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Lipase im Serum ¿ einem potentiellen Marker für Arteriosklerose","en":"Etablierung und Evaluierung eines Bluttestes für die Detektion von Endothel - Lipase im Serum ¿ einem potentiellen Marker für Arteriosklerose"},"short":"ENDOTHEL LIPASE IM SERUM","url":null,"abstract":{"de":null,"en":null},"begin_planned":"2010-01-01T01:00:00+01:00","begin_effective":"2010-03-25T01:00:00+01:00","end_planned":"2010-06-30T02:00:00+02:00","end_effective":"2010-12-24T01:00:00+01:00","assignment":"2010-01-21T13:36:00+01:00","program":null,"subprogram":null,"organization":14013,"category":10,"type":10,"partner_function":4,"manager":null,"contact":null,"status":2,"research":2,"grant":10,"event":null,"study":null,"language":null,"funders":[135],"funder_projectcode":null,"ethics_committee":null,"edudract_number":null,"persons":[]},{"id":2130,"title":{"de":"Kinder erzählen: Text- und Erzählkompetenz im Vorschulalter: eine Voraussetzung für den schulischen Erfolg.","en":"Narratives in first language acquisition."},"short":"TEXT- UND ERZÄHLKOMPETENZ","url":null,"abstract":{"de":null,"en":null},"begin_planned":"2010-03-01T01:00:00+01:00","begin_effective":"2010-03-01T01:00:00+01:00","end_planned":"2011-12-31T01:00:00+01:00","end_effective":"2011-12-31T01:00:00+01:00","assignment":"2010-02-24T10:55:39+01:00","program":null,"subprogram":null,"organization":14010,"category":10,"type":10,"partner_function":2,"manager":58883,"contact":58883,"status":2,"research":1,"grant":10,"event":null,"study":null,"language":null,"funders":[135],"funder_projectcode":null,"ethics_committee":null,"edudract_number":null,"persons":["2130-58883-10"]},{"id":2183,"title":{"de":"Entwicklung von strukturierten Oberflächen für die optimierte Adhäsion, Proliferation und Differenzierung von Zellen","en":"Entwicklung von strukturierten Oberflächen für die optimierte Adhäsion, Proliferation und Differenzierung von Zellen"},"short":"ENTWICKLUNG STRUKTUR OBERFLÄCHEN","url":null,"abstract":{"de":null,"en":null},"begin_planned":"2010-01-01T01:00:00+01:00","begin_effective":"2010-03-01T01:00:00+01:00","end_planned":"2012-12-31T01:00:00+01:00","end_effective":"2014-02-28T01:00:00+01:00","assignment":"2010-04-19T15:05:26+02:00","program":null,"subprogram":null,"organization":14050,"category":10,"type":10,"partner_function":4,"manager":61927,"contact":61927,"status":2,"research":3,"grant":10,"event":null,"study":null,"language":null,"funders":[416],"funder_projectcode":null,"ethics_committee":null,"edudract_number":null,"persons":["2183-61927-10","2183-63490-12","2183-67749-12"]},{"id":2432,"title":{"de":"BIOmarkers of Metabolic Homeostatic Robustness for Nutrition-derived Health CLAIMS Made on Food [BIOCLAIMS]","en":"BIOmarkers of Metabolic Homeostatic Robustness for Nutrition-derived Health CLAIMS Made on Food [BIOCLAIMS]"},"short":"BIOCLAIMS","url":null,"abstract":{"de":null,"en":null},"begin_planned":"2010-01-01T01:00:00+01:00","begin_effective":"2010-03-01T01:00:00+01:00","end_planned":"2014-12-31T01:00:00+01:00","end_effective":"2015-02-28T01:00:00+01:00","assignment":"2011-02-28T11:51:34+01:00","program":24,"subprogram":"KBBE-2009-2-2-03","organization":14084,"category":10,"type":10,"partner_function":2,"manager":null,"contact":null,"status":2,"research":2,"grant":10,"event":null,"study":null,"language":null,"funders":[10],"funder_projectcode":" 244995","ethics_committee":null,"edudract_number":null,"persons":[]},{"id":2017,"title":{"de":"Computational modelling of steatohepatitis based on data generated from in vitro differentiated hepatocytes derived from individual-pecific iPS cells.","en":"Computational modelling of steatohepatitis based on data generated from in vitro differentiated hepatocytes derived from individual-pecific iPS cells."