02:00","program":72,"subprogram":null,"organization":14013,"category":10,"type":10,"partner_function":4,"manager":51912,"contact":51912,"status":2,"research":1,"grant":10,"event":null,"study":null,"language":null,"funders":[9],"funder_projectcode":"P20545","ethics_committee":null,"edudract_number":null,"persons":["1505-51912-10"]},{"id":2323,"title":{"de":"Computermodelle strukturell degenerativer Herzerkrankungen","en":"Computermodelle strukturell degenerativer Herzerkrankungen"},"short":"Computermodelle Herzerkrankung","url":null,"abstract":{"de":null,"en":null},"begin_planned":"2010-11-01T01:00:00+01:00","begin_effective":"2010-11-01T01:00:00+01:00","end_planned":"2010-10-31T02:00:00+02:00","end_effective":"2010-07-31T02:00:00+02:00","assignment":"2010-10-05T11:55:03+02:00","program":null,"subprogram":null,"organization":14011,"category":10,"type":10,"partner_function":1,"manager":51502,"contact":51502,"status":2,"research":2,"grant":10,"event":null,"study":null,"language":null,"funders":[135],"funder_projectcode":null,"ethics_committee":null,"edudract_number":null,"persons":["2323-51502-10"]},{"id":1944,"title":{"de":"The role of HOXB4 in renal development, maldevelopment of the kidney and tumorigeneses of renal neoplasms","en":"The role of HOXB4 in renal development, maldevelopment of the kidney and tumorigeneses of renal neoplasms"},"short":"ROLE OF HOXB4","url":null,"abstract":{"de":null,"en":null},"begin_planned":"2009-11-01T01:00:00+01:00","begin_effective":"2009-11-01T01:00:00+01:00","end_planned":"2010-10-31T02:00:00+02:00","end_effective":"2010-10-31T02:00:00+02:00","assignment":"2009-10-07T13:44:40+02:00","program":null,"subprogram":null,"organization":14020,"category":10,"type":10,"partner_function":4,"manager":52569,"contact":null,"status":2,"research":1,"grant":10,"event":null,"study":null,"language":null,"funders":[530],"funder_projectcode":null,"ethics_committee":null,"edudract_number":null,"persons":["1944-52569-10"]},{"id":2305,"title":{"de":"Anbahnungsfinanzierung (DEVAG) - Projektnummer: 829019","en":"Anbahnungsfinanzierung (DEVAG)"},"short":"DEVAG","url":null,"abstract":{"de":null,"en":null},"begin_planned":"2010-06-03T02:00:00+02:00","begin_effective":"2010-07-01T02:00:00+02:00","end_planned":"2010-10-13T02:00:00+02:00","end_effective":"2010-10-16T02:00:00+02:00","assignment":"2010-09-17T11:46:55+02:00","program":54,"subprogram":null,"organization":14038,"category":10,"type":10,"partner_function":4,"manager":51632,"contact":51632,"status":2,"research":5,"grant":10,"event":null,"study":null,"language":null,"funders":[416],"funder_projectcode":"829019","ethics_committee":null,"edudract_number":null,"persons":["2305-51632-10"]},{"id":2569,"title":{"de":"Anbahnungsfinanzierung: Genetik von Patienten mit Meningokokkeninfektionen Projektnummer: 830184","en":"host genetics of meningococcal infections"},"short":"HOST GENETICS MENINGOCOCC INFECT","url":null,"abstract":{"de":null,"en":null},"begin_planned":"2010-06-22T02:00:00+02:00","begin_effective":"2010-06-22T02:00:00+02:00","end_planned":"2010-10-13T02:00:00+02:00","end_effective":"2010-10-13T02:00:00+02:00","assignment":"2011-09-07T13:23:21+02:00","program":54,"subprogram":null,"organization":14091,"category":10,"type":10,"partner_function":4,"manager":null,"contact":null,"status":2,"research":5,"grant":10,"event":null,"study":null,"language":null,"funders":[416],"funder_projectcode":null,"ethics_committee":null,"edudract_number":null,"persons":[]},{"id":2391,"title":{"de":"Einfluss der Knochenentnahmetechnik auf die Osteoblastenaktivität","en":"Effect of Bone Harvesting Methods