{"count":2329,"next":"https://api-test.medunigraz.at/v1/research/project/?format=json&limit=20&offset=1940&ordering=-begin_effective","previous":"https://api-test.medunigraz.at/v1/research/project/?format=json&limit=20&offset=1900&ordering=-begin_effective","results":[{"id":2028,"title":{"de":"Characterization of breast cancer stem cells and their responsiveness to osteoporose treatment","en":"Characterization of breast cancer stem cells and their responsiveness to osteoporose treatment"},"short":"BREAST CANCER STEM CELLS_OSTEO_TREAT","url":null,"abstract":{"de":null,"en":null},"begin_planned":"2010-02-01T01:00:00+01:00","begin_effective":"2010-02-01T01:00:00+01:00","end_planned":"2012-01-31T01:00:00+01:00","end_effective":"2012-07-31T02:00:00+02:00","assignment":"2009-12-22T15:26:56+01:00","program":79,"subprogram":null,"organization":14080,"category":10,"type":10,"partner_function":4,"manager":51063,"contact":51063,"status":2,"research":2,"grant":10,"event":null,"study":null,"language":null,"funders":[12],"funder_projectcode":null,"ethics_committee":null,"edudract_number":null,"persons":["2028-51063-10"]},{"id":1991,"title":{"de":"Proteomic characterization of mitochondrial ion channels","en":"Proteomic characterization of mitochondrial ion channels"},"short":"mitochondrial ion channels","url":null,"abstract":{"de":null,"en":null},"begin_planned":"2010-01-01T01:00:00+01:00","begin_effective":"2010-01-01T01:00:00+01:00","end_planned":"2012-03-13T01:00:00+01:00","end_effective":"2012-03-13T01:00:00+01:00","assignment":"2009-11-25T16:00:48+01:00","program":69,"subprogram":null,"organization":14013,"category":10,"type":10,"partner_function":4,"manager":null,"contact":null,"status":2,"research":1,"grant":10,"event":null,"study":null,"language":null,"funders":[9],"funder_projectcode":"J2968-B19","ethics_committee":null,"edudract_number":null,"persons":[]},{"id":2097,"title":{"de":"Role of SPN in PP1-mediated RyR2 regulation and intracellular Ca2+ handling","en":"Role of SPN in PP1-mediated RyR2 regulation and intracellular Ca2+ handling"},"short":"ROLE OF SPN ","url":null,"abstract":{"de":null,"en":null},"begin_planned":"2010-01-01T01:00:00+01:00","begin_effective":"2010-01-01T01:00:00+01:00","end_planned":"2011-12-31T01:00:00+01:00","end_effective":"2011-12-31T01:00:00+01:00","assignment":"2010-02-09T12:56:38+01:00","program":null,"subprogram":null,"organization":14083,"category":10,"type":10,"partner_function":4,"manager":null,"contact":null,"status":2,"research":1,"grant":10,"event":null,"study":null,"language":null,"funders":[894],"funder_projectcode":null,"ethics_committee":null,"edudract_number":null,"persons":[]},{"id":2031,"title":{"de":"Genetic variants in the RAD51, BRCA1 and BRCA2 genes as predictors of radiation response and toxicity in prostate cancer patients","en":"Genetic variants in the RAD51, BRCA1 and BRCA2 genes as predictors of radiation response and toxicity in prostate cancer patients"},"short":"GENETIC_PROSTATE_CANCER_OeNB","url":null,"abstract":{"de":null,"en":null},"begin_planned":"2010-01-01T01:00:00+01:00","begin_effective":"2010-01-01T01:00:00+01:00","end_planned":"2011-12-31T01:00:00+01:00","end_effective":"2011-12-31T01:00:00+01:00","assignment":"2010-01-11T15:12:11+01:00","program":79,"subprogram":null,"organization":14060,"category":10,"type":10,"partner_function":4,"manager":50495,"contact":null,"status":2,"research":2,"grant":10,"event":null,"study":null,"language":null,"funders":[12],"funder_projectcode":null,"ethics_committee":null,"edudract_number":null,"persons":["2031-50495-10","2031-50910-12"]},{"id":1996,"title":{"de":"Disturbed Lipid Metabolism in Gestational Diabetes - Culprit of Fetal Adverse Outcome","en":"Disturbed Lipid Metabolism in