},"short":"LivSYSiPS","url":null,"abstract":{"de":null,"en":null},"begin_planned":"2009-10-01T02:00:00+02:00","begin_effective":"2010-03-01T01:00:00+01:00","end_planned":"2012-09-30T02:00:00+02:00","end_effective":"2013-03-31T01:00:00+01:00","assignment":"2009-12-11T16:23:33+01:00","program":73,"subprogram":null,"organization":14020,"category":10,"type":10,"partner_function":2,"manager":51663,"contact":51663,"status":2,"research":2,"grant":10,"event":null,"study":null,"language":null,"funders":[152],"funder_projectcode":"823408","ethics_committee":null,"edudract_number":null,"persons":["2017-51663-10"]},{"id":2155,"title":{"de":"Remote Assessibility to Diabetes Management and Therapy in Operational healthcare Networks - REACTION","en":"Remote Assessibility to Diabetes Management and Therapy in Operational healthcare Networks - REACTION"},"short":"REACTION","url":null,"abstract":{"de":null,"en":null},"begin_planned":"2010-01-01T01:00:00+01:00","begin_effective":"2010-03-01T01:00:00+01:00","end_planned":"2013-12-31T01:00:00+01:00","end_effective":"2014-02-28T01:00:00+01:00","assignment":"2010-03-05T10:04:48+01:00","program":24,"subprogram":null,"organization":14080,"category":10,"type":10,"partner_function":2,"manager":51831,"contact":null,"status":2,"research":2,"grant":10,"event":null,"study":null,"language":null,"funders":[10],"funder_projectcode":"248590","ethics_committee":null,"edudract_number":null,"persons":["2155-51831-10","2155-59231-12","2155-64875-12","2155-65558-12"]},{"id":2630,"title":{"de":"Angiogeneseleistung von mesenchymalen Zellen der Plazenta in 3-D Zellkulturmodellen","en":"Angiogenesis  of mesenchymal cells of the placenta in 3-D cell culture models "},"short":null,"url":null,"abstract":{"de":null,"en":null},"begin_planned":"2010-03-01T01:00:00+01:00","begin_effective":"2010-03-01T01:00:00+01:00","end_planned":"2010-12-31T01:00:00+01:00","end_effective":"2010-12-31T01:00:00+01:00","assignment":"2011-11-09T12:43:52+01:00","program":null,"subprogram":null,"organization":14017,"category":10,"type":10,"partner_function":4,"manager":51718,"contact":51718,"status":2,"research":1,"grant":10,"event":null,"study":null,"language":null,"funders":[530],"funder_projectcode":null,"ethics_committee":null,"edudract_number":null,"persons":["2630-51718-10"]},{"id":1798,"title":{"de":"DALI - Vitamin D and Lifestyle Intervention for GDM Prevention","en":"DALI - Vitamin D and Lifestyle Intervention for GDM Prevention"},"short":"DALI","url":null,"abstract":{"de":"Europe is facing an unprecedented threat from Type 2 diabetes (T2D) with associated human suffering and economic burden and rapidly growing proportions. While T2D is traditionally associated with sedentary lifestyle and unhealthy diet, the currently observed growth in developed countries is greater than expected from lifestyle changes alone. Evidence is accumulating that GDM is a more important contributor to these epidemics than prevoiusly recognised.\r\n\r\nIn this study, we will use an exploratory trial approach to develop the best intervention for preventing gestational diabetes mellitus (GDM). We will concurrently use the trial data, samples and cohorts to increase our understanding of the pathophysiological mechanisms leading to enhanced diabetes and obesity risk to mother and baby. Building upon the expertise of members of the Diabetes in Pregnancy Study Group Europe (DPSG) and joined by behavioural researchers and health economists, our study is designed to collate the evidence around the epidemiology of GDM in Europe, to promote pan-European standards and measures for GDM and identify suitable preventive measures against GDM.","en":"Europe is facing an unprecedented threat from Type 2 diabetes (T2D) with associated human suffering and economic burden and rapidly growing proportions. While T2D is traditionally associated with sedentary lifestyle and unhealthy diet, the currently observed growth in developed countries is greater than expected from lifestyle changes alone. Evidence is accumulating that GDM is a more important contributor to these epidemics than prevoiusly recognised.