to the Osteoblast activity"},"short":"KNOCHENENTNAHME_OSTEOBLAST","url":null,"abstract":{"de":null,"en":null},"begin_planned":"2009-04-01T02:00:00+02:00","begin_effective":"2011-01-26T01:00:00+01:00","end_planned":"2010-10-01T02:00:00+02:00","end_effective":"2017-12-31T01:00:00+01:00","assignment":"2011-02-04T09:47:14+01:00","program":null,"subprogram":null,"organization":14057,"category":10,"type":10,"partner_function":4,"manager":null,"contact":null,"status":2,"research":4,"grant":10,"event":null,"study":null,"language":null,"funders":[135],"funder_projectcode":null,"ethics_committee":null,"edudract_number":null,"persons":[]},{"id":1937,"title":{"de":"CII-AT-0042-05-0910 - Image Processing, Information Engineering & Interdisciplinary Knowledge Exchange","en":"CII-AT-0042-05-0910 - Image Processing, Information Engineering & Interdisciplinary Knowledge Exchange"},"short":"CEEPUS  Imaging Processing","url":"http://www.ceepus.info","abstract":{"de":null,"en":null},"begin_planned":"2009-10-01T02:00:00+02:00","begin_effective":"2009-10-01T02:00:00+02:00","end_planned":"2010-09-30T02:00:00+02:00","end_effective":"2010-09-30T02:00:00+02:00","assignment":null,"program":null,"subprogram":null,"organization":14106,"category":10,"type":10,"partner_function":2,"manager":51913,"contact":null,"status":2,"research":2,"grant":10,"event":null,"study":null,"language":null,"funders":[],"funder_projectcode":null,"ethics_committee":null,"edudract_number":null,"persons":["1937-51913-10"]},{"id":1956,"title":{"de":"Schlaganfallrisikofaktoren in der Grazer Bevölkerung: Was bewirkt eine wiederholte Vorsorgeuntersuchung? Ergebnisse der Austrian Stroke Prevention Study","en":"Schlaganfallrisikofaktoren in der Grazer Bevölkerung: Was bewirkt eine wiederholte Vorsorgeuntersuchung? Ergebnisse der Austrian Stroke Prevention Study"},"short":"SCHLAGANFALLRISIKO_GRAZER_BEVOELK","url":null,"abstract":{"de":null,"en":null},"begin_planned":"2009-06-01T02:00:00+02:00","begin_effective":"2009-06-01T02:00:00+02:00","end_planned":"2010-09-30T02:00:00+02:00","end_effective":"2010-09-30T02:00:00+02:00","assignment":"2009-10-22T19:32:12+02:00","program":null,"subprogram":null,"organization":14051,"category":10,"type":10,"partner_function":4,"manager":null,"contact":null,"status":2,"research":5,"grant":10,"event":null,"study":null,"language":null,"funders":[457],"funder_projectcode":null,"ethics_committee":null,"edudract_number":null,"persons":[]},{"id":1617,"title":{"de":"Phase 4 development EORTC Quality of Life module specific to Endometrail Cancer (EORTC QLQ-EN34)","en":"Phase 4 development EORTC Quality of Life module specific to Endometrail Cancer (EORTC QLQ-EN34)"},"short":"EORTC QLQ-EN34","url":null,"abstract":{"de":"Endometrial cancer rates have risen over the last two decades, in some countries very significantly due to a combination of factors that includes an ageing population, increased obesity, and exposure to oestrogens.\r\nWith this burgeoning research agenda there is an urgent need to develop a specific quality of life measure for women with endometrial cancer that is sensitive to the impact of treatments so that their affect on quality of life can be assessed. In addition patients are increasingly encouraged to seek information about the impact of treatment on their quality of life so that they can make informed choices about their treatment and care.","en":"Endometrial cancer rates have risen over the last two decades, in some countries very significantly due to a combination of factors that includes an ageing population, increased obesity, and exposure to oestrogens.