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Mehrere neue Arten solcher Lipidmoleküle, welche die Funktion von Krebszellen beeinflussen können, wurden in den letzten Jahren entdeckt. Unter ihnen befinden sich die sogenannten Endocannabinoide, die ähnliche Wirkung haben wie die Inhaltsstoffe von Cannabis sativa, aber im Organismus selbst gebildet werden. Diese Lipide sind Botenstoffe an Krebszellen, wo sie an Rezeptoren binden und die Funktion der Zellen beeinflussen.\r\nIm vorliegenden Projekt wollen wir einen sogenannten atypischen Cannabinoid Rezeptor mit dem Namen GPR55, der an Dickdarmkrebszellen vorkommt, untersuchen. Dieser Rezeptor besitzt als aktivierenden Botenstoff nicht nur Endocannabinoide, sondern auch ein Phospholipidmolekül, genannt LPI (Lysophophatidylinositol). LPI und GPR55 bilden zusammen eine Achse, von der man glaubt, dass sie eine treibende Rolle im Dickdarmkrebs und in entzündlichen Darmerkrankungen spielt. Diese Hypothese wird durch die Tatsache untermauert, dass GPR55 sowohl in Dickdarmkrebszellen als auch im gesunden Darm vorhanden ist und in experimentellen Modellen die Entzündung und das Krebswachstum fördert. Zur Klärung der Frage, ob diese molekulare Achse auch in Darmentzündungen und im Dickdarmkrebs des Menschen Bedeutung hat, wird der Gehalt an GPR55 Rezeptoren im Tumorgewebe von Kolonkarzinompatienten und in Darmbiopsien von Patienten mit entzündlichen Darmerkrankungen mittels geeigneten biochemischen und histologischen Methoden nachgewiesen. LPI wird im Serum mittels hochauflösender Massenspektrometrie gemessen. \r\nDie wenig erforschte Rolle von GPR55 in diesen Erkrankungen wird in diesem Projekt erstmals in humanen Proben untersucht. Es wird vermutet, dass GPR55 als Bestandteil des Endocannabinoidsystems an wichtigen Schaltstellen zur Entstehung dieser Erkrankungen sitzt. Diese Tatsache macht GPR55 zu einem wichtigen Angriffspunkt einer pharmakologischen Therapie. Schließlich wird in diesem Projekt auch die Möglichkeit erforscht, ob LPI als Biomarker zur Bestimmung dieser Krankheiten geeignet ist.\r\n","en":null},"begin_planned":"2015-10-01T02:00:00+02:00","begin_effective":"2016-05-01T02:00:00+02:00","end_planned":"2018-09-30T02:00:00+02:00","end_effective":"2019-10-31T01:00:00+01:00","assignment":"2016-01-11T13:59:08+01:00","program":108,"subprogram":null,"organization":14022,"category":10,"type":10,"partner_function":4,"manager":56687,"contact":null,"status":2,"research":4,"grant":10,"event":null,"study":null,"language":null,"funders":[9],"funder_projectcode":"KLI521","ethics_committee":null,"edudract_number":null,"persons":["4220-56687-10"]},{"id":4052,"title":{"de":"Promoting Early Diagnosis of Rett Syndrome \r\nthrough Speech-Language Pathology\r\n","en":"Promoting Early Diagnosis of Rett Syndrome \r\nthrough Speech-Language 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hemochromatosis"},"short":null,"url":null,"abstract":{"de":null,"en":null},"begin_planned":"2015-10-01T02:00:00+02:00","begin_effective":"2015-10-01T02:00:00+02:00","end_planned":"2016-10-31T01:00:00+01:00","end_effective":"2021-10-31T02:00:00+02:00","assignment":"2016-02-02T09:46:50+01:00","program":null,"subprogram":null,"organization":14080,"category":10,"type":10,"partner_function":4,"manager":71449,"contact":null,"status":2,"research":4,"grant":10,"event":null,"study":null,"language":null,"funders":[1565],"funder_projectcode":null,"ethics_committee":null,"edudract_number":null,"persons":["4263-71449-10"]},{"id":4184,"title":{"de":"Kohlendioxid (CO2) in der Anpassungsphase unmittelbar nach\r\nder