Gestational Diabetes - Culprit of Fetal Adverse Outcome"},"short":"DISTURBED LIPID METABOLISM","url":null,"abstract":{"de":null,"en":null},"begin_planned":"2010-01-01T01:00:00+01:00","begin_effective":"2010-01-01T01:00:00+01:00","end_planned":"2011-12-31T01:00:00+01:00","end_effective":"2017-12-31T01:00:00+01:00","assignment":"2009-11-30T14:36:35+01:00","program":null,"subprogram":null,"organization":14020,"category":10,"type":10,"partner_function":4,"manager":52569,"contact":52569,"status":2,"research":2,"grant":10,"event":null,"study":null,"language":null,"funders":[151],"funder_projectcode":null,"ethics_committee":null,"edudract_number":null,"persons":["1996-52569-10"]},{"id":2431,"title":{"de":"Genetic predisposition to therapy-related myeloid neoplasms: involvement of the Fanconi anemia/BRCA pathway?","en":"Genetic predisposition to therapy-related myeloid neoplasms: involvement of the Fanconi anemia/BRCA pathway?"},"short":"FANCONI ANEMIA BRCA","url":null,"abstract":{"de":null,"en":null},"begin_planned":"2010-01-01T01:00:00+01:00","begin_effective":"2010-01-01T01:00:00+01:00","end_planned":"2011-12-31T01:00:00+01:00","end_effective":"2013-07-31T02:00:00+02:00","assignment":"2011-02-28T11:28:49+01:00","program":79,"subprogram":null,"organization":14082,"category":10,"type":10,"partner_function":4,"manager":51857,"contact":51857,"status":2,"research":1,"grant":10,"event":null,"study":null,"language":null,"funders":[12],"funder_projectcode":null,"ethics_committee":null,"edudract_number":null,"persons":["2431-77371-12","2431-77615-12","2431-51857-10","2431-50116-12"]},{"id":2375,"title":{"de":"Grazer Laser Studie GLAS","en":"Grazer Laser Study GLAS"},"short":"GLAS","url":null,"abstract":{"de":null,"en":null},"begin_planned":"2010-01-01T01:00:00+01:00","begin_effective":"2010-01-01T01:00:00+01:00","end_planned":"2011-04-30T02:00:00+02:00","end_effective":"2011-07-31T02:00:00+02:00","assignment":"2011-01-10T11:10:16+01:00","program":75,"subprogram":null,"organization":14043,"category":10,"type":10,"partner_function":4,"manager":null,"contact":null,"status":2,"research":4,"grant":10,"event":null,"study":null,"language":null,"funders":[135],"funder_projectcode":null,"ethics_committee":null,"edudract_number":null,"persons":[]},{"id":1868,"title":{"de":"Computer-based analysis of heart rate variability (HRV) during different methods of acupuncture","en":"Computer-based analysis of heart rate variability (HRV) during different methods of acupuncture"},"short":"HRV during acupuncture","url":null,"abstract":{"de":"Die Herzratenvariabilität stellt die prozentuelle Änderung aufeinander folgender Kammerkomplexe im EKG dar. Der Parameter HRV wird durch das Blutdruckkontrollsystem, Einflüsse vom Hypothalamus und vor allem durch den vagalen Teil des Kreislaufzentrums im unteren Hirnstamm vermittelt. Eine computergestützte Analyse der HRV soll während unterschiedlicher Methoden der Akupunktur und anderer Stimulationsmethoden im gegenständlichen Projekt zum Einsatz kommen. Für die Untersuchungen soll ein Medilog AR 12 verwendet werden. Insgesamt sollen 80 Probanden (im Alter 20-50 Jahren) während unterschiedlicher Akupunktursitzungen (Nadel- und Laserakupunktur) untersucht werden. Dabei werden die folgenden Akupunkturpunkte verwendet: Neiguan (Pe.6), Shenmen (He.7) und Hegu (Di.4). Innerhalb dieses Projektes soll die HRV auch während Stimulationen des Punktes Yintang (Ex.1) näher untersucht werden. Das Projekt könnte dazu beitragen, die Beziehungen zwischen westlicher und östlicher Medizin zu vertiefen.","en":"Die Herzratenvariabilität stellt die prozentuelle Änderung aufeinander folgender Kammerkomplexe im EKG dar. Der Parameter HRV wird durch das Blutdruckkontrollsystem, Einflüsse vom Hypothalamus