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TUMOURS","url":null,"abstract":{"de":null,"en":null},"begin_planned":"2010-08-01T02:00:00+02:00","begin_effective":"2010-08-01T02:00:00+02:00","end_planned":"2012-07-31T02:00:00+02:00","end_effective":"2013-12-31T01:00:00+01:00","assignment":"2010-07-16T15:00:22+02:00","program":79,"subprogram":null,"organization":14047,"category":10,"type":10,"partner_function":4,"manager":51751,"contact":51751,"status":2,"research":2,"grant":10,"event":null,"study":null,"language":null,"funders":[12],"funder_projectcode":null,"ethics_committee":null,"edudract_number":null,"persons":["2255-58889-12","2255-51751-10"]},{"id":2537,"title":{"de":"Klinische Relevanz von Keimbahnpolymorphismen in Wnt/Notch/Hedgehog für Prognose bei Kolonkarzinomen","en":"Clinical impact of germline polymorphisms in Wnt/Notch/Hedgehog for colon cancer outcome"},"short":"GERMLINE POLYMORPH COLON CANCER","url":null,"abstract":{"de":null,"en":null},"begin_planned":"2011-08-01T02:00:00+02:00","begin_effective":"2011-11-01T01:00:00+01:00","end_planned":"2012-07-31T02:00:00+02:00","end_effective":"2012-10-31T01:00:00+01:00","assignment":"2011-07-19T11:01:17+02:00","program":79,"subprogram":null,"organization":14085,"category":10,"type":10,"partner_function":4,"manager":58814,"contact":58814,"status":2,"research":2,"grant":10,"event":null,"study":null,"language":null,"funders":[12],"funder_projectcode":null,"ethics_committee":null,"edudract_number":null,"persons":["2537-58814-10"]},{"id":2536,"title":{"de":"Chordome: erste Schritte in der Entwicklung neuer Therapieansätze","en":"Chordomas: First steps towards a new therapy"},"short":"Chordomas: New Therapy","url":null,"abstract":{"de":null,"en":null},"begin_planned":"2011-08-01T02:00:00+02:00","begin_effective":"2011-08-01T02:00:00+02:00","end_planned":"2012-07-31T02:00:00+02:00","end_effective":"2012-10-31T01:00:00+01:00","assignment":"2011-07-18T14:17:06+02:00","program":79,"subprogram":null,"organization":14052,"category":10,"type":10,"partner_function":4,"manager":53237,"contact":53237,"status":2,"research":1,"grant":10,"event":null,"study":null,"language":null,"funders":[12],"funder_projectcode":null,"ethics_committee":null,"edudract_number":null,"persons":["2536-50696-12","2536-61131-12","2536-53237-10"]},{"id":3007,"title":{"de":"Dynamik von CaV1.2 Kalziumkanälen in neuronaler Modulation","en":"Dynamik von CaV1.2 Kalziumkanälen in neuronaler Modulation"},"short":"T443   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RISKS","url":null,"abstract":{"de":null,"en":null},"begin_planned":"2010-08-01T02:00:00+02:00","begin_effective":"2010-08-01T02:00:00+02:00","end_planned":"2012-07-30T02:00:00+02:00","end_effective":"2012-09-30T02:00:00+02:00","assignment":"2012-01-23T16:27:35+01:00","program":58,"subprogram":null,"organization":17230,"category":10,"type":10,"partner_function":2,"manager":53900,"contact":53900,"status":2,"research":5,"grant":10,"event":null,"study":null,"language":null,"funders":[],"funder_projectcode":null,"ethics_committee":null,"edudract_number":null,"persons":["2765-53900-10"]},{"id":2789,"title":{"de":"Charakterisierung der pro-apoptotischen Wirkung des alpha1-adrenergen Antagonisten Prazosin auf humane Tumorzellen","en":"Characterization of the pro-apoptotic action of the alpha1-adrenergic antagonist prazosin on malignant cells."},"short":"Prazosin induzierte Apoptose","url":null,"abstract":{"de":null,"en":null},"begin_planned":"2011-07-01T02:00:00+02:00","begin_effective":"2011-07-01T02:00:00+02:00","end_planned":"2012-07-01T02:00:00+02:00","end_effective":"2012-07-01T02:00:00+02:00","assignment":"2012-02-15T09:37:16+01:00","program":null,"subprogram":null,"organization":14014,"category":10,"type":10,"partner_function":4,"manager":null,"contact":null,"status":2,"research":1,"grant":10,"event":null,"study":null,"language":null,"funders":[530],"funder_projectcode":null,"ethics_committee":null,"edudract_number":null,"persons":[]},{"id":2363,"title":{"de":"Detektion der BRAF V600E Mutation in Lentigo Maligna Melanoma","en":"Detection of the BRAF V600E mutation in Lentigo Maligna Melanoma lesions"},"short":"BRAF V600E","url":null,"abstract":{"de":"Das maligne Melanom (MM) gilt als eine der aggressivsten Formen von Hautkrebs mit einer hohen\r\nSterblichkeitsrate und oftmals inadäquaten Therapiemöglichkeiten, insbesondere bei\r\nMetastasierung. Die Voraussetzungen für die Gabe neuer, vielversprechender Therapien sind die\r\npräzise Diagnose und das Wissen über den Mutationsstatus des Tumors.\r\nDie Diagnose der Lentigo maligna melanoma (LMM), einer Sonderform des MM, wird durch klinische\r\nund histopathologische Ähnlichkeiten mit pigmentierter aktinischer Keratose (in situ\r\nPlattenepithelkarzinom) und solarer Lentigo („einfacher Pigmentfleck“ oder „Altersfleck“) erschwert.