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28529","ethics_committee":null,"edudract_number":null,"persons":["4125-50810-10"]},{"id":3602,"title":{"de":"Imatinib als neues Prostaglandin freisetzendes Arzneimittel","en":"Imatinib as a novel prostaglandin releasing drug"},"short":null,"url":null,"abstract":{"de":null,"en":null},"begin_planned":"2013-07-01T02:00:00+02:00","begin_effective":"2014-04-01T02:00:00+02:00","end_planned":"2016-07-01T02:00:00+02:00","end_effective":"2019-09-30T02:00:00+02:00","assignment":"2014-03-11T09:48:51+01:00","program":72,"subprogram":null,"organization":14022,"category":10,"type":10,"partner_function":4,"manager":null,"contact":null,"status":2,"research":1,"grant":10,"event":null,"study":null,"language":null,"funders":[9],"funder_projectcode":"P 26185","ethics_committee":null,"edudract_number":null,"persons":[]},{"id":4054,"title":{"de":"Fetales Geschlecht beeinflusst die endotheliale Funktion","en":"Fetal sex regulates endothelial 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study"},"short":null,"url":null,"abstract":{"de":null,"en":null},"begin_planned":"2016-10-01T02:00:00+02:00","begin_effective":"2016-10-01T02:00:00+02:00","end_planned":"2019-10-01T02:00:00+02:00","end_effective":"2019-10-31T01:00:00+01:00","assignment":"2016-07-15T15:01:11+02:00","program":108,"subprogram":null,"organization":14051,"category":10,"type":10,"partner_function":4,"manager":59566,"contact":null,"status":2,"research":4,"grant":10,"event":null,"study":null,"language":null,"funders":[9],"funder_projectcode":"KLI546","ethics_committee":null,"edudract_number":null,"persons":["4522-59566-10"]},{"id":5459,"title":{"de":"Führt die Zwerchfellhernie zu Unterschieden im pulmonalen Mikrobiom und Atemgasprofil im Vergleich zu gesunden Kindern?\r\n\r\n","en":"Does congenital diaphragmatic hernia lead to alterations in pulmonary microbiome and exhaled volatile organic compounds compared to healthy children?"},"short":"CDH VOC Study","url":null,"abstract":{"de":null,"en":null},"begin_planned":"2018-10-01T02:00:00+02:00","begin_effective":"2018-09-01T02:00:00+02:00","end_planned":"2019-10-31T01:00:00+01:00","end_effective":"2019-10-31T01:00:00+01:00","assignment":"2018-08-27T14:52:47+02:00","program":null,"subprogram":null,"organization":14049,"category":10,"type":10,"partner_function":4,"manager":null,"contact":null,"status":2,"research":3,"grant":10,"event":null,"study":null,"language":null,"funders":[457],"funder_projectcode":null,"ethics_committee":null,"edudract_number":null,"persons":["5459-50778-12","5459-54087-12"]},{"id":4220,"title":{"de":"Phospholipide und deren Rezeptoren in Erkrankungen des Kolons","en":"Phospholipids and their receptors in diseases of the colon"},"short":null,"url":null,"abstract":{"de":"Phospholipide und deren Rezeptoren: mögliche Rolle in entzündlichen Darmerkrankungen und im Dickdarmkrebs \r\nLipidmoleküle sind nicht nur wichtige Spieler im Energiestoffwechsel, sondern dienen auch als Botenstoffe zur Signalübertragung. Mehrere neue Arten solcher Lipidmoleküle, welche die Funktion von Krebszellen beeinflussen können, wurden in den letzten Jahren entdeckt. Unter ihnen befinden sich die sogenannten Endocannabinoide, die ähnliche Wirkung haben wie die Inhaltsstoffe von Cannabis sativa, aber im Organismus selbst gebildet werden. Diese Lipide sind Botenstoffe an Krebszellen, wo sie an Rezeptoren binden und die Funktion der Zellen beeinflussen.