\r\n\r\nIn this study, we will use an exploratory trial approach to develop the best intervention for preventing gestational diabetes mellitus (GDM). We will concurrently use the trial data, samples and cohorts to increase our understanding of the pathophysiological mechanisms leading to enhanced diabetes and obesity risk to mother and baby. Building upon the expertise of members of the Diabetes in Pregnancy Study Group Europe (DPSG) and joined by behavioural researchers and health economists, our study is designed to collate the evidence around the epidemiology of GDM in Europe, to promote pan-European standards and measures for GDM and identify suitable preventive measures against GDM."},"begin_planned":"2010-01-01T01:00:00+01:00","begin_effective":"2010-03-01T01:00:00+01:00","end_planned":"2013-12-31T01:00:00+01:00","end_effective":"2015-12-31T01:00:00+01:00","assignment":"2009-04-27T16:25:57+02:00","program":24,"subprogram":"HEALTH-2009-2.4.3-1","organization":14038,"category":10,"type":10,"partner_function":3,"manager":51632,"contact":51632,"status":2,"research":2,"grant":10,"event":null,"study":null,"language":null,"funders":[10],"funder_projectcode":null,"ethics_committee":null,"edudract_number":null,"persons":["1798-51632-10"]},{"id":2027,"title":{"de":"Effects of 25-OH-vitamin D supplementation in coronary artery disease patients with postprandial hyperglycemia and vitamin D deficiency on endothelial function and insulin sensitivity","en":"Effects of 25-OH-vitamin D supplementation in coronary artery disease patients with postprandial hyperglycemia and vitamin D deficiency on endothelial function and insulin sensitivity"},"short":"VITAMIN D_CORONARY ARTERY","url":null,"abstract":{"de":null,"en":null},"begin_planned":"2010-03-01T01:00:00+01:00","begin_effective":"2010-03-01T01:00:00+01:00","end_planned":"2012-02-28T01:00:00+01:00","end_effective":"2013-02-28T01:00:00+01:00","assignment":"2009-12-22T13:08:42+01:00","program":79,"subprogram":null,"organization":14080,"category":10,"type":10,"partner_function":4,"manager":50838,"contact":50838,"status":2,"research":2,"grant":10,"event":null,"study":null,"language":null,"funders":[12],"funder_projectcode":null,"ethics_committee":null,"edudract_number":null,"persons":["2027-50838-10"]},{"id":2188,"title":{"de":"Zusatzfinanzierung DALI","en":"Zusatzfinanzierung DALI"},"short":"Zusatzfinanz DALI","url":null,"abstract":{"de":null,"en":null},"begin_planned":"2010-03-01T01:00:00+01:00","begin_effective":"2010-03-01T01:00:00+01:00","end_planned":"2014-08-31T02:00:00+02:00","end_effective":"2015-12-31T01:00:00+01:00","assignment":"2010-04-28T15:38:33+02:00","program":null,"subprogram":null,"organization":14038,"category":10,"type":10,"partner_function":4,"manager":51632,"contact":51632,"status":2,"research":5,"grant":10,"event":null,"study":null,"language":null,"funders":[25],"funder_projectcode":null,"ethics_committee":null,"edudract_number":null,"persons":["2188-51632-10"]},{"id":2126,"title":{"de":"Auswirkungen von Stressoren bei Kindern und Jugendlichen","en":"Effects of stress in adolescents"},"short":"STRESSOREN_KINDER_JUGENDLICHE","url":null,"abstract":{"de":null,"en":null},"begin_planned":"2010-03-01T01:00:00+01:00","begin_effective":"2010-03-01T01:00:00+01:00","end_planned":"2010-09-30T02:00:00+02:00","end_effective":"2010-09-30T02:00:00+02:00","assignment":"2010-02-22T11:26:29+01:00","program":null,"subprogram":null,"organization":29447,"category":10,"type":10,"partner_function":1,"manager":60040,"contact":60040,"status":2,"research":2,"grant":10,"event":null,"study":null,"language":null,"funders":[135],"funder_projectcode":null,"ethics_committee":null,"edudract_number":null,"persons":["2126-60040-10","2126-52274-11"]},{"id":2436,"title":{"de":"Translational Research Pilotprojekt zur ABCSG Studie: Primärtumoroperation in synchronisiert metastasiertem invasiven Brusktrebs, multizentrische prospektive randomisierte Studie zur