\r\nÜber den genetischen Charakter von LMM (insbesondere hinsichtlich BRAF), aber auch solarer\r\nLentigo ist bisher nur wenig bekannt.\r\nDie BRAF V600E Mutation ist das am häufigsten detektierte onkologische Ereignis beim MM. In der\r\nvorliegenden Studie wird der Mutationsstatus von BRAF V600E in einem genau charakterisierten\r\nKollektiv aus FFPE LMM Gewebeproben analysiert. Dazu werden drei verschiedene, auf PCR\r\nbasierende, Methoden zur Mutationsanalyse optimiert und validiert. Die BRAF V600E\r\nMutationshäufigkeit wird in einem großem LMM Kollektiv bestimmt und ihre diagnostische und\r\nklinische Relevanz durch den Vergleich mit dem Mutationsstatus bei aktinischer Keratose und solarer\r\nLentigo evaluiert. Die Ergebnisse dieser Studie sollen zur Verbesserung der Diagnostik und\r\nDifferenzialdiagnostik und auch der Therapie des MM beitragen.","en":"Malignant melanoma (MM) is considered the most aggressive form of skin cancers with a high\r\nmortality and often ineffective treatment, especially for metastasis. Prerequisites for the application\r\nof new and promising therapies are the precise diagnosis and the knowledge of the mutational status\r\nof the tumor.\r\nDiagnosis of Lentigo maligna melanoma (LMM), a special form of MM, is complicated since\r\npigmented actinic keratosis (in situ squamous cell carcinoma) and solar lentigo (‘senile freckle’) can\r\nresemble LMM clinically and histopathologically. Only few data is available concerning the genetic\r\ncharacter of both LMM and solar lentigo (especially regarding BRAF).\r\nThe BRAF V600E mutation is the most frequent oncogenic event detected in MM. The study at hand\r\nwill analyze the BRAF V600E mutational status in a well characterized collective of FFPE LMM tissue\r\nsamples. For this purpose we will optimize and validate three different PCR based methods for\r\nmutational analysis. The incidence of the BRAF V600E mutation will be determined in a large LMM\r\ncollective and the diagnostic and clinical relevance of mutated BRAF will be evaluated by comparison\r\nwith that in pigmented actinic keratosis and solar lentigo. The results of this study should help to\r\nimprove the diagnostics means and contribute to advance therapy options of MM."},"begin_planned":"2011-01-01T01:00:00+01:00","begin_effective":"2011-01-01T01:00:00+01:00","end_planned":"2012-06-30T02:00:00+02:00","end_effective":"2012-06-30T02:00:00+02:00","assignment":"2010-12-16T11:07:50+01:00","program":79,"subprogram":null,"organization":14085,"category":10,"type":10,"partner_function":null,"manager":50563,"contact":50563,"status":2,"research":2,"grant":10,"event":null,"study":null,"language":null,"funders":[12],"funder_projectcode":null,"ethics_committee":null,"edudract_number":null,"persons":["2363-50229-12","2363-50563-10","2363-51066-12","2363-51618-11"]},{"id":2872,"title":{"de":"Chordom - Charakterisierung der MUG-Chor1 Zelllinie","en":"Chordoma - Characterizing MUG-Chor1 cell line"},"short":"Chordoma","url":null,"abstract":{"de":null,"en":null},"begin_planned":"2012-04-01T02:00:00+02:00","begin_effective":"2012-04-01T02:00:00+02:00","end_planned":"2012-06-30T02:00:00+02:00","end_effective":"2012-06-30T02:00:00+02:00","assignment":"2012-05-24T12:00:53+02:00","program":null,"subprogram":null,"organization":14017,"category":10,"type":10,"partner_function":4,"manager":54171,"contact":54171,"status":2,"research":1,"grant":10,"event":null,"study":null,"language":null,"funders":[530],"funder_projectcode":null,"ethics_committee":null,"edudract_number":null,"persons":["2872-54171-10"]},{"id":2620,"title":{"de":"Etablierung des Mutationsspektrums in zirkulierenden Tumorzellen von Patienntinnen und Patienten mit Mamma- oder Prostatakarzinomen _ONCOTYROL","en":"Establishment of the mutation spectrum in circulating tumor cells of patients with breast and prostate cancer"},"short":"ONCOTYROL","url":null,"abstract":{"de":null,"en":null},"begin_planned":"2010-09-01T02:00:00+02:00","begin_effective":"2010-09-01T02:00:00+02:00","end_planned":"2012-06-30T02:00:00+02:00","end_effective":"2012-06-30T02:00:00+02:00","assignment":"2011-10-28T13:07:04+02:00","program":94,"subprogram":"Das K1 Zentrum ONCOTYROL - Center for Personalized Cancer Medicine ist im Rahmen des vom BMWA und BMVIT initiierten Strukturprogramms COMET in Zusammenarbeit mit\r\n\r\n    * Land Tirol\r\n    * Land Steiermark (Abteilung 3, Abteilung 14 und Wirtschaftsressort)\r\n    * Steirische Wirtschaftsförderung\r\n    * den drei regionalen Universitäten und der Industrie geschaffen worden.","organization":14021,"category":10,"type":10,"partner_function":1,"manager":null,"contact":null,"status":2,"research":2,"grant":10,"event":null,"study":null,"language":null,"funders":[2,416,1040,1154],"funder_projectcode":null,"ethics_committee":null,"edudract_number":null,"persons":[]}]}