{"count":2329,"next":"https://api-test.medunigraz.at/v1/research/project/?format=json&limit=20&offset=1820&ordering=end_planned","previous":"https://api-test.medunigraz.at/v1/research/project/?format=json&limit=20&offset=1780&ordering=end_planned","results":[{"id":6505,"title":{"de":"Perinatales sowie neurologisches 2-Jahres Outcome bei Kindern mit später Wachstumsrestriktion: randomisiert kontrollierte TRUFFLE-2 Studie (Österreichischer Teil der Studie)","en":"Perinatal and 2-year neurodevelopmental outcome in late preterm fetal compromise: the TRUFFLE-2 randomized, controlled trial (Austrian part of the study)"},"short":"TRUFFLE-2 Austria","url":null,"abstract":{"de":null,"en":null},"begin_planned":"2020-10-01T02:00:00+02:00","begin_effective":"2020-10-01T02:00:00+02:00","end_planned":"2024-10-01T02:00:00+02:00","end_effective":"2027-04-30T02:00:00+02:00","assignment":"2021-03-23T15:15:49+01:00","program":108,"subprogram":null,"organization":14064,"category":10,"type":10,"partner_function":3,"manager":50155,"contact":null,"status":2,"research":4,"grant":10,"event":null,"study":null,"language":null,"funders":[9],"funder_projectcode":"KLI881","ethics_committee":"32-237 ex 19/20","edudract_number":null,"persons":["6505-50155-10"]},{"id":7818,"title":{"de":"Oxidativer Stress vor und nach probiotischer Therapie bei Depression","en":"Oxidative Stress pre- and post probiotic therapy in major depression"},"short":"OXSTRESS","url":null,"abstract":{"de":null,"en":null},"begin_planned":"2023-10-05T02:00:00+02:00","begin_effective":"2023-10-05T02:00:00+02:00","end_planned":"2024-10-05T02:00:00+02:00","end_effective":"2024-10-05T02:00:00+02:00","assignment":"2023-10-09T16:03:03+02:00","program":null,"subprogram":null,"organization":29447,"category":10,"type":10,"partner_function":4,"manager":84449,"contact":null,"status":2,"research":1,"grant":10,"event":null,"study":null,"language":null,"funders":[2471],"funder_projectcode":null,"ethics_committee":null,"edudract_number":null,"persons":["7818-84449-10"]},{"id":7773,"title":{"de":"Entwicklung einer App zur Bewertung sowie Quantifizierung des Schweregrads idiopathischer epiretinaler Membranen und Vorschlag eines Punktesystems zur weiteren Therapiegliederung: eine prospektive Pilotstudie ","en":"Developing an App to assess and quantify idiopathic epiretinal membrane severity and proposing a scoring system for further treatment recommendation: a prospective pilot study"},"short":"ERM APP","url":null,"abstract":{"de":null,"en":null},"begin_planned":"2023-10-10T02:00:00+02:00","begin_effective":"2023-10-01T02:00:00+02:00","end_planned":"2024-10-10T02:00:00+02:00","end_effective":"2026-09-30T02:00:00+02:00","assignment":"2023-09-19T12:46:56+02:00","program":null,"subprogram":null,"organization":14043,"category":10,"type":10,"partner_function":4,"manager":104906,"contact":null,"status":2,"research":2,"grant":10,"event":null,"study":null,"language":null,"funders":[938,2194],"funder_projectcode":null,"ethics_committee":null,"edudract_number":null,"persons":["7773-104906-10"]},{"id":7854,"title":{"de":"LichtAktive MikroPartikel (LAMP) zur Wiederherstellung der Sehfunktion bei \r\nNetzhautdegeneration","en":"Light Active MicroParticles for vision restoration in retina degenerative diseases"},"short":"LAMP","url":null,"abstract":{"de":null,"en":null},"begin_planned":"2023-11-01T01:00:00+01:00","begin_effective":"2024-01-01T01:00:00+01:00","end_planned":"2024-10-30T01:00:00+01:00","end_effective":"2025-04-30T02:00:00+02:00","assignment":"2023-10-25T14:05:31+02:00","program":null,"subprogram":null,"organization":14011,"category":10,"type":10,"partner_function":3,"manager":99325,"contact":null,"status":2,"research":1,"grant":10,"event":null,"study":null,"language":null,"funders":[135],"funder_projectcode":null,"ethics_committee":null,"edudract_number":null,"persons":["7854-99325-10"]},{"id":6001,"title":{"de":"Das