\r\nWith this burgeoning research agenda there is an urgent need to develop a specific quality of life measure for women with endometrial cancer that is sensitive to the impact of treatments so that their affect on quality of life can be assessed. In addition patients are increasingly encouraged to seek information about the impact of treatment on their quality of life so that they can make informed choices about their treatment and care."},"begin_planned":"2008-07-01T02:00:00+02:00","begin_effective":"2008-07-01T02:00:00+02:00","end_planned":"2010-09-30T02:00:00+02:00","end_effective":"2010-09-30T02:00:00+02:00","assignment":"2008-09-16T16:47:26+02:00","program":null,"subprogram":null,"organization":14038,"category":10,"type":10,"partner_function":1,"manager":null,"contact":null,"status":2,"research":2,"grant":10,"event":null,"study":null,"language":null,"funders":[442],"funder_projectcode":null,"ethics_committee":null,"edudract_number":null,"persons":["1617-57392-12"]},{"id":1581,"title":{"de":"Identification and functional characterisation of Nuclear Orphan Receptors as Tumor Suppressor Genes in aggressive non-Hodgkin`s Lymphomas and acute lymphoblastic leukemia","en":"Identification and functional characterisation of Nuclear Orphan Receptors as Tumor Suppressor Genes in aggressive non-Hodgkin`s Lymphomas and acute lymphoblastic leukemia"},"short":"non-Hodgkin`s Lymphoma","url":null,"abstract":{"de":"NR4A1 (also called Nur77, TR3, or NGFI-B), NR4A2 (Nurr1 or RNR-1) and NR4A3 (Nor-1 or Minor) are three members of an orphan nuclear hormone receptor family referred to as Nur77 family. They are all transcription factors belonging to the superfamily of steroid nuclear hormone receptors. These nuclear hormone receptors (NR) are classified as early response genes, are induced by a diverse range of signals, including fatty acids, stress, growth factors, cytokines, peptide hormones, neurotransmitters, and physical stimuli for example magnetic fields or shear stress. In line with the pleiotropic physiological stimuli that induce the NR4A subgroup, these orphan NRs have been implicated in cell cycle regulation, apoptosis, inflammation, atherogenesis and more recently in carcinogenesis. \r\nThe ultimate growth of a tumour depends on not only the rate of tumour cell proliferation, but also the rate of tumour cell death (=apoptosis). NR4A1 controls both survival and death of cancer cells. \r\nIn contrast to NR4A1, only pro-survival effects, but not pro-apoptotic effects, have been reported for NR4A2. \r\nNR4A3 has been shown to be functionally redundant with NR4A1 in T-cell apoptosis. Results also suggest that NR4A1 and NR4A3 have non-redundant functions as well.\r\nThe most convincing evidence that nuclear orphan receptors function as critical tumor suppressors is the observation that the abrogation of nuclear receptors Nr4a3 and Nr4a1 leads to rapid development of acute myeloid leukemia. Evidence of nuclear orphan receptors acting as tumor suppressor genes in B-cell malignancies comes from the observation that Epstein-Barr virus EBNA 2 blocks NR4A1 mediated apoptosis in B-cells and from gene expression profiling in diffuse large B-cell lymphoma (DLBCL) in which over expression of NR4A3 is found in cured or refractory DLBCL, as opposed to a fatal course of disease. Hence, it is speculated that NR4A3 increases the apoptotic response to chemotherapy in curable DLBCL.\r\n\r\nThe aim of our study was to comprehensively study NR expression and function in B-cell malignancies and to define the nuclear orphan receptors NR4A1 and NR4A1 as cooperative putative tumor suppressor genes (TSG) in B-cell malignancies.