\r\nIm vorliegenden Projekt wollen wir einen sogenannten atypischen Cannabinoid Rezeptor mit dem Namen GPR55, der an Dickdarmkrebszellen vorkommt, untersuchen. Dieser Rezeptor besitzt als aktivierenden Botenstoff nicht nur Endocannabinoide, sondern auch ein Phospholipidmolekül, genannt LPI (Lysophophatidylinositol). LPI und GPR55 bilden zusammen eine Achse, von der man glaubt, dass sie eine treibende Rolle im Dickdarmkrebs und in entzündlichen Darmerkrankungen spielt. Diese Hypothese wird durch die Tatsache untermauert, dass GPR55 sowohl in Dickdarmkrebszellen als auch im gesunden Darm vorhanden ist und in experimentellen Modellen die Entzündung und das Krebswachstum fördert. Zur Klärung der Frage, ob diese molekulare Achse auch in Darmentzündungen und im Dickdarmkrebs des Menschen Bedeutung hat, wird der Gehalt an GPR55 Rezeptoren im Tumorgewebe von Kolonkarzinompatienten und in Darmbiopsien von Patienten mit entzündlichen Darmerkrankungen mittels geeigneten biochemischen und histologischen Methoden nachgewiesen. LPI wird im Serum mittels hochauflösender Massenspektrometrie gemessen. \r\nDie wenig erforschte Rolle von GPR55 in diesen Erkrankungen wird in diesem Projekt erstmals in humanen Proben untersucht. Es wird vermutet, dass GPR55 als Bestandteil des Endocannabinoidsystems an wichtigen Schaltstellen zur Entstehung dieser Erkrankungen sitzt. Diese Tatsache macht GPR55 zu einem wichtigen Angriffspunkt einer pharmakologischen Therapie. Schließlich wird in diesem Projekt auch die Möglichkeit erforscht, ob LPI als Biomarker zur Bestimmung dieser Krankheiten geeignet ist.\r\n","en":null},"begin_planned":"2015-10-01T02:00:00+02:00","begin_effective":"2016-05-01T02:00:00+02:00","end_planned":"2018-09-30T02:00:00+02:00","end_effective":"2019-10-31T01:00:00+01:00","assignment":"2016-01-11T13:59:08+01:00","program":108,"subprogram":null,"organization":14022,"category":10,"type":10,"partner_function":4,"manager":56687,"contact":null,"status":2,"research":4,"grant":10,"event":null,"study":null,"language":null,"funders":[9],"funder_projectcode":"KLI521","ethics_committee":null,"edudract_number":null,"persons":["4220-56687-10"]},{"id":5799,"title":{"de":"Bioaktive Matrix aus kollagenhältigen Ressourcen als Wundheilungssystem bei chronischen Wunden","en":"Bioactive matrix derived from secondary collagen-containing resources as a wound healing system for chronic wounds"},"short":null,"url":null,"abstract":{"de":null,"en":null},"begin_planned":"2019-02-02T01:00:00+01:00","begin_effective":"2019-02-01T01:00:00+01:00","end_planned":"2019-12-02T01:00:00+01:00","end_effective":"2019-10-31T01:00:00+01:00","assignment":"2019-05-22T11:49:19+02:00","program":null,"subprogram":null,"organization":14022,"category":10,"type":10,"partner_function":3,"manager":51832,"contact":null,"status":2,"research":1,"grant":10,"event":null,"study":null,"language":null,"funders":[762],"funder_projectcode":null,"ethics_committee":null,"edudract_number":null,"persons":["5799-51832-10"]},{"id":4981,"title":{"de":"Hautnah - 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A comprehensive approach to promote a disability-free advanced age in Europe: the ADVANTAGE initiative."},"short":"ADVANTAGE","url":null,"abstract":{"de":null,"en":null},"begin_planned":"2016-07-01T02:00:00+02:00","begin_effective":"2017-01-01T01:00:00+01:00","end_planned":"2018-06-30T02:00:00+02:00","end_effective":"2019-12-31T01:00:00+01:00","assignment":"2016-12-16T11:01:30+01:00","program":null,"subprogram":"Joint Action","organization":14046,"category":10,"type":10,"partner_function":2,"manager":51745,"contact":null,"status":2,"research":5,"grant":10,"event":null,"study":null,"language":null,"funders":[10],"funder_projectcode":"724099","ethics_committee":null,"edudract_number":null,"persons":["4737-51745-10","4737-100384-12"]},{"id":5178,"title":{"de":"Treatment