Darm-Mikrobiom im Verlauf hämato-/onkologischer Erkrankungen","en":"The Gut Microbiome in Haemato-/Oncological Patients"},"short":"MikroPHiOm","url":null,"abstract":{"de":null,"en":null},"begin_planned":"2019-11-01T01:00:00+01:00","begin_effective":"2019-11-01T01:00:00+01:00","end_planned":"2024-10-31T01:00:00+01:00","end_effective":"2024-10-31T01:00:00+01:00","assignment":"2019-12-16T10:01:50+01:00","program":null,"subprogram":null,"organization":14095,"category":10,"type":10,"partner_function":4,"manager":56810,"contact":null,"status":2,"research":4,"grant":10,"event":null,"study":null,"language":null,"funders":[1550],"funder_projectcode":null,"ethics_committee":null,"edudract_number":null,"persons":["6001-56810-10"]},{"id":6899,"title":{"de":"Wir alle sind Mischwesen: Mikrochimärsimus, Gesundheit und Evolution","en":"We All Are Multitudes: the Microchimerism, Human Health and Evolution"},"short":"Microchimerism and Evolution","url":"https://www.microchimerism.info/","abstract":{"de":"Mikrochimärismus (MC) beschreibt die Existenz einer kleinen Anzahl fremder menschlicher Zellen in einer Person. Dieses Phänomen entsteht unter anderem während der Schwangerschaft durch das Wandern von Zellen zwischen Mutter und Fötus. Das derzeitige Wissen um MC ist unvollständig und teils widersprüchlich, über die Rolle, die mikrochimäre Zellen in der Wirtsphysiologie spielen, ist wenig bekannt.\r\nWas ist der Grund der anscheinend paradoxen Effekte von MC? Welche Mechanismen sind beteiligt oder sogar verantwortlich dafür, dass mikrochimäre Zellen ins Wirtsgewebe wandern, sich dort integrieren und oftmals ein Wirtsleben lang verbleiben? Die Evolutionsbiologie und die maternal-fetale Konflikttheorie können einen Rahmen bieten, um die Persistenz mikrochimärer Zellen zu verstehen und deren Existenz mit einer erhöhten Anfälligkeit für Krankheiten zu verknüpfen.\r\nWir gehen zunächst davon aus, dass MC weiter verbreitet ist als bisher berichtet. Wir nehmen weiters an, dass mikrochimäre Zellen eine adaptive Rolle in der Physiologie des Wirts zu spielen vermögen und Vorteile für Mütter und Nachkommen bieten können, etwa durch Übertragung von Stammzellen und anderen Zelltypen aber auch durch Übertragung von wichtigen Komponenten des und Signalen für das Immunsystem. Jedoch werden sich in manchen Geweben die maternal-fötalen genetischen Interessen nicht zur Deckung bringen lassen, was eine erhöhte Anfälligkeit für Krankheiten zur Folge haben kann. Daher ist es unser Ziel, den Einfluss des MC auf Gesundheit und Krankheit zu studieren und Potential und Effekte des Zelltransfers über Generationengrenzen hinweg zu verstehen.\r\nBasis unseres Projekts ist die Verwendung modernster Technologien zur Analyse des bidirektionalen Transfers mikrochimärer Zellen zwischen Individuen und die Verteilung der mikrochimären Zellen in den Zielgeweben. Weiters widmen wir uns den Effekten, die aus der Interaktion von mikrochimären Zellen und dem Immunsystem des Wirts hervorgehen. Diese Themen studieren wir in mehreren Teilprojekten: Erstellung eines Maus-Mikrochiom-Atlas (Projekt 1), Phänotypisierung von maternalem (Projekt 2) und fetalem (Projekt 3) MC, Charakterisierung von mikrochimären Zellen in plazentanahen, -fernen Geweben und diversen Organen (Projekt 4) sowie den Zusammenhang von MC und Autoimmunerkrankung im Tiermodell (Projekt 5).