und vor allem durch den vagalen Teil des Kreislaufzentrums im unteren Hirnstamm vermittelt. Eine computergestützte Analyse der HRV soll während unterschiedlicher Methoden der Akupunktur und anderer Stimulationsmethoden im gegenständlichen Projekt zum Einsatz kommen. Für die Untersuchungen soll ein Medilog AR 12 verwendet werden. Insgesamt sollen 80 Probanden (im Alter 20-50 Jahren) während unterschiedlicher Akupunktursitzungen (Nadel- und Laserakupunktur) untersucht werden. Dabei werden die folgenden Akupunkturpunkte verwendet: Neiguan (Pe.6), Shenmen (He.7) und Hegu (Di.4). Innerhalb dieses Projektes soll die HRV auch während Stimulationen des Punktes Yintang (Ex.1) näher untersucht werden. Das Projekt könnte dazu beitragen, die Beziehungen zwischen westlicher und östlicher Medizin zu vertiefen."},"begin_planned":"2009-10-01T02:00:00+02:00","begin_effective":"2010-01-01T01:00:00+01:00","end_planned":"2011-09-30T02:00:00+02:00","end_effective":"2011-12-31T01:00:00+01:00","assignment":"2009-07-13T18:54:46+02:00","program":79,"subprogram":null,"organization":14044,"category":10,"type":10,"partner_function":4,"manager":null,"contact":null,"status":2,"research":1,"grant":10,"event":null,"study":null,"language":null,"funders":[12],"funder_projectcode":null,"ethics_committee":null,"edudract_number":null,"persons":["1868-54121-12"]},{"id":2214,"title":{"de":"Identifizierung und funktionelle Charakterisierung von nukleären Rezeptoren als Tumorsuppressorgene bei aggressiven non-Hodgkin-Lymphomen","en":"Identifizierung und funktionelle Charakterisierung von nukleären Rezeptoren als Tumorsuppressorgene bei aggressiven non-Hodgkin-Lymphomen"},"short":"Tumorsuppressorgene_non-Hodgkin-Lymphom","url":null,"abstract":{"de":null,"en":null},"begin_planned":"2010-01-01T01:00:00+01:00","begin_effective":"2010-01-01T01:00:00+01:00","end_planned":"2011-06-30T02:00:00+02:00","end_effective":"2015-04-30T02:00:00+02:00","assignment":"2010-05-26T11:09:01+02:00","program":null,"subprogram":null,"organization":14082,"category":10,"type":10,"partner_function":4,"manager":51930,"contact":51930,"status":2,"research":2,"grant":10,"event":null,"study":null,"language":null,"funders":[135],"funder_projectcode":null,"ethics_committee":null,"edudract_number":null,"persons":["2214-65239-12","2214-51930-10"]},{"id":2043,"title":{"de":"Involvement of the orphan receptor GPR55 in cannabinoid antitumoral action","en":"Involvement of the orphan receptor GPR55 in cannabinoid antitumoral action"},"short":"ORPHAN RECEPTOR GPR55","url":null,"abstract":{"de":null,"en":null},"begin_planned":"2010-01-01T01:00:00+01:00","begin_effective":"2010-01-01T01:00:00+01:00","end_planned":"2011-12-31T01:00:00+01:00","end_effective":"2011-12-31T01:00:00+01:00","assignment":"2010-01-20T12:45:29+01:00","program":92,"subprogram":null,"organization":14022,"category":10,"type":10,"partner_function":4,"manager":null,"contact":null,"status":2,"research":1,"grant":10,"event":null,"study":null,"language":null,"funders":[20],"funder_projectcode":null,"ethics_committee":null,"edudract_number":null,"persons":[]},{"id":2092,"title":{"de":"Analysis of germline polymorphisms in the VEGF/VEGFR pathway to predict colorectal cancer outcome","en":"Analysis of germline polymorphisms in the VEGF/VEGFR pathway to predict colorectal cancer outcome"},"short":"GERMLINE POLYMORPH VEGF/VEGFR","url":null,"abstract":{"de":null,"en":null},"begin_planned":"2010-01-01T01:00:00+01:00","begin_effective":"2010-01-01T01:00:00+01:00","end_planned":"2010-12-31T01:00:00+01:00","end_effective":"2011-12-31T01:00:00+01:00","assignment":"2010-02-09T11:47:57+01:00","program":null,"subprogram":null,"organization":14085,"category":10,"type":10,"partner_function":4,"manager":59304,"contact":null,"status":2,"research":1,"grant":10,"event":null,"study":null,"language":null,"funders":[894],"funder_projectcode":null,"ethics_committee":null,"edudract_number":null,"persons":["2092-59304-10","2092-58814-12"]},{"id":2192,"title":{"de":"Akupressur-Stimulationsequipment