of pediatric acute lymphoblastic leukemia with a modified resource-conserved BFM protocol in Kosovo: Monitoring outcome using minimal residual disease evaluation by flow cytometry and evaluation of toxicity and costs from dependence to independence","en":"Treatment of pediatric acute lymphoblastic leukemia with a modified resource-conserved BFM protocol in Kosovo: Monitoring outcome using minimal residual disease evaluation by flow cytometry and evaluation of toxicity and costs from dependence to independence"},"short":null,"url":null,"abstract":{"de":null,"en":null},"begin_planned":"2018-01-01T01:00:00+01:00","begin_effective":"2018-01-01T01:00:00+01:00","end_planned":"2019-10-31T01:00:00+01:00","end_effective":"2019-12-31T01:00:00+01:00","assignment":"2017-12-22T14:06:10+01:00","program":null,"subprogram":null,"organization":14092,"category":10,"type":10,"partner_function":4,"manager":51859,"contact":null,"status":2,"research":2,"grant":10,"event":null,"study":null,"language":null,"funders":[1415],"funder_projectcode":null,"ethics_committee":null,"edudract_number":null,"persons":["5178-51859-10"]},{"id":6755,"title":{"de":"Implementierung eines neuen Ausbildungskonzeptes für das Spezialgebiet „Polytraumamanagement“","en":"Implementation of new Training Concept in Poyltrauma Management"},"short":"Training Poyltrauma","url":null,"abstract":{"de":null,"en":null},"begin_planned":"2017-07-01T02:00:00+02:00","begin_effective":"2017-07-01T02:00:00+02:00","end_planned":"2019-12-31T01:00:00+01:00","end_effective":"2019-12-31T01:00:00+01:00","assignment":"2021-10-21T10:43:27+02:00","program":null,"subprogram":null,"organization":14052,"category":10,"type":10,"partner_function":4,"manager":62925,"contact":null,"status":2,"research":5,"grant":10,"event":null,"study":null,"language":null,"funders":[],"funder_projectcode":null,"ethics_committee":null,"edudract_number":null,"persons":["6755-62925-10","6755-72835-12","6755-59379-11"]},{"id":4789,"title":{"de":"Lipasen und Lipidsignaling","en":"Lipases and Lipid Signaling"},"short":"Lipid Signaling","url":null,"abstract":{"de":null,"en":null},"begin_planned":"2017-01-01T01:00:00+01:00","begin_effective":"2017-01-01T01:00:00+01:00","end_planned":"2019-12-31T01:00:00+01:00","end_effective":"2019-12-31T01:00:00+01:00","assignment":"2017-01-02T11:17:22+01:00","program":null,"subprogram":"BioTechMed Flagship Project","organization":14013,"category":10,"type":10,"partner_function":3,"manager":51904,"contact":null,"status":2,"research":1,"grant":10,"event":null,"study":null,"language":null,"funders":[2325],"funder_projectcode":null,"ethics_committee":null,"edudract_number":null,"persons":["4789-51904-10"]},{"id":5325,"title":{"de":"Untersuchungen zur immunregulatorische Funktion von Nr4a1 in aggressiven Lymphomen","en":"Elucidating the immune regulatory function of Nr4a1 in aggressive lymphomagenesis"},"short":null,"url":null,"abstract":{"de":null,"en":null},"begin_planned":"2018-04-01T02:00:00+02:00","begin_effective":"2018-04-01T02:00:00+02:00","end_planned":"2019-12-31T01:00:00+01:00","end_effective":"2019-12-31T01:00:00+01:00","assignment":"2018-04-03T12:28:18+02:00","program":null,"subprogram":null,"organization":14082,"category":10,"type":10,"partner_function":4,"manager":59183,"contact":null,"status":2,"research":1,"grant":10,"event":null,"study":null,"language":null,"funders":[1743],"funder_projectcode":"MEFO-09","ethics_committee":null,"edudract_number":null,"persons":["5325-59183-10"]}]}