\r\nUnsere Forschung dient dem Verständnis der Interaktion von mikrochimären Zellen mit dem Wirt und zur Klärung der Fragen, wie die Toleranz von MC während der Schwangerschaft und postpartum bei Müttern gewährleistet und aufrecht erhalten werden kann, welche Auswirkungen MC auf die frühe Entwicklung von Föten hat und ob es während Krankheiten zum Zusammenbruch der Immuntoleranz kommt und welche Ursachen dies hat.","en":"Microchimerism (MC) is the harboring of a small number of cells between two distinct individuals. This transfer of cells is well known to occur between mothers and offspring during gestation, though other avenues of transfer may be possible. The current understanding of MC is puzzling and little is known about the role microchimeric cells play in host physiology.\r\nWhy are the effects of MC paradoxical and what are the mechanisms responsible for maintaining microchimeric cells over an organism’s lifetime? Evolutionary biology and maternal-fetal conflict theory can provide a framework to understand the persistence of microchimeric cells, and how this may lead to disease vulnerability.\r\nWe hypothesize MC is much more common than previously reported and microchimeric cells play an adaptive role in host physiology, providing benefits for both mothers and offspring through transfers of stem and other cell types, and providing key immune system components and signals. However, in certain host tissues the maternal-fetal genetic interests may not align, potentially leading to disease vulnerability.\r\nWe aim to understand the role MC plays in health and disease, and understand the potential for and effects of subsequent generational transfers of microchimeric cells. We will use cutting edge technology to characterize MC cell distribution and trafficking between hosts and the effects of MC-host immune system interactions in various host tissues by creating a mouse Microchiome Atlas (Project 1), phenotyping human maternal MC (mMC) (Project 2), phenotyping human fetal MC (fMC) (Project 3), phenotyping microchimeric cells proximal and distal in terms of distance from the maternal-fetal interface as well as in various other organs (Project 4), and interrogating the context of MC and autoimmune disease in animal models (Project 5).\r\nOur research will determine how microchimeric cells interact with the host system to initiate and maintain tolerance of MC during pregnancy, the postpartum period for mothers and early development in offspring, and uncover if there is a breakdown in immune tolerance during disease states, and what causes it."},"begin_planned":"2022-02-01T01:00:00+01:00","begin_effective":"2021-12-01T01:00:00+01:00","end_planned":"2024-10-31T01:00:00+01:00","end_effective":"2026-08-30T02:00:00+02:00","assignment":"2022-02-01T12:59:33+01:00","program":null,"subprogram":null,"organization":14017,"category":10,"type":10,"partner_function":3,"manager":54171,"contact":null,"status":2,"research":1,"grant":10,"event":null,"study":null,"language":null,"funders":[2575],"funder_projectcode":"62214","ethics_committee":null,"edudract_number":null,"persons":["6899-104057-12","6899-54171-10","6899-82600-12","6899-104139-12","6899-114270-12","6899-115382-12","6899-116463-12"]},{"id":5343,"title":{"de":"CD Labor für Gas- und Partikeltransport durch Papier","en":"CD Laboratory for Gas and Particle Transport through