zur emotionalen Entlastung von Menschen mit geistiger Behinderung","en":"Akupressur-Stimulationsequipment zur emotionalen Entlastung von Menschen mit geistiger Behinderung"},"short":"AKUPRESSUR_STIMULATION","url":null,"abstract":{"de":null,"en":null},"begin_planned":"2010-01-01T01:00:00+01:00","begin_effective":"2010-01-01T01:00:00+01:00","end_planned":"2011-12-31T01:00:00+01:00","end_effective":"2013-12-31T01:00:00+01:00","assignment":"2010-05-03T14:28:49+02:00","program":null,"subprogram":null,"organization":14044,"category":10,"type":10,"partner_function":4,"manager":51073,"contact":51073,"status":2,"research":4,"grant":10,"event":null,"study":null,"language":null,"funders":[135],"funder_projectcode":null,"ethics_committee":null,"edudract_number":null,"persons":["2192-51073-10"]},{"id":2256,"title":{"de":"Stammbaumanalysen bei PatientInnen mit Therapie-assoziierten myeloischen Neoplasien","en":"Stammbaumanalysen bei PatientInnen mit Therapie-assoziierten myeloischen Neoplasien"},"short":"myeloische Neoplasien","url":null,"abstract":{"de":null,"en":null},"begin_planned":"2010-01-01T01:00:00+01:00","begin_effective":"2010-01-01T01:00:00+01:00","end_planned":"2011-06-30T02:00:00+02:00","end_effective":"2014-04-30T02:00:00+02:00","assignment":"2010-07-28T12:50:24+02:00","program":null,"subprogram":"Land Steiermark Abteilung 3 (Forschung); Projektsumme über 5.000,- €","organization":14082,"category":10,"type":10,"partner_function":4,"manager":51857,"contact":51857,"status":2,"research":2,"grant":10,"event":null,"study":null,"language":null,"funders":[135],"funder_projectcode":null,"ethics_committee":null,"edudract_number":null,"persons":["2256-77615-12","2256-77770-12","2256-51857-10","2256-50116-12"]},{"id":2033,"title":{"de":"Mit autologen Thrombozyten angereichertes körpereigenes Fibrin zur Förderung der Wundheilung bei chronischem Ulcus cruris venosum (kontrollierte prospektive randomisierte klinische Studie)","en":"Mit autologen Thrombozyten angereichertes körpereigenes Fibrin zur Förderung der Wundheilung bei chronischem Ulcus cruris venosum (kontrollierte prospektive randomisierte klinische Studie)"},"short":" Ulcus cruris venosum Studie","url":null,"abstract":{"de":null,"en":null},"begin_planned":"2008-10-01T02:00:00+02:00","begin_effective":"2010-01-01T01:00:00+01:00","end_planned":"2009-09-30T02:00:00+02:00","end_effective":"2011-12-31T01:00:00+01:00","assignment":"2010-01-12T17:36:20+01:00","program":null,"subprogram":null,"organization":14073,"category":10,"type":10,"partner_function":4,"manager":51612,"contact":51612,"status":2,"research":2,"grant":10,"event":null,"study":null,"language":null,"funders":[135],"funder_projectcode":null,"ethics_committee":null,"edudract_number":null,"persons":["2033-51612-10"]},{"id":2090,"title":{"de":"Expression profiling in hypoxic non-small cell lung cancer","en":"Expression profiling in hypoxic non-small cell lung cancer"},"short":"NON-SMALL CELL LUNG CANCER ","url":null,"abstract":{"de":"Das Bronchialkarzinom ist nach wie vor die führende Krebstodesursache weltweit. 