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","url":null,"abstract":{"de":null,"en":null},"begin_planned":"2016-05-01T02:00:00+02:00","begin_effective":"2016-05-01T02:00:00+02:00","end_planned":"2018-04-30T02:00:00+02:00","end_effective":"2018-04-30T02:00:00+02:00","assignment":"2016-07-08T14:56:46+02:00","program":null,"subprogram":null,"organization":14076,"category":10,"type":10,"partner_function":4,"manager":80111,"contact":null,"status":2,"research":5,"grant":10,"event":null,"study":null,"language":null,"funders":[1886],"funder_projectcode":null,"ethics_committee":null,"edudract_number":null,"persons":["4506-80111-10"]},{"id":4875,"title":{"de":"Computer Modelling for Better Health","en":"Computer Modelling for Better Health"},"short":"Modelling Health (MH)","url":null,"abstract":{"de":null,"en":null},"begin_planned":"2016-11-01T01:00:00+01:00","begin_effective":"2017-03-01T01:00:00+01:00","end_planned":"2018-04-30T02:00:00+02:00","end_effective":"2018-08-31T02:00:00+02:00","assignment":"2017-03-09T15:04:14+01:00","program":75,"subprogram":null,"organization":14020,"category":10,"type":10,"partner_function":2,"manager":51663,"contact":null,"status":2,"research":1,"grant":10,"event":null,"study":null,"language":null,"funders":[55],"funder_projectcode":null,"ethics_committee":null,"edudract_number":null,"persons":["4875-51745-12","4875-51663-10"]},{"id":4243,"title":{"de":"Synthese licht-aktiver Modulatoren/Marker von TRPC3/6-Kanälen","en":"Synthesis of light-responsive modulators/labels of TRPC3/6-channels"},"short":null,"url":null,"abstract":{"de":null,"en":"Novel light-responsive modulators/labels of TRPC3/6-channels\r\nMammalian Transient Receptor Potential (TRP) channels include six related protein\r\nfamilies. Members of the human TRP Canonical (TRPC) subfamily\r\n(TRPC1/3/4/5/6/7), form channels that mediate Ca2+- and Na+-ion entry and are\r\nexpressed in many mammalian cell types to serve a broad-range of important\r\nphysiological processes. Recently, TRPC3/6 channels have been implicated in the\r\npathogenesis of cardiovascular disorders including heart failure, arrhythmias, and\r\nsudden death. Consequently, TRPC channels have emerged as highly promising\r\ntargets for drug development, while, at the same time, their exact cellular function and\r\nprinciples of pharmacologic modulation are still incompletely understood and require\r\nbetter understanding. For this, novel strategies to experimentally control channel\r\nfunction are urgently needed. These channels are endogenously controlled by plasma\r\nmembrane lipid metabolites, which are difficult to administer in most experimental\r\nsettings. Novel modulating or blocking ligands with potentially suitable selectivity for\r\nexact experimental control of TRPC3/6 channel have just recently been reported. One\r\nobjective of this proposal is therefore the synthesis of small modulators\r\n(inhibitors/activators) of TRPC3/6-channels that response to light, allowing the\r\ncontrol of biological events with unparalleled spatial and temporal precision – so\r\ncalled “photoswitches” (e.g. azobenzens). Taking advantage of our experience in the\r\nsynthesis of pyrazole-based inhibitors of TRPC3/6-channels and benzimidazolonebased\r\nactivators as well as our expertise in microwave and continuous-flow\r\nchemistry, we aim to generate and explore various photoswitchable ligands in\r\nconnection to the emerging pharmacology of TRPC3/6-channels. Another objective\r\nof ours, involving small photoresponsive molecules, is the synthesis of photoaffinity\r\nlabels to help in the elucidation of potential ligand-binding sites in the TRPC3/6-\r\nchannels as well as on the structure elucidation of TRPC3/6-channels.\r\nThe research proposed herein is meant to become a significant contribution to\r\na thrilling and rapidly growing field for optoregulation of biological functions in\r\nmammalian cells and for better understanding on the TRPC3/6-channel machinery. If\r\npositive results are obtained, the arising pharmacology will importantly aid\r\ninvestigations of the physiological and pathophysiological roles of TRPC channels,\r\nfacilitate the validation of TRPCs as potential therapeutic targets in different\r\nchannelopathies, and possibly provide foundations for drug discovery and\r\ndevelopment."},"begin_planned":"2015-05-01T02:00:00+02:00","begin_effective":"2015-05-01T02:00:00+02:00","end_planned":"2018-04-30T02:00:00+02:00","end_effective":"2018-12-31T01:00:00+01:00","assignment":"2016-01-22T13:09:43+01:00","program":72,"subprogram":null,"organization":14011,"category":10,"type":10,"partner_function":2,"manager":78591,"contact":null,"status":2,"research":1,"grant":10,"event":null,"study":null,"language":null,"funders":[9],"funder_projectcode":"P 28243-B27   ","ethics_committee":null,"edudract_number":null,"persons":["4243-78591-10"]},{"id":4316,"title":{"de":"Relaxin","en":"Relaxin"},"short":"RELAXIN","url":null,"abstract":{"de":null,"en":null},"begin_planned":"2016-05-01T02:00:00+02:00","begin_effective":"2016-08-01T02:00:00+02:00","end_planned":"2018-04-30T02:00:00+02:00","end_effective":"2019-01-31T01:00:00+01:00","assignment":"2016-02-17T10:16:51+01:00","program":60,"subprogram":null,"organization":14073,"category":10,"type":10,"partner_function":4,"manager":50874,"contact":null,"status":2,"research":3,"grant":10,"event":null,"study":null,"language":null,"funders":[416],"funder_projectcode":"853276","ethics_committee":null,"edudract_number":null,"persons":["4316-98584-12","4316-50874-10","4316-62756-12","4316-81091-12","4316-108983-12"]}]}