Paper"},"short":null,"url":null,"abstract":{"de":null,"en":null},"begin_planned":"2017-10-01T02:00:00+02:00","begin_effective":"2018-01-01T01:00:00+01:00","end_planned":"2024-10-31T01:00:00+01:00","end_effective":"2024-12-31T01:00:00+01:00","assignment":"2018-04-16T11:35:10+02:00","program":97,"subprogram":null,"organization":14023,"category":10,"type":10,"partner_function":2,"manager":54018,"contact":null,"status":2,"research":1,"grant":10,"event":null,"study":null,"language":null,"funders":[23],"funder_projectcode":null,"ethics_committee":null,"edudract_number":null,"persons":["5343-54018-10"]},{"id":7347,"title":{"de":"Mutations-spezifische Eradikation von Myelofibrose mittels Genom-editierter humaner Stammzellen","en":"Engineered human stem cells for mutation-specific eradication of myelofibrosis"},"short":null,"url":null,"abstract":{"de":null,"en":null},"begin_planned":"2021-11-01T01:00:00+01:00","begin_effective":"2021-11-01T01:00:00+01:00","end_planned":"2024-10-31T01:00:00+01:00","end_effective":"2024-10-31T01:00:00+01:00","assignment":"2023-01-25T10:34:34+01:00","program":null,"subprogram":null,"organization":14082,"category":10,"type":10,"partner_function":2,"manager":50747,"contact":null,"status":2,"research":1,"grant":10,"event":null,"study":null,"language":null,"funders":[2647],"funder_projectcode":null,"ethics_committee":null,"edudract_number":null,"persons":["7347-50747-10"]},{"id":7574,"title":{"de":"Smarte Aktivierung zur Verbesserung Kognitiver Leistungsfähigkeit durch\r\nEntscheidungsassistenz und Digitale Biomarker","en":"Smart activation to improve cognitive functions through decision support and digital biomarker"},"short":"SmartAktiv","url":null,"abstract":{"de":null,"en":null},"begin_planned":"2023-04-01T02:00:00+02:00","begin_effective":"2023-04-17T02:00:00+02:00","end_planned":"2024-11-01T01:00:00+01:00","end_effective":"2025-03-16T01:00:00+01:00","assignment":"2023-05-17T16:17:36+02:00","program":126,"subprogram":null,"organization":14051,"category":10,"type":10,"partner_function":2,"manager":59566,"contact":null,"status":2,"research":1,"grant":10,"event":null,"study":3,"language":null,"funders":[416],"funder_projectcode":"FO999904045","ethics_committee":null,"edudract_number":null,"persons":["7574-59566-10"]},{"id":7698,"title":{"de":"Erforschung eines mechanistischen Stoffwechselweges, welcher ein potentieller Auslöser für IUGR ist.","en":"Investigation of a mechanistic metabolic pathway, potentially contributing IUGR "},"short":null,"url":null,"abstract":{"de":null,"en":null},"begin_planned":"2023-09-01T02:00:00+02:00","begin_effective":"2023-08-01T02:00:00+02:00","end_planned":"2024-11-01T01:00:00+01:00","end_effective":"2024-10-01T02:00:00+02:00","assignment":"2023-07-28T13:06:02+02:00","program":null,"subprogram":null,"organization":14017,"category":10,"type":10,"partner_function":4,"manager":82600,"contact":null,"status":2,"research":1,"grant":10,"event":null,"study":null,"language":null,"funders":[2471],"funder_projectcode":null,"ethics_committee":null,"edudract_number":null,"persons":["7698-82600-10"]},{"id":7031,"title":{"de":"Identifizierung von antigen-spezifischen T-Zellen über Ca2+-NFAT Signalweg in nicht-kleinzelligen Lungenkrebs","en":"Identification of antigen-specific T cells via Ca2+-NFAT signaling in non-small celllung cancer"},"short":null,"url":null,"abstract":{"de":null,"en":null},"begin_planned":"2021-11-01T01:00:00+01:00","begin_effective":"2022-07-01T02:00:00+02:00","end_planned":"2024-11-01T01:00:00+01:00","end_effective":"2024-06-30T02:00:00+02:00","assignment":"2022-05-23T11:06:58+02:00","program":116,"subprogram":null,"organization":14022,"category":10,"type":10,"partner_function":1,"manager":null,"contact":null,"status":2,"research":2,"grant":10,"event":null,"study":null,"language":null,"funders":[15],"funder_projectcode":null,"ethics_committee":null,"edudract_number":null,"persons":[]},{"id":7907,"title":{"de":"Untersuchung