80% sind sogenannte Nicht-kleinzellige Bronchialkarzinome (non-small cell lung cancers, NSCLC). Das Gesamtüberleben der Patienten mit NSCLC ist schlecht, trotz der derzeit vorhandenen Therapieoptionen, zum Teil wegen Resistenz gegenüber Radio- und Chemotherapie. Tumorhypoxie (verminderte Sauerstoffzufuhr im Tumor) induziert in den Tumorzellen Adaptationsvorgänge und ist zum Teil für die Therapieresistenz verantwortlich. Die genauen Mechanismen sind jedoch nicht bekannt. Unser neu etabliertes ex-vivo Modell der hypoxischen Adaptation beim NSCLC, welches auf der Verwendung von kleinsten NSCLC Fragmenten aus Operationsmaterial beruht, ist geignet, um die Vorgänge im Tumor unter hypoxischen Bedingungen zu untersuchen. Das Ziel der vorliegenden Studie ist, die Genexpressionsmuster der in Hypoxie bzw unter normalen Sauerstoffbedingungen kultivierten NSCLC Fragmente zu vergleichen. Die differenziell regulierten Gene werden dafür mittels cDNA microarrays bestimmt. Die Ergebnisse werden in nachfolgenden Einzelgen-Polymerase Kettenreaktionen validiert. Unsere Studie könnte somit das Verständnis der Pathomechanismen beim Tumorwachstum verbessern und mögliche neue Therapieoptionen beim NSCLC aufzeigen.","en":"Lung cancer is the leading cause of cancer deaths overall in the world. Non-small cell lung cancer (NSCLC) accounts for approximately 80% of lung cancers. Overall survival is poor, in part due to resistance to chemotherapy and radiotherapy. Intratumoral hypoxia (limited oxygen supply) frequently occurs in solid tumors, such as NSCLC. Hypoxia initiates adaptive responses in tumor cells and was shown to induce chemotherapy resistance and promote aggressive tumor growth. The mechanisms of hypoxia-induced adaptive responses in solid tumors are not fully elucidated, yet. We established an ex-vivo model for hypoxic adaptation using NSCLC surgery fragments. The fragments are maintained in short-time culture in hypoxia or ambient oxygen (normoxia) without significant loss of viability or increase in apoptosis and display significant induction of carbonic anhydrase IX, a marker for tumor hypoxia, under hypoxic conditions. The aim of the current study is to analyze hypoxia-induced gene expression changes using cDNA microarrays and consecutive single gene real-time polymerase chain reaction (RT-PCR) on hypoxic vs. normoxic NSCLC fragments, in order to identify genes that are consistently induced or suppressed in hypoxia.  Our study thus provides a novel approach to identify molecular pathways that are crucial for hypoxic adaptive changes in NSCLC and might represent targets for therapy."},"begin_planned":"2010-01-01T01:00:00+01:00","begin_effective":"2010-01-01T01:00:00+01:00","end_planned":"2011-12-31T01:00:00+01:00","end_effective":"2011-12-31T01:00:00+01:00","assignment":"2010-02-09T11:39:13+01:00","program":null,"subprogram":null,"organization":14087,"category":10,"type":10,"partner_function":4,"manager":57557,"contact":null,"status":2,"research":1,"grant":10,"event":null,"study":null,"language":null,"funders":[894],"funder_projectcode":null,"ethics_committee":null,"edudract_number":null,"persons":["2090-57557-10"]},{"id":2103,"title":{"de":"Fatty liver: Inhibition of Progression (Role of hepatic triglyceride lipases in the progression of NASH)","en":"Fatty liver: Inhibition of Progression (Role of hepatic triglyceride lipases in the progression of NASH)"},"short":"FLIP","url":null,"abstract":{"de":null,"en":null},"begin_planned":"2010-01-01T01:00:00+01:00","begin_effective":"2010-01-01T01:00:00+01:00","end_planned":"2012-12-31T01:00:00+01:00","end_effective":"2012-12-31T01:00:00+01:00","assignment":"2010-02-10T16:24:47+01:00","program":24,"subprogram":"HEALTH-2009-2.4.5-1","organization":14081,"category":10,"type":10,"partner_function":2,"manager":null,"contact":null,"status":2,"research":1,"grant":10,"event":null,"study":null,"language":null,"funders":[10],"funder_projectcode":"241762","ethics_committee":null,"edudract_number":null,"persons":[]},{"id":1940,"title":{"de":"Altered prostaglandin receptor function in patients with aspirin intolerance","en":"Altered prostaglandin receptor