\r\n\r\n","en":"NR4A1 (also called Nur77, TR3, or NGFI-B), NR4A2 (Nurr1 or RNR-1) and NR4A3 (Nor-1 or Minor) are three members of an orphan nuclear hormone receptor family referred to as Nur77 family. They are all transcription factors belonging to the superfamily of steroid nuclear hormone receptors. These nuclear hormone receptors (NR) are classified as early response genes, are induced by a diverse range of signals, including fatty acids, stress, growth factors, cytokines, peptide hormones, neurotransmitters, and physical stimuli for example magnetic fields or shear stress. In line with the pleiotropic physiological stimuli that induce the NR4A subgroup, these orphan NRs have been implicated in cell cycle regulation, apoptosis, inflammation, atherogenesis and more recently in carcinogenesis. \r\nThe ultimate growth of a tumour depends on not only the rate of tumour cell proliferation, but also the rate of tumour cell death (=apoptosis). NR4A1 controls both survival and death of cancer cells. \r\nIn contrast to NR4A1, only pro-survival effects, but not pro-apoptotic effects, have been reported for NR4A2. \r\nNR4A3 has been shown to be functionally redundant with NR4A1 in T-cell apoptosis. Results also suggest that NR4A1 and NR4A3 have non-redundant functions as well.\r\nThe most convincing evidence that nuclear orphan receptors function as critical tumor suppressors is the observation that the abrogation of nuclear receptors Nr4a3 and Nr4a1 leads to rapid development of acute myeloid leukemia. Evidence of nuclear orphan receptors acting as tumor suppressor genes in B-cell malignancies comes from the observation that Epstein-Barr virus EBNA 2 blocks NR4A1 mediated apoptosis in B-cells and from gene expression profiling in diffuse large B-cell lymphoma (DLBCL) in which over expression of NR4A3 is found in cured or refractory DLBCL, as opposed to a fatal course of disease. Hence, it is speculated that NR4A3 increases the apoptotic response to chemotherapy in curable DLBCL.\r\n\r\nThe aim of our study was to comprehensively study NR expression and function in B-cell malignancies and to define the nuclear orphan receptors NR4A1 and NR4A1 as cooperative putative tumor suppressor genes (TSG) in B-cell malignancies."},"begin_planned":"2008-10-01T02:00:00+02:00","begin_effective":"2008-10-01T02:00:00+02:00","end_planned":"2010-09-30T02:00:00+02:00","end_effective":"2010-09-30T02:00:00+02:00","assignment":"2008-07-17T12:24:53+02:00","program":null,"subprogram":null,"organization":14082,"category":10,"type":10,"partner_function":4,"manager":51930,"contact":51930,"status":2,"research":1,"grant":10,"event":null,"study":null,"language":null,"funders":[836],"funder_projectcode":null,"ethics_committee":null,"edudract_number":null,"persons":["1581-51930-10"]},{"id":2126,"title":{"de":"Auswirkungen von Stressoren bei Kindern und Jugendlichen","en":"Effects of stress in adolescents"},"short":"STRESSOREN_KINDER_JUGENDLICHE","url":null,"abstract":{"de":null,"en":null},"begin_planned":"2010-03-01T01:00:00+01:00","begin_effective":"2010-03-01T01:00:00+01:00","end_planned":"2010-09-30T02:00:00+02:00","end_effective":"2010-09-30T02:00:00+02:00","assignment":"2010-02-22T11:26:29+01:00","program":null,"subprogram":null,"organization":29447,"category":10,"type":10,"partner_function":1,"manager":60040,"contact":60040,"status":2,"research":2,"grant":10,"event":null,"study":null,"language":null,"funders":[135],"funder_projectcode":null,"ethics_committee":null,"edudract_number":null,"persons":["2126-60040-10","2126-52274-11"]}]}