Evaluierung des Nutzens der Lokaltherapie","en":"Pilot Translational Research Project to the ABSCG study: Primary Operation in Synchronous metastasized InVasivE breast cancer (POSYTIVE), a multicenter prospective randomized study to evaluate the use of local therapy"},"short":"Trans- POSYTIVE","url":null,"abstract":{"de":null,"en":null},"begin_planned":"2010-03-01T01:00:00+01:00","begin_effective":"2010-03-01T01:00:00+01:00","end_planned":"2012-03-01T01:00:00+01:00","end_effective":"2014-12-31T01:00:00+01:00","assignment":"2011-03-03T11:02:36+01:00","program":81,"subprogram":null,"organization":14085,"category":10,"type":10,"partner_function":4,"manager":59188,"contact":59188,"status":2,"research":2,"grant":10,"event":null,"study":null,"language":null,"funders":[52],"funder_projectcode":null,"ethics_committee":null,"edudract_number":null,"persons":["2436-80692-12","2436-50539-12","2436-59188-10"]},{"id":2210,"title":{"de":"OncoMark - Methods for systematicnext generation oncology biomarker development","en":"OncoMark - Methods for systematicnext generation oncology biomarker development"},"short":"Anbahnung OncoMark","url":null,"abstract":{"de":null,"en":null},"begin_planned":"2010-02-15T01:00:00+01:00","begin_effective":"2010-02-15T01:00:00+01:00","end_planned":"2010-05-06T02:00:00+02:00","end_effective":"2010-12-31T01:00:00+01:00","assignment":"2010-05-25T15:21:12+02:00","program":54,"subprogram":null,"organization":14020,"category":10,"type":10,"partner_function":4,"manager":null,"contact":null,"status":2,"research":2,"grant":10,"event":null,"study":null,"language":null,"funders":[416],"funder_projectcode":null,"ethics_committee":null,"edudract_number":null,"persons":[]},{"id":2039,"title":{"de":"Wilms Tumor Development as a Mirror of Nephrogenesis - The Role of Imprinted Genes","en":"Wilms Tumor Development as a Mirror of Nephrogenesis - The Role of Imprinted Genes"},"short":"WILMS TUMOR NEPHROGENESIS","url":null,"abstract":{"de":null,"en":null},"begin_planned":"2010-02-01T01:00:00+01:00","begin_effective":"2010-02-01T01:00:00+01:00","end_planned":"2012-01-31T01:00:00+01:00","end_effective":"2012-06-30T02:00:00+02:00","assignment":"2010-01-18T10:41:24+01:00","program":79,"subprogram":null,"organization":14020,"category":10,"type":10,"partner_function":4,"manager":52569,"contact":52569,"status":2,"research":2,"grant":10,"event":null,"study":null,"language":null,"funders":[12],"funder_projectcode":null,"ethics_committee":null,"edudract_number":null,"persons":["2039-52569-10"]},{"id":2146,"title":{"de":"AP@home","en":"AP@home"},"short":"AP@home","url":null,"abstract":{"de":null,"en":null},"begin_planned":"2010-10-01T02:00:00+02:00","begin_effective":"2010-02-01T01:00:00+01:00","end_planned":"2013-12-31T01:00:00+01:00","end_effective":"2014-10-31T01:00:00+01:00","assignment":"2010-03-02T11:22:16+01:00","program":24,"subprogram":"ICT: FP7-ICT-2009-4","organization":14080,"category":10,"type":10,"partner_function":2,"manager":51831,"contact":51831,"status":2,"research":2,"grant":10,"event":null,"study":null,"language":null,"funders":[10],"funder_projectcode":null,"ethics_committee":null,"edudract_number":null,"persons":["2146-51831-10","2146-50877-12","2146-61759-12","2146-56674-12","2146-50731-12"]},{"id":2099,"title":{"de":"Funktionelle MRT zur Charakterisierung der neuralen Korrelate des Multi-Tasking unter besonderer Berücksichtigung geschlechtsbezogener Unterschiede","en":"A functional MRI study probing sex-related effects in multi tasking"},"short":"Funktionelle MRT ","url":null,"abstract":{"de":null,"en":null},"begin_planned":"2010-02-01T01:00:00+01:00","begin_effective":"2010-02-01T01:00:00+01:00","end_planned":"2011-01-31T01:00:00+01:00","end_effective":"2012-06-30T02:00:00+02:00","assignment":"2010-02-09T14:28:20+01:00","program":null,"subprogram":null,"organization":14051,"category":10,"type":10,"partner_function":4,"manager":59566,"contact":59566,"status":2,"research":1,"grant":10,"event":null,"study":null,"language":null,"funders":[135],"funder_projectcode":null,"ethics_committee":null,"edudract_number":null,"persons":["2099-59566-10"]},{"id":2024,"title":{"de":"Non-invasive