function in patients with aspirin intolerance"},"short":"Prostaglandin receptor function","url":null,"abstract":{"de":"Prostaglandin E2 (PGE2) limitiert in der Lunge immunologische und entzündliche Prozesse. Eosinophile Granulozyten spielen eine entscheidende Rolle bei der Pathogenese von Asthma bronchiale. Etwa 10% der Asthmapatienten vertragen keine Analgetika vom Typ der nichtsteroidalen Antirheumatika (z.B. Aspirin). Daher ist eine effektive Schmerz- und Entzündungstherapie bei diesen Patienten schwierig. Wir konnten zeigen, dass PGE2 hemmende Effekte an eosinophilen Granulozyten hat. Die Effekte von PGE2 werden durch vier Rezeptoren vermittelt. Wir untersuchen, inwieweit die Wirkungen von PGE2 auf Eosinophile von Patienten mit Aspirin-Unverträglichkeit verändert sind und welche Rolle die PGE2 Rezeptoren spielen. Als Vergleich dienen gesunde Probanden, allergische Patienten ohne Asthma und Asthmatiker ohne Aspirin-Unverträglichkeit. Diese Studie soll das Verständnis der Rolle von PGE2 bei Asthma und Aspirin-Unverträglichkeit erweitern, und möglicherweise neue therapeutische Optionen eröffen.","en":"Prostaglandin E2 (PGE2) limitiert in der Lunge immunologische und entzündliche Prozesse. Eosinophile Granulozyten spielen eine entscheidende Rolle bei der Pathogenese von Asthma bronchiale. Etwa 10% der Asthmapatienten vertragen keine Analgetika vom Typ der nichtsteroidalen Antirheumatika (z.B. Aspirin). Daher ist eine effektive Schmerz- und Entzündungstherapie bei diesen Patienten schwierig. Wir konnten zeigen, dass PGE2 hemmende Effekte an eosinophilen Granulozyten hat. Die Effekte von PGE2 werden durch vier Rezeptoren vermittelt. Wir untersuchen, inwieweit die Wirkungen von PGE2 auf Eosinophile von Patienten mit Aspirin-Unverträglichkeit verändert sind und welche Rolle die PGE2 Rezeptoren spielen. Als Vergleich dienen gesunde Probanden, allergische Patienten ohne Asthma und Asthmatiker ohne Aspirin-Unverträglichkeit. Diese Studie soll das Verständnis der Rolle von PGE2 bei Asthma und Aspirin-Unverträglichkeit erweitern, und möglicherweise neue therapeutische Optionen eröffen."},"begin_planned":"2009-04-01T02:00:00+02:00","begin_effective":"2010-01-01T01:00:00+01:00","end_planned":"2011-03-31T02:00:00+02:00","end_effective":"2013-09-30T02:00:00+02:00","assignment":"2009-10-01T18:22:11+02:00","program":79,"subprogram":null,"organization":14022,"category":10,"type":10,"partner_function":4,"manager":null,"contact":null,"status":2,"research":2,"grant":10,"event":null,"study":null,"language":null,"funders":[12],"funder_projectcode":null,"ethics_committee":null,"edudract_number":null,"persons":[]},{"id":2051,"title":{"de":"Bedeutung des Endothelinsystems bei der Pathogenese der Präeklamsie","en":"Bedeutung des Endothelinsystems bei der Pathogenese der Präeklamsie"},"short":"Endothelinsystems und Präeklamsie","url":null,"abstract":{"de":null,"en":null},"begin_planned":"2010-01-01T01:00:00+01:00","begin_effective":"2010-01-01T01:00:00+01:00","end_planned":"2010-12-31T01:00:00+01:00","end_effective":"2011-07-30T02:00:00+02:00","assignment":"2010-01-21T12:47:04+01:00","program":null,"subprogram":"Land Steiermark-Projekt über 5.000,- Euro Antragssumme","organization":14038,"category":10,"type":10,"partner_function":4,"manager":null,"contact":null,"status":2,"research":1,"grant":10,"event":null,"study":null,"language":null,"funders":[135],"funder_projectcode":null,"ethics_committee":null,"edudract_number":null,"persons":[]},{"id":2152,"title":{"de":"Variation des Erythropoetin-Gens als Risikofaktor für Brustkrebs","en":"Variation des Erythropoetin-Gens als Risikofaktor für