{"count":2329,"next":"https://api-test.medunigraz.at/v1/research/project/?format=json&limit=20&offset=1380&ordering=-end_effective","previous":"https://api-test.medunigraz.at/v1/research/project/?format=json&limit=20&offset=1340&ordering=-end_effective","results":[{"id":4262,"title":{"de":"MicroRNA Regulation von TGFβ-vermittelter Kardioprotektion","en":"MicroRNA Regulation of TGFβ-Induced Cardio-Protective Factors"},"short":"n/a","url":null,"abstract":{"de":null,"en":null},"begin_planned":"2014-03-01T01:00:00+01:00","begin_effective":"2014-04-01T02:00:00+02:00","end_planned":"2016-02-28T01:00:00+01:00","end_effective":"2017-12-31T01:00:00+01:00","assignment":"2016-02-01T10:41:14+01:00","program":null,"subprogram":"START - Med Uni Graz","organization":14083,"category":10,"type":10,"partner_function":4,"manager":58906,"contact":null,"status":2,"research":1,"grant":10,"event":null,"study":null,"language":null,"funders":[894],"funder_projectcode":null,"ethics_committee":null,"edudract_number":null,"persons":["4262-58906-10"]},{"id":4050,"title":{"de":"Der Beitrag von I(f) und I(K1) zur ektopen Fokusbildung im linken und rechten Atrium bei Vorhofflimmern","en":"Interatrial gradients in I(f) and I(K1) and their contribution to focal activity in atrial fibrillation"},"short":null,"url":null,"abstract":{"de":"Vorhofflimmern (VHF) ist eine der häufigsten Rhythmusstörungen und ist mit einer hohen Morbidität und Mortalität assoziiert. Veränderungen der Ionenkanalfunktion werden unter anderem für die Generierung der Arrhythmien verantwortlich gemacht. Neben Arealen im Bereich der Eintrittsstellen der Pulmonalvenen in den linken Vorhof spielen dabei sowohl das linke als auch das rechte Herzohr eine Rolle. Das Ziel der Studie ist die Erforschung der Rolle des Schrittmacherstromes  If – potentiell verantwortlich für ektope Aktivitäten, und die Erforschung des einwärts gleichrichtenden Kaliumstromes IK1 – verantwortlich für ein stabiles Ruhemembranpotential bei der Generierung abnormer Automatie bei VHF. Ein spezieller Fokus wird der Vergleich interatrialer Unterschiede bei Patienten mit und ohne VHF sein. Zusätzlich werden die experimentellen Untersuchungen in ein dreidimensionales Computermodell integriert, wodurch ein Beitrag zum besseren Verständnis der Bedeutung von If- und IK1 bei der Entstehung von VHF geleistet werden soll. Darüberhinaus könnten diese Ergebnisse zu einer verbesserten Behandlung des VHF beitragen.","en":"Atrial fibrillation (AF) is the most common arrhythmia tightly associated with an increased morbidity and mortality. Alterations in ion channel function are pivotal for the generation of arrhythmias. Besides the pulmonary veins, the left atrial appendage is increasingly recognized as an important source of focal ectopic activity. This study aims to investigate the role of the pacemaker current If – a potential contributor to ectopic activity, and the inward rectifier potassium current IK1 – a key determinant for a stable resting membrane potential in the generation of abnormal automaticity in AF. Special focus is given to interatrial differences in human AF patients. The experimental results will be implemented in a 3D computational model of the atria in order to assess the contribution of If and IK1 to focal activity in AF. Findings obtained in this study will lead to a better understanding of the mechanisms underlying AF and thereby provide important information for treatment of AF. \r\n\r\n"},"begin_planned":"2015-09-01T02:00:00+02:00","begin_effective":"2015-09-01T02:00:00+02:00","end_planned":"2017-08-31T02:00:00+02:00","end_effective":"2017-12-31T01:00:00+01:00","assignment":"2015-07-08T16:46:47+02:00","program":79,"subprogram":null,"organization":14011,"category":10,"type":10,"partner_function":4,"manager":50615,"contact":null,"status":2,"research":5,"grant":10,"event":null,"study":null,"language":null,"funders":[12],"funder_projectcode":null,"ethics_committee":null,"edudract_number":null,"persons":["4050-50615-10","4050-50840-12","4050-50966-12","4050-50969-12","4050-50990-12","4050-51592-12"]},{"id":3389,"title":{"de":"ENDOTHELIAL FUNCTION, RENO-VASCULAR AND NEUROHORMONAL RESPONSES DURING ORTHOSTATIC SYNCOPE AND RECOVERY: A GENDER COMPARISON STUDY (EROS)","en":"Endothelial function, reno-vascular and neurohormonal responses during orthostatic syncope and recovery:  A gender comparative study"},"short":"EROS","url":null,"abstract":{"de":null,"en":null},"begin_planned":"2014-01-01T01:00:00+01:00","begin_effective":"2014-01-01T01:00:00+01:00","end_planned":"2015-12-31T01:00:00+01:00","end_effective":"2017-12-31T01:00:00+01:00","assignment":"2013-09-30T12:37:49+02:00","program":null,"subprogram":"Italian Space Agency (ASI); human exploration program","organization":14010,"category":10,"type":10,"partner_function":4,"manager":57932,"contact":null,"status":2,"research":1,"grant":10,"event":null,"study":null,"language":null,"funders":[1527],"funder_projectcode":null,"ethics_committee":null,"edudract_number":null,"persons":["3389-57932-10"]},{"id":3788,"title":{"de":"Chromatinveränderungen durch FXR in NAFLD","en":"Binding profiles and the chromatin landscape of the nuclear receptor FXR - a promising pharmaceutical target for non-alcoholic fatty liver disease in 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