monitoring of tissue rejection after heart transplantation","en":"Non-invasive monitoring of tissue rejection after heart transplantation"},"short":"TISSUE REJECTION HEART TRANSPLANT","url":null,"abstract":{"de":null,"en":null},"begin_planned":"2010-02-01T01:00:00+01:00","begin_effective":"2010-02-01T01:00:00+01:00","end_planned":"2012-01-31T01:00:00+01:00","end_effective":"2012-12-31T01:00:00+01:00","assignment":"2009-12-18T14:24:22+01:00","program":79,"subprogram":null,"organization":14073,"category":10,"type":10,"partner_function":4,"manager":50874,"contact":50874,"status":2,"research":2,"grant":10,"event":null,"study":null,"language":null,"funders":[12],"funder_projectcode":null,"ethics_committee":null,"edudract_number":null,"persons":["2024-50874-10"]},{"id":2038,"title":{"de":"MIGRONIS - Projektfortführung","en":"MIGRONIS - Projektfortführung"},"short":"MIGRONIS","url":null,"abstract":{"de":null,"en":null},"begin_planned":"2009-07-01T02:00:00+02:00","begin_effective":"2010-02-01T01:00:00+01:00","end_planned":"2010-07-01T02:00:00+02:00","end_effective":"2011-01-31T01:00:00+01:00","assignment":"2010-01-15T15:49:27+01:00","program":null,"subprogram":null,"organization":14028,"category":10,"type":10,"partner_function":4,"manager":50562,"contact":50562,"status":2,"research":2,"grant":10,"event":null,"study":null,"language":null,"funders":[135],"funder_projectcode":null,"ethics_committee":null,"edudract_number":null,"persons":["2038-50562-10"]},{"id":2091,"title":{"de":"Comparative in situ transcriptome analysis of the human cytotrophoblast and syncytiotrophoblast","en":"Comparative in situ transcriptome analysis of the human cytotrophoblast and syncytiotrophoblast"},"short":"HUMAN CYTOTROPHOBLAST","url":null,"abstract":{"de":null,"en":"Human placental villous trees are covered by a two-layered epithelium-like trophoblast layer, which consists of mononucleated cytotrophoblasts and an overlying multinucleated syncytiotrophoblast. Cell turnover in the trophoblast layer includes proliferation, differentiation and subsequent fusion of cytotrophoblasts with the syncytiotrophoblast. Thus, both layers represent stages of different degree of differentiation, ranging from very early differentiated (cytotrophoblast) to terminally differentiated stages (syncytiotrophoblast). Data on comparative whole transcriptome analyses between in vitro cultured mononucleated and multinucleated primary trophoblasts exist, but have their clear limitations. Withdrawal from the in vivo microenvironment as well as in vitro culture of primary cells alters gene expression profiles, which no longer resemble the in vivo situation. To overcome these limitations we intent to microdissect these two cell fractions directly from fixed, paraffin embedded placental tissue. Total RNAs from microdissected cytotrophoblasts and syncytiotrophoblast will be subjected to microarray analysis with the aim to detect differentially expressed genes. The expectations in this project are to gain insight into the spatial expression of genes relevant for trophoblast differentiation. Furthermore, this project should deliver the basis for follow-up studies comparing placentas from healthy and pathologic pregnancies."},"begin_planned":"2010-02-01T01:00:00+01:00","begin_effective":"2010-02-01T01:00:00+01:00","end_planned":"2011-07-31T02:00:00+02:00","end_effective":"2011-07-31T02:00:00+02:00","assignment":"2010-02-09T11:47:12+01:00","program":null,"subprogram":null,"organization":14017,"category":10,"type":10,"partner_function":4,"manager":53232,"contact":null,"status":2,"research":1,"grant":10,"event":null,"study":null,"language":null,"funders":[894],"funder_projectcode":null,"ethics_committee":null,"edudract_number":null,"persons":["2091-53232-10"]}]}