seltener und häufiger genetischer Varianten und spezifischer Merkmale der COPD-assoziierten pulmonalen Hypertonie","en":"Assessment of rare and common genetic variants and specific traits of COPD-associated pulmonary hypertension"},"short":"Mid-Career Grant der ÖGP 2023","url":null,"abstract":{"de":null,"en":null},"begin_planned":"2023-11-07T01:00:00+01:00","begin_effective":"2023-11-07T01:00:00+01:00","end_planned":"2024-11-07T01:00:00+01:00","end_effective":"2024-11-07T01:00:00+01:00","assignment":"2023-11-29T08:21:55+01:00","program":null,"subprogram":null,"organization":14087,"category":10,"type":10,"partner_function":4,"manager":87980,"contact":null,"status":2,"research":1,"grant":10,"event":null,"study":null,"language":null,"funders":[2396],"funder_projectcode":null,"ethics_committee":null,"edudract_number":null,"persons":["7907-87980-10"]},{"id":8139,"title":{"de":"Untersuchung verlässlicher Veränderungen für die \"Fatigue Scale for Motor and Cognitive Functions\" (FSMC)","en":"Exploring Reliable Change for the Fatigue Scale for Motor and Cognitive Functions (FSMC)\r\n"},"short":null,"url":null,"abstract":{"de":null,"en":null},"begin_planned":"2024-06-01T02:00:00+02:00","begin_effective":"2024-09-01T02:00:00+02:00","end_planned":"2024-11-30T01:00:00+01:00","end_effective":"2024-11-30T01:00:00+01:00","assignment":"2024-04-15T15:02:56+02:00","program":null,"subprogram":null,"organization":14051,"category":10,"type":10,"partner_function":4,"manager":107891,"contact":null,"status":2,"research":2,"grant":10,"event":null,"study":null,"language":null,"funders":[2539],"funder_projectcode":null,"ethics_committee":null,"edudract_number":null,"persons":["8139-107891-10"]},{"id":7895,"title":{"de":"Aberrante basaloide Zellen in der Lungenfibrose","en":"ABC in pulmonary fibrosis"},"short":"ABC pulmonary fibrosis","url":null,"abstract":{"de":null,"en":null},"begin_planned":"2023-12-01T01:00:00+01:00","begin_effective":"2023-12-01T01:00:00+01:00","end_planned":"2024-11-30T01:00:00+01:00","end_effective":"2025-12-31T01:00:00+01:00","assignment":"2023-11-21T15:13:17+01:00","program":null,"subprogram":null,"organization":14022,"category":10,"type":10,"partner_function":4,"manager":85658,"contact":null,"status":2,"research":1,"grant":10,"event":null,"study":null,"language":null,"funders":[135],"funder_projectcode":null,"ethics_committee":null,"edudract_number":null,"persons":["7895-85658-10","7895-50132-12","7895-111587-12","7895-116746-12","7895-126994-12"]},{"id":8078,"title":{"de":"Isolierung und Charakterisierung verschiedener zytosolischer Lipidspeicher im Dünndarm","en":"Isolation and characterization of different cytosolic lipid droplet stores in the small intestine"},"short":null,"url":null,"abstract":{"de":null,"en":null},"begin_planned":"2024-05-01T02:00:00+02:00","begin_effective":"2024-05-06T02:00:00+02:00","end_planned":"2024-11-30T01:00:00+01:00","end_effective":"2024-12-05T01:00:00+01:00","assignment":"2024-03-11T11:32:28+01:00","program":204,"subprogram":null,"organization":14013,"category":10,"type":10,"partner_function":4,"manager":76131,"contact":null,"status":2,"research":1,"grant":10,"event":null,"study":null,"language":null,"funders":[15],"funder_projectcode":null,"ethics_committee":null,"edudract_number":null,"persons":["8078-76131-10"]},{"id":7646,"title":{"de":"Pilotprojekt DigiDiab Assistenz Mobile Pflege","en":"Pilot DigiDiab Assistant Domiciliary Nursing