Geburt: Verlauf und Einfluss auf den Sauerstoffgehalt des Gehirns\r\n- eine prospektive Beobachtungsstudie","en":"Carbondioxid (CO2) during immediate transition after birth: course and influence on cerebral oxygenation\r\n- a prospective observational study\r\n"},"short":null,"url":null,"abstract":{"de":null,"en":null},"begin_planned":"2015-10-01T02:00:00+02:00","begin_effective":"2015-10-01T02:00:00+02:00","end_planned":"2016-10-01T02:00:00+02:00","end_effective":"2016-12-31T01:00:00+01:00","assignment":"2015-12-09T13:03:30+01:00","program":null,"subprogram":"Kulturamt Stadt Graz","organization":14094,"category":10,"type":10,"partner_function":4,"manager":50907,"contact":null,"status":2,"research":4,"grant":10,"event":null,"study":null,"language":null,"funders":[457],"funder_projectcode":null,"ethics_committee":null,"edudract_number":null,"persons":["4184-50907-10"]},{"id":4032,"title":{"de":"Imaging mit Nuclear Quadrupole Enhanced Relaxation","en":"Contrast by Nuclear Quadrupole Enhanced 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","en":"Personalised Risk assessment in febrile illness to Optimise Real-life Management across the European Union"},"short":"Perform ","url":null,"abstract":{"de":null,"en":null},"begin_planned":"2015-12-01T01:00:00+01:00","begin_effective":"2016-01-01T01:00:00+01:00","end_planned":"2020-11-30T01:00:00+01:00","end_effective":"2020-12-31T01:00:00+01:00","assignment":"2015-12-15T12:17:03+01:00","program":109,"subprogram":"Health Call: H2020-PHC-2015-two-stage.","organization":14091,"category":10,"type":10,"partner_function":2,"manager":null,"contact":null,"status":2,"research":1,"grant":10,"event":null,"study":null,"language":null,"funders":[10],"funder_projectcode":"668303","ethics_committee":null,"edudract_number":null,"persons":["4196-54004-12","4196-62056-12"]},{"id":4054,"title":{"de":"Fetales Geschlecht beeinflusst die endotheliale Funktion","en":"Fetal sex regulates endothelial function"},"short":null,"url":null,"abstract":{"de":null,"en":null},"begin_planned":"2016-01-01T01:00:00+01:00","begin_effective":"2016-01-01T01:00:00+01:00","end_planned":"2017-09-30T02:00:00+02:00","end_effective":"2019-09-30T02:00:00+02:00","assignment":"2015-07-08T17:02:32+02:00","program":79,"subprogram":null,"organization":14038,"category":10,"type":10,"partner_function":4,"manager":71568,"contact":null,"status":2,"research":1,"grant":10,"event":null,"study":null,"language":null,"funders":[12],"funder_projectcode":null,"ethics_committee":null,"edudract_number":null,"persons":["4054-71568-10"]},{"id":4164,"title":{"de":"Regulation der Eosinophilen Funktion durch kurzkettige Fettsäuren und deren Rezeptoren FFA2 und FFA3","en":"Regulation of eosinophil function by short chain fatty acids and their receptors FFA2 and FFA3"},"short":null,"url":null,"abstract":{"de":null,"en":null},"begin_planned":"2016-01-01T01:00:00+01:00","begin_effective":"2016-01-01T01:00:00+01:00","end_planned":"2018-12-31T01:00:00+01:00","end_effective":"2018-12-31T01:00:00+01:00","assignment":"2015-11-23T12:06:05+01:00","program":null,"subprogram":null,"organization":14022,"category":10,"type":10,"partner_function":4,"manager":null,"contact":null,"status":2,"research":1,"grant":10,"event":null,"study":null,"language":null,"funders":[15],"funder_projectcode":null,"ethics_committee":null,"edudract_number":null,"persons":[]},{"id":4191,"title":{"de":"Ultraschall basiertes Absetzen von Biologika bei Rheumatoider Arthritis","en":"Ultrasound based withdrawal of biologics in Rheumatoid 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