Brustkrebs"},"short":"ERYTHROPOETIN_BRUSTKREBS","url":null,"abstract":{"de":null,"en":null},"begin_planned":"2010-01-01T01:00:00+01:00","begin_effective":"2010-01-01T01:00:00+01:00","end_planned":"2010-12-31T01:00:00+01:00","end_effective":"2011-06-30T02:00:00+02:00","assignment":"2010-03-04T14:48:32+01:00","program":81,"subprogram":null,"organization":14085,"category":10,"type":10,"partner_function":4,"manager":58814,"contact":58814,"status":2,"research":1,"grant":10,"event":null,"study":null,"language":null,"funders":[52],"funder_projectcode":null,"ethics_committee":null,"edudract_number":null,"persons":["2152-58814-10"]},{"id":2095,"title":{"de":"Purkinje Topology","en":"Purkinje Topology"},"short":"PURKINJE TOPOLOGY","url":null,"abstract":{"de":"Defibrillation of the heart by timely application of an electric shock is now recognized as the only effective means to prevent sudden cardiac death. Despite the critical role that defibrillation therapy plays in saving human life, the understanding of the mechanisms by which electric shocks halt life-threatening arrhythmias remains incomplete.\r\n\r\nA major factor in the formation and maintenance of cardiac arrhythmias is the specialized conduction system of the ventricles, referred to as the Purkinje system (PS). The PS is known to be potentially pro-arrhythmic under various conditions including shock-induced arrhythmogenesis, failure of defibrillation shocks or arrhythmias induced by focal activation. Surprisingly, in most studies, both experimental as well as computational, PS effects are quite often neglected. While recent advances in experimental methodology have provided new characterizations of tissue responses to externally applied electric fields, mechanistic inquiry into the biophysics of arrhythmogenesis or defibrillation is hampered by the inability of current experimental techniques to resolve, with sufficient accuracy, electrical behavior confined to the depth of the ventricles or in the PS. Computer models quite naturally suggest themselves as a surrogate technique to bridge the gap between experimental observations, typically recorded at the epicardial surface\r\nof the heart, and electrical events occurring within the PS, at the ventricular epicardium or within the depth of ventricular walls. Despite major recent advancements in modeling technology, integrating topologically realistic models of the PS with anatomically and functionally realistic models of the ventricles remains to be challenging.\r\n\r\nThe overall objective of this research is, by employing realistic 3D simulations of ventricular\r\nactivation sequences, to bring a new level of understanding of the topological organization of the\r\nPS in the rabbit ventricles and of naturally occurring inter-subject variability in topology on the\r\nventricular activation sequence under physiological and pathological conditions. Moreover, the\r\ncomputer model will be used to study inducibility and to characterize under which conditions the\r\nPS is pro-arrhythmic or anti-arrhythmic. Eventually, understanding the implications of the PS in the formation and maintenance of arrhythmias may pave the way to novel therapeutical approaches that make use of PS properties, to prevent the formation of arrhythmias or to facilitate a termination of arrhythmias with low-voltage defibrillation or pacing strategies.\r\n\r\nThe goal of this application is to develop new modeling tools that will enable the applicant to explore questions that remained currently unexplored. Specifically, this project proposes to examine, in anatomically and functionally detailed bidomain models of the rabbit ventricles, the role of PS topology on cardiac activation sequences under physiological and pathophysiological conditions and their impact on inducibility under various induction protocols such as shock-induced arrhythmogenesis as well as triggered activity. ","en":"Defibrillation of the heart by timely application of an electric shock is now recognized as the only effective means to prevent sudden cardiac death. Despite the critical role that defibrillation therapy plays in saving human life, the understanding of the mechanisms by which electric shocks halt life-threatening arrhythmias remains incomplete.