Care"},"short":"DigiDiab","url":null,"abstract":{"de":null,"en":null},"begin_planned":"2022-12-01T01:00:00+01:00","begin_effective":"2023-06-01T02:00:00+02:00","end_planned":"2024-11-30T01:00:00+01:00","end_effective":"2025-08-31T02:00:00+02:00","assignment":"2023-07-03T17:39:49+02:00","program":null,"subprogram":null,"organization":14080,"category":10,"type":10,"partner_function":3,"manager":65558,"contact":null,"status":2,"research":2,"grant":10,"event":null,"study":null,"language":null,"funders":[2160],"funder_projectcode":null,"ethics_committee":null,"edudract_number":null,"persons":["7646-54235-12","7646-65558-10","7646-99971-12"]},{"id":8108,"title":{"de":"Immunantwort gegen Orthohantaviren","en":"Immuneresponse to orthohantaviruses"},"short":null,"url":null,"abstract":{"de":null,"en":null},"begin_planned":"2023-07-01T02:00:00+02:00","begin_effective":"2023-07-01T02:00:00+02:00","end_planned":"2024-12-01T01:00:00+01:00","end_effective":"2024-12-01T01:00:00+01:00","assignment":"2024-03-22T10:42:15+01:00","program":69,"subprogram":null,"organization":14046,"category":10,"type":10,"partner_function":2,"manager":94596,"contact":null,"status":2,"research":1,"grant":10,"event":null,"study":null,"language":null,"funders":[9],"funder_projectcode":null,"ethics_committee":null,"edudract_number":null,"persons":["8108-94596-10"]},{"id":8068,"title":{"de":"MICU1 als zentrale Schaltstelle für Signalweiterleitung und Metabolismus durch morphologische Anpassung der Cristae Junction","en":"MICU1 is a central switching point for signal transmission and metabolism through morphological adaptation of the cristae junction"},"short":null,"url":null,"abstract":{"de":null,"en":null},"begin_planned":"2024-03-01T01:00:00+01:00","begin_effective":"2024-03-01T01:00:00+01:00","end_planned":"2024-12-01T01:00:00+01:00","end_effective":"2025-12-31T01:00:00+01:00","assignment":"2024-03-05T16:07:14+01:00","program":null,"subprogram":null,"organization":14013,"category":10,"type":10,"partner_function":4,"manager":90394,"contact":null,"status":2,"research":1,"grant":10,"event":null,"study":null,"language":null,"funders":[1743],"funder_projectcode":null,"ethics_committee":null,"edudract_number":null,"persons":["8068-90394-10"]},{"id":6433,"title":{"de":"Nanopore Sequenzierung in der Augenheilkunde","en":"Nanopore sequencing in ophthalmology"},"short":null,"url":null,"abstract":{"de":null,"en":null},"begin_planned":"2020-12-01T01:00:00+01:00","begin_effective":"2020-12-01T01:00:00+01:00","end_planned":"2024-12-30T01:00:00+01:00","end_effective":"2024-12-30T01:00:00+01:00","assignment":"2021-02-03T12:32:09+01:00","program":null,"subprogram":null,"organization":14043,"category":10,"type":10,"partner_function":4,"manager":96622,"contact":null,"status":2,"research":2,"grant":10,"event":null,"study":null,"language":null,"funders":[938],"funder_projectcode":null,"ethics_committee":null,"edudract_number":null,"persons":["6433-96622-10"]},{"id":8006,"title":{"de":"Sicherheit und Wirksamkeit eines mobilen, App-basierten Decision Support Systems für  Bewegung bei Typ 1 Diabetes","en":"Safety and pilot efficacy of a mobile app-based decision support system for\r\nexercise in type 1 diabetes (AppEx)"},"short":"AppEx","url":null,"abstract":{"de":null,"en":null},"begin_planned":"2024-01-01T01:00:00+01:00","begin_effective":"2024-01-01T01:00:00+01:00","end_planned":"2024-12-31T01:00:00+01:00","end_effective":"2024-12-31T01:00:00+01:00","assignment":"2024-01-31T15:08:01+01:00","program":null,"subprogram":null,"organization":14080,"category":10,"type":10,"partner_function":2,"manager":50838,"contact":null,"status":2,"research":2,"grant":10,"event":null,"study":null,"language":null,"funders":[431],"funder_projectcode":null,"ethics_committee":null,"edudract_number":null,"persons":["8006-50838-10"]}]}