\r\n\r\nA major factor in the formation and maintenance of cardiac arrhythmias is the specialized conduction system of the ventricles, referred to as the Purkinje system (PS). The PS is known to be potentially pro-arrhythmic under various conditions including shock-induced arrhythmogenesis, failure of defibrillation shocks or arrhythmias induced by focal activation. Surprisingly, in most studies, both experimental as well as computational, PS effects are quite often neglected. While recent advances in experimental methodology have provided new characterizations of tissue responses to externally applied electric fields, mechanistic inquiry into the biophysics of arrhythmogenesis or defibrillation is hampered by the inability of current experimental techniques to resolve, with sufficient accuracy, electrical behavior confined to the depth of the ventricles or in the PS. Computer models quite naturally suggest themselves as a surrogate technique to bridge the gap between experimental observations, typically recorded at the epicardial surface\r\nof the heart, and electrical events occurring within the PS, at the ventricular epicardium or within the depth of ventricular walls. Despite major recent advancements in modeling technology, integrating topologically realistic models of the PS with anatomically and functionally realistic models of the ventricles remains to be challenging.\r\n\r\nThe overall objective of this research is, by employing realistic 3D simulations of ventricular\r\nactivation sequences, to bring a new level of understanding of the topological organization of the\r\nPS in the rabbit ventricles and of naturally occurring inter-subject variability in topology on the\r\nventricular activation sequence under physiological and pathological conditions. Moreover, the\r\ncomputer model will be used to study inducibility and to characterize under which conditions the\r\nPS is pro-arrhythmic or anti-arrhythmic. Eventually, understanding the implications of the PS in the formation and maintenance of arrhythmias may pave the way to novel therapeutical approaches that make use of PS properties, to prevent the formation of arrhythmias or to facilitate a termination of arrhythmias with low-voltage defibrillation or pacing strategies.\r\n\r\nThe goal of this application is to develop new modeling tools that will enable the applicant to explore questions that remained currently unexplored. Specifically, this project proposes to examine, in anatomically and functionally detailed bidomain models of the rabbit ventricles, the role of PS topology on cardiac activation sequences under physiological and pathophysiological conditions and their impact on inducibility under various induction protocols such as shock-induced arrhythmogenesis as well as triggered activity. "},"begin_planned":"2010-01-01T01:00:00+01:00","begin_effective":"2010-01-01T01:00:00+01:00","end_planned":"2011-12-31T01:00:00+01:00","end_effective":"2011-12-31T01:00:00+01:00","assignment":"2010-02-09T12:53:47+01:00","program":null,"subprogram":null,"organization":14010,"category":10,"type":10,"partner_function":4,"manager":50967,"contact":null,"status":2,"research":1,"grant":10,"event":null,"study":null,"language":null,"funders":[894],"funder_projectcode":null,"ethics_committee":null,"edudract_number":null,"persons":["2095-50967-10"]}]}